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Rejko Krüger

Rejko Krüger

Professor

Academic Area(s) Neurology / Multidisciplinary, general & others
Research Topics Neurodegenerative Diseases, Functional Neurogenomics, Clinical Neuroscience
Faculty or Centre Luxembourg Centre for Systems Biomedicine
Research Unit Sciences de la Vie
Postal Address Université du Luxembourg
6, avenue du Swing
L-4367 Belvaux
Campus Office BioTech II, 3.18
Email
Telephone (+352) 46 66 44 5401
Fax (+352) 46 66 44 35401
Social Media & Blogs
Video Prof. Dr. Rejko Krüger (LCSB)
Prof. Dr. Rejko Krüger (LCSB)
Speaks English, French, German
Research Stays in France
 
Prof. Dr. Rejko Krüger (LCSB)

Principal Investigator in the Clinical & Experimental Neuroscience group (Krüger Lab)

Last updated on: Wednesday, 05 August 2015

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2016

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See detailMitochondrial Defects and Neurodegeneration in Mice Overexpressing Wild Type or G399S Mutant HtrA2
Casadei, Nicolas; Sood, Poonan; Ulrich, Thomas; Kieper, Nicole; Helling, Stefan; May, Caroline; Glaab, Enrico; Chen, Jing; Nuber, Silke; Marcus, Katrin; Rapaport, Doron; Ott, Thomas; Riess, O.; Krüger, Rejko; Fitzgerald, Julia

in Human Molecular Genetics (2016), 25(3), 459-71

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See detailCost-Effectiveness of Neurostimulation in Parkinson's Disease With Early Motor Complications
Dams, J; Balzer-Geldsetzer, M; Siebert, U; Deuschl, G; Schuepbach, W.M.; Krack, P; Timmermann, L; Schnitzler, A; Reese, J-P; Dodel, R; Krüger, Rejko; EARLYSTIM-investigators

in Movement Disorders : Official Journal of the Movement Disorder Society (2016), 31(8), 1183-1191

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See detailProdromal Markers in Parkinson's Disease: Limitations in Longitudinal Studies and Lessons Learned.
Heinzel, S.; Roeben, B.; Ben-Shlomo, Y.; Lerche, S.; Alves, G.; Barone, P.; Behnke, S.; Berendse, H. W.; Bloem, B. R.; Burn, D.; Dodel, R.; Grosset, D. G.; Hu, M.; Kasten, M.; Krüger, Rejko; Moccia, M.; Mollenhauer, B.; Oertel, W.; Suenkel, U.; Walter, U.; Wirdefeldt, K.; Liepelt-Scarfone, I.; Maetzler, W.; Berg, D.

in Frontiers in aging neuroscience (2016), 8

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See detailGuidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
Klionsky, D.; Krüger, Rejko; et al.

in Autophagy (2016), 12(1), 1-222

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See detailAdvanced stages of PD: interventional therapies and related patient-centered care
Krüger, Rejko; Hilker, Rudiger; Winkler, Christian; Lorrain, Michael; Hahne, Matthias; Redecker, Christoph; Lingor, Paul; Jost, Wolfgang H.

in Journal of neural transmission (Vienna, Austria : 1996) (2016)

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See detailAiming for Study Comparability in Parkinson's Disease: Proposal for a Modular Set of Biomarker Assessments to be Used in Longitudinal Studies.
Lerche, S.; Heinzel, S.; Alves, G. W.; Barone, P.; Behnke, S.; Ben-Shlomo, Y.; Berendse, H.; Bloem, B. R.; Burn, D.; Dodel, R.; Grosset, D. G.; Hipp, G.; Hu, M. T.; Kasten, M.; Krüger, Rejko; Liepelt-Scarfone, I.; Maetzler, W.; Moccia, M.; Mollenhauer, B.; Oertel, W.; Roeben, B.; Walter, U.; Wirdefeldt, K.; Berg, D.

in Frontiers in aging neuroscience (2016), 8

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See detailTragbare und aktiv vom Parkinson-Patienten genutzte Technologie im hauslichen Umfeld: Was bringt die Zukunft?
Maetzler, W.; Krüger, Rejko; Muller, T.; Oertel, W.; Urban, P.; Warnecke, T.; Klucken, J.

in Fortschritte der Neurologie-Psychiatrie (2016), 84 Suppl 1

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See detailLoss of DJ-1 impairs antioxidant response by altered glutamine and serine metabolism
Meiser, Johannes; Delcambre, Sylvie; Wegner, André; Jäger, Christian; Ghelfi, Jenny; Fouquier d'Hérouël, Aymeric; Dong, Xiangyi; Weindl, Daniel; Stautner, Constantin; Nonnenmacher, Yannic; Michelucci, Alessandro; Popp, Oliver; Giesert, Florian; Schildknecht, Stefan; Kraemer, Lisa; Schneider, Jochen G.; Woitalla, Dirk; Wurst, Wolfgang; Skupin, Alexander; Vogt Weisenhorn, Daniela M.; Krüger, Rejko; Leist, Marcel; Hiller, Karsten

in Neurobiology of disease (2016), 89

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See detailCortical correlates of susceptibility to upper limb freezing in Parkinson's disease.
Scholten, M.; Govindan, R. B.; Braun, C.; Bloem, B. R.; Plewnia, C.; Krüger, Rejko; Gharabaghi, A.; Weiss, D.

in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology (2016), 127(6), 2386-93

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See detailNeuromuscular correlates of subthalamic stimulation and upper limb freezing in Parkinson's disease.
Scholten, M.; Klotz, R.; Plewnia, C.; Wachter, T.; Mielke, C.; Bloem, B. R.; Braun, C.; Ziemann, U.; Govindan, R.B.; Gharabaghi, A.; Krüger, Rejko; Weiss, D.

in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology (2016)

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See detailAlpha-synuclein gene variants may predict neurostimulation outcome.
Weiss, D.; Herrmann, S.; Wang, Lin; Schulte, C.; Brockmann, K.; Plewnia, C.; Gasser, T.; Sharma, M.; Gharabaghi, A.; Krüger, Rejko

in Movement disorders : official journal of the Movement Disorder Society (2016)

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See detailMutation analyses and association studies to assess the role of the presenilin-associated rhomboid-like gene in Parkinson's disease
Wüst, Richard; Maurer, Brigitte; Hauser, Kathrin; Woitalla, Dirk; Sharma, Manu; Krüger, Rejko

in Neurobiology of Aging (2016), 39

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2015

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See detailShort- and long-term outcome of chronic pallidal neurostimulation in monogenic isolated dystonia
Bruggemann, N.; Kuhn, A.; Schneider, S. A.; Kamm, C.; Wolters, A.; Krause, P.; Moro, E.; Steigerwald, F.; Wittstock, M.; Tronnier, V.; Lozano, A. M.; Hamani, C.; Poon, Y. Y.; Zittel, S.; Wachter, T.; Deuschl, G.; Krüger, Rejko; Kupsch, A.; Munchau, A.; Lohmann, K.; Volkmann, J.; Klein, C.

in Neurology (2015), 84(9), 895-903

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See detailLow-bias phosphopeptide enrichment from scarce samples using plastic antibodies
Chen, Jing; Shinde, Sudhirkumar; Koch, Markus-Hermann; Eisenacher, Martin; Galozzi, Sara; Lerari, Thilo; Barkovits, Katalin; Subedi, Prabal; Krüger, Rejko; Kuhlmann, Katja; Sellergren, Borje; Helling, Stefan; Marcus, Katrin

in Scientific reports (2015), 5

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See detailMethods in Neuroepidemiology Characterization of European Longitudinal Cohort Studies in Parkinson's Disease - Report of the JPND Working Group BioLoC-PD
Lerche, S.; Liepelt-Scarfone, I.; Alves, G.; Barone, P.; Behnke, S.; Ben-Shlomo, Y.; Berendse, H.; Burn, D.; Dodel, R.; Grosset, D.; Heinzel, S.; Hu, M.; Kasten, M.; Krüger, Rejko; Maetzler, W.; Moccia, M.; Mollenhauer, B.; Oertel, W.; Roeben, B.; Sunkel, U.; Walter, U.; Wirdefeldt, K.; Berg, D.

in Neuroepidemiology (2015), 45(4), 282-297

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See detailInitiation and dose optimization for levodopa-carbidopa intestinal gel: Insights from phase 3 clinical trials
Lew, M. F.; Slevin, J. T.; Krüger, Rejko; Martinez, Castrillo; Chatamra, K.; Dubow, J. S.; Robieson, W. Z.; Benesh, J. A.; Fung, V. S.

in Parkinsonism & related disorders (2015), 21(7), 742-748

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See detailThe NG2 Proteoglycan Protects Oligodendrocyte Precursor Cells against Oxidative Stress via Interaction with OMI/HtrA2
Maus, F.; Sakry, D.; Biname, F.; Karram, K.; Rajalingam, K.; Watts, C.; Heywood, R.; Krüger, Rejko; Stegmuller, J.; Werner, H. B.; Nave, K. A.; Kramer-Albers, E. M.; Trotter, J.

