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PMID 24203701: Jung HJ, Tu Y, Yang SH, Tatar A, Nobumori C, Wu D, Young SG, Fong LG, New Lmna knock-in mice provide a molecular mechanism for the 'segmental aging' in Hutchinson-Gilford progeria syndrome., Hum. Mol. Genet. (2014). Related reactions - re4905, re4906, re4907

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PMID 24115276: Berwick DC, Harvey K, The regulation and deregulation of Wnt signaling by PARK genes in health and disease., J Mol Cell Biol (2014). Related reactions - re2865, re2869, re2870, re2872

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PMID 23386811: Sierra A, Abiega O, Shahraz A, Neumann H, Janus-faced microglia: beneficial and detrimental consequences of microglial phagocytosis., Front Cell Neurosci (2013). Related reactions - re4982, re4995, re5012, re5026, re5035, re5040, re5045, re5060, re5070, re5100, re5123, re5139, re5177, re5214, re5229

PMID 23383169: Codolo G, Plotegher N, Pozzobon T, Brucale M, Tessari I, Bubacco L, de Bernard M, Triggering of inflammasome by aggregated α-synuclein, an inflammatory response in synucleinopathies., PLoS ONE (2013). Related reactions - re4995, re5013, re5034, re5062, re5078, re5140, re5162, re5169, re5193

PMID 23362255: Kimura T, Tsutsumi K, Taoka M, Saito T, Masuda-Suzukake M, Ishiguro K, Plattner F, Uchida T, Isobe T, Hasegawa M, Hisanaga S, Isomerase Pin1 stimulates dephosphorylation of tau protein at cyclin-dependent kinase (Cdk5)-dependent Alzheimer phosphorylation sites., J. Biol. Chem. (2013). Related reactions - re5305

PMID 23361334: Jewell JL, Russell RC, Guan KL, Amino acid signalling upstream of mTOR., Nat. Rev. Mol. Cell Biol. (2013). Related reactions - re4332, re4356, re4357, re4441, re4447, re792

PMID 23358114: Arredondo C, Orellana M, Vecchiola A, Pereira LA, Galdames L, Andrés ME, PIASγ enhanced SUMO-2 modification of Nurr1 activation-function-1 domain limits Nurr1 transcriptional synergy., PLoS ONE (2013). Related reactions - re3971

PMID 23356410: Simões-Pires C, Zwick V, Nurisso A, Schenker E, Carrupt PA, Cuendet M, HDAC6 as a target for neurodegenerative diseases: what makes it different from the other HDACs?, Mol Neurodegener (2013). Related reactions - re4787, re4798

PMID 23349115: Taetzsch T, Block ML, Pesticides, microglial NOX2, and Parkinson's disease., J. Biochem. Mol. Toxicol. (2013). Related reactions - re5236

PMID 23341612: Kadkhodaei B, Alvarsson A, Schintu N, Ramsköld D, Volakakis N, Joodmardi E, Yoshitake T, Kehr J, Decressac M, Björklund A, Sandberg R, Svenningsson P, Perlmann T, Transcription factor Nurr1 maintains fiber integrity and nuclear-encoded mitochondrial gene expression in dopamine neurons., Proc. Natl. Acad. Sci. U.S.A. (2013). Related reactions - re4477, re4525, re4526, re4527, re4528, re4529, re4535, re4637

PMID 23334208: Croft M, Benedict CA, Ware CF, Clinical targeting of the TNF and TNFR superfamilies., Nat Rev Drug Discov (2013). Related reactions - re5011, re5023

PMID 23326576: Maita C, Maita H, Iguchi-Ariga SM, Ariga H, Monomer DJ-1 and its N-terminal sequence are necessary for mitochondrial localization of DJ-1 mutants., PLoS ONE (2013). Related reactions - re3745

PMID 23325107: Jiang TF, Zhang YJ, Zhou HY, Wang HM, Tian LP, Liu J, Ding JQ, Chen SD, Curcumin ameliorates the neurodegenerative pathology in A53T α-synuclein cell model of Parkinson's disease through the downregulation of mTOR/p70S6K signaling and the recovery of macroautophagy., J Neuroimmune Pharmacol (2013). Related reactions - re3702

PMID 23318930: Caesar M, Zach S, Carlson CB, Brockmann K, Gasser T, Gillardon F, Leucine-rich repeat kinase 2 functionally interacts with microtubules and kinase-dependently modulates cell migration., Neurobiol. Dis. (2013). Related reactions - re5420, re5421, re5424

PMID 23316280: Molejon MI, Ropolo A, Re AL, Boggio V, Vaccaro MI, The VMP1-Beclin 1 interaction regulates autophagy induction., Sci Rep (2013). Related reactions - re3316, re3341

PMID 23312954: Marchetti B, Pluchino S, Wnt your brain be inflamed? Yes, it Wnt!, Trends Mol Med (2013). Related reactions - re2867, re2868

PMID 23312512: Kettenmann H, Kirchhoff F, Verkhratsky A, Microglia: new roles for the synaptic stripper., Neuron (2013). Related reactions - re5109

PMID 23303788: Aras S, Pak O, Sommer N, Finley R, Hüttemann M, Weissmann N, Grossman LI, Oxygen-dependent expression of cytochrome c oxidase subunit 4-2 gene expression is mediated by transcription factors RBPJ, CXXC5 and CHCHD2., Nucleic Acids Res. (2013). Related reactions - re5553, re5554

PMID 23297343: Hussain S, Feldman AL, Das C, Ziesmer SC, Ansell SM, Galardy PJ, Ubiquitin hydrolase UCH-L1 destabilizes mTOR complex 1 by antagonizing DDB1-CUL4-mediated ubiquitination of raptor., Mol. Cell. Biol. (2013). Related reactions - re4311, re4643, re4644, re4645

PMID 23283974: Wilkins HM, Kirchhof D, Manning E, Joseph JW, Linseman DA, Mitochondrial glutathione transport is a key determinant of neuronal susceptibility to oxidative and nitrosative stress., J. Biol. Chem. (2013). Related reactions - re3007, re3171

PMID 23283301: Peserico A, Chiacchiera F, Grossi V, Matrone A, Latorre D, Simonatto M, Fusella A, Ryall JG, Finley LW, Haigis MC, Villani G, Puri PL, Sartorelli V, Simone C, A novel AMPK-dependent FoxO3A-SIRT3 intramitochondrial complex sensing glucose levels., Cell. Mol. Life Sci. (2013). Related reactions - re4350

PMID 23276965: Zhang W, Zecca L, Wilson B, Ren HW, Wang YJ, Wang XM, Hong JS, Human neuromelanin: an endogenous microglial activator for dopaminergic neuron death., Front Biosci (Elite Ed) (2013). Related reactions - re4957, re4958

PMID 24688718: Wakabayashi S, Yoshida H, The essential biology of the endoplasmic reticulum stress response for structural and computational biologists., Comput Struct Biotechnol J (2013). Related reactions - re4222, re4245, re4246, re4247, re4248, re4249, re4250, re4251, re4252, re4253, re4255, re4264, re4290, re4291, re4292, re4293, re4294, re4295

PMID 23241745: Sheng Z, Zhang S, Bustos D, Kleinheinz T, Le Pichon CE, Dominguez SL, Solanoy HO, Drummond J, Zhang X, Ding X, Cai F, Song Q, Li X, Yue Z, van der Brug MP, Burdick DJ, Gunzner-Toste J, Chen H, Liu X, Estrada AA, Sweeney ZK, Scearce-Levie K, Moffat JG, Kirkpatrick DS, Zhu H, Ser1292 autophosphorylation is an indicator of LRRK2 kinase activity and contributes to the cellular effects of PD mutations., Sci Transl Med (2012). Related reactions - re5448, re5461

