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Jens Christian Schwamborn

Jens Christian Schwamborn

Professor

Research Topics Parkinson's disease, Systems Biomedicine, Stem Cells, Neurogenesis, Regeneration
Faculty or Centre Faculté des Sciences, de la Technologie et de la Communication
Research Unit Sciences de la Vie
Postal Address Université du Luxembourg
6, avenue du Swing
L-4367 Belvaux
Campus Office BioTech II, 3.16
Email
Telephone (+352) 46 66 44 5536
Fax (+352) 46 66 44 35536
Video Prof. Dr. Jens Schwamborn
Prof. Dr. Jens Schwamborn
 
Prof. Dr. Jens Schwamborn (LCSB)

Principal Investigator in the Developmental & Cellular Biology group (Schwamborn Lab)

Last updated on: Monday, 26 January 2015

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2016

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See detailProx1 is required for oligodendrocyte cell identity in adult neural stem cells of the subventricular zone
Bunk, Eva; Ertaylan, Goekhan; Ortega, Felipe; Pavlou, Maria; Gonzalez Cano, Laura; Stergiopoulos, Athanasios; Safaiyan, Shima; Voels, Sandra; van Cann, Marianne; Politis, Panagiotis; Berninger, Benedikt; del Sol Mesa, Antonio; Schwamborn, Jens Christian

in Stem Cells (2016)

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See detail6-hydroxydopamine-induced Parkinson's disease-like degeneration generates acute micro- and astrogliosis in the nigrostriatal system but no Bioluminescence Imaging detectable alteration in adult neurogenesis
Fricke, Inga; Viel, Thomas; Worlitzer, Maik; Collmann, Franziska; Vrachimis, Alexis; Faust, Andreas; Wachsmuth, Lydia; Faber, Cornelius; Dolle, Frederic; Kuhlmann, Michael; Schaefers, Klaus; Hermann, Sven; Schwamborn, Jens Christian; Jacobs, Andreas

in European Journal of Neuroscience (2016)

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See detailUtilization of stem cells to model Parkinson's disease – current state and future challenges
Hillje, Anna-Lena; Schwamborn, Jens Christian

in Future Neurology (2016)

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See detailExpression of the Parkinson’s Disease-Associated Gene Alpha-Synuclein is Regulated by the Neuronal Cell Fate Determinant TRIM32
Pavlou, Maria; Colombo, Nicolo; Fuertes-Alvarez, Sanda; Nicklas, Sarah; Gonzalez Cano, Laura; Marin, Maria; Goncalves, Jorge; Schwamborn, Jens Christian

in Molecular Neurobiology (2016)

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2015

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See detailTRIM32 modulates pluripotency entry and exit by directly regulating Oct4 stability
Bahnassawy, Lamia’a; Perumal, Thanneer; Gonzalez Cano, Laura; Hillje, Anna-Lena; Taher, Leila; Makalowski, Wojciech; Suzuki, Yutaka; Fuellen, Georg; del Sol Mesa, Antonio; Schwamborn, Jens Christian

in Scientific Reports (2015)

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See detailTRIM32 Senses and Restricts Influenza A Virus by Ubiquitination of PB1 Polymerase
Bishi; Wang, Lingyan; Ding, Hao; Schwamborn, Jens Christian; Li, Shitao; Dorf, Martin

in PLoS Pathogens (2015)

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See detailTripartite Containing Motif 32 Modulates Proliferation of Human Neural Precursor Cells in HIV-1 Neurodegeneration
Fatima, Mahar; Kumari, Rina; Schwamborn, Jens Christian; Mahadevan, Anita; Shankar, Susarla; Raja, R; Seth, Pankaj

in Cell Death & Differentiation (2015)

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See detailThe neural stem cell fate determinant TRIM32 regulates complex behavioral traits
Hillje, Anna-Lena; Beckmann, Elisabeth; Pavlou, Maria Angeliki; Jäger, Christian; Pacheco, Maria Irene; Sauter, Thomas; Schwamborn, Jens Christian; Lewejohann, Lars

in Frontiers in Cellular Neuroscience (2015)

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See detailNeural stem cells in Parkinson’s disease: a role for neurogenesis defects in onset and progression
Le Grand, Jaclyn Nicole; Gonzalez Cano, Laura; Pavlou, Maria Angeliki; Schwamborn, Jens Christian

in Cellular and Molecular Life Sciences : CMLS (2015)

