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Enrico Glaab

Enrico Glaab

Assistant professor / Senior research scientist in Machine Learning and Bioinformatics

Faculty or Centre Luxembourg Centre for Systems Biomedicine
Research Unit LCSB
Postal Address Université du Luxembourg
6, avenue du Swing
L-4367 Belvaux
Campus Office BioTech II Ketterthill, 4.17
Email
Telephone (+352) 46 66 44 6186
Video Dr Enrico Glaab
Dr Enrico Glaab
 
Dr Enrico Glaab

Principal Investigator in the Biomedical Data Science group (Glaab Lab) and Deputy Course Director at the University of Luxembourg.

Member of the Research Team in the National Centre of Excellence in Research on Parkinson’s Disease (NCER-PD)

Dr. Glaab is pleased to consider applications from prospective PostDocs or PhD students in bioinformatics. Students interested in pursuing a master's degree at the interface of bioinformatics and experimental biology may want to consider our programme Master in integrated systems biology.

Last updated on: Tuesday, 16 October 2018

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2019

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See detailIntegrative analysis of blood metabolomics and PET brain neuroimaging data for Parkinson's disease
Glaab, Enrico; Trezzi, Jean-Pierre; Greuel, Andrea; Jäger, Christian; Hodak, Zdenka; Drzezga, Alexander; Timmermann, Lars; Tittgemeyer, Marc; Diederich, Nico Jean; Eggers, Carsten

in Neurobiology of Disease (2019), 124(1), 555-562

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2018

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See detail3D Cultures of Parkinson's Disease‐Specific Dopaminergic Neurons for High Content Phenotyping and Drug Testing
Bolognin, Silvia; Fossépré, Marie; Qing, Xiaobing; Jarazo, Javier; Ščančar, Janez; Lucumi Moreno, Edinson; Nickels, Sarah; Wasner, Kobi; Ouzren, Nassima; Walter, Jonas; Grünewald, Anne; Glaab, Enrico; Salamanca, Luis; Fleming, Ronan M. T.; Antony, Paul; Schwamborn, Jens Christian

in Advanced Science (2018)

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See detailComputational systems biology approaches for Parkinson's disease
Glaab, Enrico

in Cell and Tissue Research (2018), 373(1), 91109

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See detailCombining PET imaging and blood metabolomics data to improve machine learning models for Parkinson’s disease diagnosis
Glaab, Enrico; Trezzi, Jean-Pierre; Greuel; Jäger, Christian; Hodak, Zdenka; Timmermann, Lars; Tittgemeyer, Marc; Diederich, Nico Jean; Eggers, Carsten

Poster (2018, October 08)

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See detailA rare loss-of function variant of ADAM17 is associated with late-onset familial Alzheimer disease
Hartl, Daniela; May, Patrick; Gu, Wei; Mayhaus, Manuel; Pichler, Sabrina; Spaniol, Christian; Glaab, Enrico; Bobbili, Dheeraj Reddy; Antony, Paul; Köglsberger, Sandra; Kurz, Alexander; Grimmer, Timo; Morgan, Kevin; Vardarajan, Badri N.; Reitz, Christiane; Hardy, John; Bras, Jose; Guerreiro, Rita; AESG; Balling, Rudi; Schneider, Jochen; Riemenschneider, Matthias

in Molecular Psychiatry (2018)

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See detailA structure-activity relationship linking non-planar PCBs to functional deficits of neural crest cells: new roles for connexins
Nyffeler, Johanna; Chovancova, Petra; Dolde, Xenia; Holzer, Anna-Katharina; Purvanov, Vladimir; Kindinger, Ilona; Kerins, Anna; Higton, David; Silvester, Steve; van Vugt-Lussenburg, Barbara M. A.; Glaab, Enrico; van der Burg, Bart; Maclennan, Richard; Legler, Daniel F.; Leist, Marcel

in Archives of Toxicology (2018), 92(3), 12251247

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2017

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See detailAbsence of regulator of G-protein signaling 4 does not protect against dopamine neuron dysfunction and injury in the mouse 6-hydroxydopamine lesion model of Parkinson's disease
Ashrafi, Amer; Garcia, Pierre; Kollmus, Heike; Schughart, Klaus; del Sol Mesa, Antonio; Buttini, Manuel; Glaab, Enrico

