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Prof. Dr. Iris Behrmann
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| Faculty or Centre | Faculty of Science, Technology and Medicine | ||||||
| Department | Department of Life Sciences and Medicine | ||||||
| Postal Address |
Université du Luxembourg 6, avenue du Swing L-4367 Belvaux |
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| Campus Office | BioTech II Ketterthill, 4.02 | ||||||
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| Telephone | (+352) 46 66 44 6740 | ||||||
Position
- Professor of Biochemistry, since 2003
- Head of the Life Sciences Research Unit
- Head of the Signal Transduction group
- Director of the European master of small animal veterinary medicine
Last updated on: Tuesday, 22 October 2019
Academic Qualifications
- Diploma in Biology, Universität Bielefeld, Germany, 1990
- PhD (Dr. rer. nat.), Universität Bielefeld, Germany, 1992 (thesis at the German Cancer Research Center, Heidelberg)
- Habilitation, venia legendi in Biochemistry, RWTH-Aachen Medical School, Germany, 2001
Last updated on: 29 Jan 2010
Research Interests
- molecular mechanisms of cytokine signal transduction,
- (patho)physiologic consequences of Jak/STAT signalling, e. g. the role of constitutively active Jak mutants in myeloproliferative neoplasms,
- microRNAs in melanoma development and growth regulation,
- cross-talk of cytokine signal transduction with other signalling pathways (hypoxia, growth factors).
Last updated on: 29 Jan 2010
2020
Systematic transcriptional profiling of responses to STAT1- and STAT3- activating cytokines in different cancer types; ; ; ; ; ; ; ; ;
in Journal of Molecular Biology (2020)
Hypoxia-Induced Adaptations of miRNomes and Proteomes in Melanoma Cells and Their Secreted Extracellular Vesicles; ; ; ; ; ; ; ; ; ;
in Cancers (2020)
Distinct Cargos of Small Extracellular Vesicles Derived from Hypoxic Cells and Their Effect on Cancer Cells; ; ;
in International Journal of Molecular Sciences (2020)
2019
miR-873-5p targets mitochondrialGNMT-Complex II interface contributing tonon-alcoholic fatty liver disease; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Molecular Metabolism (2019)
Modulation of the IL-6 signaling pathway in liver cells by miRNAs targeting gp130, JAK1 and/or STAT3; ; ; ; ; ; ;
in Molecular Therapy: Nucleic Acids (2019), 16
2018
Cytokine-mediated modulation of the hepatic miRNome: miR-146b-5p is an IL-6-inducible miRNA with multiple targets.; ; ; ; ; ; ; ; ; ; ;
in Journal of leukocyte biology (2018)
The PD-L1- and IL6-mediated dampening of the IL27/STAT1 anticancer responses are prevented by a-PD-L1 or a-IL6 antibodies; ; ; ; ; ; ; ; ; ; ; ; ;
in Journal of Leukocyte Biology (2018), 104
2017
The multi-site docking protein Gab1 is constitutively phosphorylated independent from its recruitment to the plasma membrane in Jak2-V617Fpositive cells and mediates proliferation of human erythroleukaemia cells; ; ; ; ; ; ; ; ; ;
in Cellular Signalling (2017), 35
Crosstalk between different family members: IL27 recapitulates IFNγ responses in HCC cells, but is inhibited by IL6-type cytokines; ; ; ; ; ; ; ; ; ; ;
in BBA Molecular Cell Research (2017)
2016
The role of HIF-1 in oncostatin M-dependent metabolic reprogramming of hepatic cells.; ; ; ; ; ; ;
in Cancer and Metabolism (2016), 4
Variant PNPLA3 increases the HCC risk: prospective study in patients treated at the Saarland University Medical Center; ; ; ;
in Zeitschrift für Gastroenterologie (2016), 54
2015
Circulating microRNAs as candidate biomarkers for the surveillance of melanoma patients; ;
in EBioMedicine (2015)
Comparison of a healthy miRNome with melanoma patient miRNomes: are microRNAs suitable serum biomarkers for cancer?; ; ; ; ; ; ; ;
in Oncotarget (2015), 6(14), 12110-27
ID: 194: Role of microRNAs in signal transduction pathways of the inflammatory cytokine Interleukin-6: Relevance for liver diseases; ; ; ; ; ; ; ; ;
in Cytokine (2015), 76(1), 99-
2013
JAK2 mutants (e.g., JAK2V617F) and their importance as drug targets in myeloproliferative neoplasms; ;
