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Systems Biochemistry Group

The mission of the Systems Biochemistry Group at the LCSB is to conduct fundamental research on systems of biochemical reactions in general, with particular application to Parkinson’s disease.

Systems biochemistry is the application of a systems approach to understand biochemistry. A systems approach consists of an iterative cycle of mathematical and computational modelling and quantiative experimental measurement. Mathematical and computational models are formal representations of biochemical knowledge that are used to propose hypotheses, design experiments and interpret experimental results. Quantitative experimental measurements are used to test hypotheses generated by the model and generate data used to refine the model.

The synergistic and interdiciplinary objectives of the group are:

  • to develop generally applicable mathematical optimization algorithms and software for variational kinetic modeling of genome-scale biochemical reaction systems
  • to iteratively improve the predictive capacity of computational models by development of generally applicable algorithms and software for integration of such models with experimental data
  • to develop computational models of dopaminergic neurons which are applied to optimally design in vitro experiments with dopaminergic neurons, to understand the aetiopathogenesis of Parkinson’s disease and to develop new approaches for early diagnosis and treatment of Parkinson’s disease.
  • to develop an automated microfluidic cell culture and imaging platform for experimental characterisation of dopaminergic neurons in vitro.

The Principal Investigator of the Systems Biochemistry Group is Ronan M. T. Fleming. If you are interested in our research and would like to work within the group, even if no specific position is advertised, please send the PI your CV, with a cover letter explaining your research interests.

Please find our open positions here.

Head of Team


 
Ronan Fleming (LCSB)