in Neurobiology of Aging (2017), 58

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See detailNeuroChip, an updated version of the NeuroX genotyping platform to rapidly screen for variants associated with neurological diseases
Blauwendraat, Cornelis; Faghri, Faraz; Pihlstrom, Lasse; Geiger, Joshua T.; Elbaz, Alexis; Lesage, Susanne; May, Patrick; Aude, Nicolas; Abramzon, Yevgeniya; Murphy, Natalie A.; Gibbs, J. Raphael; Ryten, Mina; Ferrari, Raffaele; Bras, Jose; Guerreiro, Rita; Williams, Julie; Sims, Rebecca; Lubbe, Steven; Hernandez, Dena G.; Mok, Kin Y.; Robak, Laurie; Camphell, Roy H.; Rogaeva, Ekaterina; Traynor, Bryan J.; Chia, Ruth; Chung, Sun Ju; International Parkinson’s Disease Genomics Consortium (IPDGC); COURAGE-PD Consortium; Glaab, Enrico; Balling, Rudi; Hardy, John A.; Brice, Alexis; Houlden, Henry; Shulman, Joshua M.; Morris, Huw R.; Gasser, Thomas; Heutink, Peter; Krüger, Rejko; Sharma, Manu; Simon-Sanchez, Javier; Nalls, Mike A.; Singleton, Andrew B.; Scholz, Sonja W.

in Neurobiology of Aging (2017)

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See detailMetformin reverses TRAP1 mutation-associated alterations in mitochondrial function in Parkinson's disease
Fitzgerald, Julia C.; Zimprich, Alexander; Carvajal-Berrio, Daniel A.; Schindler, Kevin M.; Maurer, Brigitte; Schulte, Claudia; Bus, Christine; Hauser, Anne-Kathrin; Kübler, Manuela; Lewin, Rahel; Bobbili, Dheeraj Reddy; Schwarz, Lisa M.; Vartholomaiou, Evangela; Brockmann, Kathrin; Wüst, Richard; Madlung, Johannes; Nordheim, Alfred; Riess, Olaf; Martins, L. Miguel; Glaab, Enrico; May, Patrick; Schenke-Layland, Katja; Picard, Didier; Sharma, Manu; Gasser, Thomas; Krüger, Rejko

in Brain : A Journal of Neurology (2017), 140(9), 2444-2459

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See detailBiomedical Data Science at LCSB
Glaab, Enrico

Presentation (2017)

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See detailIDENTIFICATION OF A RARE GENE VARIANT THAT IS ASSOCIATED WITH FAMILIAL ALZHEIMER DISEASE AND REGULATES APP EXPRESSION
Hartl, Daniela; May, Patrick; Gu, Wei; Mayhaus, Manuel; Glaab, Enrico; Antony, Paul; Bobbili, Dheeraj Reddy; Köglsberger, Sandra; Pichler, Sabrina; Spaniol, Christian; Kurz, Alexander; Balling, Rudi; Schneider, Jochen; Riemenschneider, Matthias

in Alzheimer's & Dementia : The Journal of the Alzheimer's Association (2017), 13(7, Supplement), 648

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See detailGender-specific expression of ubiquitin-specific peptidase 9 modulates tau expression and phosphorylation: possible implications for tauopathies
Köglsberger, Sandra; Cordero Maldonado, Maria Lorena; Antony, Paul; Forster, Julia; Garcia, Pierre; Buttini, Manuel; Crawford, Alexander Dettmar; Glaab, Enrico

in Molecular Neurobiology (2017), 54(10), 79797993

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See detailMolecular Identification of D-Ribulokinase in Budding Yeast and Mammals
Singh, Charandeep; Glaab, Enrico; Linster, Carole