in PLoS ONE (2015), 10(9), 0137311

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See detailThe COMT Val/Met polymorphism modulates effects of tDCS on response inhibition
Nieratschker, V.; Kiefer, C.; Giel, K.; Krüger, Rejko; Plewnia, C.

in Brain stimulation (2015), 8(2), 283-288

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See detailCollective physician perspectives on non-oral medication approaches for the management of clinically relevant unresolved issues in Parkinson's disease: Consensus from an international survey and discussion program
Odin, P.; Chaudhuri, K.R.; Slevin, J.T.; Volkmann, J.; Dietrichs, E.; Martinez-Martin, P.; Krauss, J.K.; Henriksen, T.; Katzenschlager, R.; Antonini, A.; Rascol, O.; Poewe, W.; Krüger, Rejko; National Steering Committees

in Parkinsonism & Related Disorders (2015)

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See detailTREM2 R47H variant and risk of essential tremor: a cross-sectional international multicenter study
Ortega-Cubero, S.; Lorenzo-Betancor, O.; Lorenzo, E.; Agundez, J. A.; Jimenez-Jimenez, F. J.; Ross, O. A.; Wurster, I.; Mielke, C.; Lin, J.J.; Coria, F.; Clarimon, J.; Ezquerra, M.; Brighina, L.; Annesi, G.; Alonso-Navarro, H.; Garcia-Martin, E.; Gironell, A.; Marti, M.J.; Yueh, K.C.; Wszolek, Z.K.; Sharma, M.; Berg, D.; Krüger, Rejko; Pastor, M.A.; Pastor, P.

in Parkinsonism & related disorders (2015), 21(3), 306-309

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See detailClinically meaningful parameters of progression and long-term outcome of Parkinson disease: An international consensus statement
Puschmann, A.; Brighina, L.; Markopoulou, K.; Aasly, J.; Chung, S. J.; Frigerio, R.; Hadjigeorgiou, G.; Koks, S.; Krüger, Rejko; Siuda, J.; Wider, C.; Zesiewicz, T. A.; Maraganore, D. M.

in Parkinsonism & related disorders (2015), 21(7), 675-682

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See detailLarge-scale assessment of polyglutamine repeat expansions in Parkinson disease
Wang, L.; Aasly, J. O.; Annesi, G.; Bardien, S.; Bozi, M.; Brice, A.; Carr, J.; Chung, S. J.; Clarke, C.; Crosiers, D.; Deutschlander, A.; Eckstein, G.; Farrer, M. J.; Goldwurm, S.; Garraux, G.; Hadjigeorgiou, G. M.; Hicks, A. A.; Hattori, N.; Klein, C.; Jeon, B.; Kim, Y. J.; Lesage, S.; Lin, J.J.; Lynch, T.; Lichtner, P.; Lang, A.E.; Mok, V.; Jasinska-Myga, B.; Mellick, G. D.; Morrison, K. E.; Opala, G.; Pihlstrom, L.; Pramstaller, P. P.; Park, S. S.; Quattrone, A.; Rogaeva, E.; Ross, O. A.; Stefanis, L.; Stockton, J. D.; Silburn, P. A.; Theuns, J.; Tan, E. K.; Tomiyama, H.; Toft, M.; Van Broeckhoven, C.; Uitti, R. J.; Wirdefeldt, K.; Wszolek, Z.; Xiromerisiou, G.; Yueh, K. C.; Zhao, Y.; Gasser, T.; Maraganore, D. M.; Krüger, Rejko; Sharma, M.

in Neurology (2015), 85(15), 1283-92

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See detailSubthalamic stimulation modulates cortical motor network activity and synchronization in Parkinson's disease
Weiss, D.; Klotz, R.; Govindan, R. B.; Scholten, M.; Naros, G.; Ramos-Murguialday, A.; Bunjes, F.; Meisner, C.; Plewnia, C.; Krüger, Rejko; Gharabaghi, A.

in Brain : a journal of neurology (2015), 138(Pt 3), 679-93

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See detailLong-term outcome of deep brain stimulation in fragile X-associated tremor/ataxia syndrome
Weiss, D.; Mielke, C.; Wachter, T.; Bender, B.; Liscic, R. M.; Scholten, M.; Naros, G.; Plewnia, C.; Gharabaghi, A.; Krüger, Rejko

in Parkinsonism & related disorders (2015), 21(3), 310-313

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2014

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See detailMitochondrial proteolytic stress induced by loss of mortalin function is rescued by Parkin and PINK1.
Burbulla, L. F.; Fitzgerald, J. C.; Stegen, K.; Westermeier, J.; Thost, A.-K.; Kato, H.; Mokranjac, D.; Sauerwald, J.; Martins, Luisa; Woitalla, D.; Rapaport, D.; Riess, O.; Proikas-Cezanne, T.; Rasse, T. M.; Krüger, Rejko

in Cell death & disease (2014), 5

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See detailOverexpression of synphilin-1 promotes clearance of soluble and misfolded alpha-synuclein without restoring the motor phenotype in aged A30P transgenic mice.
Casadei, Nicolas; Pohler, Anne-Maria; Tomas-Zapico, Cristina; Torres-Peraza, Jesus; Schwedhelm, Ivo; Witz, Annemarie; Zamolo, Irina; De Heer, Raymond; Spruijt, Berry; Noldus, Lucas P. J. J.; Klucken, Jochen; Lucas, Jose J.; Kahle, Philipp J.; Krüger, Rejko; Riess, Olaf; Nuber, Silke

in Human molecular genetics (2014), 23(3), 767-81

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See detailAlpha-synuclein repeat variants and survival in Parkinson's disease.
Chung, Sun Ju; Biernacka, Joanna M.; Armasu, Sebastian M.; Anderson, Kari; Frigerio, Roberta; Aasly, Jan O.; Annesi, Grazia; Bentivoglio, Anna Rita; Brighina, Laura; Chartier-Harlin, Marie-Christine; Goldwurm, Stefano; Hadjigeorgiou, Georgios; Jasinska-Myga, Barbara; Jeon, Beom Seok; Kim, Yun Joong; Krüger, Rejko; Lesage, Suzanne; Markopoulou, Katerina; Mellick, George; Morrison, Karen E.; Puschmann, Andreas; Tan, Eng-King; Crosiers, David; Theuns, Jessie; Van Broeckhoven, Christine; Wirdefeldt, Karin; Wszolek, Zbigniew K.; Elbaz, Alexis; Maraganore, Demetrius M.

in Movement disorders : official journal of the Movement Disorder Society (2014)

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See detailProtective effect of LRRK2 p.R1398H on risk of Parkinson's disease is independent of MAPT and SNCA variants.
Heckman, Michael G.; Elbaz, Alexis; Soto-Ortolaza, Alexandra I.; Serie, Daniel J.; Aasly, Jan O.; Annesi, Grazia; Auburger, Georg; Bacon, Justin A.; Boczarska-Jedynak, Magdalena; Bozi, Maria; Brighina, Laura; Chartier-Harlin, Marie-Christine; Dardiotis, Efthimios; Destee, Alain; Ferrarese, Carlo; Ferraris, Alessandro; Fiske, Brian; Gispert, Suzana; Hadjigeorgiou, Georgios M.; Hattori, Nobutaka; Ioannidis, John P. A.; Jasinska-Myga, Barbara; Jeon, Beom S.; Kim, Yun Joong; Klein, Christine; Krüger, Rejko; Kyratzi, Elli; Lin, Chin-Hsien; Lohmann, Katja; Loriot, Marie-Anne; Lynch, Timothy; Mellick, George D.; Mutez, Eugenie; Opala, Grzegorz; Park, Sung Sup; Petrucci, Simona; Quattrone, Aldo; Sharma, Manu; Silburn, Peter A.; Sohn, Young Ho; Stefanis, Leonidas; Tadic, Vera; Tomiyama, Hiroyuki; Uitti, Ryan J.; Valente, Enza Maria; Vassilatis, Demetrios K.; Vilarino-Guell, Carles; White, Linda R.; Wirdefeldt, Karin; Wszolek, Zbigniew K.; Wu, Ruey-Meei; Xiromerisiou, Georgia; Maraganore, Demetrius M.; Farrer, Matthew J.; Ross, Owen A.

