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The Luxembourg Centre for Systems Biomedicine develops and applies systems-level approaches to gain insight into the molecular and cellular mechanisms of human diseases. Experimental and computational approaches are combined to analyse the complexity of biological systems underlying disease pathogenesis. The LCSB is pioneering the way for a predictive, preventive and personalised medicine. Neurodegenerative diseases, especially Parkinson’s disease are major targets within LCSB’s research activities.


Our research units are:

Bioinformatics Core (R. Schneider Group)

Biomedical Data Science (Glaab Group)

Computational Biology (Del Sol Group)

Developmental & Cellular Biology (Schwamborn Group)

Digital Medicine (Klucken Group)

Environmental Cheminformatics (Schymanski Group)

Enzymology & Metabolism (Linster Group)

Gene Expression & Metabolism (Williams Group)

Immunology & Genetics (Brenner Group)

Integrative Cell Signalling (Skupin Group)

Medical Translational Research (J. Schneider Group)

Molecular & Functional Neurobiology (Grünewald Group)

Neuroinflammation (Heneka Group)

Neuropathology (Mittelbronn Group)

Systems Ecology (Wilmes Group)

Systems Control (Goncalves Group)

Translational Neuroscience (Krüger Group)


The LCSB is collaborating with worldwide leading institutions. In order to attract the best scientists, our philosophy is one of „curiosity driven research“.

The LCSB is a centre stone in the ‘Luxembourg Health Science Plan', which is providing 140 Mio. Euro to transform the country into a research and technology hub within Europe and beyond. The LCSB is playing a proactive role in the development of new systems biology technologies, i.e. in the area of high-throughput analysis and new computational tools, which are also relevant for the biomedical industry.

The LCSB is highly interdisciplinary and works closely with other departments of the University of Luxembourg, especially those, with an expertise in molecular medicine, IT and mathematics. The LCSB cooperates closely with clinical partners to identify and validate new targets for disease prevention and intervention. Model organisms, such as mice, will be studied providing a basis for cooperation with medical scientists and clinicians studying human biology and pathobiology.


Medical research is very much about data. The Bioinformatics Core of the LCSB, a group of computer scientists and bioinformaticians, works on unlocking the full potential of this ...

At the LCSB, research groups are working with patient derived stem cells in automated cell cultures to get deeper insights into the mechanisms of Parkinson's disease and screen for ...

Prenez part à la recherche sur la maladie de Parkinson!

For a better understanding of disease mechanisms and development of new tools in diagnostics and therapy.

PD map - a molecular network of Parkinson’s disease

Some of our Principal Investigators

Prof. Anne Grünewald on her research on Parkinson's disease especially the role of mitochondria, organells responsable for energy supply in the nerve cells affected by the disease.

Prof. Dr. Rejko Krüger (LCSB)

Prof. Dr. Antonio del Sol

Prof. Dr. Jorge Goncalves (LCSB)

Dr. Reinhard Schneider (LCSB)

Dr. Carole Linster (LCSB)