Prof. Dr. Jens Christian Schwamborn
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| Faculty or Centre | Luxembourg Centre for Systems Biomedicine | ||||||
| Department | Developmental and Cellular Biology | ||||||
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Université du Luxembourg 6, avenue du Swing L-4367 Belvaux |
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| Campus Office | BioTech II, 3.16 | ||||||
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| Telephone | (+352) 46 66 44 5536 | ||||||
| Video |
Prof. Dr. Jens Schwamborn
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Principal Investigator in the Developmental & Cellular Biology group (Schwamborn Lab) at the Luxembourg Centre for Systems Biomedicine (LCSB)
Last updated on: Tuesday, 22 March 2022
2022
The future of Parkinson’s disease research: A new paradigm of human-specific investigation is necessary… and possible; ; ; ; ; ; ; ; ; ;
in ALTEX: Alternatives to Animal Experimentation (2022)
PARK7/DJ-1 promotes pyruvate dehydrogenase activity and maintains T(reg) homeostasis during ageing.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Nature metabolism (2022), 4(5), 589-607
Generalising from conventional pipelines using deep learning in high‑throughput screening workfows; ; ; ; ; ; ; ; ; ;
in Scientific Reports (2022)
Microglia integration into human midbrain organoids leads to increased neuronal maturation and functionality; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Glia (2022)
Single-cell sequencing of human midbrain reveals glial activation and a Parkinson-specific neuronal state.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Brain : a journal of neurology (2022), 145(3), 964-978
An archaeal compound as a driver of Parkinson’s disease pathogenesis; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
E-print/Working paper (2022)
Midbrain organoids mimic early embryonic neurodevelopment and recapitulate LRRK2-p.Gly2019Ser-associated gene expression; ; ; ; ; ; ; ;
in American Journal of Human Genetics (2022)
2021
iPSC-Derived Microglia as a Model to Study Inflammation in Idiopathic Parkinson's Disease.; ; ; ; ; ; ; ; ; ; ; ; ;
in Frontiers in cell and developmental biology (2021), 9
A new brain organoid model to study Parkinson’s Disease; ; ; ; ; ; ; ;
in Biomedical Science and Engineering (2021)
Integrated, automated maintenance, expansion and differentiation of 2D and 3D patient-derived cellular models for high throughput drug screening; ; ; ; ; ; ; ; ;
in Scientific Reports (2021)
PINK1 deficiency impairs adult neurogenesis of dopaminergic neurons; ; ; ; ; ; ; ; ; ;
in Scientific Reports (2021)
Parkinson’s disease phenotypes in patient neuronal cultures and brain organoids improved by 2-Hydroxypropyl-b-Cyclodextrin treatment; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Movement Disorders (2021)
A human stem cell-derived test system for agents modifying neuronal N-methyl-d-aspartate-type glutamate receptor Ca2+-signalling; ; ; ; ; ; ;
in Archives of Toxicology (2021)
Method Optimization of Skin Biopsy-Derived Fibroblast Culture for Reprogramming Into Induced Pluripotent Stem Cells; ; ; ; ;
in Biopreservation and Biobanking (2021)
Structural Plasticity of Dopaminergic Neurons Requires the Activation of the D3R-nAChR Heteromer and the PI3K-ERK1/2/Akt-Induced Expression of c-Fos and p70S6K Signaling Pathway; ; ; ; ; ; ; ;
in Molecular Neurobiology (2021)
Is serine racemase (SRR) a second hit target for LRRK2-G2019S induced Parkinson’s disease?;
in Neural Regeneration Research (2021)
A Triple Combination of Targeting Ligands Increases the Penetration of Nanoparticles across a Blood-Brain Barrier Culture Model; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Pharmaceutics (2021)
The Parkinson’s-disease-associated mutation LRRK2-G2019S alters dopaminergic differentiation dynamics via NR2F1; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Cell Reports (2021)
2020
Impaired Mitochondrial-Endoplasmic Reticulum Interaction and Mitophagy in Miro1-Mutant Neurons in Parkinson’s Disease; ; ; ; ; ; ; ; ; ;
in Human Molecular Genetics (2020)
A patient-based model of RNA mis-splicing uncovers treatment targets in Parkinson's disease.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Science translational medicine (2020), 12(560),