in Neurobiology of aging (2014), 35(1), 2665-14

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See detailEIF4G1 is neither a strong nor a common risk factor for Parkinson's disease: evidence from large European cohorts
Huttenlocher, Johanna; Krüger, Rejko; Capetian, Philipp; Lohmann, Katja; Brockmann, Kathrin; Csoti, Ilona; Klein, Christine; Berg, Daniela; Gasser, Thomas; Bonin, Michael; Riess, Olaf; Bauer, Peter

in Journal of medical genetics (2014), 0

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See detailComparison of beamformers for EEG source signal reconstruction
Jonmohamadi, Yaqub; Poudel; Innes, Carrie; Weiss, Daniel; Krüger, Rejko; Jones, Richard

in Biomedical Signal Processing and Control (2014), 14

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See detailFrom genome-wide association studies to next-generation sequencing: lessons from the past and planning for the future.
Sharma, Manu; Krüger, Rejko; Gasser, Thomas

in JAMA neurology (2014), 71(1), 5-6

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See detailMutant COQ2 in multiple-system atrophy.
Sharma, Manu; Wenning, Gregor; Krüger, Rejko

in The New England journal of medicine (2014), 371(1), 80-1

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See detailGlobal investigation and meta-analysis of the C9orf72 (G4C2)n repeat in Parkinson disease.
Theuns, Jessie; Verstraeten, Aline; Sleegers, Kristel; Wauters, Eline; Gijselinck, Ilse; Smolders, Stefanie; Crosiers, David; Corsmit, Ellen; Elinck, Ellen; Sharma, Manu; Krüger, Rejko; Lesage, Suzanne; Brice, Alexis; Chung, Sun Ju; Kim, Mi-Jung; Kim, Young Jin; Ross, Owen A.; Wszolek, Zbigniew K.; Rogaeva, Ekaterina; Xi, Zhengrui; Lang, Anthony E.; Klein, Christine; Weissbach, Anne; Mellick, George D.; Silburn, Peter A.; Hadjigeorgiou, Georgios M.; Dardiotis, Efthimios; Hattori, Nobutaka; Ogaki, Kotaro; Tan, Eng-King; Zhao, Yi; Aasly, Jan; Valente, Enza Maria; Petrucci, Simona; Annesi, Grazia; Quattrone, Aldo; Ferrarese, Carlo; Brighina, Laura; Deutschlander, Angela; Puschmann, Andreas; Nilsson, Christer; Garraux, Gaetan; LeDoux, Mark S.; Pfeiffer, Ronald F.; Boczarska-Jedynak, Magdalena; Opala, Grzegorz; Maraganore, Demetrius M.; Engelborghs, Sebastiaan; De Deyn, Peter Paul; Cras, Patrick; Cruts, Marc; Van Broeckhoven, Christine

in Neurology (2014)

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See detailThe subthalamic nucleus modulates the early phase of probabilistic classification learning.
Weiss, Daniel; Lam, Judith M.; Breit, Sorin; Gharabaghi, Alireza; Krüger, Rejko; Luft, Andreas R.; Wachter, Tobias

in Experimental brain research (2014), 232(7), 2255-62

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2013

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See detailThe hallmarks of Parkinson's disease.
Antony, Paul; Diederich, Nico; Krüger, Rejko; Balling, Rudi

in FEBS Journal (2013)

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See detailA novel heterozygous OPA3 mutation located in the mitochondrial target sequence results in altered steady-state levels and fragmented mitochondrial network.
Grau, Tanja; Burbulla, Lena F.; Engl, Gertraud; Delettre, Cecile; Delprat, Benjamin; Oexle, Konrad; Leo-Kottler, Beate; Roscioli, Tony; Krüger, Rejko; Rapaport, Doron; Wissinger, Bernd; Schimpf-Linzenbold, Simone

in Journal of medical genetics (2013), 50(12), 848-58

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See detailPopulation-specific frequencies for LRRK2 susceptibility variants in the Genetic Epidemiology of Parkinson's Disease (GEO-PD) Consortium.
Heckman, Michael G.; Soto-Ortolaza, Alexandra I.; Aasly, Jan O.; Abahuni, Nadine; Annesi, Grazia; Bacon, Justin A.; Bardien, Soraya; Bozi, Maria; Brice, Alexis; Brighina, Laura; Carr, Jonathan; Chartier-Harlin, Marie-Christine; Dardiotis, Efthimios; Dickson, Dennis W.; Diehl, Nancy N.; Elbaz, Alexis; Ferrarese, Carlo; Fiske, Brian; Gibson, J. Mark; Gibson, Rachel; Hadjigeorgiou, Georgios M.; Hattori, Nobutaka; Ioannidis, John P. A.; Boczarska-Jedynak, Magdalena; Jasinska-Myga, Barbara; Jeon, Beom S.; Kim, Yun Joong; Klein, Christine; Krüger, Rejko; Kyratzi, Elli; Lesage, Suzanne; Lin, Chin-Hsien; Lynch, Timothy; Maraganore, Demetrius M.; Mellick, George D.; Mutez, Eugenie; Nilsson, Christer; Opala, Grzegorz; Park, Sung Sup; Petrucci, Simona; Puschmann, Andreas; Quattrone, Aldo; Sharma, Manu; Silburn, Peter A.; Sohn, Young Ho; Stefanis, Leonidas; Tadic, Vera; Theuns, Jessie; Tomiyama, Hiroyuki; Uitti, Ryan J.; Valente, Enza Maria; Van Broeckhoven, Christine; van de Loo, Simone; Vassilatis, Demetrios K.; Vilarino-Guell, Carles; White, Linda R.; Wirdefeldt, Karin; Wszolek, Zbigniew K.; Wu, Ruey-Meei; Hentati, Faycal; Farrer, Matthew J.; Ross, Owen A.

in Movement disorders : official journal of the Movement Disorder Society (2013), 28(12), 1740-4

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See detailDe novo mutations in hereditary diffuse leukoencephalopathy with axonal spheroids (HDLS).
Karle, Kathrin N.; Biskup, Saskia; Schule, Rebecca; Schweitzer, Katherine J.; Krüger, Rejko; Bauer, Peter; Bender, Benjamin; Nagele, Thomas; Schols, Ludger

in Neurology (2013), 81(23), 2039-44

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See detailEffects of transcranial direct current stimulation (tDCS) on executive functions: influence of COMT Val/Met polymorphism.
Plewnia, Christian; Zwissler, Bastian; Langst, Isabella; Maurer, Brigitte; Giel, Katrin; Krüger, Rejko

in Cortex; a journal devoted to the study of the nervous system and behavior (2013), 49(7), 1801-7

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See detailGenetic correction of a LRRK2 mutation in human iPSCs links parkinsonian neurodegeneration to ERK-dependent changes in gene expression.
Reinhardt, Peter; Schmid, Benjamin; Burbulla, Lena F.; Schondorf, David C.; Wagner, Lydia; Glatza, Michael; Hoing, Susanne; Hargus, Gunnar; Heck, Susanna A.; Dhingra, Ashutosh; Wu, Guangming; Muller, Stephan; Brockmann, Kathrin; Kluba, Torsten; Maisel, Martina; Krüger, Rejko; Berg, Daniela; Tsytsyura, Yaroslav; Thiel, Cora S.; Psathaki, Olympia-Ekaterini; Klingauf, Jurgen; Kuhlmann, Tanja; Klewin, Marlene; Muller, Heiko; Gasser, Thomas; Scholer, Hans R.; Sterneckert, Jared

in Cell stem cell (2013), 12(3), 354-67

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See detailNovel SLC9A6 mutations in two families with Christianson syndrome.
Riess, A.; Rossier, E.; Krüger, Rejko; Dufke, A.; Beck-Woedl, S.; Horber, V.; Alber, M.; Glaser, D.; Riess, O.; Tzschach, A.

in Clinical genetics (2013), 83(6), 596-7

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See detailNeurostimulation for Parkinson's disease with early motor complications.
Schuepbach, W. M. M.; Rau, J.; Knudsen, K.; Volkmann, J.; Krack, P.; Timmermann, L.; Halbig, T. D.; Hesekamp, H.; Navarro, S. M.; Meier, N.; Falk, D.; Mehdorn, M.; Paschen, S.; Maarouf, M.; Barbe, M. T.; Fink, G. R.; Kupsch, A.; Gruber, D.; Schneider, G.-H.; Seigneuret, E.; Kistner, A.; Chaynes, P.; Ory-Magne, F.; Brefel Courbon, C.; Vesper, J.; Schnitzler, A.; Wojtecki, L.; Houeto, J.-L.; Bataille, B.; Maltete, D.; Damier, P.; Raoul, S.; Sixel-Doering, F.; Hellwig, D.; Gharabaghi, A.; Krüger, Rejko; Pinsker, M. O.; Amtage, F.; Regis, J.-M.; Witjas, T.; Thobois, S.; Mertens, P.; Kloss, M.; Hartmann, A.; Oertel, W. H.; Post, B.; Speelman, H.; Agid, Y.; Schade-Brittinger, C.; Deuschl, G.

