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Prof Luonan Chen - Hunt for the tipping points of diseases by dynamic network biomarkers

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Event date: Monday, 19 June 2017, 16:00 - 18:30
Place: House of Biomedicine II
6 avenue du Swing
4367 Belvaux
Speaker

Prof Luonan CHEN is Director, Key Laboratory of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences

Abstract

Considerable evidence suggests that during the progression of complex diseases, the deteriorations are not necessarily smooth but are abrupt, and may cause a critical transition from one state to another at a tipping point. Here, we develop a model-free method to detect early-warning signals of such critical transitions, even with only a small number of samples. Specifically, we theoretically derive an index based on a dynamical network biomarker (DNB) that serves as a general early-warning signal indicating an imminent bifurcation or sudden deterioration before the critical transition occurs. Based on theoretical analyses, we show that predicting a sudden transition from small samples is achievable provided that there are a large number of measurements for each sample, e.g., high-throughput data. We employ RNA-seq and microarray data of three diseases (cancers) to demonstrate the effectiveness of our method. The relevance of DNBs with the diseases was also validated by related experimental data and functional analysis.

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Schedule

16.00 - 17.00: Lecture

17.00 - 18.30: Meet the speaker. Registration required for the 'Meet the Speaker' - send us an email