Serge Haan

Serge Haan

Full professor in Biological chemistry

Faculty or Centre Faculty of Science, Technology and Communication
Research Unit RU Life Sciences
Postal Address Université du Luxembourg
Maison du Savoir
2, Avenue de l'Université
L-4365 Esch-sur-Alzette
Campus Office MSA, E16 1625-150
Email
Telephone (+352) 46 66 44 6437
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2018

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See detailThe PD-L1- and IL6-mediated dampening of the IL27/STAT1 anticancer responses are prevented by a-PD-L1 or a-IL6 antibodies
Rolvering, Catherine; Zimmer, Andreas David; Ginolhac, Aurélien; Margue, Christiane; Kirchmeyer, Mélanie; Servais, Florence; Hermanns, Heike M.; Hergovits, Sabine; Nazarov, Petr V.; Nicot, Nathalie; Kreis, Stephanie; Haan, Serge; Behrmann, Iris; Haan, Claude

in Journal of Leukocyte Biology (2018), 104

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See detailThe microRNA-371~373 cluster represses colon cancer initiation and metastatic colonization by inhibiting the TGFBR2/ID1 signaling axis.
Ullmann, Pit; Rodriguez, Fabien; Schmitz, Martine; Meurer, Steffen K.; Qureshi-Baig, Komal; Felten, Paul; Ginolhac, Aurélien; Antunes, Laurent; Frasquilho, Sonia; Zugel, Nikolaus; Weiskirchen, Ralf; Haan, Serge; Letellier, Elisabeth

in Cancer research (2018)

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2017

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See detailInsights into ligand stimulation effects on gastro-intestinal stromal tumors signalling.
Bahlawane, Christelle; Schmitz, Martine; Letellier, Elisabeth; Arumugam, Karthik; Nicot, Nathalie; Nazarov, Petr; Haan, Serge

in Cell Signal (2017)

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See detailLoss of Myosin Vb in colorectal cancer is a strong prognostic factor for disease recurrence
Letellier, Elisabeth; Schmitz, Martine; Ginolhac, Aurélien; Rodriguez, Fabien; Ullmann, Pit; Qureshi-Baig, Komal; Frasquilho, Sonia; Antunes, Laurent; Haan, Serge

in British Journal of Cancer (2017), 117(11), 1689-1701

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See detailTumor-Initiating Cells: a criTICal review of isolation approaches and new challenges in targeting strategies
qureshi-baig, komal; Ullmann, Pit; Haan, Serge; Letellier, Elisabeth

in Molecular Cancer (2017)

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See detailCrosstalk between different family members: IL27 recapitulates IFNγ responses in HCC cells, but is inhibited by IL6-type cytokines
Rolvering, Catherine; Zimmer, Andreas; Kozar, Ines; Hermanns; Letellier, Elisabeth; Vallar, Laurent; Nazarov, Petr; Nicot, Nathalie; Ginolhac, Aurélien; Haan, Serge; Behrmann, Iris; Haan, Claude

in BBA Molecular Cell Research (2017)

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See detailFrom meta-genomics to causality: Understanding the role of colon cancer-associated bacteria in colorectal cancer
Ternes, Dominik; Wilmes, Paul; Letellier, Elisabeth; Haan, Serge

Poster (2017, February 05)

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2016

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See detailData on quantification of signaling pathways activated by KIT and PDGFRA mutants.
Bahlawane, Christelle; Schmitz, Martine; Letellier, Elisabeth; Arumugam, Karthik; Nicot, Nathalie; Nazarov, Petr; Haan, Serge

in Data in Brief (2016)