in The New England journal of medicine (2013), 368(7), 610-22

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See detailNigral stimulation for resistant axial motor impairment in Parkinson's disease? A randomized controlled trial.
Weiss, Daniel; Walach, Margarete; Meisner, Christoph; Fritz, Melanie; Scholten, Marlieke; Breit, Sorin; Plewnia, Christian; Bender, Benjamin; Gharabaghi, Alireza; Wachter, Tobias; Krüger, Rejko

in Brain : a journal of neurology (2013), 136(Pt 7), 2098-108

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See detailKnockdown of Hsc70-5/mortalin induces loss of synaptic mitochondria in a Drosophila Parkinson's disease model.
Zhu, Jun-Yi; Vereshchagina, Natalia; Sreekumar, Vrinda; Burbulla, Lena F.; Costa, Ana C.; Daub, Katharina J.; Woitalla, Dirk; Martins, Luisa; Krüger, Rejko; Rasse, Tobias M.

in PloS one (2013), 8(12), 83714

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2012

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See detailGuidelines for the use and interpretation of assays for monitoring autophagy.
Klionsky, Daniel J.; Abdalla, Fabio C.; Abeliovich, Hagai; Abraham, Robert T.; Acevedo-Arozena, Abraham; Adeli, Khosrow; Agholme, Lotta; Agnello, Maria; Agostinis, Patrizia; Aguirre-Ghiso, Julio A.; Ahn, Hyung Jun; Ait-Mohamed, Ouardia; Ait-Si-Ali, Slimane; Akematsu, Takahiko; Akira, Shizuo; Al-Younes, Hesham M.; Al-Zeer, Munir A.; Albert, Matthew L.; Albin, Roger L.; Alegre-Abarrategui, Javier; Aleo, Maria Francesca; Alirezaei, Mehrdad; Almasan, Alexandru; Almonte-Becerril, Maylin; Amano, Atsuo; Amaravadi, Ravi; Amarnath, Shoba; Amer, Amal O.; Andrieu-Abadie, Nathalie; Anantharam, Vellareddy; Ann, David K.; Anoopkumar-Dukie, Shailendra; Aoki, Hiroshi; Apostolova, Nadezda; Arancia, Giuseppe; Aris, John P.; Asanuma, Katsuhiko; Asare, Nana Y. O.; Ashida, Hisashi; Askanas, Valerie; Askew, David S.; Auberger, Patrick; Baba, Misuzu; Backues, Steven K.; Baehrecke, Eric H.; Bahr, Ben A.; Bai, Xue-Yuan; Bailly, Yannick; Baiocchi, Robert; Baldini, Giulia; Balduini, Walter; Ballabio, Andrea; Bamber, Bruce A.; Bampton, Edward T. W.; Banhegyi, Gabor; Bartholomew, Clinton R.; Bassham, Diane C.; Bast, Robert C. 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See detailThe use of primary human fibroblasts for monitoring mitochondrial phenotypes in the field of Parkinson's disease.
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See detailPhosphorylation of HtrA2 by cyclin-dependent kinase-5 is important for mitochondrial function.
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See detailThe modulation of Amyotrophic Lateral Sclerosis risk by ataxin-2 intermediate polyglutamine expansions is a specific effect.
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See detailLarge-scale replication and heterogeneity in Parkinson disease genetic loci.
Sharma, Manu; Ioannidis, John P. A.; Aasly, Jan O.; Annesi, Grazia; Brice, Alexis; Van Broeckhoven, Christine; Bertram, Lars; Bozi, Maria; Crosiers, David; Clarke, Carl; Facheris, Maurizio; Farrer, Matthew; Garraux, Gaetan; Gispert, Suzana; Auburger, Georg; Vilarino-Guell, Carles; Hadjigeorgiou, Georgios M.; Hicks, Andrew A.; Hattori, Nobutaka; Jeon, Beom; Lesage, Suzanne; Lill, Christina M.; Lin, Juei-Jueng; Lynch, Timothy; Lichtner, Peter; Lang, Anthony E.; Mok, Vincent; Jasinska-Myga, Barbara; Mellick, George D.; Morrison, Karen E.; Opala, Grzegorz; Pramstaller, Peter P.; Pichler, Irene; Park, Sung Sup; Quattrone, Aldo; Rogaeva, Ekaterina; Ross, Owen A.; Stefanis, Leonidas; Stockton, Joanne D.; Satake, Wataru; Silburn, Peter A.; Theuns, Jessie; Tan, Eng-King; Toda, Tatsushi; Tomiyama, Hiroyuki; Uitti, Ryan J.; Wirdefeldt, Karin; Wszolek, Zbigniew; Xiromerisiou, Georgia; Yueh, Kuo-Chu; Zhao, Yi; Gasser, Thomas; Maraganore, Demetrius; Krüger, Rejko

in Neurology (2012), 79(7), 659-67

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See detailLRRK2: Understanding the role of common and rare variants in Parkinson's disease.
Sharma, Manu; Krüger, Rejko; Gasser, Thomas

in Movement disorders : official journal of the Movement Disorder Society (2012), 27(4), 475

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See detailSubthalamic nucleus stimulation restores the efferent cortical drive to muscle in parallel to functional motor improvement.
Weiss, Daniel; Breit, Sorin; Hoppe, Julia; Hauser, Ann-Kathrin; Freudenstein, Dirk; Krüger, Rejko; Sauseng, Paul; Govindan, Rathinaswamy B.; Gerloff, Christian

in The European journal of neuroscience (2012), 35(6), 896-908

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See detailLong-term follow-up of subthalamic nucleus stimulation in glucocerebrosidase-associated Parkinson's disease.
Weiss, Daniel; Brockmann, Kathrin; Srulijes, Karin; Meisner, Christoph; Klotz, Rosa; Reinbold, Sophia; Hauser, Ann-Kathrin; Schulte, Claudia; Berg, Daniela; Gasser, Thomas; Plewnia, Christian; Gharabaghi, Alireza; Breit, Sorin; Wachter, Tobias; Krüger, Rejko

in Journal of neurology (2012), 259(9), 1970-2

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2011

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See detailEffects of subthalamic nucleus stimulation on emotional prosody comprehension in Parkinson's disease.
Bruck, Carolin; Wildgruber, Dirk; Kreifelts, Benjamin; Krüger, Rejko; Wachter, Tobias

in PloS one (2011), 6(4), 19140

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See detailConverging environmental and genetic pathways in the pathogenesis of Parkinson's disease.
Burbulla, Lena F.; Krüger, Rejko

in Journal of the neurological sciences (2011), 306(1-2), 1-8

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See detailIndependent and joint effects of the MAPT and SNCA genes in Parkinson disease.
Elbaz, Alexis; Ross, Owen A.; Ioannidis, John P. A.; Soto-Ortolaza, Alexandra I.; Moisan, Frederic; Aasly, Jan; Annesi, Grazia; Bozi, Maria; Brighina, Laura; Chartier-Harlin, Marie-Christine; Destee, Alain; Ferrarese, Carlo; Ferraris, Alessandro; Gibson, J. Mark; Gispert, Suzana; Hadjigeorgiou, Georgios M.; Jasinska-Myga, Barbara; Klein, Christine; Krüger, Rejko; Lambert, Jean-Charles; Lohmann, Katja; van de Loo, Simone; Loriot, Marie-Anne; Lynch, Timothy; Mellick, George D.; Mutez, Eugenie; Nilsson, Christer; Opala, Grzegorz; Puschmann, Andreas; Quattrone, Aldo; Sharma, Manu; Silburn, Peter A.; Stefanis, Leonidas; Uitti, Ryan J.; Valente, Enza Maria; Vilarino-Guell, Carles; Wirdefeldt, Karin; Wszolek, Zbigniew K.; Xiromerisiou, Georgia; Maraganore, Demetrius M.; Farrer, Matthew J.

in Annals of neurology (2011), 69(5), 778-92

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See detailA large-scale genetic association study to evaluate the contribution of Omi/HtrA2 (PARK13) to Parkinson's disease.
Krüger, Rejko; Sharma, Manu; Riess, Olaf; Gasser, Thomas; Van Broeckhoven, Christine; Theuns, Jessie; Aasly, Jan; Annesi, Grazia; Bentivoglio, Anna Rita; Brice, Alexis; Djarmati, Ana; Elbaz, Alexis; Farrer, Matthew; Ferrarese, Carlo; Gibson, J. Mark; Hadjigeorgiou, Georgios M.; Hattori, Nobutaka; Ioannidis, John P. A.; Jasinska-Myga, Barbara; Klein, Christine; Lambert, Jean-Charles; Lesage, Suzanne; Lin, Juei-Jueng; Lynch, Timothy; Mellick, George D.; de Nigris, Francesa; Opala, Grzegorz; Prigione, Alessandro; Quattrone, Aldo; Ross, Owen A.; Satake, Wataru; Silburn, Peter A.; Tan, Eng King; Toda, Tatsushi; Tomiyama, Hiroyuki; Wirdefeldt, Karin; Wszolek, Zbigniew; Xiromerisiou, Georgia; Maraganore, Demetrius M.

