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Evan Williams

Associate professor / Chief scientist 2

Faculty or Centre Luxembourg Centre for Systems Biomedicine
Department Gene Expression and Metabolism
Postal Address Université du Luxembourg
2, Avenue de l'Université
L-4365 Esch-sur-Alzette
Email

Principal Investigator of the Gene Expression & Metabolism group (Williams lab)

Last updated on: Tuesday, 30 June 2020

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2020

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See detailA Conserved Mito-Cytosolic Translational Balance Links Two Longevity Pathways.
Molenaars, Marte; Janssens, Georges E.; Williams, Evan; Jongejan, Aldo; Lan, Jiayi; Rabot, Sylvie; Joly, Fatima; Moerland, Perry D.; Schomakers, Bauke V.; Lezzerini, Marco; Liu, Yasmine J.; McCormick, Mark A.; Kennedy, Brian K.; van Weeghel, Michel; van Kampen, Antoine H. C.; Aebersold, Ruedi; MacInnes, Alyson W.; Houtkooper, Riekelt H.

in Cell metabolism (2020), 31(3), 549-5637

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2019

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See detailMild inborn errors of metabolism in commonly used inbred mouse strains.
Leandro, Joao; Violante, Sara; Argmann, Carmen A.; Hagen, Jacob; Dodatko, Tetyana; Bender, Aaron; Zhang, Wei; Williams, Evan; Bachmann, Alexis M.; Auwerx, Johan; Yu, Chunli; Houten, Sander M.

in Molecular genetics and metabolism (2019), 126(4), 388-396

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See detailMulti-omic measurements of heterogeneity in HeLa cells across laboratories.
Liu, Yansheng; Mi, Yang; Mueller, Torsten; Kreibich, Saskia; Williams, Evan; Van Drogen, Audrey; Borel, Christelle; Frank, Max; Germain, Pierre-Luc; Bludau, Isabell; Mehnert, Martin; Seifert, Michael; Emmenlauer, Mario; Sorg, Isabel; Bezrukov, Fedor; Bena, Frederique Sloan; Zhou, Hu; Dehio, Christoph; Testa, Giuseppe; Saez-Rodriguez, Julio; Antonarakis, Stylianos E.; Hardt, Wolf-Dietrich; Aebersold, Ruedi

in Nature biotechnology (2019), 37(3), 314-322

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See detailDiet modulates cecum bacterial diversity and physiological phenotypes across the BXD mouse genetic reference population.
Perez-Munoz, Maria Elisa; McKnite, Autumn M.; Williams, Evan; Auwerx, Johan; Williams, Robert W.; Peterson, Daniel A.; Ciobanu, Daniel C.

in PloS one (2019), 14(10), 0224100

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See detailA new class of protein biomarkers based on subcellular distribution: application to a mouse liver cancer model.
Sajic, Tatjana; Ciuffa, Rodolfo; Lemos, Vera; Xu, Pan; Leone, Valentina; Li, Chen; Williams, Evan; Makris, Georgios; Banaei-Esfahani, Amir; Heikenwalder, Mathias; Schoonjans, Kristina; Aebersold, Ruedi

in Scientific reports (2019), 9(1), 6913

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See detailJCAD: from systems genetics identification to the experimental validation of a coronary artery disease risk locus.
Williams, Evan; Stein, Sokrates

in European heart journal (2019), 40(29), 2409-2412

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2018

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See detailGenetic cartography of longevity in humans and mice: Current landscape and horizons.
Hook, Michael; Roy, Suheeta; Williams, Evan; Bou Sleiman, Maroun; Mozhui, Khyobeni; Nelson, James F.; Lu, Lu; Auwerx, Johan; Williams, Robert W.

in Biochimica et biophysica acta. Molecular basis of disease (2018), 1864(9 Pt A), 2718-2732

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See detailSystems Analyses Reveal Physiological Roles and Genetic Regulators of Liver Lipid Species.
Jha, Pooja; McDevitt, Molly T.; Gupta, Rahul; Quiros, Pedro M.; Williams, Evan; Gariani, Karim; Sleiman, Maroun B.; Diserens, Leo; Jochem, Adam; Ulbrich, Arne; Coon, Joshua J.; Auwerx, Johan; Pagliarini, David J.