PMID 23241358: Biosa A, Trancikova A, Civiero L, Glauser L, Bubacco L, Greggio E, Moore DJ, GTPase activity regulates kinase activity and cellular phenotypes of Parkinson's disease-associated LRRK2., Hum. Mol. Genet. (2013). Related reactions - re5428

PMID 23236464: Oikawa D, Kitamura A, Kinjo M, Iwawaki T, Direct association of unfolded proteins with mammalian ER stress sensor, IRE1β., PLoS ONE (2012). Related reactions - re4243, re4302

PMID 23220632: Decressac M, Kadkhodaei B, Mattsson B, Laguna A, Perlmann T, Björklund A, α-Synuclein-induced down-regulation of Nurr1 disrupts GDNF signaling in nigral dopamine neurons., Sci Transl Med (2012). Related reactions - re2846, re2848, re4319, re4320

PMID 23216354: Llorente-Folch I, Sahún I, Contreras L, Casarejos MJ, Grau JM, Saheki T, Mena MA, Satrústegui J, Dierssen M, Pardo B, AGC1-malate aspartate shuttle activity is critical for dopamine handling in the nigrostriatal pathway., J. Neurochem. (2013). Related reactions - re4960, re4962, re4963, re4964, re4977

PMID 23212910: Rakovic A, Shurkewitsch K, Seibler P, Grünewald A, Zanon A, Hagenah J, Krainc D, Klein C, Phosphatase and tensin homolog (PTEN)-induced putative kinase 1 (PINK1)-dependent ubiquitination of endogenous Parkin attenuates mitophagy: study in human primary fibroblasts and induced pluripotent stem cell-derived neurons., J. Biol. Chem. (2013). Related reactions - re1694

PMID 23211418: Köroğlu Ç, Baysal L, Cetinkaya M, Karasoy H, Tolun A, DNAJC6 is responsible for juvenile parkinsonism with phenotypic variability., Parkinsonism Relat. Disord. (2013). Related reactions - re3617

PMID 23201762: Johnson WM, Wilson-Delfosse AL, Mieyal JJ, Dysregulation of glutathione homeostasis in neurodegenerative diseases., Nutrients (2012). Related reactions - re3117, re3118, re3121, re3145, re3146

PMID 23201127: Lu B, Lee J, Nie X, Li M, Morozov YI, Venkatesh S, Bogenhagen DF, Temiakov D, Suzuki CK, Phosphorylation of human TFAM in mitochondria impairs DNA binding and promotes degradation by the AAA+ Lon protease., Mol. Cell (2013). Related reactions - re4009

PMID 23190742: Marker DF, Puccini JM, Mockus TE, Barbieri J, Lu SM, Gelbard HA, LRRK2 kinase inhibition prevents pathological microglial phagocytosis in response to HIV-1 Tat protein., J Neuroinflammation (2012). Related reactions - re5251, re5500

PMID 23186369: Cao S, Standaert DG, Harms AS, The gamma chain subunit of Fc receptors is required for alpha-synuclein-induced pro-inflammatory signaling in microglia., J Neuroinflammation (2012). Related reactions - re5004, re5085

PMID 23169921: Sathe K, Maetzler W, Lang JD, Mounsey RB, Fleckenstein C, Martin HL, Schulte C, Mustafa S, Synofzik M, Vukovic Z, Itohara S, Berg D, Teismann P, S100B is increased in Parkinson's disease and ablation protects against MPTP-induced toxicity through the RAGE and TNF-α pathway., Brain (2012). Related reactions - re4933, re5215

PMID 23151077: Wang S, Chong ZZ, Shang YC, Maiese K, WISP1 neuroprotection requires FoxO3a post-translational modulation with autoregulatory control of SIRT1., Curr Neurovasc Res (2013). Related reactions - re4323, re5545, re5547

PMID 23149385: Koopman WJ, Distelmaier F, Smeitink JA, Willems PH, OXPHOS mutations and neurodegeneration., EMBO J. (2013). Related reactions - re2920, re2921, re2922, re2923, re2924, re2925, re3218, re3220, re3221, re3225, re3226, re3228, re3230, re3232, re5540, re5541, re5544

PMID 23140641: Lokireddy S, Wijesoma IW, Teng S, Bonala S, Gluckman PD, McFarlane C, Sharma M, Kambadur R, The ubiquitin ligase Mul1 induces mitophagy in skeletal muscle in response to muscle-wasting stimuli., Cell Metab. (2012). Related reactions - re4381

PMID 23140636: Attaix D, Taillandier D, The missing link: Mul1 signals mitophagy and muscle wasting., Cell Metab. (2012). Related reactions - re4067, re4068, re4380, re4382, re4383, re4384, re4385, re4397, re4398, re4399, re4400, re4401, re4402

PMID 23129554: Carvalho AN, Marques C, Rodrigues E, Henderson CJ, Wolf CR, Pereira P, Gama MJ, Ubiquitin-proteasome system impairment and MPTP-induced oxidative stress in the brain of C57BL/6 wild-type and GSTP knockout mice., Mol. Neurobiol. (2013). Related reactions - re2, re4650

PMID 23108585: Fellner L, Irschick R, Schanda K, Reindl M, Klimaschewski L, Poewe W, Wenning GK, Stefanova N, Toll-like receptor 4 is required for α-synuclein dependent activation of microglia and astroglia., Glia (2013). Related reactions - re4991, re5053

PMID 23087045: Tönges L, Frank T, Tatenhorst L, Saal KA, Koch JC, Szego ÉM, Bähr M, Weishaupt JH, Lingor P, Inhibition of rho kinase enhances survival of dopaminergic neurons and attenuates axonal loss in a mouse model of Parkinson's disease., Brain (2012). Related reactions - re4341

PMID 23082216: Trancikova A, Mamais A, Webber PJ, Stafa K, Tsika E, Glauser L, West AB, Bandopadhyay R, Moore DJ, Phosphorylation of 4E-BP1 in the mammalian brain is not altered by LRRK2 expression or pathogenic mutations., PLoS ONE (2012). Related reactions - re5473

PMID 23079555: Sidransky E, Lopez G, The link between the GBA gene and parkinsonism., Lancet Neurol (2012). Related reactions - re3676, re4680

PMID 23077045: Morganti JM, Nash KR, Grimmig BA, Ranjit S, Small B, Bickford PC, Gemma C, The soluble isoform of CX3CL1 is necessary for neuroprotection in a mouse model of Parkinson's disease., J. Neurosci. (2012). Related reactions - re5014

PMID 23075850: Liu GH, Qu J, Suzuki K, Nivet E, Li M, Montserrat N, Yi F, Xu X, Ruiz S, Zhang W, Wagner U, Kim A, Ren B, Li Y, Goebl A, Kim J, Soligalla RD, Dubova I, Thompson J, Yates J, Esteban CR, Sancho-Martinez I, Izpisua Belmonte JC, Progressive degeneration of human neural stem cells caused by pathogenic LRRK2., Nature (2012). Related reactions - re5498

PMID 23064436: Hauser DN, Hastings TG, Mitochondrial dysfunction and oxidative stress in Parkinson's disease and monogenic parkinsonism., Neurobiol. Dis. (2013). Related reactions - re3745, re3753

PMID 23060438: Sun Y, Vashisht AA, Tchieu J, Wohlschlegel JA, Dreier L, Voltage-dependent anion channels (VDACs) recruit Parkin to defective mitochondria to promote mitochondrial autophagy., J. Biol. Chem. (2012). Related reactions - re3354