in Neurobiology of aging (2011), 32(3), 5489-18

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See detailOlfactory neuron-specific expression of A30P alpha-synuclein exacerbates dopamine deficiency and hyperactivity in a novel conditional model of early Parkinson's disease stages.
Nuber, Silke; Petrasch-Parwez, Elisabeth; Arias-Carrion, Oscar; Koch, Leanie; Kohl, Zacharias; Schneider, Jacqueline; Calaminus, Carsten; Dermietzel, Rolf; Samarina, Anna; Boy, Jana; Nguyen, Huu P.; Teismann, Peter; Velavan, Thirumalaisamy Palanichamy; Kahle, Philipp J.; von Horsten, Stephan; Fendt, Markus; Krüger, Rejko; Riess, Olaf

in Neurobiology of disease (2011), 44(2), 192-204

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See detailAssociation of LRRK2 exonic variants with susceptibility to Parkinson's disease: a case-control study.
Ross, Owen A.; Soto-Ortolaza, Alexandra I.; Heckman, Michael G.; Aasly, Jan O.; Abahuni, Nadine; Annesi, Grazia; Bacon, Justin A.; Bardien, Soraya; Bozi, Maria; Brice, Alexis; Brighina, Laura; Van Broeckhoven, Christine; Carr, Jonathan; Chartier-Harlin, Marie-Christine; Dardiotis, Efthimios; Dickson, Dennis W.; Diehl, Nancy N.; Elbaz, Alexis; Ferrarese, Carlo; Ferraris, Alessandro; Fiske, Brian; Gibson, J. Mark; Gibson, Rachel; Hadjigeorgiou, Georgios M.; Hattori, Nobutaka; Ioannidis, John P. A.; Jasinska-Myga, Barbara; Jeon, Beom S.; Kim, Yun Joong; Klein, Christine; Krüger, Rejko; Kyratzi, Elli; Lesage, Suzanne; Lin, Chin-Hsien; Lynch, Timothy; Maraganore, Demetrius M.; Mellick, George D.; Mutez, Eugenie; Nilsson, Christer; Opala, Grzegorz; Park, Sung Sup; Puschmann, Andreas; Quattrone, Aldo; Sharma, Manu; Silburn, Peter A.; Sohn, Young Ho; Stefanis, Leonidas; Tadic, Vera; Theuns, Jessie; Tomiyama, Hiroyuki; Uitti, Ryan J.; Valente, Enza Maria; van de Loo, Simone; Vassilatis, Demetrios K.; Vilarino-Guell, Carles; White, Linda R.; Wirdefeldt, Karin; Wszolek, Zbigniew K.; Wu, Ruey-Meei; Farrer, Matthew J.

in Lancet neurology (2011), 10(10), 898-908

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See detailSuppression of extrapyramidal side effects of doxepin by thalamic deep brain stimulation for Tourette syndrome.
Rzesnitzek, L.; Wachter, T.; Krüger, Rejko; Gharabaghi, A.; Plewnia, C.

in Neurology (2011), 77(18), 1708-9

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See detailRole of sepiapterin reductase gene at the PARK3 locus in Parkinson's disease.
Sharma, Manu; Maraganore, Demetrius M.; Ioannidis, John P. A.; Riess, Olaf; Aasly, Jan O.; Annesi, Grazia; Abahuni, Nadine; Bentivoglio, Anna Rita; Brice, Alexis; Van Broeckhoven, Christine; Chartier-Harlin, Marie-Christine; Destee, Alain; Djarmati, Ana; Elbaz, Alexis; Farrer, Matthew; Ferrarese, Carlo; Gibson, J. Mark; Gispert, Suzana; Hattori, Nobutaka; Jasinska-Myga, Barbara; Klein, Christine; Lesage, Suzanne; Lynch, Timothy; Lichtner, Peter; Lambert, Jean-Charles; Lang, Anthony E.; Mellick, George D.; De Nigris, Francesa; Opala, Grzegorz; Quattrone, Aldo; Riva, Chiara; Rogaeva, Ekaterina; Ross, Owen A.; Satake, Wataru; Silburn, Peter A.; Theuns, Jessie; Toda, Tatsushi; Tomiyama, Hiroyuki; Uitti, Ryan J.; Wirdefeldt, Karin; Wszolek, Zbigniew; Gasser, Thomas; Krüger, Rejko

in Neurobiology of aging (2011), 32(11), 21081-5

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See detailSlowly progressive Parkinson syndrome due to thalamic butterfly astrocytoma.
Wachter, T.; Engeholm, M.; Bisdas, S.; Schittenhelm, J.; Gasser, T.; Krüger, Rejko

in Neurology (2011), 77(4), 404-5

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See detailRapid emergence of temporal and pulvinar lesions in MELAS mimicking Creutzfeldt-Jakob disease.
Weiss, D.; Brockmann, K.; Nagele, T.; Gasser, T.; Krüger, Rejko

in Neurology (2011), 77(9), 914

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See detailCombined stimulation of the substantia nigra pars reticulata and the subthalamic nucleus is effective in hypokinetic gait disturbance in Parkinson's disease.
Weiss, Daniel; Breit, Sorin; Wachter, Tobias; Plewnia, Christian; Gharabaghi, Alireza; Krüger, Rejko

in Journal of neurology (2011), 258(6), 1183-5

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See detailCentral oscillators in a patient with neuropathic tremor: evidence from intraoperative local field potential recordings.
Weiss, Daniel; Govindan, Rathinaswamy B.; Rilk, Albrecht; Wachter, Tobias; Breit, Sorin; Zizlsperger, Leopold; Haarmeier, Thomas; Plewnia, Christian; Krüger, Rejko; Gharabaghi, Alireza

in Movement disorders : official journal of the Movement Disorder Society (2011), 26(2), 323-7

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See detailCombined STN/SNr-DBS for the treatment of refractory gait disturbances in Parkinson's disease: study protocol for a randomized controlled trial.
Weiss, Daniel; Wachter, Tobias; Meisner, Christoph; Fritz, Melanie; Gharabaghi, Alireza; Plewnia, Christian; Breit, Sorin; Krüger, Rejko

in Trials (2011), 12

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2010

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See detailEffective long-term subthalamic stimulation in PARK8 positive Parkinson's disease.
Breit, Sorin; Wachter, T.; Schmid-Bielenberg, D.; Weiss, D.; Leitner, P.; Nagele, T.; Freudenstein, D.; Gasser, T.; Krüger, Rejko

in Journal of neurology (2010), 257(7), 1205-7

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See detailBalance is the challenge--the impact of mitochondrial dynamics in Parkinson's disease.
Burbulla, Lena F.; Krebiehl, Guido; Krüger, Rejko

in European journal of clinical investigation (2010), 40(11), 1048-60

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See detailDissecting the role of the mitochondrial chaperone mortalin in Parkinson's disease: functional impact of disease-related variants on mitochondrial homeostasis.
Burbulla, Lena F.; Schelling, Carina; Kato, Hiroki; Rapaport, Doron; Woitalla, Dirk; Schiesling, Carola; Schulte, Claudia; Sharma, Manu; Illig, Thomas; Bauer, Peter; Jung, Stephan; Nordheim, Alfred; Schols, Ludger; Riess, Olaf; Krüger, Rejko

in Human molecular genetics (2010), 19(22), 4437-52

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See detailModulation of mitochondrial function and morphology by interaction of Omi/HtrA2 with the mitochondrial fusion factor OPA1.
Kieper, Nicole; Holmstrom, Kira M.; Ciceri, Dalila; Fiesel, Fabienne C.; Wolburg, Hartwig; Ziviani, Elena; Whitworth, Alexander J.; Martins, Luisa; Kahle, Philipp J.; Krüger, Rejko

in Experimental cell research (2010), 316(7), 1213-24

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See detailReduced basal autophagy and impaired mitochondrial dynamics due to loss of Parkinson's disease-associated protein DJ-1.
Krebiehl, Guido; Ruckerbauer, Sabine; Burbulla, Lena F.; Kieper, Nicole; Maurer, Brigitte; Waak, Jens; Wolburg, Hartwig; Gizatullina, Zemfira; Gellerich, Frank N.; Woitalla, Dirk; Riess, Olaf; Kahle, Philipp J.; Proikas-Cezanne, Tassula; Krüger, Rejko

in PloS one (2010), 5(2), 9367

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See detailTransgenic overexpression of the alpha-synuclein interacting protein synphilin-1 leads to behavioral and neuropathological alterations in mice.
Nuber, Silke; Franck, Thomas; Wolburg, Hartwig; Schumann, Ulrike; Casadei, Nicolas; Fischer, Kristina; Calaminus, Carsten; Pichler, Bernd J.; Chanarat, Sittinan; Teismann, Peter; Schulz, Jorg B.; Luft, Andreas R.; Tomiuk, Jurgen; Wilbertz, Johannes; Bornemann, Antje; Krüger, Rejko; Riess, Olaf