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See detailSOCS2: physiological and pathological functions.
Letellier, Elisabeth; Haan, Serge

in Frontiers in bioscience (Elite edition) (2016), 8

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See detailDissecting functions of the N-terminal domain and GAS-site recognition in STAT3
Martincuks, Antons; Fahrenkamp, Dirk; Haan, Serge; Herrmann, Andreas; Küster, Andrea; Müller-Newen, Gerhard

in Cellular Signalling (2016), 28(8), 810-25

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See detailWhat Do We Learn from Spheroid Culture Systems? Insights from Tumorspheres Derived from Primary Colon Cancer Tissue.
Qureshi-Baig, Komal; Ullmann, Pit; Rodriguez, Fabien; frasquilho, sonia; nazarov, peter; Haan, Serge; Letellier, Elisabeth

in PLoS ONE (2016), 11

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See detailA Probabilistic Boolean Network Approach for the Analysis of Cancer-Specific Signalling: A Case Study of Deregulated PDGF Signalling in GIST.
Trairatphisan, Panuwat; Wiesinger, Monique; Bahlawane, Christelle; Haan, Serge; Sauter, Thomas

in PloS one (2016), 11(5), 0156223

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See detailHypoxia-responsive miR-210 promotes self-renewal capacity of colon tumor-initiating cells by repressing ISCU and by inducing lactate production
Ullmann, Pit; qureshi-baig, komal; Rodriguez, Fabien; Ginolhac, Aurélien; nonnenmacher, yannic; Ternes, Dominik; Weiler, Jil; Gaebler, Karoline; bahlawane, Christelle; hiller, karsten; Haan, Serge; Letellier, Elisabeth

in Oncotarget (2016)

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2015

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See detailConstitutive activation of oncogenic PDGFRalpha-mutant proteins occurring in GIST patients induces receptor mislocalisation and alters PDGFRalpha signalling characteristics.
Bahlawane, Christelle; Eulenfeld, Rene; Wiesinger, Monique; Wang, Jiali; Muller, Arnaud; Girod, Andreas; Nazarov, Petr V.; Felsch, Kathrin; Vallar, Laurent; Sauter, Thomas; Satagopam, Venkata; Haan, Serge

in Cell Communication and Signaling (2015), 13

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See detailThe oncogenic FIP1L1-PDGFRalpha fusion protein displays skewed signaling properties compared to its wild-type PDGFRalpha counterpart.
Haan, Serge; Bahlawane, Christelle; Wang, Jiali; Nazarov, Petr V.; Muller, Arnaud; Eulenfeld, Rene; Haan, Claude; Rolvering, Catherine; Vallar, Laurent; Satagopam, Venkata; Sauter, Thomas; Wiesinger, Monique

in JAK-STAT (2015), 4(1), 1062596

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2014

See detailKapitel 35: Rezeptoren und ihre Signaltransduktion
Heinrich, Peter C.; Haan, Serge; Hermanns, Heike M.; Müller-Newen, Gerhard; Schaper, Fred

in Heinrich, Peter C.; Müller, Matthias; Graeve, Lutz (Eds.) Biochemie und Pathobiochemie (2014)

See detailKapitel 34: Mediatoren
Heinrich, Peter C.; Haan, Serge; Hermanns, Heike M.; Müller-Newen, Gerhard; Schaper, Fred

in Heinrich, Peter C.; Müller, Matthias; Graeve, Lutz (Eds.) Biochemie und Pathobiochemie (2014)

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See detailIdentification of SOCS2 and SOCS6 as biomarkers in human colorectal cancer.
Letellier, Elisabeth; Schmitz, Martine; Baig, Komal; Beaume, Nicolas; Schwartz, C.; Frasquilho, S.; Antunes, L.; Marcon, N.; Nazarov, P. V.; Vallar, L.; Even, J.; Haan, Serge

in British journal of cancer (2014), 111(4), 726-35

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2013

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See detailJAK2-V617F-induced MAPK activity is regulated by PI3K and acts synergistically with PI3K on the proliferation of JAK2-V617F-positive cells.
Wolf, Alexandra; Eulenfeld, Rene; Gäbler, Karoline; Rolvering, Catherine; Haan, Serge; Behrmann, Iris; Denecke, Bernd; Haan, Claude; Schaper, Fred

in JAK-STAT (2013), 2(3), 24574

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2012

See detailRegulation of JAKs: Insights gleaned from the functional protein domains
Haan, Claude; Ungureanu, Daniela; Pekkala, Tuija; Silvennoinen, Olli; Haan, Serge

in Decker, Thomas; Müller, Mathias (Eds.) JAK-STAT Signaling – From Basics to Disease (2012)