in Journal of Biological Chemistry (2017), 292(3), 1005-1028

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2016

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See detailCrowdsourced estimation of cognitive decline and resilience in Alzheimer's disease
Allen, Genevera; Amoroso, Nicola; Anghel, Catalina; Balagurusamy, Venkat; Bare, Christopher; Beaton, Derek; Bellotti, Roberto; Bennett, David; Boehme, Kevin; Caberlotto, Laura; Campbell, Frederick; Chang, Yu-Chuan; Chen, Beibei; Chen, Chien-Yu; Chien, Ting-Ying; Clark, Tim; Das, Sudeshna; Davatzikos, Christos; Deng, Jieyao; Dillenberger, Donna; Dobson, Richard; Dong, Qilin; Doshi, Jimit; Duma, Denise; Errico, Rosangela; Erus, Guray; Everett, Evan; Fardo, David; Friend, Stephen; Fröhlich, Holger; Gan, Jessica; St George-Hyslop, Peter; Ghosh, Satrajit; Glaab, Enrico; Green, Robert; Guan, Yuanfang; Hong, Ming-Yi; Huang, Chao; Hwang, Jinseub; Ibrahim, Joseph; Inglese, Paolo; Jiang, Qijia; Katsumata, Yurik; Kauwe, Jo; Klein, Arno; Kong, Dehan; Krause, Roland; Lalonde, Emilie; Lauria, Mari; Lee, Eunjee; Lin, Xihui; Liu, Zhandong; Livingstone, Julie; Logsdon, Benjami; Lovestone, Simon; Iyappan, Anandhi; Ma, Tsung-wei; Malhotra, Ashutos; Maxwell, Taylor; Merrill, Emily; Nagorski, John; Alex Namasivayam, Aishwarya; Narayan, Manjari; Naz, Mufassra; Neto, Elias Chaibub; Newhouse, Stephen; Norman, Thea; Nurtdinov, Ramil; Oyang, Yen-Jen; Boutros, Paul; Pawitan, Yudi; Peng, Shengwen; Peters, Mette; Piccolo, Stephen; Praveen, Paurush; Priami, Corrado; Sabelnykova, Veronica; Senger, Philipp; Shen, Xia; Simmons, Andrew; Sotiras, Aristeidis; Stolovitzky, Gustavo; Tangaro, Sabina; Tateo, Andrea; Tung, Yi-An; Tustison, Nicholas; Varol, Erdem; Vradenburg, George; Weiner, Michael; Xiao, Guanghua; Xie, Lei; Xie, Yang; Xu, Jia; Yang, Hojin; Zhan, Xiaowei; Zhou, Yunyun; Zhu, Fan; Zhu, Hongtu; Zhu, Shanfeng; Alzheimer's Disease Neuroimaging Initiative

in Alzheimer's & Dementia : The Journal of the Alzheimer's Association (2016), 12(6), 645-653

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See detailMitochondrial Defects and Neurodegeneration in Mice Overexpressing Wild Type or G399S Mutant HtrA2
Casadei, Nicolas; Sood, Poonan; Ulrich, Thomas; Kieper, Nicole; Helling, Stefan; May, Caroline; Glaab, Enrico; Chen, Jing; Nuber, Silke; Marcus, Katrin; Rapaport, Doron; Ott, Thomas; Riess, O.; Krüger, Rejko; Fitzgerald, Julia

in Human Molecular Genetics (2016), 25(3), 459-71

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See detailConversion of non-proliferating astrocytes into neurogenic neural stem cells: control by FGF2 and IFN-gamma
Kleiderman, Susanne; Gutbier, Simon; Tufekci, Kemal U.; Ortega, Felipe; Sá, João V.; Teixeira, Ana P.; Brito, Catarina; Glaab, Enrico; Berninger, Benedikt; Alves, Paula M.; Leist, Marcel

in Stem Cells (2016), 34(12), 28612874

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See detailFunctional and phenotypic differences of pure populations of stem cell-derived astrocytes and neuronal precursor cells
Kleiderman, Susanne; Sá, Joao; Teixeira, Ana; Brito, Catarina; Gutbier, Simon; Evje, Lars; Hadera, Mussie; Glaab, Enrico; Henry, Margit; Agapios, Sachinidis; Alves, Paula; Sonnewald, Ursula; Leist, Marcel