in Neurogenetics (2010), 11(1), 107-20

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See detailFirst appraisal of brain pathology owing to A30P mutant alpha-synuclein.
Seidel, Kay; Schols, Ludger; Nuber, Silke; Petrasch-Parwez, Elisabeth; Gierga, Kristin; Wszolek, Zbigniew; Dickson, Dennis; Gai, Wei P.; Bornemann, Antje; Riess, Olaf; Rami, Abdelhaq; Den Dunnen, Wilfried F. A.; Deller, Thomas; Rub, Udo; Krüger, Rejko

in Annals of neurology (2010), 67(5), 684-9

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See detailPeriphilin is a novel interactor of synphilin-1, a protein implicated in Parkinson's disease.
Soehn, Anne S.; Franck, Thomas; Biskup, Saskia; Giaime, Emilie; Melle, Christian; Rott, Ruth; Cebo, Daniel; Kalbacher, Hubert; Ott, Erwin; Pahnke, Jens; Meitinger, Thomas; Krüger, Rejko; Gasser, Thomas; Berg, Daniela; von Eggeling, Ferdinand; Engelender, Simone; da Costa, Cristine Alves; Riess, Olaf

in Neurogenetics (2010), 11(2), 203-15

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See detailComplex hyperkinetic movement disorders associated with POLG mutations.
Synofzik, Matthis; Schule, Rebecca; Schulte, Claudia; Krüger, Rejko; Lindig, Tobias; Schols, Ludger; Asmus, Friedrich

in Movement disorders : official journal of the Movement Disorder Society (2010), 25(14), 2472-5

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See detailSevere orthostatic dysregulation associated with Wolfram syndrome.
Synofzik, Matthis; Weiss, Daniel; Erharhaghen, Jite; Krüger, Rejko; Schols, Ludger

in Journal of neurology (2010), 257(10), 1751-3

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See detailInvoluntary eyelid closure after STN-DBS: evidence for different pathophysiological entities.
Weiss, Daniel; Wachter, Tobias; Breit, Sorin; Jacob, Simon N.; Pomper, Jorn K.; Asmus, Friedrich; Valls-Sole, Josep; Plewnia, Christian; Gasser, Thomas; Gharabaghi, Alireza; Krüger, Rejko

in Journal of neurology, neurosurgery, and psychiatry (2010), 81(9), 1002-7

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2009

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See detailEffective thalamic deep brain stimulation for neuropathic tremor in a patient with severe demyelinating neuropathy.
Breit, S.; Wachter, T.; Schols, L.; Gasser, T.; Nagele, T.; Freudenstein, D.; Krüger, Rejko

in Journal of neurology, neurosurgery, and psychiatry (2009), 80(2), 235-6

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See detailSingle-cell expression profiling of dopaminergic neurons combined with association analysis identifies pyridoxal kinase as Parkinson's disease gene.
Elstner, Matthias; Morris, Christopher M.; Heim, Katharina; Lichtner, Peter; Bender, Andreas; Mehta, Divya; Schulte, Claudia; Sharma, Manu; Hudson, Gavin; Goldwurm, Stefano; Giovanetti, Alessandro; Zeviani, Massimo; Burn, David J.; McKeith, Ian G.; Perry, Robert H.; Jaros, E.; Krüger, Rejko; Wichmann, H.-Erich; Schreiber, Stefan; Campbell, Harry; Wilson, James F.; Wright, Alan F.; Dunlop, Malcolm; Pistis, Giorgio; Toniolo, Daniela; Chinnery, Patrick F.; Gasser, Thomas; Klopstock, Thomas; Meitinger, Thomas; Prokisch, Holger; Turnbull, Douglass M.

in Annals of neurology (2009), 66(6), 792-8

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See detailFurther delineation of the association signal on chromosome 5 from the first whole genome association study in Parkinson's disease.
Sharma, Manu; Lichtner, Peter; Krüger, Rejko; Berg, Daniela; Schulte, Claudia; Illig, Thomas; Riess, Olaf; Gasser, Thomas

in Neurobiology of aging (2009), 30(10), 1706-9

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See detailGenome-wide association study reveals genetic risk underlying Parkinson's disease.
Simon-Sanchez, Javier; Schulte, Claudia; Bras, Jose M.; Sharma, Manu; Gibbs, J. Raphael; Berg, Daniela; Paisan-Ruiz, Coro; Lichtner, Peter; Scholz, Sonja W.; Hernandez, Dena G.; Krüger, Rejko; Federoff, Monica; Klein, Christine; Goate, Alison; Perlmutter, Joel; Bonin, Michael; Nalls, Michael A.; Illig, Thomas; Gieger, Christian; Houlden, Henry; Steffens, Michael; Okun, Michael S.; Racette, Brad A.; Cookson, Mark R.; Foote, Kelly D.; Fernandez, Hubert H.; Traynor, Bryan J.; Schreiber, Stefan; Arepalli, Sampath; Zonozi, Ryan; Gwinn, Katrina; van der Brug, Marcel; Lopez, Grisel; Chanock, Stephen J.; Schatzkin, Arthur; Park, Yikyung; Hollenbeck, Albert; Gao, Jianjun; Huang, Xuemei; Wood, Nick W.; Lorenz, Delia; Deuschl, Gunther; Chen, Honglei; Riess, Olaf; Hardy, John A.; Singleton, Andrew B.; Gasser, Thomas

in Nature genetics (2009), 41(12), 1308-12

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See detailSevere muscular fasciculations as an uncommon side-effect due to microdefect of an extension wire in deep brain stimulation.
Wachter, Tobias; Weiss, Daniel; Breit, Sorin; Gasser, Thomas; Krüger, Rejko; Gharabaghi, Alireza

in Movement disorders : official journal of the Movement Disorder Society (2009), 24(14), 2161-2

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2008

See detailMicroarray expression analysis reveals genetic pathways implicated in C621 synphilin-1-mediated toxicity.
Bonin, M.; Marx, F. P.; Kautzmann, S.; Riess, O.; Krüger, Rejko

in Journal of neural transmission (Vienna, Austria : 1996) (2008), 115(7), 941-58

See detailNovel ATP1A3 mutation in a sporadic RDP patient with minimal benefit from deep brain stimulation.
Kamm, C.; Fogel, W.; Wachter, T.; Schweitzer, K.; Berg, D.; Krüger, Rejko; Freudenstein, D.; Gasser, T.

in Neurology (2008), 70(16 Pt 2), 1501-3

See detailSustained improvement of obsessive-compulsive disorder by deep brain stimulation in a woman with residual schizophrenia.
Plewnia, Christian; Schober, Franziska; Rilk, Albrecht; Buchkremer, Gerhard; Reimold, Matthias; Wachter, Tobias; Breit, Sorin; Weiss, Daniel; Krüger, Rejko; Freudenstein, Dirk

in The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) (2008), 11(8), 1181-3

See detailMitochondrial protein quality control by the proteasome involves ubiquitination and the protease Omi.
Radke, Susanne; Chander, Harish; Schafer, Patrick; Meiss, Gregor; Krüger, Rejko; Schulz, Jorg B.; Germain, Doris

in The Journal of biological chemistry (2008), 283(19), 12681-5

See detailReview: Familial Parkinson's disease--genetics, clinical phenotype and neuropathology in relation to the common sporadic form of the disease.
Schiesling, Carola; Kieper, Nicole; Seidel, Kay; Krüger, Rejko

in Neuropathology and applied neurobiology (2008), 34(3), 255-71

See detailVertebral artery dissection presenting with ispilateral acute C5 and C6 sensorimotor radiculopathy: A case report.
Tabatabai, Ghazaleh; Schober, Wolfgang; Ernemann, Ulrike; Weller, Michael; Krüger, Rejko

in Cases journal (2008), 1(1), 139

See detailA comprehensive genetic study of the proteasomal subunit S6 ATPase in German Parkinson's disease patients.
Wahl, Claudia; Kautzmann, Sabine; Krebiehl, Guido; Strauss, Karsten; Woitalla, Dirk; Muller, Thomas; Bauer, Peter; Riess, Olaf; Krüger, Rejko

in Journal of neural transmission (Vienna, Austria : 1996) (2008), 115(8), 1141-8

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2007

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See detailMitochondrial translation initiation factor 3 gene polymorphism associated with Parkinson's disease.
Abahuni, Nadine; Gispert, Suzana; Bauer, Peter; Riess, Olaf; Krüger, Rejko; Becker, Tim; Auburger, Georg

in Neuroscience letters (2007), 414(2), 126-9

See detailLoss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin.
Exner, Nicole; Treske, Bettina; Paquet, Dominik; Holmstrom, Kira; Schiesling, Carola; Gispert, Suzana; Carballo-Carbajal, Iria; Berg, Daniela; Hoepken, Hans-Hermann; Gasser, Thomas; Krüger, Rejko; Winklhofer, Konstanze F.; Vogel, Frank; Reichert, Andreas S.; Auburger, Georg; Kahle, Philipp J.; Schmid, Bettina; Haass, Christian

in The Journal of neuroscience : the official journal of the Society for Neuroscience (2007), 27(45), 12413-8