in JAK-STAT (2013), 2(3), 25025
Cooperative effects of Janus and Aurora kinase inhibition by CEP701 in cells expressing Jak2V617F; ; ; ; ; ; ; ;
in Journal of Cellular and Molecular Medicine (2013), 17(2), 265-276
New Target Genes of MITF-Induced microRNA-211 Contribute to Melanoma Cell Invasion; ; ; ; ;
in PLoS ONE (2013), 8(9),
JAK2-V617F-induced MAPK activity is regulated by PI3K and acts synergistically with PI3K on the proliferation of JAK2-V617F-positive cells.; ; ; ; ; ; ; ;
in JAK-STAT (2013), 2(3), 24574
2012
Dynamic regulation of microRNA expression following interferonγ- induced gene transcription; ; ; ; ; ; ; ;
in RNA Biology (2012), 9(7), 987-989
Interferon-γ-induced activation of Signal Transducer and Activator of Transcription 1 (STAT1) up-regulates the tumor suppressing microRNA-29 family in melanoma cells; ; ; ; ; ; ;
in Cell Communication and Signaling (2012), 10
MiRNA-29: A microRNA family with tumor-suppressing and immune-modulating properties; ; ;
in Current Molecular Medicine (2012), 13(4), 572-585
2011
Jak1 has a dominant role over Jak3 in signal transduction through γc-containing cytokine receptors; ; ; ; ; ; ;
in Chemistry and Biology (2011), 18(3), 314-323
2010
Signal transduction, receptors, mediators and genes: Younger than ever - The 13th meeting of the Signal Transduction Society focused on aging and immunology; ; ; ; ; ; ; ; ; ; ; ;
in Cell Communication and Signaling (2010), 8
Perspectives for the use of structural information and chemical genetics to develop inhibitors of Janus kinases.; ;
in Journal of Cellular and Molecular Medicine (2010), 14(3), 504-27
Signatures of MicroRNAs and selected MicroRNA target genes in human melanoma; ; ; ; ; ; ; ; ;
in Cancer Research (2010), 70(10), 4163-4173
Cross-regulation of cytokine signalling: Pro-inflammatory cytokines restrict IL-6 signalling through receptor internalisation and degradation; ; ; ; ; ; ; ; ; ; ; ;
in Journal of Cell Science (2010), 123(6), 947-959
Oncostatin M up-regulates the ER chaperone Grp78/BiP in liver cells; ;
in Biochemical Pharmacology (2010), 80(12), 2066-2073
2009
An unusual insertion in Jak2 is crucial for kinase activity and differentially affects cytokine responses; ; ; ; ; ; ; ;
in Journal of Immunology (2009), 182(5), 2969-2977
SOCS-mediated downregulation of mutant Jak2 (V617F, T875N and K539L) counteracts cytokine-independent signaling.; ; ; ; ; ;
in Oncogene (2009), 28(34), 3069-80
Hypoxia-inducible factor 1alpha is up-regulated by oncostatin M and participates in oncostatin M signaling; ; ; ; ; ; ; ;
in Hepatology (2009), 2009(3),
2008
Dual role of the Jak1 FERM and kinase domains in cytokine receptor binding and in stimulation-dependent Jak activation; ; ; ; ; ; ;
in Journal of Immunology (2008), 180(2), 998-1007
Cell density dependent increase of constitutive signal transducers and activators of transcription 3 activity in melanoma cells is mediated by Janus kinases; ; ; ;
in Molecular Cancer Research (2008), 5(12), 1331-41
IL-24: a classic cytokine and/or a potential cure for cancer?; ; ;
in Journal of Cellular and Molecular Medicine (2008), 12(6A), 2505-2510
2007
A cost effective non-commercial ECL-solution for Western blot detections yielding strong signals and low background;
in Journal of Immunological Methods (2007), 318(1-2), 11-9
Constitutive suppressor of cytokine signaling 3 expression confers a growth advantage to a human melanoma cell line; ; ; ;
in Molecular Cancer Research (2007), 5(3), 271-81
Recombinant interleukin-24 lacks apoptosis-inducing properties in melanoma cells; ; ; ; ; ; ;
in PLoS ONE (2007), 2(12), 1300
STAT1 regulates p73-mediated Bax gene expression; ; ; ; ; ; ; ;
in FEBS Letters (2007), 581(6), 1217-26
2006
Jaks and cytokine receptors - an intimate relationship; ; ;
in Biochemical Pharmacology (2006), 72(11), 1538-46
Three dileucine-like motifs within the interbox1/2 region of the human oncostatin M receptor prevent efficient surface expression in the absence of an associated Janus kinase; ; ; ;