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2010

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See detailPerspectives for the use of structural information and chemical genetics to develop inhibitors of Janus kinases.
Haan, Claude; Behrmann, Iris; Haan, Serge

in Journal of Cellular & Molecular Medicine (2010), 14(3), 504-27

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See detailInterleukin-27 acts on hepatic stellate cells and induces signal transducer and activator of transcription 1-dependent responses.
Schoenherr, Caroline; Weiskirchen, Ralf; Haan, Serge

in Cell Communication and Signaling (2010), 8

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2009

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See detailInterleukin-27 displays interferon-gamma-like functions in human hepatoma cells and hepatocytes.
Bender, Herdis; Wiesinger, Monique; Nordhoff, Carolin; Schoenherr, Caroline; Haan, Claude; Ludwig, Stephan; Weiskirchen, Ralf; Kato, Nobuyuki; Heinrich, Peter C.; Haan, Serge

in Hepatology (Baltimore, Md.) (2009), 50(2), 585-91

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See detailAn unusual insertion in Jak2 is crucial for kinase activity and differentially affects cytokine responses
Haan, Claude; Kroy, Daniela C.; Wüller, Stefan; Sommer, Ulrike; Nöcker, Tanja; Rolvering, Catherine; Behrmann, Iris; Heinrich, Peter C.; Haan, Serge

in Journal of Immunology (2009), 182(5), 2969-2977

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See detailSOCS-mediated downregulation of mutant Jak2 (V617F, T875N and K539L) counteracts cytokine-independent signaling.
Haan, Serge; Wuller, S.; Kaczor, Jakub; Rolvering, Catherine; Nocker, T.; Behrmann, Iris; Haan, Claude

in Oncogene (2009), 28(34), 3069-80

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See detailDevelopment of an IL-6 inhibitor based on the functional analysis of murine IL-6Ralpha(1).
Wiesinger, Monique; Haan, Serge; Wuller, Stefan; Kauffmann, Maria-Elisabeth; Recker, Tobias; Kuster, Andrea; Heinrich, Peter C.; Muller-Newen, Gerhard

in Chemistry & Biology (2009), 16(7), 783-94

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2008

See detailDual role of the Jak1 FERM and kinase domains in cytokine receptor binding and in stimulation-dependent Jak activation
Haan, Serge; Margue, Christiane; Engrand, A.; Rolvering, Catherine; Schmitz-Van de Leur, H.; Heinrich, P. C.; Behrmann, Iris; Haan, Claude

in Journal of Immunology (2008), 180(2), 998-1007

See detailCell density dependent increase of constitutive signal transducers and activators of transcription 3 activity in melanoma cells is mediated by Janus kinases
Kreis, Stephanie; Munz, G. A.; Haan, Serge; Heinrich, P. C.; Behrmann, Iris

in Molecular Cancer Research (2008), 5(12), 1331-41

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2007

See detailKapitel 25: Kommunikation zwischen Zellen: Extrazelluläre Signalmoleküle, Rezeptoren und Signaltransduktion
Heinrich, Peter C.; Haan, Serge; Hermanns, Heike M.; Löffler, Georg; Müller-Newen, Gerhard; Schaper, Fred

in Löffler, Georg; Petrides, P. E.; Heinrich, Peter C. (Eds.) Biochemie und Pathobiochemie (2007)

