Dr. Claude Haan

Claude Haan

Research scientist

Faculty or Centre Faculty of Science, Technology and Communication
Research Unit RU Life Sciences
Postal Address Université du Luxembourg
6, avenue du Swing
L-4367 Belvaux
Campus Office BioTech II, 4.25
Telephone (+352) 46 66 44 6438

Dr. rer. nat. (PhD)

Academic degrees

• Dr. rer. nat. (PhD) in Biochemistry
RWTH-Aachen University, Germany, 2000
• Diploma in Chemistry
RWTH-Aachen University, Germany, 1996

Research Interests

Current topics:
• Signalling of constitutively active JAK-mutants in disease
• Inhibition of kinases by pharmacological compounds
• Crosstalk of hypoxia and cytokine signalling
• Systems biology approaches in interferon signalling
• Contributions of Jak1 and Jak3 in IL2 signaling

Last updated on: Wednesday, 02 October 2019

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See detailMany ways to resistance: How melanoma cells evade targeted therapies
Kozar, Ines; Margue, Christiane; Rothengatter, Sonja; Haan, Claude; Kreis, Stephanie

in Biochimica et Biophysica Acta - Reviews on Cancer (2019), 1871(2), 313-322

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See detailKinase inhibitor library screening identifies synergistic drug combinations effective in sensitive and resistant melanoma cells
Margue, Christiane; Philippidou, Demetra; Kozar, Ines; Cesi, Giulia; Felten, Paul; Kulms, Dagmar; Letellier, Elisabeth; Haan, Claude; Kreis, Stephanie

in Journal of Experimental and Clinical Cancer Research (2019), 38(1),

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See detailModulation of the IL-6 signaling pathway in liver cells by miRNAs targeting gp130, JAK1 and/or STAT3
Servais, Florence; Kirchmeyer, Mélanie; Hamdorf, Matthias; Minoungou, Wendkouni Nadège; Rose-John, Stefan; Kreis, Stephanie; Haan, Claude; Behrmann, Iris

in Molecular Therapy: Nucleic Acids (2019), 16

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See detailA new ALK isoform transported by extracellular vesicles confers drug resistance to melanoma cells
Cesi, Giulia; Philippidou, Demetra; Kozar, Ines; Kim, Y. J.; Bernardin, F.; Van Niel, G.; Wienecke-Baldacchino, A.; Felten, Paul; Letellier, Elisabeth; Dengler, S.; Nashan, D.; Haan, Claude; Kreis, Stephanie

in Molecular Cancer (2018), (17:145),

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See detailThe PD-L1- and IL6-mediated dampening of the IL27/STAT1 anticancer responses are prevented by a-PD-L1 or a-IL6 antibodies
Rolvering, Catherine; Zimmer, Andreas David; Ginolhac, Aurélien; Margue, Christiane; Kirchmeyer, Mélanie; Servais, Florence; Hermanns, Heike M.; Hergovits, Sabine; Nazarov, Petr V.; Nicot, Nathalie; Kreis, Stephanie; Haan, Serge; Behrmann, Iris; Haan, Claude

in Journal of Leukocyte Biology (2018), 104

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See detailThe multi-site docking protein Gab1 is constitutively phosphorylated independent from its recruitment to the plasma membrane in Jak2-V617Fpositive cells and mediates proliferation of human erythroleukaemia cells
Bongartz, Hannes; Hessenkemper, Wiebke; Müller, Christian; Fensky, Melissa; Fritsch, Johannes; Mandel, Katharina; Behrmann, Iris; Haan, Claude; Fischer, Thomas; Feller, Stephan M.; Schaper, Fred

in Cellular Signalling (2017), 35

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See detailROS production induced by BRAF inhibitor treatment rewires metabolic processes affecting cell growth of melanoma cells
Cesi, Giulia; Walbrecq, Geoffroy; Zimmer, Andreas David; Kreis, Stephanie; Haan, Claude

in Molecular Cancer (2017), 8(june),

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See detailCrosstalk between different family members: IL27 recapitulates IFNγ responses in HCC cells, but is inhibited by IL6-type cytokines
Rolvering, Catherine; Zimmer, Andreas; Kozar, Ines; Hermanns; Letellier, Elisabeth; Vallar, Laurent; Nazarov, Petr; Nicot, Nathalie; Ginolhac, Aurélien; Haan, Serge; Behrmann, Iris; Haan, Claude

in BBA Molecular Cell Research (2017)

