Robert Kumsta
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| Department | Department of Behavioural and Cognitive Sciences | ||||
| Postal Address |
Université du Luxembourg Maison des Sciences Humaines 11, Porte des Sciences L-4366 Esch-sur-Alzette |
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| Campus Office | MSH, E04 45-040 | ||||
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| Telephone | (+352) 46 66 44 9173 | ||||
Robert Kumsta was appointed Professor of Biopsychology at the University of Luxemburg in May 2021. He studied psychology at the University of Trier, Germany, and received his Ph.D. in Psychobiology from the University of Trier in 2007. Funded by a postdoctoral fellowship from the German Academy of Sciences Leopoldina, he joined the Social, Genetic & Developmental Psychiatry Centre, Institute of Psychiatry, King’s College London, to study the effects of severe institutional deprivation in the English and Romanian Adoptees Study. From 2010 until 2013, he held a Research Fellow position at the Laboratory for Biological and Personality Psychology at the University of Freiburg. Since October 2013, Robert Kumsta has been Professor and Chair of Genetic Psychology at Ruhr University Bochum.
One of his major research goals is to establish a better mechanistic understanding of how early psychosocial risk is ‘biologically embedded’ and increases the risk of long term health problems. A particular focus is on the role of stress physiology and the oxytocin system. Furthermore, he is interested in mechanisms of gene-environment interplay and epigenetic processes.
Using a range of methods, including the study of genetic variation, gene expression patterns, epigenetics, multi-comics integration, as well as the characterization of stress physiology, he is trying to understand how genetic and environmental factors work together to shape developmental trajectories and outcomes across the life-span
Last updated on: Thursday, 27 May 2021
2023
Structural architecture and brain network efficiency link polygenic scores to intelligence.; ; ; ; ; ; ; ; ; ;
in Human brain mapping (2023)
A matter of habit? Stressful life events and cognitive flexibility in 15-month-olds; ; ;
in Infant Behavior and Development (2023), 71 file://localhost/Users/robert.kumsta/Documents/Papers%20Library/Tisborn-A%20matter%20of%20habit-%20Stressful%20life%20events%20and%20cognitive%20flexibility%20in%2015-month-olds-2023-Infant%20Behavior%20and%20Development.pdf
Proteome analysis of monocytes implicates altered mitochondrial biology in adults reporting adverse childhood experiences.; ; ; ; ; ; ; ; ;
in Translational psychiatry (2023), 13(1), 31
2022
Urbanicity, behavior problems and HPA axis regulation in preschoolers; ; ; ; ; ; ; ; ; ;
in Psychoneuroendocrinology (2022), 137
Less efficient cognitive pain modulation in healthy older adults – the impact of executive functions, chronic stress, and physical activity; ; ; ; ; ;
in Heinrichs, Markus; Schönauer, Monika (Eds.) 47. Jahrestagung Psychologie und Gehirn (2022)
Mitochondrial DNA as a marker for treatment-response in post-traumatic stress disorder.; ; ; ; ; ;
in Psychoneuroendocrinology (2022), 148
No evidence for intervention-associated DNA methylation changes in monocytes of patients with posttraumatic stress disorder.; ; ; ; ; ; ; ; ; ; ; ;
in Scientific reports (2022), 12(1), 17347
Prenatal exposure to endocrine disrupting chemicals is associated with altered DNA methylation in cord blood; ; ; ; ; ; ; ; ; ; ;
in Epigenetics (2022), 17(9), 935-952
Investigating mental health of children in out-of-home care during the COVID-19 pandemic; ;
Scientific Conference (2022, September 16)
Investigating subjective well-being and mental health of children in out-of-home care during the COVID-19 pandemic; ;
Scientific Conference (2022, September 15)
2021
The brain under stress—A systematic review and activation likelihood estimation meta-analysis of changes in BOLD signal associated with acute stress exposure; ; ; ;
in Neuroscience and Biobehavioral Reviews (2021), 124
Polygenic Scores for Cognitive Abilities and Their Association with Different Aspects of General Intelligence—A Deep Phenotyping Approach; ; ; ; ; ; ; ; ; ;
in Molecular Neurobiology (2021)
Polygenic scores for handedness and their association with asymmetries in brain structure; ; ; ; ; ; ; ;
in Brain Structure and Function (2021)
Genes in treatment: Polygenic risk scores for different psychopathologies, neuroticism, educational attainment and IQ and the outcome of two different exposure-based fear treatments; ; ; ; ; ; ; ; ; ; ;
in World Journal of Biological Psychiatry (2021)
2020