PMID 23060190: Jahn R, Fasshauer D, Molecular machines governing exocytosis of synaptic vesicles., Nature (2012). Related reactions - re1335

PMID 23056511: Ambacher KK, Pitzul KB, Karajgikar M, Hamilton A, Ferguson SS, Cregan SP, The JNK- and AKT/GSK3β- signaling pathways converge to regulate Puma induction and neuronal apoptosis induced by trophic factor deprivation., PLoS ONE (2012). Related reactions - re4333, re4408, re4436

PMID 23025925: Zhang M, An C, Gao Y, Leak RK, Chen J, Zhang F, Emerging roles of Nrf2 and phase II antioxidant enzymes in neuroprotection., Prog. Neurobiol. (2013). Related reactions - re3115, re3116, re3117, re3119, re3120, re3121, re3153, re3154, re3155, re3157, re3158, re3159, re3160

PMID 23025503: Zito E, PRDX4, an endoplasmic reticulum-localized peroxiredoxin at the crossroads between enzymatic oxidative protein folding and nonenzymatic protein oxidation., Antioxid. Redox Signal. (2013). Related reactions - re4956

PMID 22998870: Matta S, Van Kolen K, da Cunha R, van den Bogaart G, Mandemakers W, Miskiewicz K, De Bock PJ, Morais VA, Vilain S, Haddad D, Delbroek L, Swerts J, Chávez-Gutiérrez L, Esposito G, Daneels G, Karran E, Holt M, Gevaert K, Moechars DW, De Strooper B, Verstreken P, LRRK2 controls an EndoA phosphorylation cycle in synaptic endocytosis., Neuron (2012). Related reactions - re3615, re3618, re3621

PMID 22988863: Lee S, Imai Y, Gehrke S, Liu S, Lu B, The synaptic function of LRRK2., Biochem. Soc. Trans. (2012). Related reactions - re5487

PMID 22976837: Magiera MM, Mora S, Mojsa B, Robbins I, Lassot I, Desagher S, Trim17-mediated ubiquitination and degradation of Mcl-1 initiate apoptosis in neurons., Cell Death Differ. (2013). Related reactions - re2851, re2852, re2853, re2854, re3730

PMID 22976834: Kang S, Louboutin JP, Datta P, Landel CP, Martinez D, Zervos AS, Strayer DS, Fernandes-Alnemri T, Alnemri ES, Loss of HtrA2/Omi activity in non-neuronal tissues of adult mice causes premature aging., Cell Death Differ. (2013). Related reactions - re4201, re4202

PMID 22965115: Hirotsu Y, Katsuoka F, Funayama R, Nagashima T, Nishida Y, Nakayama K, Engel JD, Yamamoto M, Nrf2-MafG heterodimers contribute globally to antioxidant and metabolic networks., Nucleic Acids Res. (2012). Related reactions - re4502, re4503, re4504, re4505, re4506, re4508, re4510, re4511, re4514, re4515, re4516, re4518, re4523, re5549

PMID 22936770: Youle RJ, van der Bliek AM, Mitochondrial fission, fusion, and stress., Science (2012). Related reactions - re2929, re4044

PMID 22932698: La Spada AR, PPARGC1A/PGC-1α, TFEB and enhanced proteostasis in Huntington disease: defining regulatory linkages between energy production and protein-organelle quality control., Autophagy (2012). Related reactions - re4353

PMID 22929228: Bauer PO, Hudec R, Goswami A, Kurosawa M, Matsumoto G, Mikoshiba K, Nukina N, ROCK-phosphorylated vimentin modifies mutant huntingtin aggregation via sequestration of IRBIT., Mol Neurodegener (2012). Related reactions - re4165, re4166, re4168, re4169, re4170, re4171

PMID 22922102: Hongo H, Kihara T, Kume T, Izumi Y, Niidome T, Sugimoto H, Akaike A, Glycogen synthase kinase-3β activation mediates rotenone-induced cytotoxicity with the involvement of microtubule destabilization., Biochem. Biophys. Res. Commun. (2012). Related reactions - re5342

PMID 22915595: Sekine S, Kanamaru Y, Koike M, Nishihara A, Okada M, Kinoshita H, Kamiyama M, Maruyama J, Uchiyama Y, Ishihara N, Takeda K, Ichijo H, Rhomboid protease PARL mediates the mitochondrial membrane potential loss-induced cleavage of PGAM5., J. Biol. Chem. (2012). Related reactions - re4017, re4050, re4060, re4066

PMID 22892098: Ren H, Fu K, Mu C, Zhen X, Wang G, L166P mutant DJ-1 promotes cell death by dissociating Bax from mitochondrial Bcl-XL., Mol Neurodegener (2012). Related reactions - re3750, re3751, re3752

PMID 22889933: Wang Y, Nartiss Y, Steipe B, McQuibban GA, Kim PK, ROS-induced mitochondrial depolarization initiates PARK2/PARKIN-dependent mitochondrial degradation by autophagy., Autophagy (2012). Related reactions - re1695

PMID 22875931: Kwak YD, Wang B, Li JJ, Wang R, Deng Q, Diao S, Chen Y, Xu R, Masliah E, Xu H, Sung JJ, Liao FF, Upregulation of the E3 ligase NEDD4-1 by oxidative stress degrades IGF-1 receptor protein in neurodegeneration., J. Neurosci. (2012). Related reactions - re4360

PMID 22858546: Ramonet D, Perier C, Recasens A, Dehay B, Bové J, Costa V, Scorrano L, Vila M, Optic atrophy 1 mediates mitochondria remodeling and dopaminergic neurodegeneration linked to complex I deficiency., Cell Death Differ. (2013). Related reactions - re4064, re4065

PMID 22847264: Covy JP, Waxman EA, Giasson BI, Characterization of cellular protective effects of ATP13A2/PARK9 expression and alterations resulting from pathogenic mutants., J. Neurosci. Res. (2012). Related reactions - re4657, re4658, re4659, re4660, re4661, re4662, re4663

PMID 22842492: Alvira CM, Umesh A, Husted C, Ying L, Hou Y, Lyu SC, Nowak J, Cornfield DN, Voltage-dependent anion channel-2 interaction with nitric oxide synthase enhances pulmonary artery endothelial cell nitric oxide production., Am. J. Respir. Cell Mol. Biol. (2012). Related reactions - re1925

PMID 22842232: Heinzen EL, Swoboda KJ, Hitomi Y, Gurrieri F, Nicole S, de Vries B, Tiziano FD, Fontaine B, Walley NM, Heavin S, Panagiotakaki E, NA NA, NA NA, NA NA, Fiori S, Abiusi E, Di Pietro L, Sweney MT, Newcomb TM, Viollet L, Huff C, Jorde LB, Reyna SP, Murphy KJ, Shianna KV, Gumbs CE, Little L, Silver K, Ptáček LJ, Haan J, Ferrari MD, Bye AM, Herkes GK, Whitelaw CM, Webb D, Lynch BJ, Uldall P, King MD, Scheffer IE, Neri G, Arzimanoglou A, van den Maagdenberg AM, Sisodiya SM, Mikati MA, Goldstein DB, De novo mutations in ATP1A3 cause alternating hemiplegia of childhood., Nat. Genet. (2012). Related reactions - re4939

PMID 22836916: Almeida A, Regulation of APC/C-Cdh1 and its function in neuronal survival., Mol. Neurobiol. (2012). Related reactions - re3469, re3470, re3471, re3472, re3473, re3474

