Prof. Dr. Anne Grünewald
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| Faculty or Centre | Luxembourg Centre for Systems Biomedicine | ||||
| Department | Molecular and Functional Neurobiology | ||||
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Université du Luxembourg 6, avenue du Swing L-4367 Belvaux |
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| Campus Office | BioTech II, 1.16 | ||||
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| Telephone | (+352) 46 66 44 9793 | ||||
| Video |
Prof. Anne Grünewald
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Principal Investigator in the Molecular and Functional Neurobiology (Grünewald Lab)
Last updated on: Friday, 26 August 2022
2023
Molecular phenotypes of mitochondrial dysfunction in clinically non-manifesting heterozygous PRKN variant carriers; ; ; ; ; ; ; ; ; ; ;
in NPJ Parkinson's Disease (2023)
Novel insights into Parkin-mediated mitochondrial dysfunction and neuroinflammation in Parkinson's disease; ; ; ;
in Current Opinion in Neurobiology (2023), 80
Selective PDE4 subtype inhibition provides new opportunities to intervene in neuroinflammatory versus myelin damaging hallmarks of multiple sclerosis.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Brain, behavior, and immunity (2023), 109
2022
Neurodegeneration and Neuroinflammation in Parkinson’s Disease: a Self-Sustained Loop; ; ; ; ;
in Current Neurology and Neuroscience Reports (2022), 22(8), 427440
PINK1 Protects against Staurosporine-Induced Apoptosis by Interacting with Beclin1 and Impairing Its Pro-Apoptotic Cleavage.; ; ; ; ; ; ;
in Cells (2022), 11(4),
Coffee, smoking and aspirin are associated with age at onset in idiopathic Parkinson's disease.; ; ; ; ; ; ; ; ;
in Journal of neurology (2022)
A genome on shaky ground: exploring the impact of mitochondrial DNA integrity on Parkinson's disease by highlighting the use of cybrid models.; ; ; ;
in Cellular and molecular life sciences : CMLS (2022), 79(5), 283
Benchmarking Low-Frequency Variant Calling With Long-Read Data on Mitochondrial DNA; ; ; ; ;
in Frontiers in Genetics (2022), 13
Single-cell sequencing of human midbrain reveals glial activation and a Parkinson-specific neuronal state.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Brain : a journal of neurology (2022), 145(3), 964-978
Mitochondrial DNA heteroplasmy distinguishes disease manifestation in PINK1- and PRKN-linked Parkinson's disease 2022.05.17.22275087; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
E-print/Working paper (2022)
Mitochondrial DNA heteroplasmy distinguishes disease manifestation in PINK1/PRKN-linked Parkinson’s disease; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Brain (2022)
Molecular mechanisms defining penetrance of LRRK2-associated Parkinson’s disease; ; ; ; ;
in Medizinische Genetik (2022), 34(2), 103--116
Parkin Deficiency Impairs Mitochondrial DNA Dynamics and Propagates Inflammation.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Movement disorders : official journal of the Movement Disorder Society (2022)
Midbrain organoids mimic early embryonic neurodevelopment and recapitulate LRRK2-p.Gly2019Ser-associated gene expression; ; ; ; ; ; ; ;
in American Journal of Human Genetics (2022)
2021
The Contribution of Microglia to Neuroinflammation in Parkinson's Disease.; ; ; ;
in International journal of molecular sciences (2021), 22(9),
iPSC-Derived Microglia as a Model to Study Inflammation in Idiopathic Parkinson's Disease.; ; ; ; ; ; ; ; ; ; ; ; ;
in Frontiers in cell and developmental biology (2021), 9
Coffee, smoking and aspirin are associated with age at onset and clinical severity in idiopathic Parkinson’s disease; ; ; ; ; ; ; ; ; ;
E-print/Working paper (2021)
Functional and Molecular Properties of DYT-SGCE Myoclonus-Dystonia Patient-Derived Striatal Medium Spiny Neurons.; ; ; ; ; ; ; ; ; ; ;
in International journal of molecular sciences (2021), 22(7),
Nanopore Single-Molecule Sequencing for Mitochondrial DNA Methylation Analysis: Investigating Parkin-Associated Parkinsonism as a Proof of Concept; ; ; ; ; ; ; ; ;
in Frontiers in Aging Neuroscience (2021)
Astrocyte-Neuron Metabolic Crosstalk in Neurodegeneration: A Mitochondrial Perspective.; ;
in Frontiers in endocrinology (2021), 12
LIPAD (LRRK2/Luebeck International Parkinson's Disease) Study Protocol: Deep Phenotyping of an International Genetic Cohort; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Frontiers in Neurology (2021), 12
2020
Impaired Mitochondrial-Endoplasmic Reticulum Interaction and Mitophagy in Miro1-Mutant Neurons in Parkinson’s Disease; ; ; ; ; ; ; ; ; ;