Event-related functional MRI of awake behaving pigeons at 7T; ; ; ; ; ; ; ; ; ; ; ;
in Nature Communications (2020), 11(1),
Exploring hair steroid concentrations in asylum seekers, internally displaced refugees, and immigrants; ; ; ; ;
in Stress (2020), 23(5), 538-545
Stress genomics revisited: gene co-expression analysis identifies molecular signatures associated with childhood adversity; ;
in Translational Psychiatry (2020), 10(1),
The mediating role of KITLG DNA methylation in the association between childhood adversity and cortisol stress reactivity does not replicate in monocytes; ; ; ; ; ; ;
in Psychoneuroendocrinology (2020), 116
Why does early childhood deprivation increase the risk for depression and anxiety in adulthood? A developmental cascade model; ; ; ; ; ; ; ; ; ;
in Journal of Child Psychology and Psychiatry and Allied Disciplines (2020), 61(9), 1043-1053
Early childhood deprivation is associated with alterations in adult brain structure despite subsequent environmental enrichment; ; ; ; ; ; ; ;
in Proceedings of the National Academy of Sciences of the United States of America (2020), 117(1), 641-649
Targeted bisulfite sequencing: A novel tool for the assessment of DNA methylation with high sensitivity and increased coverage; ; ; ; ; ; ; ; ; ; ;
in Psychoneuroendocrinology (2020), 120
Genetik und Epigenetik in der Psychotherapie von Depression und Angststörungen; ; ; ;
in Verhaltenstherapie (2020), 30(1), 58-67
Angiotensin involvement in trauma processing—exploring candidate neurocognitive mechanisms of preventing post-traumatic stress symptoms; ; ; ; ; ;
in Neuropsychopharmacology (2020), 45(3), 507-514
Highs and lows: Genetic susceptibility to daily events; ; ; ; ; ; ;
in PLoS ONE (2020), 15(8 August),
Oxytocin and the stress buffering effect of social company: A genetic study in daily life; ; ; ; ; ;
in Social Cognitive and Affective Neuroscience (2020), 15(3), 293-301
Adoptees' responses to separation from, and reunion with, their adoptive parent at age 4 years is associated with long-term persistence of autism symptoms following early severe institutional deprivation; ; ; ; ; ; ; ; ;
in Development and Psychopathology (2020), 32(2), 631-640
The role of the 5-HTTLPR polymorphism in acquired capability for suicide; ; ; ; ; ; ; ; ;
in Suicide and Life-Threatening Behavior (2020), 50(6), 1121-1126
2019
Cortisol awakening response in children and adolescents with autism spectrum disorder: A systematic review and meta-analysis; ; ; ;
in Evidence-Based Mental Health (2019), 22(3), 118-124
The role of epigenetics for understanding mental health difficulties and its implications for psychotherapy researchin Psychology and Psychotherapy (2019), 92(2), 190-207
Genetic variation of the mineralocorticoid receptor gene (MR, NR3C2) is associated with a conceptual endophenotype of “CRF-hypoactivity”; ; ; ;
in Psychoneuroendocrinology (2019), 105
Cortisol modulates the engagement of multiple memory systems: Exploration of a common NR3C2 polymorphism; ; ; ;
in Psychoneuroendocrinology (2019), 107
Schizotypy and altered hemispheric asymmetries: The role of cilia genes; ; ; ; ; ; ; ;
in Psychiatry Research. Neuroimaging (2019), 294
DNA methylation of dopamine-related gene promoters is associated with line bisection deviation in healthy adults; ; ; ;
in Scientific Reports (2019), 9(1),
Oxytocin administration and emotion recognition abilities in adults with a history of childhood adversity; ;
in Psychoneuroendocrinology (2019), 99
Temporal dynamics of cortisol-associated changes in mRNA expression of glucocorticoid responsive genes FKBP5, GILZ, SDPR, PER1, PER2 and PER3 in healthy humans; ; ; ; ; ; ;
in Psychoneuroendocrinology (2019), 102
2018
Exploring mental health status and syndrome patterns among young refugee children in Germany; ; ; ;
in Frontiers in Psychiatry (2018), 9(MAY),
The OXTR single-nucleotide polymorphism rs53576 moderates the impact of childhood maltreatment on empathy for social pain in female participants: Evidence for differential susceptibility; ; ;
in Frontiers in Psychiatry (2018), 9(AUG),
Cell-free DNA release under psychosocial and physical stress conditions; ; ; ; ; ; ; ; ; ;
in Translational Psychiatry (2018), 8(1),
KIAA0319 promoter DNA methylation predicts dichotic listening performance in forced-attention conditions; ; ; ;
in Behavioural Brain Research (2018), 337
Mechanisms, genes and treatment: Experimental fear conditioning, the serotonin transporter gene, and the outcome of a highly standardized exposure-based fear treatment; ; ; ; ;
in Behaviour Research and Therapy (2018), 107
The Return of Fear: Variation of the Serotonin Transporter Gene Predicts Outcome of a Highly Standardized Exposure-Based One-Session Fear Treatment; ; ; ;