in Cell systems (2018), 6(6), 722-7336

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See detailGenetic Regulation of Plasma Lipid Species and Their Association with Metabolic Phenotypes.
Jha, Pooja; McDevitt, Molly T.; Halilbasic, Emina; Williams, Evan; Quiros, Pedro M.; Gariani, Karim; Sleiman, Maroun B.; Gupta, Rahul; Ulbrich, Arne; Jochem, Adam; Coon, Joshua J.; Trauner, Michael; Pagliarini, David J.; Auwerx, Johan

in Cell systems (2018), 6(6), 709-7216

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See detailSimilarities and Differences of Blood N-Glycoproteins in Five Solid Carcinomas at Localized Clinical Stage Analyzed by SWATH-MS.
Sajic, Tatjana; Liu, Yansheng; Arvaniti, Eirini; Surinova, Silvia; Williams, Evan; Schiess, Ralph; Huttenhain, Ruth; Sethi, Atul; Pan, Sheng; Brentnall, Teresa A.; Chen, Ru; Blattmann, Peter; Friedrich, Betty; Nimeus, Emma; Malander, Susanne; Omlin, Aurelius; Gillessen, Silke; Claassen, Manfred; Aebersold, Ruedi

in Cell reports (2018), 23(9), 2819-28315

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See detailQuantifying and Localizing the Mitochondrial Proteome Across Five Tissues in A Mouse Population.
Williams, Evan; Wu, Yibo; Wolski, Witold; Kim, Jun Yong; Lan, Jiayi; Hasan, Moaraj; Halter, Christian; Jha, Pooja; Ryu, Dongryeol; Auwerx, Johan; Aebersold, Ruedi

in Molecular and Cellular Proteomics (2018), 17(9), 1766-1777

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2017

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See detailSystematic proteome and proteostasis profiling in human Trisomy 21 fibroblast cells.
Liu, Yansheng; Borel, Christelle; Li, Li; Muller, Torsten; Williams, Evan; Germain, Pierre-Luc; Buljan, Marija; Sajic, Tatjana; Boersema, Paul J.; Shao, Wenguang; Faini, Marco; Testa, Giuseppe; Beyer, Andreas; Antonarakis, Stylianos E.; Aebersold, Ruedi

in Nature communications (2017), 8(1), 1212

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See detailResources for Systems Genetics.
Williams, Robert W.; Williams, Evan

in Methods in molecular biology (Clifton, N.J.) (2017), 1488

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See detailApplication of SWATH Proteomics to Mouse Biology.
Wu, Yibo; Williams, Evan; Aebersold, Ruedi

in Current protocols in mouse biology (2017), 7(2), 130-143

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2016

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See detailTwo Conserved Histone Demethylases Regulate Mitochondrial Stress-Induced Longevity.
Merkwirth, Carsten; Jovaisaite, Virginija; Durieux, Jenni; Matilainen, Olli; Jordan, Sabine D.; Quiros, Pedro M.; Steffen, Kristan K.; Williams, Evan; Mouchiroud, Laurent; Tronnes, Sarah U.; Murillo, Virginia; Wolff, Suzanne C.; Shaw, Reuben J.; Auwerx, Johan; Dillin, Andrew

in Cell (2016), 165(5), 1209-1223

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See detailThe Movement Tracker: A Flexible System for Automated Movement Analysis in Invertebrate Model Organisms.
Mouchiroud, Laurent; Sorrentino, Vincenzo; Williams, Evan; Cornaglia, Matteo; Frochaux, Michael V.; Lin, Tao; Nicolet-Dit-Felix, Amandine A.; Krishnamani, Gopal; Ouhmad, Tarik; Gijs, Martin A. M.; Deplancke, Bart; Auwerx, Johan

in Current protocols in neuroscience (2016), 77

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See detailUrolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents.
Ryu, Dongryeol; Mouchiroud, Laurent; Andreux, Penelope A.; Katsyuba, Elena; Moullan, Norman; Nicolet-Dit-Felix, Amandine A.; Williams, Evan; Jha, Pooja; Lo Sasso, Giuseppe; Huzard, Damien; Aebischer, Patrick; Sandi, Carmen; Rinsch, Chris; Auwerx, Johan

in Nature medicine (2016), 22(8), 879-88

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See detailJoint mouse-human phenome-wide association to test gene function and disease risk.
Wang, Xusheng; Pandey, Ashutosh K.; Mulligan, Megan K.; Williams, Evan; Mozhui, Khyobeni; Li, Zhengsheng; Jovaisaite, Virginija; Quarles, L. Darryl; Xiao, Zhousheng; Huang, Jinsong; Capra, John A.; Chen, Zugen; Taylor, William L.; Bastarache, Lisa; Niu, Xinnan; Pollard, Katherine S.; Ciobanu, Daniel C.; Reznik, Alexander O.; Tishkov, Artem V.; Zhulin, Igor B.; Peng, Junmin; Nelson, Stanley F.; Denny, Joshua C.; Auwerx, Johan; Lu, Lu; Williams, Robert W.

