Paul Antony
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| Faculty or Centre | Luxembourg Centre for Systems Biomedicine | ||||||
| Department | Scientific Central Services | ||||||
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Université du Luxembourg 6, avenue du Swing L-4367 Belvaux |
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| Campus Office | BioTech II, 2.17 | ||||||
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| Telephone | (+352) 46 66 44 6986 | ||||||
| Video |
Dr. Paul Antony (LCSB)
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Manager of the Bioimaging Platform
Last updated on: Sunday, 16 October 2022
2022
Single-cell sequencing of human midbrain reveals glial activation and a Parkinson-specific neuronal state.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Brain : a journal of neurology (2022), 145(3), 964-978
Parkin Deficiency Impairs Mitochondrial DNA Dynamics and Propagates Inflammation.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Movement disorders : official journal of the Movement Disorder Society (2022)
2021
iPSC-Derived Microglia as a Model to Study Inflammation in Idiopathic Parkinson's Disease.; ; ; ; ; ; ; ; ; ; ; ; ;
in Frontiers in cell and developmental biology (2021), 9
Gene-corrected p.A30P SNCA patient-derived isogenic neurons rescue neuronal branching and function; ; ; ; ; ; ; ; ; ;
in Scientific Reports (2021), 11
A new brain organoid model to study Parkinson’s Disease; ; ; ; ; ; ; ;
in Biomedical Science and Engineering (2021)
Integrated, automated maintenance, expansion and differentiation of 2D and 3D patient-derived cellular models for high throughput drug screening; ; ; ; ; ; ; ; ;
in Scientific Reports (2021)
PINK1 deficiency impairs adult neurogenesis of dopaminergic neurons; ; ; ; ; ; ; ; ; ;
in Scientific Reports (2021)
Parkinson’s disease phenotypes in patient neuronal cultures and brain organoids improved by 2-Hydroxypropyl-b-Cyclodextrin treatment; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Movement Disorders (2021)
The Parkinson’s-disease-associated mutation LRRK2-G2019S alters dopaminergic differentiation dynamics via NR2F1; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Cell Reports (2021)
2020
Impaired Mitochondrial-Endoplasmic Reticulum Interaction and Mitophagy in Miro1-Mutant Neurons in Parkinson’s Disease; ; ; ; ; ; ; ; ; ;
in Human Molecular Genetics (2020)
Mitochondrial and Clearance Impairment in p.D620N VPS35 Patient-Derived Neurons; ; ; ; ; ; ; ; ;
in Movement Disorders (2020)
A rare loss-of function variant of ADAM17 is associated with late-onset familial Alzheimer disease; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Molecular Psychiatry (2020), 25(3), 629-639
Fibroblast mitochondria in idiopathic Parkinson’s disease display morphological changes and enhanced resistance to depolarization; ; ; ; ; ; ; ; ; ; ;
in Scientific Reports (2020)
Machine learning-assisted neurotoxicity prediction in human midbrain organoids; ; ; ; ; ; ; ; ; ;
in Parkinsonism and Related Disorders (2020)
Single-cell sequencing of the human midbrain reveals glial activation and a neuronal state specific to Parkinson’s disease; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
E-print/Working paper (2020)
Mitochondria interaction networks show altered topological patterns in Parkinson's disease.; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in NPJ systems biology and applications (2020), 6(1), 38
2019
Automated high-throughput high-content autophagy and mitophagy analysis platform; ; ; ; ; ; ;
in Scientific Reports (2019)
Variants in Miro1 cause alterations of ER-mitochondria contact sites in fibroblasts from Parkinson's disease patients; ; ; ; ; ; ; ; ; ;
in Journal of Clinical Medicine (2019)
From tech to bench: Deep Learning pipeline for image segmentation of high-throughput high-content microscopy data; ; ; ; ; ; ; ; ; ;
Poster (2019, November 29)
Transcriptome profiling data reveals Ubiquitin-Specific Peptidase 9 knockdown effects; ; ; ; ; ; ;
in Data in Brief (2019), 25(1), 104130
Mutations in RHOT1 disrupt ER-mitochondria contact sites interfering with calcium homeostasis and mitochondrial dynamics in Parkinson's disease.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Antioxidants & redox signaling (2019)
