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Parkinson's disease map

Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease in the world. Although many genetic and environmental factors contributing to the risk of PD have been identified, no unique causal mechanism is defined.


Information on various aspects of PD pathogenesis is rapidly increasing and needs to be efficiently organized, so that the resulting data is available for exploration and analysis. To that end, LCSB, in the collaboration with the Systems Biology Institute, Tokyo (SBI), has developed the Parkinson’s disease (PD) map (Fujita et al.).



The PD map is a manually curated knowledge repository established to describe molecular mechanisms of PD. It compiles literature-based information on PD into an easy to explore and freely accessible molecular interaction map and offers research-facilitating functionalities such as the overlay of experimental data and the identification of drug targets on the map (see user guide).

We envision the PD map as a hub for the PD community to deal with the exponentially increasing information on PD and we encourage the PD community to join forces and support this project by integrating their expertise to continuously refine and expand the knowledge within the PD map (see community).

With our continuous efforts in developing the computational tools and the joint curation of content with the PD community, we hope that thefreely accessible PD map opens new avenues in PD research.

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PD map update - October ’16 edition

A new version of the PD map is available! In this release we include two new submaps, and a lot of user feedback.

PD map meets the community in October’16

We had an inspiring and productive dialog with the PD community during two back-to-back PD conferences in Belval, Luxembourg. We held two workshops and had many discussions by our PD map stand at the venue.

PD map update - June '16 edition

A new version of the PD map is available! This release can be dubbed as "the big LRRK2 edition", where we've integrated the outcomes LRRK2 curation workshop and more. (Published 15 July 2016)

  • First curation workshop in Geneva, 2013
  • The hallmarks of Parkinson's disease
  • The PD map at the Bremen Expo, 2013
  • An early version of the PD map      </p>

  • Parkinson's disease puzzle