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See detailDifferentiation of neuroepithelial stem cells into functional dopaminergic neurons in 3D microfluidic cell culture
Lucumi Moreno, Edinson; Hachi, Siham; Hemmer, Kathrin; Trietsch, Sebastian; Baumuratov, Aidos; Hankemeier, Thomas; Vulto, Paul; Schwamborn, Jens Christian; Fleming, Ronan MT

in Lab on a Chip - Miniaturisation for Chemistry & Biology (2015), 15

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See detailThe RNA helicase DDX6 regulates cell-fate specification in neural stem cells via miRNAs
Nicklas, Sarah; Okawa, Satoshi; Hillje, Anna-Lena; Gonzalez Cano, Laura; del Sol Mesa, Antonio; Schwamborn, Jens Christian

in Nucleic Acids Research (2015)

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See detailRapid and robust generation of long-term self-renewing human neural stem cells with the ability to generate mature astroglia
Palm, Thomas; Bolognin, Silvia; Meiser, Johannes; Nickels, Sarah Louise; Traeger, Claudia; Meilenbrock, Ralf-Leslie; Brockhaus, Johannes; Streitmueller, Miriam; Missler, Markus; Schwamborn, Jens Christian

in Scientific Reports (2015), 5

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2014

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See detailGene regulatory network analysis reveals differences in site-specific cell fate determination in mammalian brain
Ertaylan, Gökhan; Okawa, Satoshi; Schwamborn, Jens Christian; del Sol Mesa, Antonio

in Frontiers in Cellular Neuroscience (2014)

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See detailOrigin-Dependent Neural Cell Identities in Differentiated Human iPSCs In Vitro and after Transplantation into the Mouse Brain
Hargus, Gunnar; Ehrlicher, Marc; Arauzo-Bravo, Marcos; Hemmer, Kathrin; Hallmann, Anna-Lena; Reinhardt, Peter; Kee-Pyo, Kim; Adachi, Kenjiro; Santourlidis; Ghanjati, Foued; Fauser, Mareike; Ossig, Christiana; Storch; Kim, Jeong Beom; Schwamborn, Jens Christian; Sterneckert, Jared; Schoeler, Hans; Kuhlmann, Tanja; Zaehres, Holm

in Cell Reports (2014)

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See detailInduced Neural Stem Cells Achieve Long-Term Survival and Functional Integration in the Adult Mouse Brain
Hemmer, Kathrin; Zhang, Mingyue; van Wuellen, Thea; Sakalem, Marna; Tapia, Natalia; Baumuratov, Aidos; Kaltschmidt, Christian; Kaltschmidt, Barbara; Schoeler, Hans R.; Zhang, Weiqi; Schwamborn, Jens Christian

in Stem Cell Reports (2014)

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2013

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See detailThe Parkinson's Disease-Associated LRRK2 Mutation R1441G Inhibits Neuronal Differentiation of Neural Stem Cells.
Bahnassawy, Lamia A; Nicklas, Sarah; Palm, Thomas; Menzl, Ingeborg; Birzele, Fabian; Gillardon, Frank; Schwamborn, Jens Christian

in Stem Cells & Development (2013)

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See detailRegulatory feedback loop between TP73 and TRIM32.
Gonzalez-Cano, L.; Hillje, Anna-Lena; Fuertes-Alvarez, S.; Marques, M. M.; Blanch, A.; Ian, R. W.; Irwin, M. S.; Schwamborn, Jens Christian; Marin, M. C.

in Cell Death & Disease (2013), 4

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See detailTRIM32-dependent transcription in adult neural progenitor cells regulates neuronal differentiation
Hillje, Anna-Lena; Pavlou, Maria Angeliki; Beckmann, Elisabeth; Worlitzer, Maik; Bahnassawy, Lamiaa; Lewejohann, Lars; Palm, Thomas; Schwamborn, Jens Christian

in Cell Death & Disease (2013)