in Glia (2016), 64(5), 695-715

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See detailToward Omics-Based, Systems Biomedicine, and Path and Drug Discovery Methodologies for Depression-Inflammation Research
Maes; Nowak, Gabriel; Caso, Javier; Leza, Juan Carlos; Song, Cai; Kubera, Marta; Klein, Hans; Galecki, Pjotr; Noto, Cristiano; Glaab, Enrico; Balling, Rudi; Berk, Michael

in Molecular Neurobiology (2016), 53(5), 2927-2935

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See detailA microfluidics-based in vitro model of the gastrointestinal human-microbe interface.
Shah, Pranjul; Fritz, Joëlle; Glaab, Enrico; Desai, Mahesh S.; Greenhalgh, Kacy; Frachet Bour, Audrey; Niegowska, Magdalena; Estes, Matthew; Jäger, Christian; Seguin-Devaux, Carole; Zenhausern, Frederic; Wilmes, Paul

in Nature communications (2016), 7

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2015

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See detailTranscriptomic analyses of primary astrocytes under TNFα treatment
Birck, Cindy; Koncina, Eric; Heurtaux, Tony; Glaab, Enrico; Michelucci, Alessandro; Heuschling, Paul; Grandbarbe, Luc

in Genomics Data (2015), 7

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See detailInflammation Promotes a Conversion of Astrocytes into Neural Progenitor Cells via NF-κB Activation
Gabel, Sebastien; Koncina, Eric; Dorban, Gauthier; Heurtaux, Tony; Birck, Cindy; Glaab, Enrico; Michelucci, Alessandro; Heuschling, Paul; Grandbarbe, Luc

in Molecular Neurobiology (2015), 53(8), 5041-5055

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See detailBuilding a virtual ligand screening pipeline using free software: a survey
Glaab, Enrico

in Briefings in Bioinformatics (2015)

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See detailRepExplore: Addressing technical replicate variance in proteomics and metabolomics data analysis
Glaab, Enrico; Schneider, Reinhard

in Bioinformatics (2015), 31(13), 2235

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See detailThe Mouse Brain Metabolome: Region-Specific Signatures and Response to Excitotoxic Neuronal Injury
Jäger, Christian; Glaab, Enrico; Michelucci, Alessandro; Binz, Tina; Köglsberger, Sandra; Garcia, Pierre; Trezzi, Jean-Pierre; Ghelfi, Jenny; Balling, Rudi; Buttini, Manuel

in American Journal of Pathology (2015), 185(6), 1699-1712

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See detailInference of longevity-related genes from a robust co-expression network of seed maturation identifies new regulators linking seed storability to biotic defense-related pathways
Righetti, Karima; Vu, Joseph Ly; Pelletier, Sandra; Vu, Benoit Ly; Glaab, Enrico; Lalanne, David; Pasha, Asher; Patel, Rohan V; Provart, Nicholas; Verdier, Jerome; Leprince, Olivier

in Plant Cell (2015), 27(10), 2692-2708

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See detailGenePEN: analysis of network activity alterations in complex diseases via the pairwise elastic net
Vlassis, Nikos; Glaab, Enrico

in Statistical Applications in Genetics and Molecular Biology (2015), 14(2), 221-224

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2014

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See detailIntegrating Pathways of Parkinson's Disease in a Molecular Interaction Map
Fujita, Kazuhiro A.; Ostaszewski, Marek; Matsuoka, Yukiko; Ghosh, Samik; Glaab, Enrico; Trefois, Christophe; Crespo, Isaac; Perumal, Thanneer Malai; Jurkowski, Wiktor; Antony, Paul; Diederich, Nico; Buttini, Manuel; Kodama, Akihiko; Satagopam, Venkata; Eifes, Serge; del Sol Mesa, Antonio; Schneider, Reinhard; Kitano, Hiroaki; Balling, Rudi

in Molecular Neurobiology (2014)

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See detailAddressing Technical Replicate Variance in Omics Data Analysis
Glaab, Enrico; Schneider, Reinhard

Poster (2014)