Synapse alterations precede neuronal damage and storage pathology in a human cerebral organoid model of CLN3-juvenile neuronal ceroid lipofuscinosis; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Acta Neuropathologica Communications (2020)
Mitochondrial and Clearance Impairment in p.D620N VPS35 Patient-Derived Neurons; ; ; ; ; ; ; ; ;
in Movement Disorders (2020)
Passive controlled flow for Parkinson’s disease neuronal cell culture in 3D microfluidic devices; ; ; ;
in Organs-on-a-Chip (2020)
Reduced astrocytic reactivity in human brains and midbrain organoids with PRKN mutations; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in NPJ Parkinson's Disease (2020)
Peptide-Imprinted Poly(hydroxymethyl 3,4-ethylenedioxythiophene) Nanotubes for Detection of Alpha Synuclein in Human Brain Organoids; ; ; ; ; ; ; ; ; ;
in ACS Applied Nano Materials (2020)
Epitope imprinting of alpha-synuclein for sensing in Parkinson's brain organoid culture medium; ; ; ; ; ; ; ;
in Biosensors and Bioelectronics (2020)
Machine learning-assisted neurotoxicity prediction in human midbrain organoids; ; ; ; ; ; ; ; ; ;
in Parkinsonism and Related Disorders (2020)
Reproducible generation of human midbrain organoids for in vitro modeling of Parkinson’s disease; ; ; ; ;
in Stem Cell Research (2020)
Genetic Architecture of Parkinson's Disease in the Indian Population: Harnessing Genetic Diversity to Address Critical Gaps in Parkinson's Disease Research.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Frontiers in neurology (2020), 11
Single-cell sequencing of the human midbrain reveals glial activation and a neuronal state specific to Parkinson’s disease; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
E-print/Working paper (2020)
Single-cell transcriptomics reveals multiple neuronal cell types in human midbrain-specific organoids; ; ; ; ; ; ; ; ; ;
in Cell and Tissue Research (2020)
Midbrain organoids: A new tool to investigate Parkinson's disease;
in Frontiers in Cell and Developmental Biology (2020)
2019
Automated high-throughput high-content autophagy and mitophagy analysis platform; ; ; ; ; ; ;
in Scientific Reports (2019)
From tech to bench: Deep Learning pipeline for image segmentation of high-throughput high-content microscopy data; ; ; ; ; ; ; ; ; ;
Poster (2019, November 29)
Deep Learning Quality Control for High-Throughput High-Content Screening Microscopy Images; ; ; ;
Poster (2019, October 10)
Quality Control Strategy for CRISPRCas9- based Gene Editing Complicated by a Pseudogene; ; ; ;
in Frontiers in Genetics (2019)
Successes and Hurdles in Stem Cells Application and Production for Brain Transplantation; ; ; ;
in Frontiers in Neuroscience (2019)
Guidelines for Fluorescent Guided Biallelic HDR Targeting Selection With PiggyBac System Removal for Gene Editing; ;
in Frontiers in Genetics (2019)
Automated microfluidic cell culture of stem cell derived dopaminergic neurons; ; ; ; ; ; ; ; ; ;
in Scientific Reports (2019)
Impaired serine metabolism complements LRRK2-G2019S pathogenicity in PD patients; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Parkinsonism and Related Disorders (2019)
Single-cell transcriptomics reveals multiple neuronal cell types in human midbrain-specific organoids; ; ; ; ; ; ;
E-print/Working paper (2019)
Modeling Parkinson’s disease in midbrain-like organoids; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in NPJ Parkinson's Disease (2019)
Cultivation and characterization of human midbrain organoids in sensor integrated microfluidic chips; ; ; ; ; ; ; ; ;
E-print/Working paper (2019)
Neural Stem Cells of Parkinson's Disease Patients Exhibit Aberrant Mitochondrial Morphology and Functionality; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Stem Cell Reports (2019)
Non-proteolytic ubiquitination of OTULIN regulates NF-κB signaling pathway; ; ; ; ; ; ; ; ; ; ;
in Journal of Molecular Cell Biology (2019)
Absence of TRIM32 Leads to Reduced GABAergic Interneuron Generation and Autism-like Behaviors in Mice via Suppressing mTOR Signaling; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Cerebral Cortex (2019)
2018
Millifluidic culture improves human midbrain organoid vitality and differentiation; ; ; ; ; ; ; ;
in Lab on a Chip - Miniaturisation for Chemistry and Biology (2018)
3D Cultures of Parkinson's Disease‐Specific Dopaminergic Neurons for High Content Phenotyping and Drug Testing; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Advanced Science (2018)