See detailAcute parkinsonism with corresponding lesions in the basal ganglia after heroin abuse.
Matzler, Walter; Nagele, Thomas; Gasser, Thomas; Krüger, Rejko

in Neurology (2007), 68(6), 414

See detailTranscranial ultrasound in different monogenetic subtypes of Parkinson's disease.
Schweitzer, Katherine J.; Brussel, Theresa; Leitner, Petra; Krüger, Rejko; Bauer, Peter; Woitalla, Dirk; Tomiuk, Jurgen; Gasser, Thomas; Berg, Daniela

in Journal of neurology (2007), 254(5), 613-6

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2006

See detailLack of replication of thirteen single-nucleotide polymorphisms implicated in Parkinson's disease: a large-scale international study.
Elbaz, Alexis; Nelson, Lorene M.; Payami, Haydeh; Ioannidis, John P. A.; Fiske, Brian K.; Annesi, Grazia; Carmine Belin, Andrea; Factor, Stewart A.; Ferrarese, Carlo; Hadjigeorgiou, Georgios M.; Higgins, Donald S.; Kawakami, Hideshi; Krüger, Rejko; Marder, Karen S.; Mayeux, Richard P.; Mellick, George D.; Nutt, John G.; Ritz, Beate; Samii, Ali; Tanner, Caroline M.; Van Broeckhoven, Christine; Van Den Eeden, Stephen K.; Wirdefeldt, Karin; Zabetian, Cyrus P.; Dehem, Marie; Montimurro, Jennifer S.; Southwick, Audrey; Myers, Richard M.; Trikalinos, Thomas A.

in Lancet neurology (2006), 5(11), 917-23

See detailCollaborative analysis of alpha-synuclein gene promoter variability and Parkinson disease.
Maraganore, Demetrius M.; de Andrade, Mariza; Elbaz, Alexis; Farrer, Matthew J.; Ioannidis, John P.; Krüger, Rejko; Rocca, Walter A.; Schneider, Nicole K.; Lesnick, Timothy G.; Lincoln, Sarah J.; Hulihan, Mary M.; Aasly, Jan O.; Ashizawa, Tetsuo; Chartier-Harlin, Marie-Christine; Checkoway, Harvey; Ferrarese, Carlo; Hadjigeorgiou, Georgios; Hattori, Nobutaka; Kawakami, Hideshi; Lambert, Jean-Charles; Lynch, Timothy; Mellick, George D.; Papapetropoulos, Spiridon; Parsian, Abbas; Quattrone, Aldo; Riess, Olaf; Tan, Eng-King; Van Broeckhoven, Christine

in JAMA : the journal of the American Medical Association (2006), 296(6), 661-70

See detailGenetic causes of Parkinson's disease: extending the pathway.
Riess, O.; Krüger, Rejko; Hochstrasser, H.; Soehn, A. S.; Nuber, S.; Franck, T.; Berg, D.

in Journal of neural transmission. Supplementum (2006), (70), 181-9

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2005

See detailFunctional relevance of ceruloplasmin mutations in Parkinson's disease.
Hochstrasser, Helmine; Tomiuk, Jurgen; Walter, Uwe; Behnke, Stefanie; Spiegel, Jorg; Krüger, Rejko; Becker, Georg; Riess, Olaf; Berg, Daniela

in FASEB journal : official publication of the Federation of American Societies for Experimental Biology (2005), 19(13), 1851-3

See detailThe role of alpha-synuclein gene multiplications in early-onset Parkinson's disease and dementia with Lewy bodies.
Hofer, A.; Berg, D.; Asmus, F.; Niwar, M.; Ransmayr, G.; Riemenschneider, M.; Bonelli, S.-B.; Steffelbauer, M.; Ceballos-Baumann, A.; Haussermann, P.; Behnke, S.; Krüger, Rejko; Prestel, J.; Sharma, M.; Zimprich, A.; Riess, O.; Gasser, T.

in Journal of neural transmission (Vienna, Austria : 1996) (2005), 112(9), 1249-54

See detailLoss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease.
Strauss, Karsten M.; Martins, Luisa; Plun-Favreau, Helene; Marx, Frank P.; Kautzmann, Sabine; Berg, Daniela; Gasser, Thomas; Wszolek, Zbginiew; Muller, Thomas; Bornemann, Antje; Wolburg, Hartwig; Downward, Julian; Riess, Olaf; Schulz, Jorg B.; Krüger, Rejko

in Human molecular genetics (2005), 14(15), 2099-111

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2004

See detailScreening for mutations in synaptotagmin XI in Parkinson's disease.
Glass, A. S.; Huynh, D. P.; Franck, Th; Woitalla, D.; Muller, Th; Pulst, S. M.; Berg, D.; Krüger, Rejko; Riess, O.

in Journal of neural transmission. Supplementum (2004), (68), 21-8

See detailExtended mutation analysis and association studies of Nurr1 (NR4A2) in Parkinson disease.
Hering, R.; Petrovic, S.; Mietz, E.-M.; Holzmann, C.; Berg, D.; Bauer, P.; Woitalla, D.; Muller, T.; Berger, K.; Krüger, Rejko; Riess, O.

in Neurology (2004), 62(7), 1231-2

See detailNovel homozygous p.E64D mutation in DJ1 in early onset Parkinson disease (PARK7).
Hering, Robert; Strauss, Karsten M.; Tao, Xiao; Bauer, Andreas; Woitalla, Dirk; Mietz, Eva-Maria; Petrovic, Slobodanka; Bauer, Peter; Schaible, Wilhelm; Muller, Thomas; Schols, Ludger; Klein, Christine; Berg, Daniela; Meyer, Philipp T.; Schulz, Jorg B.; Wollnik, Bernd; Tong, Liang; Krüger, Rejko; Riess, Olaf

in Human mutation (2004), 24(4), 321-9

See detailGenes in familial parkinsonism and their role in sporadic Parkinson's disease.
Krüger, Rejko

in Journal of neurology (2004), 251 Suppl 6

See detailThe role of synphilin-1 in synaptic function and protein degradation.
Krüger, Rejko

in Cell and tissue research (2004), 318(1), 195-9

See detailUCHL1 is a Parkinson's disease susceptibility gene.
Maraganore, Demetrius M.; Lesnick, Timothy G.; Elbaz, Alexis; Chartier-Harlin, Marie-Christine; Gasser, Thomas; Krüger, Rejko; Hattori, Nobutaka; Mellick, George D.; Quattrone, Aldo; Satoh, Jun-Ichi; Toda, Tatsushi; Wang, Jian; Ioannidis, John P. A.; de Andrade, Mariza; Rocca, Walter A.

in Annals of neurology (2004), 55(4), 512-21

See detailAntiapoptotic effects of budipine.
Muller, T.; Przuntek, H.; Krüger, Rejko; Mackowiak, A.

in Journal of neural transmission (Vienna, Austria : 1996) (2004), 111(10-11), 1365-73

See detailNew developments in diagnosis and treatment of Parkinson's disease--from basic science to clinical applications.
Storch, Alexander; Hofer, Anne; Krüger, Rejko; Schulz, Jorg B.; Winkler, Jurgen; Gerlach, Manfred

in Journal of neurology (2004), 251 Suppl 6

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2003

See detailPolymorphisms of the alpha-synuclein promoter: expression analyses and association studies in Parkinson's disease.
Holzmann, C.; Krüger, Rejko; Saecker, A. M. M. Vieira; Schmitt, I.; Schols, L.; Berger, K.; Riess, O.

in Journal of neural transmission (Vienna, Austria : 1996) (2003), 110(1), 67-76

See detailHaploinsufficiency at the alpha-synuclein gene underlies phenotypic severity in familial Parkinson's disease.
Kobayashi, Hirokazu; Krüger, Rejko; Markopoulou, Katerina; Wszolek, Zbigniew; Chase, Bruce; Taka, Hikaru; Mineki, Reiko; Murayama, Kimie; Riess, Olaf; Mizuno, Yoshikuni; Hattori, Nobutaka

in Brain : a journal of neurology (2003), 126(Pt 1), 32-42

See detailMutation analysis of the neurofilament M gene in Parkinson's disease.
Krüger, Rejko; Fischer, Christian; Schulte, Thorsten; Strauss, Karsten M.; Muller, Thomas; Woitalla, Dirk; Berg, Daniela; Hungs, Marcel; Gobbele, Rene; Berger, Klaus; Epplen, Jorg T.; Riess, Olaf; Schols, Ludger

in Neuroscience letters (2003), 351(2), 125-9

See detailIdentification and functional characterization of a novel R621C mutation in the synphilin-1 gene in Parkinson's disease.
Marx, Frank P.; Holzmann, Carsten; Strauss, Karsten M.; Li, Lei; Eberhardt, Olaf; Gerhardt, Ellen; Cookson, Mark R.; Hernandez, Dena; Farrer, Matt J.; Kachergus, Jennifer; Engelender, Simone; Ross, Christopher A.; Berger, Klaus; Schols, Ludger; Schulz, Jorg B.; Riess, Olaf; Krüger, Rejko

in Human molecular genetics (2003), 12(11), 1223-31

See detailTherapeutic strategies for Parkinson's disease based on data derived from genetic research.
Riess, Olaf; Berg, Daniela; Krüger, Rejko; Schulz, Jorg B.