PMID 22833673: Desplats P, Spencer B, Crews L, Pathel P, Morvinski-Friedmann D, Kosberg K, Roberts S, Patrick C, Winner B, Winkler J, Masliah E, α-Synuclein induces alterations in adult neurogenesis in Parkinson disease models via p53-mediated repression of Notch1., J. Biol. Chem. (2012). Related reactions - re4702, re4703

PMID 22789442: van Tiel CM, Kurakula K, Koenis DS, van der Wal E, de Vries CJ, Dual function of Pin1 in NR4A nuclear receptor activation: enhanced activity of NR4As and increased Nur77 protein stability., Biochim. Biophys. Acta (2012). Related reactions - re2842

PMID 22769591: Thompson AD, Scaglione KM, Prensner J, Gillies AT, Chinnaiyan A, Paulson HL, Jinwal UK, Dickey CA, Gestwicki JE, Analysis of the tau-associated proteome reveals that exchange of Hsp70 for Hsp90 is involved in tau degradation., ACS Chem. Biol. (2012). Related reactions - re5319

PMID 22764206: Cooper O, Seo H, Andrabi S, Guardia-Laguarta C, Graziotto J, Sundberg M, McLean JR, Carrillo-Reid L, Xie Z, Osborn T, Hargus G, Deleidi M, Lawson T, Bogetofte H, Perez-Torres E, Clark L, Moskowitz C, Mazzulli J, Chen L, Volpicelli-Daley L, Romero N, Jiang H, Uitti RJ, Huang Z, Opala G, Scarffe LA, Dawson VL, Klein C, Feng J, Ross OA, Trojanowski JQ, Lee VM, Marder K, Surmeier DJ, Wszolek ZK, Przedborski S, Krainc D, Dawson TM, Isacson O, Pharmacological rescue of mitochondrial deficits in iPSC-derived neural cells from patients with familial Parkinson's disease., Sci Transl Med (2012). Related reactions - re5265, re5267

PMID 22761832: Ghosh AP, Klocke BJ, Ballestas ME, Roth KA, CHOP potentially co-operates with FOXO3a in neuronal cells to regulate PUMA and BIM expression in response to ER stress., PLoS ONE (2012). Related reactions - re4265, re4266, re4297, re4298, re4299, re4301, re4323, re4343, re5336

PMID 22748923: Leboucher GP, Tsai YC, Yang M, Shaw KC, Zhou M, Veenstra TD, Glickman MH, Weissman AM, Stress-induced phosphorylation and proteasomal degradation of mitofusin 2 facilitates mitochondrial fragmentation and apoptosis., Mol. Cell (2012). Related reactions - re4040

PMID 22735187: Exner N, Lutz AK, Haass C, Winklhofer KF, Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences., EMBO J. (2012). Related reactions - re3986, re3987

PMID 22723946: Dzamko N, Inesta-Vaquera F, Zhang J, Xie C, Cai H, Arthur S, Tan L, Choi H, Gray N, Cohen P, Pedrioli P, Clark K, Alessi DR, The IkappaB kinase family phosphorylates the Parkinson's disease kinase LRRK2 at Ser935 and Ser910 during Toll-like receptor signaling., PLoS ONE (2012). Related reactions - re5251, re5503, re5504

PMID 22705949: Siddiqui A, Chinta SJ, Mallajosyula JK, Rajagopolan S, Hanson I, Rane A, Melov S, Andersen JK, Selective binding of nuclear alpha-synuclein to the PGC1alpha promoter under conditions of oxidative stress may contribute to losses in mitochondrial function: implications for Parkinson's disease., Free Radic. Biol. Med. (2012). Related reactions - re4388, re4696, re4699

PMID 22692423: Roczniak-Ferguson A, Petit CS, Froehlich F, Qian S, Ky J, Angarola B, Walther TC, Ferguson SM, The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis., Sci Signal (2012). Related reactions - re4352, re4354

PMID 22675361: Desideri E, Martins LM, Mitochondrial Stress Signalling: HTRA2 and Parkinson's Disease., Int J Cell Biol (2012). Related reactions - re3987, re4000

PMID 22661957: Yin Y, She H, Li W, Yang Q, Guo S, Mao Z, Modulation of Neuronal Survival Factor MEF2 by Kinases in Parkinson's Disease., Front Physiol (2012). Related reactions - re3481, re3483, re4455

PMID 22647602: Dehay B, Ramirez A, Martinez-Vicente M, Perier C, Canron MH, Doudnikoff E, Vital A, Vila M, Klein C, Bezard E, Loss of P-type ATPase ATP13A2/PARK9 function induces general lysosomal deficiency and leads to Parkinson disease neurodegeneration., Proc. Natl. Acad. Sci. U.S.A. (2012). Related reactions - re3669, re3673, re3693, re3701

PMID 22645310: Nakamura K, Kosugi I, Lee DY, Hafner A, Sinclair DA, Ryo A, Lu KP, Prolyl isomerase Pin1 regulates neuronal differentiation via β-catenin., Mol. Cell. Biol. (2012). Related reactions - re4959

PMID 22643835: Lee HJ, Jang SH, Kim H, Yoon JH, Chung KC, PINK1 stimulates interleukin-1β-mediated inflammatory signaling via the positive regulation of TRAF6 and TAK1., Cell. Mol. Life Sci. (2012). Related reactions - re1941, re1993

PMID 22639965: Niu J, Yu M, Wang C, Xu Z, Leucine-rich repeat kinase 2 disturbs mitochondrial dynamics via Dynamin-like protein., J. Neurochem. (2012). Related reactions - re5268, re5269, re5270, re5288

PMID 22612223: Rudenko IN, Kaganovich A, Hauser DN, Beylina A, Chia R, Ding J, Maric D, Jaffe H, Cookson MR, The G2385R variant of leucine-rich repeat kinase 2 associated with Parkinson's disease is a partial loss-of-function mutation., Biochem. J. (2012). Related reactions - re5431

PMID 22610403: Koh H, Chung J, PINK1 as a molecular checkpoint in the maintenance of mitochondrial function and integrity., Mol. Cells (2012). Related reactions - re4321, re4351, re4371, re4391, re4393, re4396, re4426, re4895, re5470

PMID 22594666: Greggio E, Civiero L, Bisaglia M, Bubacco L, Parkinson's disease and immune system: is the culprit LRRKing in the periphery?, J Neuroinflammation (2012). Related reactions - re4999, re5000, re5048, re5051, re5091, re5112, re5113, re5121, re5132, re5157, re5179, re5240, re5505

PMID 22581777: Chorley BN, Campbell MR, Wang X, Karaca M, Sambandan D, Bangura F, Xue P, Pi J, Kleeberger SR, Bell DA, Identification of novel NRF2-regulated genes by ChIP-Seq: influence on retinoid X receptor alpha., Nucleic Acids Res. (2012). Related reactions - re4498, re4502, re4504, re4505, re4506, re4508, re4510, re4511, re4515, re4516, re4517, re4518, re4523

PMID 22579715: Sanjuán Szklarz LK, Scorrano L, The antiapoptotic OPA1/Parl couple participates in mitochondrial adaptation to heat shock., Biochim. Biophys. Acta (2012). Related reactions - re4049

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PMID 22475393: Wang S, Chong ZZ, Shang YC, Maiese K, WISP1 (CCN4) autoregulates its expression and nuclear trafficking of β-catenin during oxidant stress with limited effects upon neuronal autophagy., Curr Neurovasc Res (2012). Related reactions - re5547

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PMID 19133145: Kell DB, Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases., BMC Med Genomics (2009). Related reactions - re4688, re4689