in Human Molecular Genetics (2020)
Mitochondrial damage-associated inflammation highlights biomarkers in PRKN/PINK1 parkinsonism; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Brain: a Journal of Neurology (2020)
Mitochondria and Parkinson's Disease: Clinical, Molecular, and Translational Aspects; ; ;
in Journal of Parkinson's Disease (2020)
Mitochondrial Mechanisms of LRRK2 G2019S Penetrance; ; ; ; ; ; ; ; ; ; ;
in Frontiers in Neurology (2020)
Discordant Monozygotic Parkinson Disease Twins: Role of Mitochondrial Integrity; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Annals of Neurology (2020)
Age at Onset of LRRK2 p.Gly2019Ser Is Related to Environmental and Lifestyle Factors; ; ; ; ; ; ;
in Movement Disorders (2020), 35(10), 1854-1858
Haploinsufficiency due to a novel ACO2 deletion causes mitochondrial dysfunction in fibroblasts from a patient with dominant optic nerve atrophy; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Scientific Reports (2020)
Single-cell sequencing of the human midbrain reveals glial activation and a neuronal state specific to Parkinson’s disease; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
E-print/Working paper (2020)
Parkin-linked Parkinson's disease: From clinical insights to pathogenic mechanisms and novel therapeutic approaches; ;
in Neuroscience Research (2020)
2019
Variants in Miro1 cause alterations of ER-mitochondria contact sites in fibroblasts from Parkinson's disease patients; ; ; ; ; ; ; ; ; ;
in Journal of Clinical Medicine (2019)
Mutations in RHOT1 disrupt ER-mitochondria contact sites interfering with calcium homeostasis and mitochondrial dynamics in Parkinson's disease.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Antioxidants & redox signaling (2019)
New insights into the complex role of mitochondria in Parkinson's disease; ;
in Progress in Neurobiology (2019), 177
MtDNA deletions discriminate affected from unaffected LRRK2 mutation carriers; ; ; ; ; ; ; ; ;
in Annals of Neurology (2019), 86(2), 324-326
2018
3D Cultures of Parkinson's Disease‐Specific Dopaminergic Neurons for High Content Phenotyping and Drug Testing; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Advanced Science (2018)
Mutationen im VSP13D-Gen verursachen eine oftmals frühkindliche spastische Ataxiein DGNeurologie (2018), 1(1), 58-59
Genotype-phenotype relations for the Parkinson’s disease genes SNCA, LRRK2, VPS35: MDSGene Review.; ; ; ; ; ; ; ; ; ; ; ; ;
in Movement Disorders (2018), 33(12), 1857-1870
Subcellular origin of mitochondrial DNA deletions in human skeletal muscle.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Annals of Neurology (2018), 84(2), 289-301
2017
Faithful SGCE imprinting in iPSC-derived cortical neurons: an endogenous cellular model of myoclonus-dystonia; ; ; ; ; ; ;
in Scientific Reports (2017)
Acylated and unacylated ghrelin confers neuroprotection to mesencephalic neurons; ; ; ; ; ; ; ; ;
in Neuroscience (2017)
SLP-2 interacts with Parkin in mitochondria and prevents mitochondrial dysfunction in Parkin-deficient human iPSC-derived neurons and Drosophila; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Human Molecular Genetics (2017)
2016
Mitochondrial DNA depletion in respiratory chain-deficient Parkinson disease neurons.; ; ; ; ;
in Annals of Neurology (2016), 79(3), 366-378
2015
SCNT-derived ESCs with mismatched mitochondria trigger an immune response in allogeneic hosts.; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Cell Stem Cell (2015), 16(1), 33-8
A novel immunofluorescent assay to investigate oxidative phosphorylation deficiency in mitochondrial myopathy: understanding mechanisms and improving diagnosis.; ; ; ; ; ; ;
in Scientific reports (2015), 5
2014
THAP1, the gene mutated in DYT6 dystonia, autoregulates its own expression.; ; ; ; ; ; ; ; ; ; ; ;
in Biochimica et biophysica acta (2014), 1839(11), 1196-204
Does uncoupling protein 2 expression qualify as marker of disease status in LRRK2-associated Parkinson's disease?; ; ; ; ;
in Antioxidants & redox signaling (2014), 20(13), 1955-60
Quantitative quadruple-label immunofluorescence of mitochondrial and cytoplasmic proteins in single neurons from human midbrain tissue.; ; ; ; ; ; ;
in Journal of Neuroscience Methods (2014), 232
Genome-wide association study in musician's dystonia: a risk variant at the arylsulfatase G locus?; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Movement Disorders (2014), 29(7), 921-7
PINK1 loss-of-function mutations affect mitochondrial complex I activity via NdufA10 ubiquinone uncoupling.; ; ; ; ; ; ; ; ; ; ; ; ;