See detailDynamic modelling of ROS management and ROS-induced mitophagy
Kolodkin, Alexey; Ignatenko, Andrew; Sangar, Vineet; Glaab, Enrico; Peters, Bernhard; Price, Nathan; Brady, Nathan; Balling, Rudi

Poster (2014, June)

See detailROS-management in Parkinson’s disease: Dynamic blue-print domino-based model and design principles study. Dynamic modelling of ROS management and ROS-induced mitophagy
Kolodkin, Alexey; Ignatenko, Andrew; Sangar, Vineet; Simeonidis, Vangelis; Glaab, Enrico; Peters, Bernhard; Brady, Nathan; Price, Nathan; Balling, Rudi

Poster (2014, October)

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2013

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See detailFunctional Genomics, Proteomics, Metabolomics and Bioinformatics for Systems Biology
Ballereau, S.; Glaab, Enrico; Kolodkin, Alexey; Chaiboonchoe, A.; Biryukov, Maria; Vlassis, Nikos; Ahmed, H.; Pellet, J.; Baliga, N.; Hood, Leroy; Schneider, Reinhard; Balling, Rudi; Auffray, C.

in Prokop, Ales; Csukás, Bela (Eds.) Systems Biology: Integrative Biology and Simulation Tools (2013)

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See detailNetwork analysis for systems biology
Chaiboonchoe, A.; Jurkowski, Wiktor; Pellet, J.; Glaab, Enrico; Kolodkin, Alexey; Raussel, Antonio; Le Béchec, Antony; Meyniel, L.; Ballereau, S.; Crespo, Isaac; Ahmed, H.; Volpert, V.; Lotteau, V.; Baliga, N.; Hood, Leroy; del Sol, A.; Balling, Rudi; Auffray, C.

in Prokop, Aleš; Csukás (Eds.) Springer book in Systems Biology, Vol.1: Systems Biology:, Integrative Biology and Simulation Tools (2013)

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See detailOn different aspects of network analysis in systems biology
Chaiboonchoe, Amphun; Jurkowski, Wiktor; Pellet, Johann; Glaab, Enrico; Kolodkin, Alexey; Raussel, Antonio; Le Béchec, Antony; Ballereau, Stéphane; Meyniel, Laurene; Crespo, Isaac; Ahmed, Hassan; Volpert, Vitaly; Lotteau, Vincent; Baliga, Nitin; Hood, Leroy; Sol, Antonio del; Balling, Rudi; Auffray, Charles

in Systems Biology (2013), 1

See detailMeta-omic Analyses of the Microbiome in a Family Study of Diabetes Mellitus
Heintz, Anna; May, Patrick; Lebrun, Laura; Ferrand, J; Trezzi, Jean-Pierre; Collignon, S; Wampach, Linda; Glaab, Enrico; Laczny, Cedric Christian; Martins Conde, Patricia; Kaysen, Anne; Schneider, Jochen; Hiller, Karsten; Hogan, Angela; Wilmes, Paul; de Beaufort, Carine

Poster (2013, October)

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See detailCondensing the omics fog of microbial communities
Muller, Emilie; Glaab, Enrico; May, Patrick; Vlassis, Nikos; Wilmes, Paul

in Trends in Microbiology (2013), 21(7), 325333

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See detailThe Parkinson's Disease Map: A Framework for Integration, Curation and Exploration of Disease-related Pathways
Ostaszewski, Marek; Fujita, Kazuhiro; Matsuoka, Yukiko; Ghosh, Samik; Glaab, Enrico; Trefois, Christophe; Crespo, Isaac; Perumal, Thanneer Malai; Jurkowski, Wiktor; Antony, Paul; Diederich, Nico; Buttini, Manuel; Kolodkin, Alexey; Kodama, Akihiko; Satagopam, Venkata; Biryukov, Maria; Eifes, Serge; del Sol Mesa, Antonio; Schneider, Reinhard; Kitano, Hiroaki; Balling, Rudi

Poster (2013, March 09)

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See detailNetwork deregulation analysis in complex diseases via the pairwise elastic net
Vlassis, Nikos; Glaab, Enrico

in Proc 8th BeNeLux Bioinformatics Conference (2013)