in Nature communications (2016), 7

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See detailSystems proteomics of liver mitochondria function.
Williams, Evan; Wu, Yibo; Jha, Pooja; Dubuis, Sebastien; Blattmann, Peter; Argmann, Carmen A.; Houten, Sander M.; Amariuta, Tiffany; Wolski, Witold; Zamboni, Nicola; Aebersold, Ruedi; Auwerx, Johan

in Science (New York, N.Y.) (2016), 352(6291), 0189

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2015

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See detailTetracyclines Disturb Mitochondrial Function across Eukaryotic Models: A Call for Caution in Biomedical Research.
Moullan, Norman; Mouchiroud, Laurent; Wang, Xu; Ryu, Dongryeol; Williams, Evan; Mottis, Adrienne; Jovaisaite, Virginija; Frochaux, Michael V.; Quiros, Pedro M.; Deplancke, Bart; Houtkooper, Riekelt H.; Auwerx, Johan

in Cell reports (2015), 10(10), 1681-1691

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See detailEvidence for a direct effect of the NAD+ precursor acipimox on muscle mitochondrial function in humans.
van de Weijer, Tineke; Phielix, Esther; Bilet, Lena; Williams, Evan; Ropelle, Eduardo R.; Bierwagen, Alessandra; Livingstone, Roshan; Nowotny, Peter; Sparks, Lauren M.; Paglialunga, Sabina; Szendroedi, Julia; Havekes, Bas; Moullan, Norman; Pirinen, Eija; Hwang, Jong-Hee; Schrauwen-Hinderling, Vera B.; Hesselink, Matthijs K. C.; Auwerx, Johan; Roden, Michael; Schrauwen, Patrick

in Diabetes (2015), 64(4), 1193-201

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See detailThe Convergence of Systems and Reductionist Approaches in Complex Trait Analysis.
Williams, Evan; Auwerx, Johan

in Cell (2015), 162(1), 23-32

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2014

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See detailRegulation of steatohepatitis and PPARgamma signaling by distinct AP-1 dimers.
Hasenfuss, Sebastian C.; Bakiri, Latifa; Thomsen, Martin K.; Williams, Evan; Auwerx, Johan; Wagner, Erwin F.

in Cell metabolism (2014), 19(1), 84-95

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See detailPharmacological Inhibition of poly(ADP-ribose) polymerases improves fitness and mitochondrial function in skeletal muscle.
Pirinen, Eija; Canto, Carles; Jo, Young Suk; Morato, Laia; Zhang, Hongbo; Menzies, Keir J.; Williams, Evan; Mouchiroud, Laurent; Moullan, Norman; Hagberg, Carolina; Li, Wei; Timmers, Silvie; Imhof, Ralph; Verbeek, Jef; Pujol, Aurora; van Loon, Barbara; Viscomi, Carlo; Zeviani, Massimo; Schrauwen, Patrick; Sauve, Anthony A.; Schoonjans, Kristina; Auwerx, Johan

in Cell metabolism (2014), 19(6), 1034-41

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See detailAn evolutionarily conserved role for the aryl hydrocarbon receptor in the regulation of movement.
Williams, Evan; Mouchiroud, Laurent; Frochaux, Michael; Pandey, Ashutosh; Andreux, Penelope A.; Deplancke, Bart; Auwerx, Johan

in PLoS genetics (2014), 10(9), 1004673

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See detailMultilayered genetic and omics dissection of mitochondrial activity in a mouse reference population.
Wu, Yibo; Williams, Evan; Dubuis, Sebastien; Mottis, Adrienne; Jovaisaite, Virginija; Houten, Sander M.; Argmann, Carmen A.; Faridi, Pouya; Wolski, Witold; Kutalik, Zoltan; Zamboni, Nicola; Auwerx, Johan; Aebersold, Ruedi

in Cell (2014), 158(6), 1415-1430

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2012

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See detailSystems genetics of metabolism: the use of the BXD murine reference panel for multiscalar integration of traits.
Andreux, Penelope A.; Williams, Evan; Koutnikova, Hana; Houtkooper, Riekelt H.; Champy, Marie-France; Henry, Hugues; Schoonjans, Kristina; Williams, Robert W.; Auwerx, Johan

in Cell (2012), 150(6), 1287-99

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See detailMurine gut microbiota is defined by host genetics and modulates variation of metabolic traits.
McKnite, Autumn M.; Perez-Munoz, Maria Elisa; Lu, Lu; Williams, Evan; Brewer, Simon; Andreux, Penelope A.; Bastiaansen, John W. M.; Wang, Xusheng; Kachman, Stephen D.; Auwerx, Johan; Williams, Robert W.; Benson, Andrew K.; Peterson, Daniel A.; Ciobanu, Daniel C.

in PloS one (2012), 7(6), 39191

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2011

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See detailNCoR1 is a conserved physiological modulator of muscle mass and oxidative function.
Yamamoto, Hiroyasu; Williams, Evan; Mouchiroud, Laurent; Canto, Carles; Fan, Weiwei; Downes, Michael; Heligon, Christophe; Barish, Grant D.; Desvergne, Beatrice; Evans, Ronald M.; Schoonjans, Kristina; Auwerx, Johan

in Cell (2011), 147(4), 827-39

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