In vivo Phenotyping of Human Parkinson’s Disease-Specific Stem Cells Carrying the LRRK2-G2019S Mutation Reveals Increased a-Synuclein Levels but Absence of Spreading; ; ;
in Opera Medica et Physiologica (2018)
Activity of translation regulator eukaryotic elongation factor-2 kinase is increased in Parkinson disease brain and its inhibition reduces alpha synuclein toxicity; ; ; ; ; ; ; ; ; ; ; ;
in Acta Neuropathologica Communications (2018)
A complex of the ubiquitin ligase TRIM32 and the deubiquitinase USP7 balances the level of c-Myc ubiquitination and thereby determines neural stem cell fate specification; ; ; ; ; ; ;
in Cell Death and Differentiation (2018)
Advanced Good Cell Culture Practice for human primary, stem cell-derived and organoid models as well as microphysiological systems; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in ALTEX : Alternativen zu Tierexperimenten (2018)
Nuclear localization and phosphorylation modulate pathological effects of Alpha-Synuclein; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Human Molecular Genetics (2018)
Is Parkinson’s disease a neurodevelopmental disorder and will brain organoids help us to understand it?in Stem Cells and Development (2018)
2017
FACS-Assisted CRISPR-Cas9 Genome Editing Facilitates Parkinson's Disease Modeling; ; ; ; ; ; ; ;
in Stem Cell Reports (2017)
Parkinson’s Disease-Associated Mutant LRRK2-Mediated Inhibition of miRNA Activity is Antagonized by TRIM32; ; ; ;
in Molecular Neurobiology (2017)
Automated micro uidic cell culture of stem cell derived dopaminergic neurons in Parkinson's disease; ; ; ; ; ; ; ; ;
in bioRxiv (2017)
Derivation of Human Midbrain-Specific Organoids from Neuroepithelial Stem Cells; ; ; ; ; ; ; ; ; ; ; ; ;
in Stem Cell Reports (2017)
Nurr1:RXRα heterodimer activation as monotherapy for Parkinson’s disease; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Proceedings of the National Academy of Sciences of the United States of America (2017)
Human induced pluripotent stem cell-derived neuronal progenitors are a suitable and effective drug discovery model for neurological mtDNA disorders; ;
in Stem Cell Investigation (2017)
2016
Prox1 is required for oligodendrocyte cell identity in adult neural stem cells of the subventricular zone; ; ; ; ; ; ; ; ; ; ; ;
in Stem Cells (2016)
Tripartite Containing Motif 32 Modulates Proliferation of Human Neural Precursor Cells in HIV-1 Neurodegeneration; ; ; ; ; ;
in Cell Death and Differentiation (2016)
6-hydroxydopamine-induced Parkinson's disease-like degeneration generates acute micro- and astrogliosis in the nigrostriatal system but no Bioluminescence Imaging detectable alteration in adult neurogenesis; ; ; ; ; ; ; ; ; ; ; ; ;
in European Journal of Neuroscience (2016)
Utilization of stem cells to model Parkinson's disease – current state and future challenges;
in Future Neurology (2016)
A generalized gene regulatory network model of stem cell differentiation for predicting lineage specifiers; ; ; ;
in Stem Cell Reports (2016)
Expression of the Parkinson’s Disease-Associated Gene Alpha-Synuclein is Regulated by the Neuronal Cell Fate Determinant TRIM32; ; ; ; ; ; ;
in Molecular Neurobiology (2016)
Environmental enrichment and physical exercise revert behavioral and electrophysiological impairments caused by reduced adult neurogenesis; ; ; ; ; ; ; ; ;
in Hippocampus (2016)
2015
TRIM32 modulates pluripotency entry and exit by directly regulating Oct4 stability; ; ; ; ; ; ; ; ;
in Scientific Reports (2015)
TRIM32 Senses and Restricts Influenza A Virus by Ubiquitination of PB1 Polymerase; ; ; ; ;
in PLoS Pathogens (2015)
The neural stem cell fate determinant TRIM32 regulates complex behavioral traits; ; ; ; ; ; ;
in Frontiers in Cellular Neuroscience (2015)
Neural stem cells in Parkinson’s disease: a role for neurogenesis defects in onset and progression; ; ;
in Cellular and Molecular Life Sciences (2015)
Differentiation of neuroepithelial stem cells into functional dopaminergic neurons in 3D microfluidic cell culture; ; ; ; ; ; ; ;
in Lab on a Chip - Miniaturisation for Chemistry and Biology (2015), 15
The RNA helicase DDX6 regulates cell-fate specification in neural stem cells via miRNAs; ; ; ; ;
in Nucleic Acids Research (2015)
Rapid and robust generation of long-term self-renewing human neural stem cells with the ability to generate mature astroglia; ; ; ; ; ; ; ; ;