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See detailThe role of HIF-1 in oncostatin M-dependent metabolic reprogramming of hepatic cells.
Battello, Nadia; Zimmer, Andreas David; Goebel, Carole; Dong, Xiangyi; Behrmann, Iris; Haan, Claude; Hiller, Karsten; Wegner, Andre

in Cancer & metabolism (2016), 4

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See detailPhosphorylation of the PDH complex precedes HIF-1-mediated effects and PDK1 upregulation during the first hours of hypoxic treatment in HCC cells
Zimmer, Andreas David; Walbrecq, Geoffroy; Kozar, Ines; Behrmann, Iris; Haan, Claude

in Hypoxia (2016), 4

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See detailThe oncogenic FIP1L1-PDGFRalpha fusion protein displays skewed signaling properties compared to its wild-type PDGFRalpha counterpart.
Haan, Serge; Bahlawane, Christelle; Wang, Jiali; Nazarov, Petr V.; Muller, Arnaud; Eulenfeld, Rene; Haan, Claude; Rolvering, Catherine; Vallar, Laurent; Satagopam, Venkata; Sauter, Thomas; Wiesinger, Monique

in JAK-STAT (2015), 4(1), 1062596

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See detailID: 194: Role of microRNAs in signal transduction pathways of the inflammatory cytokine Interleukin-6: Relevance for liver diseases
Servais, Florence; Kirchmeyer, Mélanie; Hamdorf, Matthias; Haan, Claude; Casper, Markus; Lammert, Frank; Nazarov, Petr; Vallar, Laurent; Kreis, Stephanie; Behrmann, Iris

in Cytokine (2015), 76(1), 99-

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See detailJAK2 mutants (e.g., JAK2V617F) and their importance as drug targets in myeloproliferative neoplasms
Gäbler, Karoline; Behrmann, Iris; Haan, Claude

in JAK-STAT (2013), 2(3), 25025

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See detailCooperative effects of Janus and Aurora kinase inhibition by CEP701 in cells expressing Jak2V617F
Gäbler, Karoline; Rolvering, Catherine; Kaczor, Jakub; Eulenfeld, R.; Méndez, S. A.; Berchem, G.; Palissot, V.; Behrmann, Iris; Haan, Claude

in Journal of Cellular & Molecular Medicine (2013), 17(2), 265-276

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See detailJAK2-V617F-induced MAPK activity is regulated by PI3K and acts synergistically with PI3K on the proliferation of JAK2-V617F-positive cells.
Wolf, Alexandra; Eulenfeld, Rene; Gäbler, Karoline; Rolvering, Catherine; Haan, Serge; Behrmann, Iris; Denecke, Bernd; Haan, Claude; Schaper, Fred

in JAK-STAT (2013), 2(3), 24574

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See detailRegulation of JAKs: Insights gleaned from the functional protein domains
Haan, Claude; Ungureanu, Daniela; Pekkala, Tuija; Silvennoinen, Olli; Haan, Serge

in Decker, Thomas; Müller, Mathias (Eds.) JAK-STAT Signaling – From Basics to Disease (2012)

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See detailJak1 has a dominant role over Jak3 in signal transduction through γc-containing cytokine receptors
Haan, Claude; Rolvering, Catherine; Raulf, F.; Kapp, M.; Drückes, P.; Thoma, G.; Behrmann, Iris; Zerwes, H.-G.

in Chemistry & Biology (2011), 18(3), 314-323

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See detailPerspectives for the use of structural information and chemical genetics to develop inhibitors of Janus kinases.
Haan, Claude; Behrmann, Iris; Haan, Serge

in Journal of Cellular & Molecular Medicine (2010), 14(3), 504-27

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See detailOncostatin M up-regulates the ER chaperone Grp78/BiP in liver cells
Vollmer, Stefan; Haan, Claude; Behrmann, Iris

in Biochemical Pharmacology (2010), 80(12), 2066-2073

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See detailInterleukin-27 displays interferon-gamma-like functions in human hepatoma cells and hepatocytes.
Bender, Herdis; Wiesinger, Monique; Nordhoff, Carolin; Schoenherr, Caroline; Haan, Claude; Ludwig, Stephan; Weiskirchen, Ralf; Kato, Nobuyuki; Heinrich, Peter C.; Haan, Serge

in Hepatology (Baltimore, Md.) (2009), 50(2), 585-91

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See detailAn unusual insertion in Jak2 is crucial for kinase activity and differentially affects cytokine responses
Haan, Claude; Kroy, Daniela C.; Wüller, Stefan; Sommer, Ulrike; Nöcker, Tanja; Rolvering, Catherine; Behrmann, Iris; Heinrich, Peter C.; Haan, Serge

in Journal of Immunology (2009), 182(5), 2969-2977

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See detailSOCS-mediated downregulation of mutant Jak2 (V617F, T875N and K539L) counteracts cytokine-independent signaling.
Haan, Serge; Wuller, S.; Kaczor, Jakub; Rolvering, Catherine; Nocker, T.; Behrmann, Iris; Haan, Claude

in Oncogene (2009), 28(34), 3069-80

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See detailOncostatin M-induced and constitutive activation of the JAK2/STAT5/CIS pathway suppresses CCL1, but not CCL7 and CCL8, chemokine expression
Hintzen, Christoph; Haan, Claude; Tuckermann, Jan P.; Heinrich, Peter C.; Hermanns, Heike M.