in Journal of Biological Chemistry (2006), 281(7), 4024-34
Biological responses to PDGF-BB versus PDGF-DD in human mesangial cells; ; ; ; ; ; ; ; ; ;
in Kidney International (2006), 69(8), 1393-402
2005
Multiple reasons for an inefficient STAT1 response upon IL-6-type cytokine stimulation; ; ; ;
in Cellular Signalling (2005), 17(12), 1542-50
Promoter-hypermethylation is causing functional relevant downregulation of methylthioadenosine phosphorylase (MTAP) expression in hepatocellular carcinoma; ; ; ; ; ; ; ;
in Carcinogenesis (2005), 27(1), 64-72
The Jak1 SH2 domain does not fulfill a classical SH2 function in Jak/STAT signaling but plays a structural role for receptor interaction and up-regulation of receptor surface expression; ; ; ; ; ; ; ; ;
in Journal of Biological Chemistry (2005), 280(27), 25760-8
STAT5 contributes to interferon resistance of melanoma cells; ; ; ; ; ; ; ; ;
in Current Biology (2005), 15(18), 1629-39
2004
Janus kinase (Jak) subcellular localization revisited: the exclusive membrane localization of endogenous Janus kinase 1 by cytokine receptor interaction uncovers the Jak.receptor complex to be equivalent to a receptor tyrosine kinase; ; ; ; ; ; ; ;
in Journal of Biological Chemistry (2004), 279(34), 35486-93
The role of the inhibitors of interleukin-6 signal transduction SHP2 and SOCS3 for desensitization of interleukin-6 signalling; ; ; ; ; ; ; ; ; ; ; ;
in Biochemical Journal (2004), 378(Pt 2), 449-60
Interferon-gamma-mediated growth regulation of melanoma cells: involvement of STAT1-dependent and STAT1-independent signals; ; ; ; ;
in Journal of Investigative Dermatology (2004), 122(2), 414-22
2003
Characterization of methylthioadenosin phosphorylase (MTAP) expression in malignant melanoma; ; ; ; ; ;
in American Journal of Pathology (2003), 163(2), 683-90
Long term association of the cytokine receptor gp130 and the Janus kinase Jak1 revealed by FRAP analysis; ; ; ; ; ; ; ; ; ;
in Journal of Biological Chemistry (2003), 278(40), 39205-13
Principles of interleukin (IL)-6-type cytokine signalling and its regulation; ; ; ; ;
in Biochemical Journal (2003), 374(Pt 1), 1-20
Akt modulates STAT3-mediated gene expression through a FKHR (FOXO1a)-dependent mechanism; ; ; ; ; ; ; ;
in Journal of Biological Chemistry (2003), 278(7), 5242-9
2002
Identification of the critical sequence elements in the cytoplasmic domain of leptin receptor isoforms required for Janus kinase/signal transducer and activator of transcription activation by receptor heterodimers; ; ; ; ; ;
in Molecular Endocrinology (2002), 16(4), 859-72
Orientational constraints of the gp130 intracellular juxtamembrane domain for signaling; ; ; ;
in Journal of Biological Chemistry (2002), 277(30), 26959-65
SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130; ; ; ; ; ; ; ; ; ; ; ; ;
in Journal of Biological Chemistry (2002), 278(1), 661-71
Novel role of Janus kinase 1 in the regulation of oncostatin M receptor surface expression; ; ; ; ; ;
in Journal of Biological Chemistry (2002), 277(13), 11297-305
The matrix metalloproteinase 9 (mmp-9) hemopexin domain is a novel gelatin binding domain and acts as an antagonist; ; ; ; ; ; ;
in Journal of Biological Chemistry (2002), 277(52), 50326-32
2001
Interleukin-6-resistant melanoma cells exhibit reduced activation of STAT3 and lack of inhibition of cyclin E-associated kinase activity; ; ; ; ; ; ; ; ;
in Journal of Investigative Dermatology (2001), 117(1), 132-40
Structural requirements of the interleukin-6 signal transducer gp130 for its interaction with Janus kinase 1: the receptor is crucial for kinase activation; ;
in Biochemical Journal (2001), 361(Pt 1), 105-11
A single amino acid substitution (Trp(666)-->Ala) in the interbox1/2 region of the interleukin-6 signal transducer gp130 abrogates binding of JAK1, and dominantly impairs signal transduction; ; ;
in Biochemical Journal (2001), 349(Pt 1), 261-6
Mapping of a region within the N terminus of Jak1 involved in cytokine receptor interaction; ; ; ; ; ; ;
in Journal of Biological Chemistry (2001), 276(40), 37451-8