See detailNucleocytoplasmic shuttling of persistently activated STAT3.
Herrmann, Andreas; Vogt, Michael; Monnigmann, Martin; Clahsen, Thomas; Sommer, Ulrike; Haan, Serge; Poli, Valeria; Heinrich, Peter C.; Muller-Newen, Gerhard

in Journal of Cell Science (2007), 120(Pt 18), 3249-61

See detailSustained IL-6/STAT-3 signaling in cholangiocarcinoma cells due to SOCS-3 epigenetic silencing.
Isomoto, Hajime; Mott, Justin L.; Kobayashi, Shogo; Werneburg, Nathan W.; Bronk, Steve F.; Haan, Serge; Gores, Gregory J.

in Gastroenterology (2007), 132(1), 384-96

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2006

See detailDeterminants governing the potency of STAT3 activation via the individual STAT3-recruiting motifs of gp130.
Lehmann, Ute; Sommer, Ulrike; Smyczek, Tanya; Hortner, Michael; Frisch, Wiltrud; Volkmer-Engert, Rudolf; Heinrich, Peter C.; Schaper, Fred; Haan, Serge

in Cellular Signalling (2006), 18(1), 40-9

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2005

See detailMultiple reasons for an inefficient STAT1 response upon IL-6-type cytokine stimulation
Haan, Serge; Keller, J. F.; Behrmann, Iris; Heinrich, P. C.; Haan, Claude

in Cellular Signalling (2005), 17(12), 1542-50

See detailBow to your partner for signaling.
Hermanns, Heike M.; Muller-Newen, Gerhard; Heinrich, Peter C.; Haan, Serge

in Nature Structural & Molecular Biology (2005), 12(6), 476-8

See detailAre STATS arginine-methylated?
Komyod, W.; Bauer, U. M.; Heinrich, P. C.; Haan, Serge; Behrmann, Iris

in Journal of Biological Chemistry (2005), 280(23), 21700-5

See detailThe Jak1 SH2 domain does not fulfill a classical SH2 function in Jak/STAT signaling but plays a structural role for receptor interaction and up-regulation of receptor surface expression
Radtke, S.; Haan, Serge; Jörissen, A.; Hermanns, H. M.; Diefenbach, S.; Smyczek, T.; Schmitz-Vandeleur, H.; Heinrich, P. C.; Behrmann, Iris; Haan, Claude

in Journal of Biological Chemistry (2005), 280(27), 25760-8

See detailMechanisms of SOCS3 phosphorylation upon interleukin-6 stimulation. Contributions of Src- and receptor-tyrosine kinases.
Sommer, Ulrike; Schmid, Christine; Sobota, Radoslaw M.; Lehmann, Ute; Stevenson, Nigel J.; Johnston, James A.; Schaper, Fred; Heinrich, Peter C.; Haan, Serge

in Journal of Biological Chemistry (2005), 280(36), 31478-88

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2004

See detailJanus kinase (Jak) subcellular localization revisited: the exclusive membrane localization of endogenous Janus kinase 1 by cytokine receptor interaction uncovers the Jak.receptor complex to be equivalent to a receptor tyrosine kinase
Behrmann, Iris; Smyczek, Tanja; Heinrich, Peter C.; Schmitz-Van de Leur, Hildegard; Komyod, Waraporn; Giese, Bernd; Muller-Newen, Gerhard; Haan, Serge; Haan, Claude

in Journal of Biological Chemistry (2004), 279(34), 35486-93

See detailThe role of the inhibitors of interleukin-6 signal transduction SHP2 and SOCS3 for desensitization of interleukin-6 signalling
Fischer, P.; Lehmann, U.; Sobota, R. M.; Schmitz, J.; Niemand, C.; Linnemann, S.; Haan, Serge; Behrmann, Iris; Yoshimura, A.; Johnston, J. A.; Müller-Newen, G.; Heinrich, P. C.; Schaper, F.