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PMID 19081074: Loktev AV, Zhang Q, Beck JS, Searby CC, Scheetz TE, Bazan JF, Slusarski DC, Sheffield VC, Jackson PK, Nachury MV, A BBSome subunit links ciliogenesis, microtubule stability, and acetylation., Dev. Cell (2008). Related reactions - re5423

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PMID 19052620: de Brito OM, Scorrano L, Mitofusin 2 tethers endoplasmic reticulum to mitochondria., Nature (2008). Related reactions - re4736, re4737

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PMID 19004816: Inglis KJ, Chereau D, Brigham EF, Chiou SS, Schöbel S, Frigon NL, Yu M, Caccavello RJ, Nelson S, Motter R, Wright S, Chian D, Santiago P, Soriano F, Ramos C, Powell K, Goldstein JM, Babcock M, Yednock T, Bard F, Basi GS, Sham H, Chilcote TJ, McConlogue L, Griswold-Prenner I, Anderson JP, Polo-like kinase 2 (PLK2) phosphorylates alpha-synuclein at serine 129 in central nervous system., J. Biol. Chem. (2009). Related reactions - re71

PMID 19001277: Bilbao A, Parkitna JR, Engblom D, Perreau-Lenz S, Sanchis-Segura C, Schneider M, Konopka W, Westphal M, Breen G, Desrivieres S, Klugmann M, Guindalini C, Vallada H, Laranjeira R, de Fonseca FR, Schumann G, Schütz G, Spanagel R, Loss of the Ca2+/calmodulin-dependent protein kinase type IV in dopaminoceptive neurons enhances behavioral effects of cocaine., Proc. Natl. Acad. Sci. U.S.A. (2008). Related reactions - re931

PMID 18990698: Townsend DM, Manevich Y, He L, Hutchens S, Pazoles CJ, Tew KD, Novel role for glutathione S-transferase pi. Regulator of protein S-Glutathionylation following oxidative and nitrosative stress., J. Biol. Chem. (2009). Related reactions - re3490

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PMID 18929623: Arosio P, Ingrassia R, Cavadini P, Ferritins: a family of molecules for iron storage, antioxidation and more., Biochim. Biophys. Acta (2009). Related reactions - re4744

PMID 18838687: Cereghetti GM, Stangherlin A, Martins de Brito O, Chang CR, Blackstone C, Bernardi P, Scorrano L, Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria., Proc. Natl. Acad. Sci. U.S.A. (2008). Related reactions - re4022

PMID 18818692: Maestre C, Delgado-Esteban M, Gomez-Sanchez JC, Bolaños JP, Almeida A, Cdk5 phosphorylates Cdh1 and modulates cyclin B1 stability in excitotoxicity., EMBO J. (2008). Related reactions - re3469, re3470, re3471, re3475

PMID 18813292: Anjum R, Blenis J, The RSK family of kinases: emerging roles in cellular signalling., Nat. Rev. Mol. Cell Biol. (2008). Related reactions - re1798

PMID 18794901: Dong XP, Cheng X, Mills E, Delling M, Wang F, Kurz T, Xu H, The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel., Nature (2008). Related reactions - re4880, re4881, re4894, re4899

PMID 18794531: Ahn BH, Kim HS, Song S, Lee IH, Liu J, Vassilopoulos A, Deng CX, Finkel T, A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis., Proc. Natl. Acad. Sci. U.S.A. (2008). Related reactions - re720

PMID 18790661: Ross OA, Soto AI, Vilariño-Güell C, Heckman MG, Diehl NN, Hulihan MM, Aasly JO, Sando S, Gibson JM, Lynch T, Krygowska-Wajs A, Opala G, Barcikowska M, Czyzewski K, Uitti RJ, Wszolek ZK, Farrer MJ, Genetic variation of Omi/HtrA2 and Parkinson's disease., Parkinsonism Relat. Disord. (2008). Related reactions - re3999

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PMID 18728184: Agbaga MP, Brush RS, Mandal MN, Henry K, Elliott MH, Anderson RE, Role of Stargardt-3 macular dystrophy protein (ELOVL4) in the biosynthesis of very long chain fatty acids., Proc. Natl. Acad. Sci. U.S.A. (2008). Related reactions - re1183

PMID 18725538: Axe EL, Walker SA, Manifava M, Chandra P, Roderick HL, Habermann A, Griffiths G, Ktistakis NT, Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum., J. Cell Biol. (2008). Related reactions - re4649

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PMID 18710944: Sundaresan NR, Samant SA, Pillai VB, Rajamohan SB, Gupta MP, SIRT3 is a stress-responsive deacetylase in cardiomyocytes that protects cells from stress-mediated cell death by deacetylation of Ku70., Mol. Cell. Biol. (2008). Related reactions - re658, re659, re696

PMID 18707016: Grover GJ, Marone PA, Koetzner L, Seto-Young D, Energetic signalling in the control of mitochondrial F1F0 ATP synthase activity in health and disease., Int. J. Biochem. Cell Biol. (2008). Related reactions - re4449

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PMID 18694939: Grimsey N, Han GS, O'Hara L, Rochford JJ, Carman GM, Siniossoglou S, Temporal and spatial regulation of the phosphatidate phosphatases lipin 1 and 2., J. Biol. Chem. (2008). Related reactions - re1178

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PMID 18680753: Schlicker C, Gertz M, Papatheodorou P, Kachholz B, Becker CF, Steegborn C, Substrates and regulation mechanisms for the human mitochondrial sirtuins Sirt3 and Sirt5., J. Mol. Biol. (2008). Related reactions - re725, re892

PMID 18669654: Scherzer CR, Grass JA, Liao Z, Pepivani I, Zheng B, Eklund AC, Ney PA, Ng J, McGoldrick M, Mollenhauer B, Bresnick EH, Schlossmacher MG, GATA transcription factors directly regulate the Parkinson's disease-linked gene alpha-synuclein., Proc. Natl. Acad. Sci. U.S.A. (2008). Related reactions - re4915

PMID 18635547: Rudrabhatla P, Zheng YL, Amin ND, Kesavapany S, Albers W, Pant HC, Pin1-dependent prolyl isomerization modulates the stress-induced phosphorylation of high molecular weight neurofilament protein., J. Biol. Chem. (2008). Related reactions - re5317

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PMID 18614015: Pagliarini DJ, Calvo SE, Chang B, Sheth SA, Vafai SB, Ong SE, Walford GA, Sugiana C, Boneh A, Chen WK, Hill DE, Vidal M, Evans JG, Thorburn DR, Carr SA, Mootha VK, A mitochondrial protein compendium elucidates complex I disease biology., Cell (2008). Related reactions - re1, re10, re11, re12, re13, re14, re15, re16, re17, re18, re19, re2, re20, re21, re22, re3, re3505, re3509, re3531, re4, re41, re42, re43, re45, re46, re47, re48, re49, re5, re50, re52, re53, re54, re55, re56, re57, re6, re62, re63, re64, re65, re66, re67, re68, re7, re8, re9

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PMID 18508033: Chen YY, Chen G, Fan Z, Luo J, Ke ZJ, GSK3beta and endoplasmic reticulum stress mediate rotenone-induced death of SK-N-MC neuroblastoma cells., Biochem. Pharmacol. (2008). Related reactions - re2850, re5342, re5348, re5349

PMID 18504291: Pott Godoy MC, Tarelli R, Ferrari CC, Sarchi MI, Pitossi FJ, Central and systemic IL-1 exacerbates neurodegeneration and motor symptoms in a model of Parkinson's disease., Brain (2008). Related reactions - re5163, re5175