in Psychotherapy and Psychosomatics (2018), 87(2), 95-104
2017
Testosterone and androgen receptor gene polymorphism are associated with confidence and competitiveness in men; ; ; ;
in Hormones and Behavior (2017), 92
Adult disinhibited social engagement in adoptees exposed to extreme institutional deprivation: Examination of its clinical status and functional impact; ; ; ; ; ; ; ; ;
in British Journal of Psychiatry (2017), 211(5), 289-295
HPA axis dysregulation in adult adoptees twenty years after severe institutional deprivation in childhood; ; ; ; ; ; ; ; ;
in Psychoneuroendocrinology (2017), 86
The Genetics of asymmetry: Whole exome sequencing in a consanguineous Turkish family with an overrepresentation of left-handedness; ; ; ; ; ; ; ;
in Symmetry (2017), 9(5),
Epigenetic regulation of lateralized fetal spinal gene expression underlies hemispheric asymmetries; ; ; ; ; ; ; ; ; ; ;
in eLife (2017), 6
Poverty, early care, and stress reactivity in adolescence: Findings from a prospective, longitudinal study in South Africa; ; ; ; ; ;
in Development and Psychopathology (2017), 29(2), 449-464
Child-to-adult neurodevelopmental and mental health trajectories after early life deprivation: the young adult follow-up of the longitudinal English and Romanian Adoptees study; ; ; ; ; ; ; ;
in The Lancet (2017), 389(10078), 1539-1548
Sex-specific association between functional neuropeptide S receptor gene (NPSR1) variants and cortisol and central stress responses; ; ; ; ; ; ; ; ; ; ;
in Psychoneuroendocrinology (2017), 76
2016
Stress and Depression: a Crucial Role of the Mineralocorticoid Receptor; ; ; ; ; ; ;
in Journal of Neuroendocrinology (2016), 28(8),
Enhanced startle responsivity 24 hours after acute stress exposure; ; ; ; ;
in Behavioral Neuroscience (2016), 130(5), 521-530
Oxytocin receptor gene polymorphism modulates the effects of social support on heart rate variability; ; ; ; ;
in Biological Psychology (2016), 117
Early severe institutional deprivation is associated with a persistent variant of adult attention-deficit/hyperactivity disorder: clinical presentation, developmental continuities and life circumstances in the English and Romanian Adoptees study; ; ; ; ; ; ; ;
in Journal of Child Psychology and Psychiatry and Allied Disciplines (2016), 57(10), 1113-1125
Severe psychosocial deprivation in early childhood is associated with increased DNA methylation across a region spanning the transcription start site of CYP2E1; ; ; ; ; ; ;
in Translational Psychiatry (2016), 6(6),
Altered Stress-Induced Regulation of Genes in Monocytes in Adults with a History of Childhood Adversity; ; ; ; ; ; ; ;
in Neuropsychopharmacology (2016), 41(10), 2530-2540
2015
Genetic modulation of oxytocin sensitivity: A pharmacogenetic approach; ; ; ; ; ;
in Translational Psychiatry (2015), 5(10),
Psychological consequences of early global deprivation; ; ; ; ;
in European Psychologist (2015), 20(2), 138-151
2013
Neuropeptide S receptor gene is associated with cortisol responses to social stress in humans; ; ;
in Biological Psychology (2013), 93(2), 304-307
Oxytocin, stress and social behavior: Neurogenetics of the human oxytocin system;
in Current Opinion in Neurobiology (2013), 23(1), 11-16
Epigenetic regulation of the oxytocin receptor gene: Implications for behavioral neuroscience; ; ;
in Frontiers in Neuroscience (2013), (7 MAY),
2012
Adolescent callous-unemotional traits and conduct disorder in adoptees exposed to severe early deprivation; ;
in British Journal of Psychiatry (2012), 200(3), 197-201
Longitudinal studies using a "natural experiment" design: The case of adoptees from Romanian institutions; ; ;
in Journal of the American Academy of Child and Adolescent Psychiatry (2012), 51(8), 762-770
2011
Transcriptional control of the human glucocorticoid receptor: Identification and analysis of alternative promoter regions; ; ; ; ; ;
in Human Genetics (2011), 129(5), 533-543
Oxytocin and intergroup relations: Goodwill is not a fixed pie; ;
in Proceedings of the National Academy of Sciences of the United States of America (2011), 108(13),
Common oxytocin receptor gene (OXTR) polymorphism and social support interact to reduce stress in humans; ; ; ; ;
in Proceedings of the National Academy of Sciences of the United States of America (2011), 108(50), 19937-19942
Stress exposure in intrauterine life is associated with shorter telomere length in young adulthood; ; ; ; ; ; ;
in Proceedings of the National Academy of Sciences of the United States of America (2011), 108(33), 513-518