in Journal of neurology (2003), 250 Suppl 1

See detailModulation of disease risk according to a cathepsin D / apolipoprotein E genotype in Parkinson's disease.
Schulte, T.; Bohringer, S.; Schols, L.; Muller, T.; Fischer, C.; Riess, O.; Przuntek, H.; Berger, K.; Epplen, J. T.; Krüger, Rejko

in Journal of neural transmission (Vienna, Austria : 1996) (2003), 110(7), 749-55

See detailGiant cavernoma of the brain stem: value of delayed MR imaging after contrast injection.
Thiex, R.; Krüger, Rejko; Friese, S.; Gronewaller, E.; Kuker, W.

in European radiology (2003), 13 Suppl 6

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2002

See detailParkinson's disease: one biochemical pathway to fit all genes?
Krüger, Rejko; Eberhardt, Olaf; Riess, Olaf; Schulz, Jorg B.

in Trends in molecular medicine (2002), 8(5), 236-40

See detailNeurofilament L gene is not a genetic factor of sporadic and familial Parkinson's disease.
Rahner, Nils; Holzmann, Carsten; Krüger, Rejko; Schols, Ludger; Berger, Klaus; Riess, Olaf

in Brain research (2002), 951(1), 82-6

See detailSpectrum of phenotypes and genotypes in Parkinson's disease.
Riess, Olaf; Krüger, Rejko; Schulz, Jorg B.

in Journal of neurology (2002), 249 Suppl 3

See detailPolymorphisms in the interleukin-1 alpha and beta genes and the risk for Parkinson's disease.
Schulte, Thorsten; Schols, Ludger; Muller, Thomas; Woitalla, Dirk; Berger, Klaus; Krüger, Rejko

in Neuroscience letters (2002), 326(1), 70-2

See detail14-3-3 protein is a component of Lewy bodies in Parkinson's disease-mutation analysis and association studies of 14-3-3 eta.
Ubl, Andreas; Berg, Daniela; Holzmann, Carsten; Krüger, Rejko; Berger, Klaus; Arzberger, Thomas; Bornemann, Antje; Riess, Olaf

in Brain research. Molecular brain research (2002), 108(1-2), 33-9

Full Text
See detailMutation analysis and association studies of nuclear factor-kappaB1 in sporadic Parkinson's disease patients.
Wintermeyer, P.; Riess, O.; Schols, L.; Przuntek, H.; Miterski, B.; Epplen, J. T.; Krüger, Rejko

in Journal of neural transmission (Vienna, Austria : 1996) (2002), 109(9), 1181-8

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2001

See detailFamilial parkinsonism with synuclein pathology: clinical and PET studies of A30P mutation carriers.
Krüger, Rejko; Kuhn, W.; Leenders, K. L.; Sprengelmeyer, R.; Muller, T.; Woitalla, D.; Portman, A. T.; Maguire, R. P.; Veenma, L.; Schroder, U.; Schols, L.; Epplen, J. T.; Riess, O.; Przuntek, H.

in Neurology (2001), 56(10), 1355-62

See detailEvaluation of the gamma-synuclein gene in German Parkinson's disease patients.
Krüger, Rejko; Schols, L.; Muller, T.; Kuhn, W.; Woitalla, D.; Przuntek, H.; Epplen, J. T.; Riess, O.

in Neuroscience letters (2001), 310(2-3), 191-3

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2000

See detailGenetic analysis of immunomodulating factors in sporadic Parkinson's disease.
Krüger, Rejko; Hardt, C.; Tschentscher, F.; Jackel, S.; Kuhn, W.; Muller, T.; Werner, J.; Woitalla, D.; Berg, D.; Kuhnl, N.; Fuchs, G. A.; Santos, E. J.; Przuntek, H.; Epplen, J. T.; Schols, L.; Riess, O.

in Journal of neural transmission (Vienna, Austria : 1996) (2000), 107(5), 553-62

See detailGenetic analysis of the alpha2-macroglobulin gene in early- and late-onset Parkinson's disease.
Krüger, Rejko; Menezes-Saecker, A. M.; Schols, L.; Kuhn, W.; Muller, T.; Woitalla, D.; Berg, D.; Berger, K.; Przuntek, H.; Epplen, J. T.; Riess, O.

in Neuroreport (2000), 11(11), 2439-42

See detailInvolvement of alpha-synuclein in Parkinson's disease and other neurodegenerative disorders.
Krüger, Rejko; Muller, T.; Riess, O.

in Journal of neural transmission (Vienna, Austria : 1996) (2000), 107(1), 31-40

See detailPCR/SSCP detects reliably and efficiently DNA sequence variations in large scale screening projects.
Miterski, B.; Krüger, Rejko; Wintermeyer, P.; Epplen, J. T.

in Combinatorial chemistry & high throughput screening (2000), 3(3), 211-8

See detailGenetic influence on the development of Parkinson's disease.
Riess, O.; Kuhn, W.; Krüger, Rejko

in Journal of neurology (2000), 247 Suppl 2

See detailExtrapyramidal motor signs in degenerative ataxias.
Schols, L.; Peters, S.; Szymanski, S.; Krüger, Rejko; Lange, S.; Hardt, C.; Riess, O.; Przuntek, H.

in Archives of neurology (2000), 57(10), 1495-500

See detailMutation analysis and association studies of the UCHL1 gene in German Parkinson's disease patients.
Wintermeyer, P.; Krüger, Rejko; Kuhn, W.; Muller, T.; Woitalla, D.; Berg, D.; Becker, Gilles; Leroy, E.; Polymeropoulos, M.; Berger, K.; Przuntek, H.; Schols, L.; Epplen, J. T.; Riess, O.

in Neuroreport (2000), 11(10), 2079-82

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1999

See detailThe alpha1-antichymotrypsin A-allele in German Parkinson disease patients.
Grasbon-Frodl, E. M.; Egensperger, R.; Kosel, S.; Krüger, Rejko; Riess, O.; Mehraein, P.; Graeber, M. B.

in Journal of neural transmission (Vienna, Austria : 1996) (1999), 106(7-8), 729-36

See detailAnalysis of the parkin deletion in sporadic and familial Parkinson's disease. Short communication.
Krüger, Rejko; Vieira-Sacker, A. M.; Kuhn, W.; Muller, T.; Woitalla, D.; Schols, L.; Przuntek, H.; Epplen, J. T.; Riess, O.

in Journal of neural transmission (Vienna, Austria : 1996) (1999), 106(2), 159-63

See detailIncreased susceptibility to sporadic Parkinson's disease by a certain combined alpha-synuclein/apolipoprotein E genotype.
Krüger, Rejko; Vieira-Saecker, A. M.; Kuhn, W.; Berg, D.; Muller, T.; Kuhnl, N.; Fuchs, G. A.; Storch, A.; Hungs, M.; Woitalla, D.; Przuntek, H.; Epplen, J. T.; Schols, L.; Riess, O.

in Annals of neurology (1999), 45(5), 611-7

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1998

See detailAla30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease.
Krüger, Rejko; Kuhn, W.; Muller, T.; Woitalla, D.; Graeber, M.; Kosel, S.; Przuntek, H.; Epplen, J. T.; Schols, L.; Riess, O.

in Nature genetics (1998), 18(2), 106-8

See detailSelegiline as immunostimulant--a novel mechanism of action?
Muller, T.; Kuhn, W.; Krüger, Rejko; Przuntek, H.

in Journal of neural transmission. Supplementum (1998), 52

See detailGenetic dissection of familial Parkinson's disease.
Riess, O.; Jakes, R.; Krüger, Rejko

in Molecular medicine today (1998), 4(10), 438-44

See detailSpinocerebellar ataxia type 6: genotype and phenotype in German kindreds.
Schols, L.; Krüger, Rejko; Amoiridis, G.; Przuntek, H.; Epplen, J. T.; Riess, O.

in Journal of neurology, neurosurgery, and psychiatry (1998), 64(1), 67-73

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1996

See detailSelegiline stimulates biosynthesis of cytokines interleukin-1 beta and interleukin-6.
Wilfried, K.; Muller, T.; Krüger, Rejko; Horst, P.

in Neuroreport (1996), 7(18), 2847-8

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