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Publications

Publications since 2006

(Signal transduction Group)

Peer-reviewed original publications

2010

  1. Margue C, Kreis S. IL-24: Physiological and Supraphysiological Effects on Normal and Malignant Cells Curr Med Chem. 2010 Aug 16. [Epub ahead of print]
  2. Philippidou, D., Schmitt, M., Moser, D., Margue, C., Nazarov, P. V., Muller, A., Vallar, L., Nashan, D., Behrmann, I., and Kreis, S. (2010) Signatures of microRNAs and selected microRNA target genes in human melanoma.   Cancer Res.,   in press.
  3. Radtke, S., Wüller S., Yang, X.-P., Lippok, B. E., Mütze, B., Mais, C., Schmitz-Van de Leur, H., Bode, J. G., Gaestel, M., Heinrich, P. C., Behrmann, I., Schaper, F., and Hermanns, H. M. (2010)   Cross-regulation of cytokine signalling: Pro-inflammatory cytokines restrict IL-6 signalling through receptor internalization and degradation.   J. Cell Sci.,   125: 947-959.

2009

  1. Wiesinger, M. Y., Haan, S., Wüller, S., Kaufmann, M.E., Recker, T., Küster, A., Heinrich, P. C. and Müller-Newen, G. (2009) Development of an IL-6 inhibitor based on the functional analysis of murine IL-6Ra. Chemistry & Biology, 16: 783-94
  2. Haan, S., Wüller, S., Kaczor, J., Rolvering, C., Nöcker, T., Behrmann, I., and Haan, C. (2009) SOCS-mediated down-regulation of mutant Jak2 (V617F, T875N and K539L) counteracts cytokine-independent signaling.   Oncogene 28:3069-3080
  3. Bender, H., Wiesinger, M. Y., Nordhoff, C., Schoenherr, C., Haan, C., Ludwig, S., Weiskirchen, R., Kato, N., Heinrich, P. C., and Haan, S. (2009) Interleukin-27 displays interferon -like functions in human hepatoma cells and hepatocytes. Hepatology, 50: 585-591
  4. Vollmer, S., Kappler, V., Kaczor, J., Flügel, D., Rolvering, C., Kato, N., Kietzmann, T., Behrmann, I., and Haan, C. (2009) Hypoxia-inducible factor is upregulated by Oncostatin M and participates in Oncostatin M signaling. Hepatology, 50:253-260
  5. Haan, C., Kroy, D., Nöcker, T., Wüller, S., Sommer, U., Behrmann, I., Heinrich, P. C., and Haan, S. (2009) An unusual insertion in Janus kinase 2 is crucial for kinase activity and differentially affects cytokine responses. J Immunol, 182:2969-2977

2008

  1. Hintzen, C., Haan, C., Tuckermann, J. P., Heinrich, P. C., and Hermanns, H. M. (2008) Oncostatin M-induced and constitutive activation of the Jak2/STAT5/CIS pathway suppresses CCL1, but not CCL7 and CCL8, chemokine expression. J Immunol 181: 7341-7349
  2. Haan, S., Margue, C., Engrand, A., Rolvering, C., Schmitz-Van de Leur, H., Heinrich, P. C., Behrmann, I., and Haan, C. (2008) Dual role of the Jak1 FERM- and kinase-domains in cytokine receptor binding and in stimulation-dependent Jak activation.   J Immunol 180: 998-1007

2007

  1. Kreis, S., Philippidou, D., Margue, C., Rolvering, C., Haan, C., Dumontier, L., Renauld, J.-C., and Behrmann, I. (2007) Recombinant IL-24 lacks apoptosis-inducing properties in melanoma cells.   PLoS ONE, e1300
  2. Kreis, S., Munz, G. A., Haan, S., Heinrich, P. C., and Behrmann, I. (2007) Cell-density dependent increase of constitutive STAT3 activity in melanoma cells is mediated by Janus kinases.   Mol Cancer Res 5: 1331-1341
  3. Soond, S. M., Carroll, C., Townsend, P. A., Sayan, E., Melino, G., Behrmann, I., Knight, R. A., Latchman, D. S., Stephanou, A. (2007) STAT1 regulates p73-mediated Bax gene expression. FEBS let 581: 1217-1226
  4. Komyod W., Böhm, M., Metze, D., Heinrich, P. C., and Behrmann, I. (2007) Constitutive SOCS3 expression confers a growth advantage to a human melanoma cell line. Mol Cancer Res 5:271-281
  5. Haan, C., and Behrmann, I. (2007) A cost-effective non-commercial ECL solution for Western Blot detections yielding strong signals and low background.   J Immunol Meth 318: 11-19