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PMID 18455495: Locke GA, Cheng D, Witmer MR, Tamura JK, Haque T, Carney RF, Rendina AR, Marcinkeviciene J, Differential activation of recombinant human acetyl-CoA carboxylases 1 and 2 by citrate., Arch. Biochem. Biophys. (2008). Related reactions - re1157

PMID 18445495: Shin N, Jeong H, Kwon J, Heo HY, Kwon JJ, Yun HJ, Kim CH, Han BS, Tong Y, Shen J, Hatano T, Hattori N, Kim KS, Chang S, Seol W, LRRK2 regulates synaptic vesicle endocytosis., Exp. Cell Res. (2008). Related reactions - re5286, re5287

PMID 18411301: Huang J, Dibble CC, Matsuzaki M, Manning BD, The TSC1-TSC2 complex is required for proper activation of mTOR complex 2., Mol. Cell. Biol. (2008). Related reactions - re4379

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PMID 18364387: Simón-Sánchez J, Singleton AB, Sequencing analysis of OMI/HTRA2 shows previously reported pathogenic mutations in neurologically normal controls., Hum. Mol. Genet. (2008). Related reactions - re3999

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PMID 18331844: Berndt C, Lillig CH, Holmgren A, Thioredoxins and glutaredoxins as facilitators of protein folding., Biochim. Biophys. Acta (2008). Related reactions - re3132

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PMID 18321988: Fujita N, Itoh T, Omori H, Fukuda M, Noda T, Yoshimori T, The Atg16L complex specifies the site of LC3 lipidation for membrane biogenesis in autophagy., Mol. Biol. Cell (2008). Related reactions - re3341

PMID 18311135: Correia SS, Bassani S, Brown TC, Lisé MF, Backos DS, El-Husseini A, Passafaro M, Esteban JA, Motor protein-dependent transport of AMPA receptors into spines during long-term potentiation., Nat. Neurosci. (2008). Related reactions - re898

PMID 18309064: Marsh M, van Meer G, Cell biology. No ESCRTs for exosomes., Science (2008). Related reactions - re1381

PMID 18307977: Daiyasu H, Watanabe K, Toh H, Recruitment of thioredoxin-like domains into prostaglandin synthases., Biochem. Biophys. Res. Commun. (2008). Related reactions - re1297

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PMID 18292238: Liu MH, Li J, Shen P, Husna B, Tai ES, Yong EL, A natural polymorphism in peroxisome proliferator-activated receptor-alpha hinge region attenuates transcription due to defective release of nuclear receptor corepressor from chromatin., Mol. Endocrinol. (2008). Related reactions - re4449

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PMID 18287535: Dávila D, Torres-Aleman I, Neuronal death by oxidative stress involves activation of FOXO3 through a two-arm pathway that activates stress kinases and attenuates insulin-like growth factor I signaling., Mol. Biol. Cell (2008). Related reactions - re4326, re4327, re4328, re4330, re4331, re4333, re4407, re4435, re5546

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PMID 18273910: Apopa PL, He X, Ma Q, Phosphorylation of Nrf2 in the transcription activation domain by casein kinase 2 (CK2) is critical for the nuclear translocation and transcription activation function of Nrf2 in IMR-32 neuroblastoma cells., J. Biochem. Mol. Toxicol. (2008). Related reactions - re1556

PMID 18245082: Devi L, Raghavendran V, Prabhu BM, Avadhani NG, Anandatheerthavarada HK, Mitochondrial import and accumulation of alpha-synuclein impair complex I in human dopaminergic neuronal cultures and Parkinson disease brain., J. Biol. Chem. (2008). Related reactions - re1363, re1364, re1368, re332

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PMID 18218981: Bossuyt J, Helmstadter K, Wu X, Clements-Jewery H, Haworth RS, Avkiran M, Martin JL, Pogwizd SM, Bers DM, Ca2+/calmodulin-dependent protein kinase IIdelta and protein kinase D overexpression reinforce the histone deacetylase 5 redistribution in heart failure., Circ. Res. (2008). Related reactions - re969

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PMID 18201976: Mishra A, Dikshit P, Purkayastha S, Sharma J, Nukina N, Jana NR, E6-AP promotes misfolded polyglutamine proteins for proteasomal degradation and suppresses polyglutamine protein aggregation and toxicity., J. Biol. Chem. (2008). Related reactions - re3715, re3716

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PMID 17965833: Takahashi K, Uchida C, Shin RW, Shimazaki K, Uchida T, Prolyl isomerase, Pin1: new findings of post-translational modifications and physiological substrates in cancer, asthma and Alzheimer's disease., Cell. Mol. Life Sci. (2008). Related reactions - re5305

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PMID 17803915: Yao I, Takagi H, Ageta H, Kahyo T, Sato S, Hatanaka K, Fukuda Y, Chiba T, Morone N, Yuasa S, Inokuchi K, Ohtsuka T, Macgregor GR, Tanaka K, Setou M, SCRAPPER-dependent ubiquitination of active zone protein RIM1 regulates synaptic vesicle release., Cell (2007). Related reactions - re1681, re813

PMID 17785525: Boyault C, Zhang Y, Fritah S, Caron C, Gilquin B, Kwon SH, Garrido C, Yao TP, Vourc'h C, Matthias P, Khochbin S, HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates., Genes Dev. (2007). Related reactions - re4788

PMID 17766642: Gopalakrishnan A, Sievert M, Ruoho AE, Identification of the substrate binding region of vesicular monoamine transporter-2 (VMAT-2) using iodoaminoflisopolol as a novel photoprobe., Mol. Pharmacol. (2007). Related reactions - re12

PMID 17761882: Kim J, Inoue K, Ishii J, Vanti WB, Voronov SV, Murchison E, Hannon G, Abeliovich A, A MicroRNA feedback circuit in midbrain dopamine neurons., Science (2007). Related reactions - re2786

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PMID 17711846: Greer EL, Oskoui PR, Banko MR, Maniar JM, Gygi MP, Gygi SP, Brunet A, The energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3 transcription factor., J. Biol. Chem. (2007). Related reactions - re4338

PMID 17681178: Gassler N, Roth W, Funke B, Schneider A, Herzog F, Tischendorf JJ, Grund K, Penzel R, Bravo IG, Mariadason J, Ehemann V, Sykora J, Haas TL, Walczak H, Ganten T, Zentgraf H, Erb P, Alonso A, Autschbach F, Schirmacher P, Knüchel R, Kopitz J, Regulation of enterocyte apoptosis by acyl-CoA synthetase 5 splicing., Gastroenterology (2007). Related reactions - re1164

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PMID 17670976: Corti C, Battaglia G, Molinaro G, Riozzi B, Pittaluga A, Corsi M, Mugnaini M, Nicoletti F, Bruno V, The use of knock-out mice unravels distinct roles for mGlu2 and mGlu3 metabotropic glutamate receptors in mechanisms of neurodegeneration/neuroprotection., J. Neurosci. (2007). Related reactions - re3545, re3548

PMID 17668387: Ostergaard E, Christensen E, Kristensen E, Mogensen B, Duno M, Shoubridge EA, Wibrand F, Deficiency of the alpha subunit of succinate-coenzyme A ligase causes fatal infantile lactic acidosis with mitochondrial DNA depletion., Am. J. Hum. Genet. (2007). Related reactions - re403