in Journal of Immunology (2009), 181(10), 7341-7349

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See detailHypoxia-inducible factor 1alpha is up-regulated by oncostatin M and participates in oncostatin M signaling
Vollmer, Stefan; Kappler, Valérie; Kaczor, Jakub; Flügel, Daniela; Rolvering, Catherine; Kato, Nobuyuki; Kietzmann, Thomas; Behrmann, Iris; Haan, Claude

in Hepatology (Baltimore, Md.) (2009), 2009(3),

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See detailDual role of the Jak1 FERM and kinase domains in cytokine receptor binding and in stimulation-dependent Jak activation
Haan, Serge; Margue, Christiane; Engrand, A.; Rolvering, Catherine; Schmitz-Van de Leur, H.; Heinrich, P. C.; Behrmann, Iris; Haan, Claude

in Journal of Immunology (2008), 180(2), 998-1007

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See detailA cost effective non-commercial ECL-solution for Western blot detections yielding strong signals and low background
Haan, Claude; Behrmann, Iris

in Journal of Immunological Methods (2007), 318(1-2), 11-9

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See detailRecombinant interleukin-24 lacks apoptosis-inducing properties in melanoma cells
Kreis, Stephanie; Philippidou, Demetra; Margue, Christiane; Rolvering, Catherine; Haan, Claude; Dumoutier, Laure; Renauld, Jean-Christophe; Behrmann, Iris

in PLoS ONE (2007), 2(12), 1300

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See detailJaks and cytokine receptors - an intimate relationship
Haan, Claude; Kreis, Stephanie; Margue, Christiane; Behrmann, Iris

in Biochemical Pharmacology (2006), 72(11), 1538-46

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See detailMultiple reasons for an inefficient STAT1 response upon IL-6-type cytokine stimulation
Haan, Serge; Keller, J. F.; Behrmann, Iris; Heinrich, P. C.; Haan, Claude

in Cellular Signalling (2005), 17(12), 1542-50

See detailThe Jak1 SH2 domain does not fulfill a classical SH2 function in Jak/STAT signaling but plays a structural role for receptor interaction and up-regulation of receptor surface expression
Radtke, S.; Haan, Serge; Jörissen, A.; Hermanns, H. M.; Diefenbach, S.; Smyczek, T.; Schmitz-Vandeleur, H.; Heinrich, P. C.; Behrmann, Iris; Haan, Claude

in Journal of Biological Chemistry (2005), 280(27), 25760-8

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See detailJanus kinase (Jak) subcellular localization revisited: the exclusive membrane localization of endogenous Janus kinase 1 by cytokine receptor interaction uncovers the Jak.receptor complex to be equivalent to a receptor tyrosine kinase
Behrmann, Iris; Smyczek, Tanja; Heinrich, Peter C.; Schmitz-Van de Leur, Hildegard; Komyod, Waraporn; Giese, Bernd; Muller-Newen, Gerhard; Haan, Serge; Haan, Claude

in Journal of Biological Chemistry (2004), 279(34), 35486-93

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See detailLong term association of the cytokine receptor gp130 and the Janus kinase Jak1 revealed by FRAP analysis
Giese, B.; Au-Yeung, C. K.; Herrmann, A.; Diefenbach, S.; Haan, Claude; Küster, A.; Wortmann, S. B.; Roderburg, C.; Heinrich, P. C.; Behrmann, Iris; Müller-Newen, G.

in Journal of Biological Chemistry (2003), 278(40), 39205-13

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See detailNovel role of Janus kinase 1 in the regulation of oncostatin M receptor surface expression
Radtke, S.; Hermanns, H. M.; Haan, Claude; Schmitz-Van De Leur, H.; Gascan, H.; Heinrich, P. C.; Behrmann, Iris

in Journal of Biological Chemistry (2002), 277(13), 11297-305

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See detailMapping of a region within the N terminus of Jak1 involved in cytokine receptor interaction
Haan, Claude; Isharc, H.; Hermanns, H. M.; Schmitz-Van De Leur, H.; Kerr, I. M.; Heinrich, P. C.; Grötzinger, J.; Behrmann, Iris

in Journal of Biological Chemistry (2001), 276(40), 37451-8

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See detailSignalling of interleukin-6 type cytokines via gp130, leukemia inhibitory factor (LIF) receptor and oncostatin M receptor
Behrmann, Iris; Hermanns, H. M.; Haan, Claude; Kortylewski, M.; Radtke, S.; Greiser, J. S.; Heinrich, P. C.

in European Cytokine Network (2000), 11(3), 491-2

See detailContributions of leukemia inhibitory factor receptor and oncostatin M receptor to signal transduction in heterodimeric complexes with glycoprotein 130
Hermanns, H. M.; Radtke, S.; Haan, Claude; Schmitz-Van de Leur, H.; Tavernier, J.; Heinrich, P. C.; Behrmann, Iris

in Journal of Immunology (2000), 163(12), 6651-8

See detailTermination of IL-6-induced STAT activation is independent of receptor internalization but requires de novo protein synthesis
Thiel, S.; Sommer, U.; Kortylewski, M.; Haan, Claude; Behrmann, Iris; Heinrich, P. C.; Graeve, L.

in FEBS Letters (2000), 470(1), 15-9

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