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Parkinson's disease map

Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease in the world. Although many genetic and environmental factors contributing to the risk of PD have been identified, no unique causal mechanism is defined.

 

Information on various aspects of PD pathogenesis is rapidly increasing and needs to be efficiently organized, so that the resulting data is available for exploration and analysis. To that end, LCSB, in the collaboration with the Systems Biology Institute, Tokyo (SBI), has developed the Parkinson’s disease (PD) map (Fujita et al.).

 

 

The PD map is a manually curated knowledge repository established to describe molecular mechanisms of PD. It compiles literature-based information on PD into an easy to explore and freely accessible molecular interaction map and offers research-facilitating functionalities such as the overlay of experimental data and the identification of drug targets on the map (see user guide).

We envision the PD map as a hub for the PD community to deal with the exponentially increasing information on PD and we encourage the PD community to join forces and support this project by integrating their expertise to continuously refine and expand the knowledge within the PD map (see community).

With our continuous efforts in developing the computational tools and the joint curation of content with the PD community, we hope that thefreely accessible PD map opens new avenues in PD research.

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Blog

PD map update - March '16 edition

A new version of the PD map is available! We added new PD-related mechanisms of synaptic function, ER stress and mitochondrial processes. Read more about the details in the blog entry describing this release, or simply visit the PD map. (Published 15 April 2016)

Curation workshop with the team of Katrin Marcus

In January we held an exciting workshop together with the team of Katrin Marcus from Medizinisches Proteom-Center (MPC), Ruhr Universität Bochum, Germany. This blog entry describes our exchange with the colleagues from MPC, and its outcomes. (Published 5 February 2016)

PD map update – December’15 edition

A new version of the PD map is available! This is a big update, featuring a number of content and functionality improvements. We added new PD-related mechanism of synuclein interaction with ion channels and its transcriptional regulation. Read about the details in the blog entry describing this release, or simply visit the PD map. (Published 7 January 2016)

  • First curation workshop in Geneva, 2013
  • The hallmarks of Parkinson's disease
  • The PD map at the Bremen Expo, 2013
  • An early version of the PD map      </p>

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  • Parkinson's disease puzzle