Integrative Cell Signalling
The Integrative Cell Signalling group.
Top row (from left to right): Ricardo Cabezas, Aymeric Fouquier D'Herouël, Mahsa Moein, Suresh Poovantinghal, Felix Kleine Borgmann, Alexey Kolodkin, Kamil Grzyb, Nils Christian, Aidos Baumuratov, Alexander Skupin, Guadalupe Clara Garcia, Olga Boyd
Second row (from left to right): Niko Komin, Tomasz Ingac, Luis Salamanca
About the Integrative Cell Signalling group
The general approach of the Integrative Cell Signalling group lead by Dr. Alexander Skupin is to combine state-of-the-art imaging and single cell techniques with mechanistic modelling and bioinformatics analyses to investigate how the emergent behaviour of cells, organs and organisms originates from molecular entities. To understand the underlying cell signalling mechanisms, we focus on live cell imaging and multi-scale simulations with consideration of (epi)genetic constrains. Our major interests are signalling pathways related to Parkinson’s disease (PD) with a particular focus on mitochondrial dysfunction and dynamic coupling between energy metabolism and cell signalling such as Ca2+ dynamics. Therefore we use diverse cell lines and phenotyping assays including sophisticated image analysis and information theory based methods to reveal the dynamic consequences of disease-related perturbations at single cell resolution.