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2012

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See detailUsing rule-based machine learning for candidate disease gene prioritization and sample classification of cancer gene expression data
Glaab, Enrico; Bacardit, Jaume; Garibaldi, Jonathan M.; Krasnogor, Natalio

in PLoS ONE (2012), 7(7), 39932-39932

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See detailEnrichNet: network-based gene set enrichment analysis
Glaab, Enrico; Baudot, A.; Krasnogor, N.; Schneider, Reinhard; Valencia, A.

in Bioinformatics (2012), 28(18), 451-457

See detailConstructing a comprehensive map of Parkinson’s disease to elucidate underlying mechanisms of its multifaceted molecular pathology
Trefois, Christophe; Fujita, A. K.; Ostaszewski, Marek; Matsuoka, Yukiko; Ghosh, Samic; Glaab, Enrico; Crespo, Isaac; Perumal, T. M.; Jurkowski, Wiktor; Antony, Paul; Diederich, Nico; Buttini, Manuel; Kodama, Akihiko; Satagopam, Venkata; Eifes, Serge; del Sol Mesa, Antonio; Schneider, Reinhard; Kitano, Hiroaki; Balling, Rudi

Poster (2012, August)

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2011

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See detailFunctional Network Construction in Arabidopsis Using Rule-Based Machine Learning on Large-Scale Data Sets
Bassel, George W.; Glaab, Enrico; Marquez, Julietta; Holdsworth, Michael J.; Bacardit, Jaume

in Plant Cell (2011)

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See detailA genome-wide network model capturing seed germination reveals co-ordinated regulation of plant cellular phase transitions
Bassel, George W.; Lanc, Hui; Glaab, Enrico; Gibbs, Daniel J.; Gerjets, Tanja; Krasnogor, Natalio; Bonner, Anthony J.; Holdsworth, Michael J.; Provart, Nicholas J.

in Proceedings of the National Academy of Sciences of the United States of America (2011), 108(23), 9709-9714

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See detailA low protein diet during early gestation in sheep detrimentally impacts hepatic glucose metabolism in the adult offspring
Gardner, David S.; Rhodes, Phillip; Karamitri, Angeliki; Glaab, Enrico; Rhind, Stuart M.

in Proceedings of the Nutrition Society 2011 (2011)

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See detailRERG (Ras-like, oestrogen-regulated, growth-inhibitor) expression in breast cancer: a marker of ER-positive luminal-like subtype
Habashy, Hany O.; Powe, Desmond G.; Glaab, Enrico; Ball, Graham; Spiteri, Immaculada; Krasnogor, Natalio; Garibaldi, Jonathan M.; Rakha, Emad A.; Green, Andrew R.; Caldas, Carlos; Ellis, Ian O.

in Breast Cancer Research and Treatment (2011), 128(2), 315-326

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2010

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See detailExtending pathways and processes using molecular interaction networks to analyse cancer genome data
Glaab, Enrico; Baudot, Anais; Krasnogor, Natalio; Valencia, Alfonso

in BMC Bioinformatics (2010), 11(1), 597-597

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See detailTopoGSA: network topological gene set analysis
Glaab, Enrico; Baudot, Anais; Krasnogor, Natalio; Valencia, Alfonso

in Bioinformatics (2010), 26(9), 1271-1272

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See detailLearning pathway-based decision rules to classify microarray cancer samples
Glaab, Enrico; Garibaldi, Jonathan M.; Krasnogor, N.

in German Conference on Bioinformatics 2010, Lecture Notes in Informatics (LNI) (2010)

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See detailVRMLGen: An R package for 3D Data Visualization on the Web
Glaab, Enrico; Garibaldi, Jonathan M.; Krasnogor, Natalio

in Journal of Statistical Software (2010), 36(8), 1-18

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2009

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See detailArrayMining: a modular web-application for microarray analysis combining ensemble and consensus methods with cross-study normalization
Glaab, Enrico; Garibaldi, Jonathan M.; Krasnogor, N.

in BMC Bioinformatics (2009), 10(1), 358-358

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