in Scientific Reports (2015), 5
2014
Gene regulatory network analysis reveals differences in site-specific cell fate determination in mammalian brain; ; ;
in Frontiers in Cellular Neuroscience (2014)
Origin-Dependent Neural Cell Identities in Differentiated Human iPSCs In Vitro and after Transplantation into the Mouse Brain; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Cell Reports (2014)
Induced Neural Stem Cells Achieve Long-Term Survival and Functional Integration in the Adult Mouse Brain; ; ; ; ; ; ; ; ; ;
in Stem Cell Reports (2014)
2013
The Parkinson's Disease-Associated LRRK2 Mutation R1441G Inhibits Neuronal Differentiation of Neural Stem Cells.; ; ; ; ; ;
in Stem Cells and Development (2013)
Regulatory feedback loop between TP73 and TRIM32.; ; ; ; ; ; ; ;
in Cell Death and Disease (2013), 4
TRIM32-dependent transcription in adult neural progenitor cells regulates neuronal differentiation; ; ; ; ; ; ;
in Cell Death and Disease (2013)
A systemic transcriptome analysis reveals the regulation of neural stem cell maintenance by an E2F1-miRNA feedback loop.; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Nucleic Acids Research (2013), 41(6), 3699-712
Derivation and expansion using only small molecules of human neural progenitors for neurodegenerative disease modeling.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in PLoS ONE (2013), 8(3), 59252
2012
Direct reprogramming of fibroblasts into neural stem cells by defined factors.; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Cell Stem Cell (2012), 10(4), 465-72
Discovery of inhibitors of microglial neurotoxicity acting through multiple mechanisms using a stem-cell-based phenotypic assay.; ; ; ; ; ; ; ; ; ; ; ; ;
in Cell Stem Cell (2012), 11(5), 620-32
Regrowing the adult brain: NF-kappaB controls functional circuit formation and tissue homeostasis in the dentate gyrus.; ; ; ; ; ; ; ; ; ; ; ;
in PLoS ONE (2012), 7(2), 30838
Abundant occurrence of basal radial glia in the subventricular zone of embryonic neocortex of a lissencephalic primate, the common marmoset Callithrix jacchus.; ; ; ; ; ; ; ; ; ; ; ;
in Cerebral Cortex (2012), 22(2), 469-81
TRIM32 regulates skeletal muscle stem cell differentiation and is necessary for normal adult muscle regeneration.; ; ; ; ; ; ; ; ; ;
in PLoS ONE (2012), 7(1), 30445
MiRNAs and neural stem cells: a team to treat Parkinson's disease?; ;
in RNA Biology (2012), 9(6), 720-30
JAM-C is an apical surface marker for neural stem cells.; ; ; ; ; ; ; ; ; ; ;
in Stem Cells and Development (2012), 21(5), 757-66
Induced pluripotent stem cells generated from adult bone marrow-derived cells of the nonhuman primate (Callithrix jacchus) using a novel quad-cistronic and excisable lentiviral vector.; ; ; ; ; ; ; ; ; ;
in Cellular reprogramming (2012), 14(6), 485-96
Anti-inflammatory treatment induced regenerative oligodendrogenesis in parkinsonian mice.; ; ;
in Stem Cell Research and Therapy (2012), 3(4), 33
2011
Cellular organization of adult neurogenesis in the Common Marmoset.; ; ; ; ;
in Aging Cell (2011), 10(1), 28-38
Neural stem cells maintain their stemness through protein kinase C zeta-mediated inhibition of TRIM32.; ; ;
in Stem Cells (2011), 29(9), 1437-47
The E3-ubiquitin ligase TRIM2 regulates neuronal polarization.; ; ; ; ; ; ;
in Journal of Neurochemistry (2011), 117(1), 29-37
2010
JAM-A is a novel surface marker for NG2-Glia in the adult mouse brain.; ;
in BMC Neuroscience (2010), 11
2009
The stimulation of dendrite growth by Sema3A requires integrin engagement and focal adhesion kinase.; ; ; ;
in Journal of Cell Science (2009), 122(Pt 12), 2034-42
The TRIM-NHL protein TRIM32 activates microRNAs and prevents self-renewal in mouse neural progenitors.; ;
in Cell (2009), 136(5), 913-25
2008
2007
Elongation of axons during regeneration involves retinal crystallin beta b2 (crybb2).; ; ;
in Molecular and Cellular Proteomics (2007), 6(5), 895-907
2006
2004
Semaphorin 3A stimulates neurite extension and regulates gene expression in PC12 cells.; ; ; ; ;
in Journal of Biological Chemistry (2004), 279(30), 30923-6
The sequential activity of the GTPases Rap1B and Cdc42 determines neuronal polarity.;
in Nature Neuroscience (2004), 7(9), 923-9
2003
Microarray analysis of tumor necrosis factor alpha induced gene expression in U373 human glioblastoma cells.; ; ; ; ; ; ; ; ;
in BMC Genomics (2003), 4(1), 46