A functional variant of the serotonin transporter gene ((SLC6A4) moderates impulsive choice in attention-deficit/hyperactivity disorder boys and siblings; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Biological Psychiatry (2011), 70(3), 230-236
2010
Developmental course of deprivation-specific psychological patterns: Early manifestations, persistence to age 15, and clinical features; ; ; ; ; ;
in Monographs of the Society for Research in Child Development (2010), 75(1), 79-101
Working memory performance Is associated with common glucocorticoid receptor gene polymorphisms; ; ; ; ;
in Neuropsychobiology (2010), 61(1), 49-56
Deprivation-specific psychological patterns; ; ; ; ; ;
in Monographs of the Society for Research in Child Development (2010), 75(1), 48-78
Risk, causation, mediation, and moderation; ; ;
in Monographs of the Society for Research in Child Development (2010), 75(1), 187-211
5HTT genotype moderates the influence of early institutional deprivation on emotional problems in adolescence: Evidence from the English and Romanian Adoptee (ERA) study; ; ; ; ; ; ; ;
in Journal of Child Psychology and Psychiatry and Allied Disciplines (2010), 51(7), 755-762
Functional mineralocorticoid receptor (MR) gene variation influences the cortisol awakening response after dexamethasone; ; ; ; ; ;
in Psychoneuroendocrinology (2010), 35(3), 339-349
2009
Parents' Evaluation of Adoption Success: A Follow-Up Study of Intercountry and Domestic Adoptions; ; ; ; ; ; ; ; ; ;
in American Journal of Orthopsychiatry (2009), 79(4), 522-531
Prenatal Psychosocial Stress Exposure Is Associated With Subsequent Working Memory Performance in Young Women; ; ; ; ;
in Behavioral Neuroscience (2009), 123(4), 886-893
Prenatal exposure to maternal psychosocial stress and HPA axis regulation in young adults; ; ; ;
in Hormones and Behavior (2009), 55(2), 292-298
Characterization of a glucocorticoid receptor gene (GR, NR3C1) promoter polymorphism reveals functionality and extends a haplotype with putative clinical relevance; ; ; ; ;
in American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics (2009), 150(4), 476-482
Functional analysis of a potassium-chloride co-transporter 3 (SLC12A6) promoter polymorphism leading to an additional DNA methylation site; ; ; ; ; ; ;
in Neuropsychopharmacology (2009), 34(2), 458-467
Dopamine transporter gene polymorphism moderates the effects of severe deprivation on ADHD symptoms: Developmental continuities in gene - Environment interplay; ; ; ; ;
in American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics (2009), 150(6), 753-761
Sex-specific association between the 5-HTT gene-linked polymorphic region and basal cortisol secretion; ; ; ; ; ;
in Psychoneuroendocrinology (2009), 34(7), 972-982
2008
Influence of prenatal psychosocial stress on cytokine production in adult women; ; ; ; ;
in Developmental Psychobiology (2008), 50(6), 579-587
Prenatal psychosocial stress exposure is associated with insulin resistance in young adults; ; ; ; ; ;
in American Journal of Obstetrics and Gynecology (2008), 199(5), 4981-4987
Glucocorticoid receptor gene polymorphisms and glucocorticoid sensitivity of subdermal blood vessels and leukocytes; ; ; ; ;
in Biological Psychology (2008), 79(2), 179-184
G72 and its association with major depression and neuroticism in large population-based groups from Germany; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in American Journal of Psychiatry (2008), 165(6), 753-762
Covariance between psychological and endocrine responses to pharmacological challenge and psychosocial stress: A question of timing; ; ; ; ;
in Psychosomatic Medicine (2008), 70(7), 787-796
2007
Cortisol and ACTH responses to psychosocial stress are modulated by corticosteroid binding globulin levels; ; ;
in Psychoneuroendocrinology (2007), 32(8-10), 1153-1157
Sex Specific Associations between Common Glucocorticoid Receptor Gene Variants and Hypothalamus-Pituitary-Adrenal Axis Responses to Psychosocial Stress; ; ; ; ;
in Biological Psychiatry (2007), 62(8), 863-869
The glucocorticoid receptor gene exon 1-F promoter is not methylated at the NGFI-A binding site in human hippocampus; ; ; ; ;
in World Journal of Biological Psychiatry (2007), 8(4), 262-268
2004
Free cortisol awakening responses are influenced by awakening time; ; ; ; ;
in Psychoneuroendocrinology (2004), 29(2), 174-184
A psychobiological perspective on genetic determinants of hypothalamus-pituitary-adrenal axis activity; ; ; ; ; ;
in Annals of the New York Academy of Sciences (2004), 1032
Common Polymorphisms in the Glucocorticoid Receptor Gene Are Associated with Adrenocortical Responses to Psychosocial Stress; ; ; ; ;
in Journal of Clinical Endocrinology and Metabolism (2004), 89(2), 565-573