2006

  1. Van Roeyen, C. R. C., Ostendorf, T., Denecke, B., Bokemeyer, D., Behrmann, I., Strutz, F., Lichenstein, H.S., LaRochelle, W. J., Pena, C., Chaudhun, A., and Floege, J. (2006) Biological responses to PDGF-BB versus PDGF-DD in human mesangial cells. Kidney intern 69:1393-1402
  2. Radtke, S., Jörissen, A., Schmitz-Van de Leur, H., Heinrich, P. C., and Behrmann, I. (2006) Three dileucine-like motifs within the interbox1/2 region of the human oncostatin M receptor prevent efficient surface expression in absence of an associated Janus kinase. J Biol Chem 281: 4024-4034
  3. Hellerbrand, C., Mühlbauer, M., Wallner, S., Schuierer, M., Behrmann, I., Bataille, F., Schölmerich, J., and Bosserhoff, A. K. (2006) Promotor-hypermethylation is causing functional relevant downregulation of methylthioadenosine phosphorylase (MTAP) expression in hepatocellular carcinoma. Carcinogenesis 27: 64-72

2005

  1. Wellbrock, C., Weisser, C., Hassel, J. C., Fischer, P., Becker, J., Vetter, C. S., Behrmann, I., Kortylewski, M., Heinrich, P. C., and Schartl, M. (2005) STAT5 contributes to interferon resistance of melanoma cells. Curr Biol 15: 1629-1639
  2. Haan, S., Keller, J. F., Behrmann, I., Heinrich, P. C., and Haan, C. (2005) Multiple reasons for an inefficient STAT1 response upon IL-6-type cytokine stimulation. Cell Signal 17: 1542-1550
  3. Radtke, S., Haan, S., Jörissen, A., Hermanns, H. M., Diefenbach, S., Smyczek, T., Schmitz-Van de Leur, H., Heinrich, P. C., Behrmann, I., and Haan, C. (2005) The Jak1 SH2 domain does not fulfill a classical SH2 function in Jak/STAT signaling but plays a structural role for receptor interaction and up-regulation of receptor surface expression. J Biol Chem 280: 25760-25768
Review articles / text book chapter

 
 

  1. Entschladen, F., Altschmied, J., Baumgrass, R., Behrmann, I., Giehl, K., Hermanns, H., Huber, O., Kieser, A., Klotz, L. O., Kubatzky, K. F., Hass, R., Janssen, O., Friedrich, K. 2010. Signal transduction, receptors, mediators and genes: younger than ever – the 13th meeting of the Signal Transduction Society focused on aging and immunology.
     Cell Commun Signal. 8:2
  2. Haan, S., Behrmann, I., and Haan, C. (2010) Perspectives for the use of structural information and chemical genetics to develop inhibitors of Janus kinases. J Cell Mol Med, in press.
  3. Friedrich, K., and Behrmann, I. (2009) Zelluläre Signalprozesse. In: Biochemie und Molekularbiologie des Menschen, Elsevier, Hrsg.: M. Schartl, M. Gessler, A. von Eckardstein pp. 631-669.
  4. Kreis, S., Philippidou, D., Margue, C., and Behrmann, I. (2008) IL-24: a classic cytokine and/or a potential cure for cancer?   J Cell Mol Med 12: 2505-2510
  5. Haan, C., Kreis, S., Margue, C., and Behrmann, I. (2006) Jaks and cytokine receptors – an intimate relationship.   Biochem. Pharmacol. 72: 1538-1546