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PMID 17588900: Outeiro TF, Kontopoulos E, Altmann SM, Kufareva I, Strathearn KE, Amore AM, Volk CB, Maxwell MM, Rochet JC, McLean PJ, Young AB, Abagyan R, Feany MB, Hyman BT, Kazantsev AG, Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease., Science (2007). Related reactions - re1287, re4820, re4848, re4849, re4850

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PMID 17432878: Bzymek KP, Colman RF, Role of alpha-Asp181, beta-Asp192, and gamma-Asp190 in the distinctive subunits of human NAD-specific isocitrate dehydrogenase., Biochemistry (2007). Related reactions - re410

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PMID 17410128: Koizumi S, Shigemoto-Mogami Y, Nasu-Tada K, Shinozaki Y, Ohsawa K, Tsuda M, Joshi BV, Jacobson KA, Kohsaka S, Inoue K, UDP acting at P2Y6 receptors is a mediator of microglial phagocytosis., Nature (2007). Related reactions - re5144, re5189

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PMID 17311912: Yang L, Sun M, Sun XM, Cheng GZ, Nicosia SV, Cheng JQ, Akt attenuation of the serine protease activity of HtrA2/Omi through phosphorylation of serine 212., J. Biol. Chem. (2007). Related reactions - re4003

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PMID 17158099: Donkor J, Sariahmetoglu M, Dewald J, Brindley DN, Reue K, Three mammalian lipins act as phosphatidate phosphatases with distinct tissue expression patterns., J. Biol. Chem. (2007). Related reactions - re1178

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PMID 17098212: Tew KD, Redox in redux: Emergent roles for glutathione S-transferase P (GSTP) in regulation of cell signaling and S-glutathionylation., Biochem. Pharmacol. (2007). Related reactions - re3132

PMID 17075902: Haas MA, Vickers JC, Dickson TC, Rho kinase activates ezrin-radixin-moesin (ERM) proteins and mediates their function in cortical neuron growth, morphology and motility in vitro., J. Neurosci. Res. (2007). Related reactions - re5379

PMID 17070842: Liu Y, Tong Q, Zhou Y, Lee HW, Yang JJ, Bühring HJ, Chen YT, Ha B, Chen CX, Yang Y, Zen K, Functional elements on SIRPalpha IgV domain mediate cell surface binding to CD47., J. Mol. Biol. (2007). Related reactions - re5252

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PMID 16972273: Olanow CW, McNaught KS, Ubiquitin-proteasome system and Parkinson's disease., Mov. Disord. (2006). Related reactions - re1606

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PMID 16877542: Wu DC, Ré DB, Nagai M, Ischiropoulos H, Przedborski S, The inflammatory NADPH oxidase enzyme modulates motor neuron degeneration in amyotrophic lateral sclerosis mice., Proc. Natl. Acad. Sci. U.S.A. (2006). Related reactions - re4361

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PMID 16839884: Cipolat S, Rudka T, Hartmann D, Costa V, Serneels L, Craessaerts K, Metzger K, Frezza C, Annaert W, D'Adamio L, Derks C, Dejaegere T, Pellegrini L, D'Hooge R, Scorrano L, De Strooper B, Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling., Cell (2006). Related reactions - re4049, re4052

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PMID 16620771: Agarwal AK, Barnes RI, Garg A, Functional characterization of human 1-acylglycerol-3-phosphate acyltransferase isoform 8: cloning, tissue distribution, gene structure, and enzymatic activity., Arch. Biochem. Biophys. (2006). Related reactions - re1176

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PMID 16554819: Pastorino L, Sun A, Lu PJ, Zhou XZ, Balastik M, Finn G, Wulf G, Lim J, Li SH, Li X, Xia W, Nicholson LK, Lu KP, The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-beta production., Nature (2006). Related reactions - re5306

PMID 16518376: Jacobson KA, Gao ZG, Adenosine receptors as therapeutic targets., Nat Rev Drug Discov (2006). Related reactions - re2936, re2938, re2942, re2943, re5007

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PMID 16480958: Xu S, Zhou M, Yu S, Cai Y, Zhang A, Uéda K, Chan P, Oxidative stress induces nuclear translocation of C-terminus of alpha-synuclein in dopaminergic cells., Biochem. Biophys. Res. Commun. (2006). Related reactions - re4696

PMID 16467521: Majed HH, Chandran S, Niclou SP, Nicholas RS, Wilkins A, Wing MG, Rhodes KE, Spillantini MG, Compston A, A novel role for Sema3A in neuroprotection from injury mediated by activated microglia., J. Neurosci. (2006). Related reactions - re4983, re5008, re5038, re5052, re5120, re5134, re5146, re5207, re5222, re5224, re5244

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PMID 16407541: Smith PD, Mount MP, Shree R, Callaghan S, Slack RS, Anisman H, Vincent I, Wang X, Mao Z, Park DS, Calpain-regulated p35/cdk5 plays a central role in dopaminergic neuron death through modulation of the transcription factor myocyte enhancer factor 2., J. Neurosci. (2006). Related reactions - re3481, re3483, re4455

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PMID 16393992: Mander PK, Jekabsone A, Brown GC, Microglia proliferation is regulated by hydrogen peroxide from NADPH oxidase., J. Immunol. (2006). Related reactions - re5210, re5253

PMID 16368075: McKenna MC, Waagepetersen HS, Schousboe A, Sonnewald U, Neuronal and astrocytic shuttle mechanisms for cytosolic-mitochondrial transfer of reducing equivalents: current evidence and pharmacological tools., Biochem. Pharmacol. (2006). Related reactions - re4960, re4962, re4963, re4964

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PMID 16298734: Li HM, Niki T, Taira T, Iguchi-Ariga SM, Ariga H, Association of DJ-1 with chaperones and enhanced association and colocalization with mitochondrial Hsp70 by oxidative stress., Free Radic. Res. (2005). Related reactions - re3745

PMID 16288047: Pastorino JG, Hoek JB, Shulga N, Activation of glycogen synthase kinase 3beta disrupts the binding of hexokinase II to mitochondria by phosphorylating voltage-dependent anion channel and potentiates chemotherapy-induced cytotoxicity., Cancer Res. (2005). Related reactions - re2861, re2862

PMID 16276355: Conn PJ, Battaglia G, Marino MJ, Nicoletti F, Metabotropic glutamate receptors in the basal ganglia motor circuit., Nat. Rev. Neurosci. (2005). Related reactions - re3261, re3262, re3265, re3267, re3533, re3534, re3536, re3537, re3538, re3539, re3544, re3549, re4144, re4145, re4167

PMID 16267049: Herzog B, Cardenas J, Hall RK, Villena JA, Budge PJ, Giguère V, Granner DK, Kralli A, Estrogen-related receptor alpha is a repressor of phosphoenolpyruvate carboxykinase gene transcription., J. Biol. Chem. (2006). Related reactions - re2023

PMID 16260611: Arimura N, Ménager C, Kawano Y, Yoshimura T, Kawabata S, Hattori A, Fukata Y, Amano M, Goshima Y, Inagaki M, Morone N, Usukura J, Kaibuchi K, Phosphorylation by Rho kinase regulates CRMP-2 activity in growth cones., Mol. Cell. Biol. (2005). Related reactions - re5316, re5414

PMID 16247008: Heise H, Hoyer W, Becker S, Andronesi OC, Riedel D, Baldus M, Molecular-level secondary structure, polymorphism, and dynamics of full-length alpha-synuclein fibrils studied by solid-state NMR., Proc. Natl. Acad. Sci. U.S.A. (2005). Related reactions - re1287, re2950, re68