in Biochemical Journal (2004), 378(Pt 2), 449-60

See detailSTAT3 is enriched in nuclear bodies.
Herrmann, Andreas; Sommer, Ulrike; Pranada, Albert L.; Giese, Bernd; Kuster, Andrea; Haan, Serge; Becker, Walter; Heinrich, Peter C.; Muller-Newen, Gerhard

in Journal of Cell Science (2004), 117(Pt 2), 339-49

See detailThe chemoattractants, IL-8 and formyl-methionyl-leucyl-phenylalanine, regulate granulocyte colony-stimulating factor signaling by inducing suppressor of cytokine signaling-1 expression.
Stevenson, Nigel J.; Haan, Serge; McClurg, Angela E.; McGrattan, Michael J.; Armstrong, Marilyn A.; Heinrich, Peter C.; Johnston, James A.

in Journal of immunology (Baltimore, Md. : 1950) (2004), 173(5), 3243-9

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2003

See detailA fusion protein of the gp130 and interleukin-6Ralpha ligand-binding domains acts as a potent interleukin-6 inhibitor.
Ancey, Cecile; Kuster, Andrea; Haan, Serge; Herrmann, Andreas; Heinrich, Peter C.; Muller-Newen, Gerhard

in Journal of Biological Chemistry (2003), 278(19), 16968-72

See detailTyrosine phosphorylation disrupts elongin interaction and accelerates SOCS3 degradation.
Haan, Serge; Ferguson, Paul; Sommer, Ulrike; Hiremath, Meena; McVicar, Daniel W.; Heinrich, Peter C.; Johnston, James A.; Cacalano, Nicholas A.

in Journal of Biological Chemistry (2003), 278(34), 31972-9

See detailPrinciples of interleukin (IL)-6-type cytokine signalling and its regulation
Heinrich, P. C.; Behrmann, Iris; Haan, Serge; Hermanns, H. M.; Müller-Newen, G.; Schaper, F.

in Biochemical Journal (2003), 374(Pt 1), 1-20

See detailFusionierte lösliche Rezeptoren als hochaktive Zytokin-Inhibitoren.
Müller-Newen, Gerhard; Haan, Serge; Heinrich, Peter C.

in Biospektrum (2003), Sonderausgabe(9. Jahrgang), 480-483

See detailActivation of STAT3 by IL-6 and IL-10 in primary human macrophages is differentially modulated by suppressor of cytokine signaling 3.
Niemand, Claudia; Nimmesgern, Ariane; Haan, Serge; Fischer, Patrick; Schaper, Fred; Rossaint, Rolf; Heinrich, Peter C.; Muller-Newen, Gerhard

in Journal of immunology (Baltimore, Md. : 1950) (2003), 170(6), 3263-72

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2002

See detailA new high affinity binding site for suppressor of cytokine signaling-3 on the erythropoietin receptor.
Hortner, Michael; Nielsch, Ulrich; Mayr, Lorenz M.; Heinrich, Peter C.; Haan, Serge

in European Journal of Biochemistry (2002), 269(10), 2516-26

See detailSuppressor of cytokine signaling-3 is recruited to the activated granulocyte-colony stimulating factor receptor and modulates its signal transduction.
Hortner, Michael; Nielsch, Ulrich; Mayr, Lorenz M.; Johnston, James A.; Heinrich, Peter C.; Haan, Serge

in Journal of immunology (Baltimore, Md. : 1950) (2002), 169(3), 1219-27

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2000

See detailCytoplasmic STAT proteins associate prior to activation
Haan, Serge; Kortylewski, M.; Behrmann, Iris; Müller-Esterl, W.; Heinrich, P. C.; Schaper, F.

in Biochemical Journal (2000), 345 Pt 3

See detailSOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130.
Schmitz, J.; Weissenbach, M.; Haan, Serge; Heinrich, P. C.; Schaper, F.

in Journal of Biological Chemistry (2000), 275(17), 12848-56

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1999

See detailCharacterization and binding specificity of the monomeric STAT3-SH2 domain.
Haan, Serge; Hemmann, U.; Hassiepen, U.; Schaper, F.; Schneider-Mergener, J.; Wollmer, A.; Heinrich, P. C.; Grotzinger, J.

in Journal of Biological Chemistry (1999), 274(3), 1342-8

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