Home // Research // FSTC // Life Science... // Systems Biology // Publications

Publications

Selected publications

Signal transduction

  • Witt J, Barisic S, Schumann E, Allgöwer F, Sawodny O, Sauter T, Kulms D. (2009) Mechanism of PP2A-mediated IKK beta dephosphorylation: a systems biological approach. BMC Syst Biol. 2009 Jul 16;3:71.
  • Schlatter, R.; Conzelmann, H.; Gilles, E.D.; Sawodny, O.; Sauter, T. (2009), ‘ Analysis of an apoptotic core model focused on experimental design using artificial data’, IET Syst Biol Jul;3(4):255-65.
  • Schlatter R, Schmich K, Avalos Vizcarra I, Scheurich P, Sauter T, Borner C, Ederer M, Merfort I, Sawodny O. (2009) ON/OFF and beyond--a boolean model of apoptosis. PLoS Comput Biol. Dec;5(12):e1000595. Epub
  • Bender H*, Wiesinger MY*, Nordhoff C, Schoenherr C, Haan C, Ludwig S, Weiskirchen R, Kato N, Heinrich PC, Haan S (*authors contributed equally) (2009) Interleukin-27 displays interferon γ-like functions in human hepatoma cells and hepatocytes. Hepatology. 2009 Apr 6;50(2):585-591
  • Metz S, Wiesinger MY, Vogt M, Lauks H, Schmalzing G, Heinrich PC, Müller-Newen G. (2007) Characterization of the Interleukin (IL)-6 Inhibitor IL-6-RFP: fused receptor domains act as high affinity cytokine-binding proteins . J Biol Chem., 282(2):1238-48.
  • Conzelmann, H.; Saez-Rodriguez, J.; Sauter, T.; Kholodenko, B. & Gilles, E. (2006), 'A domain-oriented approach to the reduction of combinatorial complexity in signal transduction networks.' , BMC Bioinformatics 7(1), 34.
  • Hao, H.; Zak, D.E.; Sauter, T.; Schwaber, J. & Ogunnaike, B.A. (2006), 'Modeling the VPAC2-activated cAMP/PKA signaling pathway: from receptor to circadian clock gene induction.', Biophys J 90(5), 1560-71.
  • Conzelmann, H.; Saez-Rodriguez, J.; Sauter, T.; Bullinger, E.; Allgöwer, F. & Gilles, E. (2004), 'Reduction of mathematical models of signal transduction networks: simulation-based approach applied to EGF receptor signalling.', Syst Biol (Stevenage) 1(1), 159-69.
  • Kremling, A.; Fischer, S.; Doyle, F.; Gadkar, K.; Sauter, T.; Bullinger, E.; Gilles, E. & Allgöwer, F. (2004), ' A benchmark for methods in reverse engineering and model discrimination: problem formulation and solutions', Genome research 14(9), 1773-85.

Bacterial metabolism

  • Feuer, R.; Ederer, M.; Gilles, E. D.; Sprenger, G. A.; Sawodny, O. & Sauter, T. (2008), Analyse der evolutiven Adaptation am Beispiel einer pyruvat-auxotrophen Escherichia coli-Mutante, Automatisierungstechnik, 56(5):257-268
  • Bettenbrock, K.; Sauter, T.; Jahreis, K.; Kremling, A.; Lengeler, J. & Gilles, E. (2007), 'Analysis of the Correlation between Growth rates, EIIACrr Phosphorylation and Intracellular cAMP Levels in Escherichia coli K-12.', J Bacteriol 189(19):6891-900.
  • Bettenbrock, K.; Fischer, S.; Kremling, A.; Jahreis, K.; Sauter, T. & Gilles, E. (2006), 'A Quantitative Approach to Catabolite Repression in Escherichia coli.' , J Biol Chem 281(5), 2578-84.
  • Sauter, T. & Gilles, E. (2004), 'Modeling and experimental validation of the signal transduction via the Escherichia coli sucrose phosphotransferase system ', J. Biotechnol. 110, 181-199.

Plant metabolism

  • Naegele T, Henkel S, Hormiller I, Sauter T, Sawodny O, Ederer M, Heyer A.G. (2010) Mathematical modelling of the central carbohydrate metabolism in Arabidopsis thaliana reveals a substantial regulatory influence of vacuolar invertase on whole plant carbon metabolism. Plant Physiology 10.1104/pp.110.154443