PMID 16243425: Jankovic J, Chen S, Le WD, The role of Nurr1 in the development of dopaminergic neurons and Parkinson's disease., Prog. Neurobiol. (2005 Sep-Oct). Related reactions - re4477, re4535, re4536, re4537, re4538, re4541, re4542, re4543, re4544, re4637

PMID 16227987: LaVoie MJ, Ostaszewski BL, Weihofen A, Schlossmacher MG, Selkoe DJ, Dopamine covalently modifies and functionally inactivates parkin., Nat. Med. (2005). Related reactions - re5560, re5563

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PMID 16156895: Mander P, Brown GC, Activation of microglial NADPH oxidase is synergistic with glial iNOS expression in inducing neuronal death: a dual-key mechanism of inflammatory neurodegeneration., J Neuroinflammation (2005). Related reactions - re5211

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PMID 16054096: Woods A, Dickerson K, Heath R, Hong SP, Momcilovic M, Johnstone SR, Carlson M, Carling D, Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells., Cell Metab. (2005). Related reactions - re4337

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PMID 16054087: Sundqvist A, Bengoechea-Alonso MT, Ye X, Lukiyanchuk V, Jin J, Harper JW, Ericsson J, Control of lipid metabolism by phosphorylation-dependent degradation of the SREBP family of transcription factors by SCF(Fbw7)., Cell Metab. (2005). Related reactions - re4155, re4156, re4158

PMID 16051150: Beaulieu JM, Sotnikova TD, Marion S, Lefkowitz RJ, Gainetdinov RR, Caron MG, An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior., Cell (2005). Related reactions - re3299, re3300

PMID 16049940: Head RA, Brown RM, Zolkipli Z, Shahdadpuri R, King MD, Clayton PT, Brown GK, Clinical and genetic spectrum of pyruvate dehydrogenase deficiency: dihydrolipoamide acetyltransferase (E2) deficiency., Ann. Neurol. (2005). Related reactions - re396

PMID 16036915: Grayson C, Molday RS, Dominant negative mechanism underlies autosomal dominant Stargardt-like macular dystrophy linked to mutations in ELOVL4., J. Biol. Chem. (2005). Related reactions - re1183

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PMID 16025099: Youle RJ, Karbowski M, Mitochondrial fission in apoptosis., Nat. Rev. Mol. Cell Biol. (2005). Related reactions - re1650, re4020, re4021, re4023

PMID 16023992: Stadler SC, Polanetz R, Meier S, Mayerhofer PU, Herrmann JM, Anslinger K, Roscher AA, Röschinger W, Holzinger A, Mitochondrial targeting signals and mature peptides of 3-methylcrotonyl-CoA carboxylase., Biochem. Biophys. Res. Commun. (2005). Related reactions - re1145

PMID 16012194: Fuxe K, Ferré S, Canals M, Torvinen M, Terasmaa A, Marcellino D, Goldberg SR, Staines W, Jacobsen KX, Lluis C, Woods AS, Agnati LF, Franco R, Adenosine A2A and dopamine D2 heteromeric receptor complexes and their function., J. Mol. Neurosci. (2005). Related reactions - re2931

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PMID 16005139: Rzem R, Van Schaftingen E, Veiga-da-Cunha M, The gene mutated in l-2-hydroxyglutaric aciduria encodes l-2-hydroxyglutarate dehydrogenase., Biochimie (2006). Related reactions - re406

PMID 15998743: Li J, Baud O, Vartanian T, Volpe JJ, Rosenberg PA, Peroxynitrite generated by inducible nitric oxide synthase and NADPH oxidase mediates microglial toxicity to oligodendrocytes., Proc. Natl. Acad. Sci. U.S.A. (2005). Related reactions - re4692, re5067

PMID 15983381: Junn E, Taniguchi H, Jeong BS, Zhao X, Ichijo H, Mouradian MM, Interaction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell death., Proc. Natl. Acad. Sci. U.S.A. (2005). Related reactions - re2995, re2996, re2997, re4894

PMID 15961413: Strauss KM, Martins LM, Plun-Favreau H, Marx FP, Kautzmann S, Berg D, Gasser T, Wszolek Z, Müller T, Bornemann A, Wolburg H, Downward J, Riess O, Schulz JB, Krüger R, Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease., Hum. Mol. Genet. (2005). Related reactions - re3998, re3999

PMID 15953362: Babu JR, Geetha T, Wooten MW, Sequestosome 1/p62 shuttles polyubiquitinated tau for proteasomal degradation., J. Neurochem. (2005). Related reactions - re5307, re5319

PMID 15946682: Brautigam CA, Chuang JL, Tomchick DR, Machius M, Chuang DT, Crystal structure of human dihydrolipoamide dehydrogenase: NAD+/NADH binding and the structural basis of disease-causing mutations., J. Mol. Biol. (2005). Related reactions - re396, re405

PMID 15936278: Westhoff B, Chapple JP, van der Spuy J, Höhfeld J, Cheetham ME, HSJ1 is a neuronal shuttling factor for the sorting of chaperone clients to the proteasome., Curr. Biol. (2005). Related reactions - re20, re4651

PMID 15935055: Toonen RF, de Vries KJ, Zalm R, Südhof TC, Verhage M, Munc18-1 stabilizes syntaxin 1, but is not essential for syntaxin 1 targeting and SNARE complex formation., J. Neurochem. (2005). Related reactions - re19

PMID 15916966: Kovacs JJ, Murphy PJ, Gaillard S, Zhao X, Wu JT, Nicchitta CV, Yoshida M, Toft DO, Pratt WB, Yao TP, HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor., Mol. Cell (2005). Related reactions - re4787

PMID 15877282: Elpeleg O, Miller C, Hershkovitz E, Bitner-Glindzicz M, Bondi-Rubinstein G, Rahman S, Pagnamenta A, Eshhar S, Saada A, Deficiency of the ADP-forming succinyl-CoA synthase activity is associated with encephalomyopathy and mitochondrial DNA depletion., Am. J. Hum. Genet. (2005). Related reactions - re404

PMID 15864268: Mueller BK, Mack H, Teusch N, Rho kinase, a promising drug target for neurological disorders., Nat Rev Drug Discov (2005). Related reactions - re4084, re5399, re5400, re5402, re5404, re5407, re5408, re5409, re5410, re5411, re5416, re5417

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PMID 15851778: Tribl F, Gerlach M, Marcus K, Asan E, Tatschner T, Arzberger T, Meyer HE, Bringmann G, Riederer P, "Subcellular proteomics" of neuromelanin granules isolated from the human brain., Mol. Cell Proteomics (2005). Related reactions - re4810

PMID 15845384: Ohira RH, Dipple KM, Zhang YH, McCabe ER, Human and murine glycerol kinase: influence of exon 18 alternative splicing on function., Biochem. Biophys. Res. Commun. (2005). Related reactions - re1173

PMID 15790532: Blackinton J, Ahmad R, Miller DW, van der Brug MP, Canet-Avilés RM, Hague SM, Kaleem M, Cookson MR, Effects of DJ-1 mutations and polymorphisms on protein stability and subcellular localization., Brain Res. Mol. Brain Res. (2005). Related reactions - re3745

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PMID 15652488: Yoshimura T, Kawano Y, Arimura N, Kawabata S, Kikuchi A, Kaibuchi K, GSK-3beta regulates phosphorylation of CRMP-2 and neuronal polarity., Cell (2005). Related reactions - re5414

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PMID 15355958: Tanida I, Ueno T, Kominami E, Human light chain 3/MAP1LC3B is cleaved at its carboxyl-terminal Met121 to expose Gly120 for lipidation and targeting to autophagosomal membranes., J. Biol. Chem. (2004). Related reactions - re3395

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