in Science (2014), 344(6180), 203-7
2013
Probenecid potentiates MPTP/MPP+ toxicity by interference with cellular energy metabolism.; ; ; ; ; ; ; ; ; ; ;
in Journal of neurochemistry (2013), 127(6), 782-92
Bee venom and its component apamin as neuroprotective agents in a Parkinson disease mouse model.; ; ; ; ; ; ; ; ;
in PloS one (2013), 8(4), 61700
Mortalin mutations are not a frequent cause of early-onset Parkinson disease.; ; ; ; ; ; ; ;
in Neurobiology of Aging (2013), 34(11), 269419-20
Next-generation phenotyping using the parkin example: time to catch up with genetics.; ; ;
in JAMA neurology (2013), 70(9), 1186-91
Next-generation phenotyping and genomic incidental findings--reply.; ;
in JAMA neurology (2013), 70(12), 1590-1
Glucocerebrosidase mutations in a Serbian Parkinson's disease population.; ; ; ; ; ; ; ; ; ; ; ; ;
in European journal of neurology (2013), 20(2), 402-5
Targeted next generation sequencing in SPAST-negative hereditary spastic paraplegia.; ; ; ; ; ; ; ; ; ; ;
in Journal of neurology (2013), 260(10), 2516-22
Phosphatase and tensin homolog (PTEN)-induced putative kinase 1 (PINK1)-dependent ubiquitination of endogenous Parkin attenuates mitophagy: study in human primary fibroblasts and induced pluripotent stem cell-derived neurons.; ; ; ; ; ; ;
in The Journal of biological chemistry (2013), 288(4), 2223-37
Prominent psychiatric comorbidity in the dominantly inherited movement disorder myoclonus-dystonia.; ; ; ; ; ;
in Parkinsonism and Related Disorders (2013), 19(4), 422-5
2012
ATP13A2 mutations impair mitochondrial function in fibroblasts from patients with Kufor-Rakeb syndrome.; ; ; ; ; ; ;
in Neurobiology of Aging (2012), 33(8), 18431-7
Two faces of the same coin: benign familial infantile seizures and paroxysmal kinesigenic dyskinesia caused by PRRT2 mutations.; ; ; ; ; ; ; ; ; ; ;
in Archives of neurology (2012), 69(5), 668-70
Mutations in the phospholipid remodeling gene SERAC1 impair mitochondrial function and intracellular cholesterol trafficking and cause dystonia and deafness.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Nature genetics (2012), 44(7), 797-802
2011
Bioenergetic consequences of PINK1 mutations in Parkinson disease.; ; ; ; ;
in PloS one (2011), 6(10), 25622
An unusual neurological syndrome of crawling gait, dystonia, pyramidal signs, and limited speech.; ; ; ; ; ; ; ; ; ; ;
in Movement Disorders (2011), 26(12), 2279-83
Mutations in PINK1 and Parkin impair ubiquitination of Mitofusins in human fibroblasts.; ; ; ; ; ;
in PloS one (2011), 6(3), 16746
PINK1-interacting proteins: Proteomic analysis of overexpressed PINK1; ; ; ; ; ;
in Parkinsons Dis (2011), 2011
2010
Mutant Parkin impairs mitochondrial function and morphology in human fibroblasts.; ; ; ; ; ; ; ; ; ; ; ;
in PloS one (2010), 5(9), 12962
Effect of endogenous mutant and wild-type PINK1 on Parkin in fibroblasts from Parkinson disease patients.; ; ; ; ; ; ;
in Human molecular genetics (2010), 19(16), 3124-37
2009
Differential effects of PINK1 nonsense and missense mutations on mitochondrial function and morphology.; ; ; ; ; ;
in Experimental neurology (2009), 219(1), 266-73
2008
Re: Alpha-synuclein gene duplication is present in sporadic Parkinson disease.; ; ; ; ; ; ; ;
in Neurology (2008), 71(16), 12941294
Myoclonus-dystonia: significance of large SGCE deletions.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Human mutation (2008), 29(2), 331-2
The DRD2 TaqIA polymorphism and demand of dopaminergic medication in Parkinson's disease.; ; ; ; ; ; ; ;
in Movement Disorders (2008), 23(4), 599-602
2007
Rapid and reliable detection of exon rearrangements in various movement disorders genes by multiplex ligation-dependent probe amplification.; ; ; ; ; ; ; ; ; ; ;
in Movement Disorders (2007), 22(12), 1708-14
Biological effects of the PINK1 c.1366C>T mutation: implications in Parkinson disease pathogenesis.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Neurogenetics (2007), 8(2), 103-9
Autosomal dominant myoclonus-dystonia and Tourette syndrome in a family without linkage to the SGCE gene.; ; ; ; ; ; ; ; ;
in Movement Disorders (2007), 22(14), 2090-6
2006
Clinical spectrum of homozygous and heterozygous PINK1 mutations in a large German family with Parkinson disease: role of a single hit?; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Archives of neurology (2006), 63(6), 833-8
Early-onset parkinsonism associated with PINK1 mutations: frequency, genotypes, and phenotypes.; ;
in Neurology (2006), 66(7), 1129-301129-30