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See detailA systemic transcriptome analysis reveals the regulation of neural stem cell maintenance by an E2F1-miRNA feedback loop.
Palm, Thomas; Hemmer, Kathrin; Winter, Julia; Fricke, Inga B.; Tarbashevich, Katsiaryna; Sadeghi Shakib, Fereshteh; Rudolph, Ina-Maria; Hillje, Anna-Lena; De Luca, Paola; Bahnassawy, Lamia A; Madel, Rabea; Viel, Thomas; De Siervi, Adriana; Jacobs, Andreas H.; Diederichs, Sven; Schwamborn, Jens Christian

in Nucleic Acids Research (2013), 41(6), 3699-712

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See detailDerivation and expansion using only small molecules of human neural progenitors for neurodegenerative disease modeling.
Reinhardt, Peter; Glatza, Michael; Hemmer, Kathrin; Tsytsyura, Yaroslav; Thiel, Cora S.; Hoing, Susanne; Moritz, Soren; Parga, Juan A.; Wagner, Lydia; Bruder, Jan M.; Wu, Guangming; Schmid, Benjamin; Ropke, Albrecht; Klingauf, Jurgen; Schwamborn, Jens Christian; Gasser, Thomas; Scholer, Hans R.; Sterneckert, Jared

in PLoS ONE (2013), 8(3), 59252

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2012

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See detailDirect reprogramming of fibroblasts into neural stem cells by defined factors.
Han, Dong Wook; Tapia, Natalia; Hermann, Andreas; Hemmer, Kathrin; Hoing, Susanne; Arauzo-Bravo, Marcos J.; Zaehres, Holm; Wu, Guangming; Frank, Stefan; Moritz, Soren; Greber, Boris; Yang, Ji Hun; Lee, Hoon Taek; Schwamborn, Jens Christian; Storch, Alexander; Scholer, Hans R.

in Cell stem cell (2012), 10(4), 465-72

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See detailDiscovery of inhibitors of microglial neurotoxicity acting through multiple mechanisms using a stem-cell-based phenotypic assay.
Hoing, Susanne; Rudhard, York; Reinhardt, Peter; Glatza, Michael; Stehling, Martin; Wu, Guangming; Peiker, Christiane; Bocker, Alexander; Parga, Juan A.; Bunk, Eva; Schwamborn, Jens Christian; Slack, Mark; Sterneckert, Jared; Scholer, Hans R.

in Cell stem cell (2012), 11(5), 620-32

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See detailRegrowing the adult brain: NF-kappaB controls functional circuit formation and tissue homeostasis in the dentate gyrus.
Imielski, Yvonne; Schwamborn, Jens Christian; Luningschror, Patrick; Heimann, Peter; Holzberg, Magdalena; Werner, Hendrikje; Leske, Oliver; Puschel, Andreas W.; Memet, Sylvie; Heumann, Rolf; Israel, Alain; Kaltschmidt, Christian; Kaltschmidt, Barbara

in PLoS ONE (2012), 7(2), 30838

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See detailAbundant occurrence of basal radial glia in the subventricular zone of embryonic neocortex of a lissencephalic primate, the common marmoset Callithrix jacchus.
Kelava, Iva; Reillo, Isabel; Murayama, Ayako Y.; Kalinka, Alex T.; Stenzel, Denise; Tomancak, Pavel; Matsuzaki, Fumio; Lebrand, Cecile; Sasaki, Erika; Schwamborn, Jens Christian; Okano, Hideyuki; Huttner, Wieland B.; Borrell, Victor

in Cerebral Cortex (2012), 22(2), 469-81

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See detailTRIM32 regulates skeletal muscle stem cell differentiation and is necessary for normal adult muscle regeneration.
Nicklas, Sarah; Otto, Anthony; Wu, Xiaoli; Miller, Pamela; Stelzer, Sandra; Wen, Yefei; Kuang, Shihuan; Wrogemann, Klaus; Patel, Ketan; Ding, Hao; Schwamborn, Jens Christian

in PLoS ONE (2012), 7(1), 30445

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See detailMiRNAs and neural stem cells: a team to treat Parkinson's disease?
Palm, Thomas; Bahnassawy, Lamia A; Schwamborn, Jens Christian

in RNA Biology (2012), 9(6), 720-30

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See detailJAM-C is an apical surface marker for neural stem cells.
Stelzer, Sandra; Worlitzer, Maik M. A.; Bahnassawy, Lamia A; Hemmer, Kathrin; Rugani, Kirite; Werthschulte, Inga; Schon, Anna-Lena; Brinkmann, Benjamin F.; Bunk, Eva C.; Palm, Thomas; Ebnet, Klaus; Schwamborn, Jens Christian