Impaired serine metabolism complements LRRK2-G2019S pathogenicity in PD patients; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Parkinsonism and Related Disorders (2019)
Single-cell transcriptomics reveals multiple neuronal cell types in human midbrain-specific organoids; ; ; ; ; ; ;
E-print/Working paper (2019)
Modeling Parkinson’s disease in midbrain-like organoids; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in NPJ Parkinson's Disease (2019)
Neural Stem Cells of Parkinson's Disease Patients Exhibit Aberrant Mitochondrial Morphology and Functionality; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Stem Cell Reports (2019)
2018
Millifluidic culture improves human midbrain organoid vitality and differentiation; ; ; ; ; ; ; ;
in Lab on a Chip - Miniaturisation for Chemistry and Biology (2018)
3D Cultures of Parkinson's Disease‐Specific Dopaminergic Neurons for High Content Phenotyping and Drug Testing; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Advanced Science (2018)
2017
IDENTIFICATION OF A RARE GENE VARIANT THAT IS ASSOCIATED WITH FAMILIAL ALZHEIMER DISEASE AND REGULATES APP EXPRESSION; ; ; ; ; ; ; ; ; ; ; ; ;
in Alzheimer's and Dementia: the Journal of the Alzheimer's Association (2017), 13(7, Supplement), 648
Gender-specific expression of ubiquitin-specific peptidase 9 modulates tau expression and phosphorylation: possible implications for tauopathies; ; ; ; ; ; ;
in Molecular Neurobiology (2017), 54(10), 79797993
2016
Characterization of Differentiated SH-SY5Y as Neuronal Screening Model Reveals Increased Oxidative Vulnerability; ; ; ; ; ; ;
in Journal of Biomolecular Screening (2016)
Enteric neurons from Parkinson's disease patients display ex vivo aberrations in mitochondrial structure.; ; ; ; ; ; ; ; ; ;
in Scientific reports (2016), 6
2015
Staining for unphosphorylated alpha-synuclein in the colon mucosa. No difference between patients with Parkinson's disease and healthy controls; ; ; ; ; ; ; ; ;
Scientific Conference (2015, June)
Platelet mitochondrial membrane potential in Parkinson's disease.; ; ; ; ; ; ; ; ; ;
in Annals of clinical and translational neurology (2015), 2(1), 67-73
Evaluation of Cell Line Suitability for Disease Specific Perturbation Experiments.; ; ; ;
in Lausen, Berthold; Krolak-Schwerdt, Sabine; Böhmer, Matthias (Eds.) Data Science, Learning by Latent Structures, and Knowledge Discovery (2015, February 20)
Critical transitions in chronic disease: transferring concepts from ecology to systems medicine; ; ; ;
in Current Opinion in Biotechnology (2015), 34
2014
Analysis of mitochondrial membrane potential in idiopathic Parkinson's disease: A case-control study; ; ; ; ; ;
Scientific Conference (2014, June 12)
Curation of complex molecular pathways of Parkinson's disease as a collaborative scientific community effort; ; ; ; ; ;
Scientific Conference (2014, June 12)
Integrating Pathways of Parkinson's Disease in a Molecular Interaction Map; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Molecular Neurobiology (2014)
Systems genomics evaluation of the SH-SY5Y neuroblastoma cell line as a model for Parkinson’s disease; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in BMC Genomics (2014), 15(1154),
Automated nuclei clump splitting by combining local concavity orientation and graph partitioning; ; ;
in International Conference on Biomedical and Health Informatics (2014)
2013
Light microscopy applications in systems biology: opportunities and challenges.; ; ; ;
in Cell Communication and Signaling (2013), 11(1), 1-19
The Parkinson's Disease Map: A Framework for Integration, Curation and Exploration of Disease-related Pathways; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
Poster (2013, March 09)
2012
From Systems Biology to Systems Biomedicine; ;
in Current Opinion in Biotechnology (2012), 23(4), 604-8
Constructing a comprehensive map of Parkinson’s disease to elucidate underlying mechanisms of its multifaceted molecular pathology; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
Poster (2012, August)
2011
Parkinson’s disease mouse models in translational research; ;
in Mammalian Genome (2011), 22(7-8), 401-19
2009
Identification and functional dissection of localization signals within ataxin-3.; ; ; ; ; ;
in Neurobiology of Disease (2009), 36(2), 280-92
2007
Localization signals within ataxin-3 influence the formation of intranuclear aggregates in spinocerebellar ataxia type 3; ; ; ; ;
in Aktuelle Neurologie (2007)