Non-redundant signal transduction of interleukin-6-type cytokines. The adapter protein Shc is specifically recruited to rhe oncostatin M receptor; ; ; ;
in Journal of Biological Chemistry (2001), 275(52), 40742-8
A region encompassing the FERM domain of Jak1 is necessary for binding to the cytokine receptor gp130; ; ; ; ; ;
in FEBS Letters (2001), 505(1), 87-91
Mitogen-activated protein kinases control p27/Kip1 expression and growth of human melanoma cells; ; ; ; ;
in Biochemical Journal (2001), 357(Pt 1), 297-303
Cytokine-mediated growth inhibition of human melanoma cells; ; ;
in Advances in Experimental Medicine and Biology (2001), 495
STAT3 is constitutively activated in Hodgkin cell lines; ; ; ; ; ; ; ;
in Blood (2001), 98(3), 762-70
A completely foreign receptor can mediate an interferon-gamma-like response; ; ; ; ; ; ; ; ; ; ; ; ;
in EMBO Journal (2001), 20(19), 5431-42
Neutralizing monoclonal antibodies can potentiate IL-5 signaling; ; ; ; ; ; ; ; ;
in European Journal of Immunology (2001), 31(4), 1087-97
2000
Signal transduction of IL-6, leukemia-inhibitory factor, and oncostatin M: structural receptor requirements for signal attenuation; ; ; ; ; ; ; ; ;
in Journal of Immunology (2000), 165(5), 2535-43
Signalling of interleukin-6 type cytokines via gp130, leukemia inhibitory factor (LIF) receptor and oncostatin M receptor; ; ; ; ; ;
in European Cytokine Network (2000), 11(3), 491-2
Cytoplasmic STAT proteins associate prior to activation; ; ; ; ;
in Biochemical Journal (2000), 345 Pt 3
Contributions of leukemia inhibitory factor receptor and oncostatin M receptor to signal transduction in heterodimeric complexes with glycoprotein 130; ; ; ; ; ;
in Journal of Immunology (2000), 163(12), 6651-8
An MMP-9 mutant without gelatinolytic activity as a novel TIMP-1-antagonist; ; ; ;
in FASEB Journal (2000), 14(12), 1671-3
Differential inhibition of IL-6-type cytokine-induced STAT activation by PMA; ; ; ; ; ; ;
in FEBS Letters (2000), 478(1-2), 100-4
Termination of IL-6-induced STAT activation is independent of receptor internalization but requires de novo protein synthesis; ; ; ; ; ;
in FEBS Letters (2000), 470(1), 15-9
1999
Interleukin-6 and oncostatin M-induced growth inhibition of human A375 melanoma cells is STAT-dependent and involves upregulation of the cyclin-dependent kinase inhibitor p27/Kip1; ; ; ; ; ; ; ;
in Oncogene (1999), 18(25), 3742-53
Identification of a Leu-lle internalization motif within the cytoplasmic domain of the leukaemia inhibitory factor receptor; ; ; ; ; ; ; ; ;
in Biochemical Journal (1999), 339 (Pt 1)
1998
Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway; ; ; ;
in Biochemical Journal (1998), 334 (Pt 2)
Internalization of the interleukin 6 signal transducer gp130 does not require activation of the Jak/STAT pathway; ; ; ; ; ; ;
in Biochemical Journal (1998), 330 (Pt 1)
1997
A single STAT recruitment module in a chimeric cytokine receptor complex is sufficient for STAT activation; ; ; ; ; ; ; ; ;
in Journal of Biological Chemistry (1997), 272(8), 5269-74
1996
Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor; ; ; ; ; ;
in EMBO Journal (1996), 14(22), 5579-88
1995
APO-I-mediated apoptosis in normal and malignant lymphocytes; ; ; ; ; ; ; ; ;
in Biochemical Society Transactions (1995), 22(3), 598-600
The role of APO-1-mediated apoptosis in the immune system; ; ; ; ; ; ; ; ;
in Immunological Reviews (1995), 142
1994
Regulation of apoptosis in the immune system; ; ; ;
in Current Opinion in Immunology (1994), 6(2), 279-89
1992
Purification and molecular cloning of the APO-1 cell surface antigen, a member of the tumor necrosis factor/nerve growth factor receptor superfamily. Sequence identity with the Fas antigen; ; ; ; ; ; ; ; ;
in Journal of Biological Chemistry (1992), 267(15), 10709-15
1990
Overexpression of a Streptomyces viridochromogenes gene (glnII) encoding a glutamine synthetase similar to those of eucaryotes confers resistance against the antibiotic phosphinothricyl-alanyl-alanine; ; ; ;
in Journal of Bacteriology (1990), 172(9), 5326-34