in Stem Cells & Development (2012), 21(5), 757-66

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See detailInduced pluripotent stem cells generated from adult bone marrow-derived cells of the nonhuman primate (Callithrix jacchus) using a novel quad-cistronic and excisable lentiviral vector.
Wiedemann, Anastasia; Hemmer, Kathrin; Bernemann, Inga; Gohring, Gudrun; Pogozhykh, Olena; Figueiredo, Constanca; Glage, Silke; Schambach, Axel; Schwamborn, Jens Christian; Blasczyk, Rainer; Muller, Thomas

in Cellular reprogramming (2012), 14(6), 485-96

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See detailAnti-inflammatory treatment induced regenerative oligodendrogenesis in parkinsonian mice.
Worlitzer, Maik Ma; Bunk, Eva C.; Hemmer, Kathrin; Schwamborn, Jens Christian

in Stem cell research & therapy (2012), 3(4), 33

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2011

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See detailCellular organization of adult neurogenesis in the Common Marmoset.
Bunk, Eva C.; Stelzer, Sandra; Hermann, Sven; Schafers, Michael; Schlatt, Stefan; Schwamborn, Jens Christian

in Aging Cell (2011), 10(1), 28-38

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See detailNeural stem cells maintain their stemness through protein kinase C zeta-mediated inhibition of TRIM32.
Hillje, Anna-Lena; Worlitzer, Maik M. A.; Palm, Thomas; Schwamborn, Jens Christian

in Stem cells (Dayton, Ohio) (2011), 29(9), 1437-47

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See detailThe E3-ubiquitin ligase TRIM2 regulates neuronal polarization.
Khazaei, Mohammad R.; Bunk, Eva C.; Hillje, Anna-Lena; Jahn, Hannah M.; Riegler, Eva M.; Knoblich, Jurgen A.; Young, Peter; Schwamborn, Jens Christian

in Journal of Neurochemistry (2011), 117(1), 29-37

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2010

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See detailBrain tumor stem cells.
Palm, Thomas; Schwamborn, Jens Christian

in Biological Chemistry (2010), 391(6), 607-17

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See detailJAM-A is a novel surface marker for NG2-Glia in the adult mouse brain.
Stelzer, Sandra; Ebnet, Klaus; Schwamborn, Jens Christian

in BMC Neuroscience (2010), 11

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2009

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See detailThe stimulation of dendrite growth by Sema3A requires integrin engagement and focal adhesion kinase.
Schlomann, Uwe; Schwamborn, Jens Christian; Muller, Myriam; Fassler, Reinhard; Puschel, Andreas W.

in Journal of Cell Science (2009), 122(Pt 12), 2034-42

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See detailThe TRIM-NHL protein TRIM32 activates microRNAs and prevents self-renewal in mouse neural progenitors.
Schwamborn, Jens Christian; Berezikov, Eugene; Knoblich, Juergen A.

in Cell (2009), 136(5), 913-25

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2008

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See detailLIS1 and spindle orientation in neuroepithelial cells.
Schwamborn, Jens Christian; Knoblich, Juergen A.

in Cell stem cell (2008), 2(3), 193-4

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2007

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See detailElongation of axons during regeneration involves retinal crystallin beta b2 (crybb2).
Liedtke, Thomas; Schwamborn, Jens Christian; Schroer, Uwe; Thanos, Solon

in Molecular & cellular proteomics : MCP (2007), 6(5), 895-907

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2006

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See detailGTPases and the control of neuronal polarity.
Schwamborn, Jens Christian; Li, Yinghua; Puschel, Andreas W.

in Methods in Enzymology (2006), 406

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2004

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See detailSemaphorin 3A stimulates neurite extension and regulates gene expression in PC12 cells.
Schwamborn, Jens Christian; Fiore, Roberto; Bagnard, Dominique; Kappler, Joachim; Kaltschmidt, Christian; Puschel, Andreas W.

in Journal of Biological Chemistry (2004), 279(30), 30923-6

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See detailThe sequential activity of the GTPases Rap1B and Cdc42 determines neuronal polarity.
Schwamborn, Jens Christian; Puschel, Andreas W.

in Nature Neuroscience (2004), 7(9), 923-9

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2003

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See detailMicroarray analysis of tumor necrosis factor alpha induced gene expression in U373 human glioblastoma cells.
Schwamborn, Jens Christian; Lindecke, Antje; Elvers, Margitta; Horejschi, Volker; Kerick, Martin; Rafigh, Mehran; Pfeiffer, Julia; Prullage, Maria; Kaltschmidt, Barbara; Kaltschmidt, Christian

in BMC Genomics (2003), 4(1), 46

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