Dr. Claude Haan

Claude Haan

Research scientist

Faculty or Centre Faculty of Science, Technology and Medicine
Department Department of Life Sciences and Medicine
Postal Address Université du Luxembourg
6, avenue du Swing
L-4367 Belvaux
Campus Office BioTech II, 4.25
Telephone (+352) 46 66 44 6438
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See detailSystematic transcriptional profiling of responses to STAT1- and STAT3- activating cytokines in different cancer types
Kirchmeyer, Mélanie; Servais, Florence; Ginolhac, Aurélien; Nazarov, Petr V.; Margue, Christiane; Philippidou, Demetra; Nicot, Nathalie; Behrmann, Iris; Haan, Claude; Kreis, Stephanie

in Journal of Molecular Biology (2020)

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See detailMany ways to resistance: How melanoma cells evade targeted therapies
Kozar, Ines; Margue, Christiane; Rothengatter, Sonja; Haan, Claude; Kreis, Stephanie

in Biochimica et Biophysica Acta - Reviews on Cancer (2019), 1871(2), 313-322

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See detailKinase inhibitor library screening identifies synergistic drug combinations effective in sensitive and resistant melanoma cells
Margue, Christiane; Philippidou, Demetra; Kozar, Ines; Cesi, Giulia; Felten, Paul; Kulms, Dagmar; Letellier, Elisabeth; Haan, Claude; Kreis, Stephanie

in Journal of Experimental and Clinical Cancer Research (2019), 38(1),

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See detailModulation of the IL-6 signaling pathway in liver cells by miRNAs targeting gp130, JAK1 and/or STAT3
Servais, Florence; Kirchmeyer, Mélanie; Hamdorf, Matthias; Minoungou, Wendkouni Nadège; Rose-John, Stefan; Kreis, Stephanie; Haan, Claude; Behrmann, Iris

in Molecular Therapy: Nucleic Acids (2019), 16

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See detailA new ALK isoform transported by extracellular vesicles confers drug resistance to melanoma cells
Cesi, Giulia; Philippidou, Demetra; Kozar, Ines; Kim, Y. J.; Bernardin, F.; Van Niel, G.; Wienecke-Baldacchino, A.; Felten, Paul; Letellier, Elisabeth; Dengler, S.; Nashan, D.; Haan, Claude; Kreis, Stephanie

in Molecular Cancer (2018), (17:145),

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See detailThe PD-L1- and IL6-mediated dampening of the IL27/STAT1 anticancer responses are prevented by a-PD-L1 or a-IL6 antibodies
Rolvering, Catherine; Zimmer, Andreas David; Ginolhac, Aurélien; Margue, Christiane; Kirchmeyer, Mélanie; Servais, Florence; Hermanns, Heike M.; Hergovits, Sabine; Nazarov, Petr V.; Nicot, Nathalie; Kreis, Stephanie; Haan, Serge; Behrmann, Iris; Haan, Claude

in Journal of Leukocyte Biology (2018), 104

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See detailThe multi-site docking protein Gab1 is constitutively phosphorylated independent from its recruitment to the plasma membrane in Jak2-V617Fpositive cells and mediates proliferation of human erythroleukaemia cells
Bongartz, Hannes; Hessenkemper, Wiebke; Müller, Christian; Fensky, Melissa; Fritsch, Johannes; Mandel, Katharina; Behrmann, Iris; Haan, Claude; Fischer, Thomas; Feller, Stephan M.; Schaper, Fred

in Cellular Signalling (2017), 35

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See detailROS production induced by BRAF inhibitor treatment rewires metabolic processes affecting cell growth of melanoma cells
Cesi, Giulia; Walbrecq, Geoffroy; Zimmer, Andreas David; Kreis, Stephanie; Haan, Claude

in Molecular Cancer (2017), 8(june),

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See detailCrosstalk between different family members: IL27 recapitulates IFNγ responses in HCC cells, but is inhibited by IL6-type cytokines
Rolvering, Catherine; Zimmer, Andreas; Kozar, Ines; Hermanns; Letellier, Elisabeth; Vallar, Laurent; Nazarov, Petr; Nicot, Nathalie; Ginolhac, Aurélien; Haan, Serge; Behrmann, Iris; Haan, Claude

in BBA Molecular Cell Research (2017)

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See detailThe role of HIF-1 in oncostatin M-dependent metabolic reprogramming of hepatic cells.
Battello, Nadia; Zimmer, Andreas David; Goebel, Carole; Dong, Xiangyi; Behrmann, Iris; Haan, Claude; Hiller, Karsten; Wegner, Andre

in Cancer and Metabolism (2016), 4

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See detailPhosphorylation of the PDH complex precedes HIF-1-mediated effects and PDK1 upregulation during the first hours of hypoxic treatment in HCC cells
Zimmer, Andreas David; Walbrecq, Geoffroy; Kozar, Ines; Behrmann, Iris; Haan, Claude

in Hypoxia (2016), 4

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See detailThe oncogenic FIP1L1-PDGFRalpha fusion protein displays skewed signaling properties compared to its wild-type PDGFRalpha counterpart.
Haan, Serge; Bahlawane, Christelle; Wang, Jiali; Nazarov, Petr V.; Muller, Arnaud; Eulenfeld, Rene; Haan, Claude; Rolvering, Catherine; Vallar, Laurent; Satagopam, Venkata; Sauter, Thomas; Wiesinger, Monique

in JAK-STAT (2015), 4(1), 1062596

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See detailID: 194: Role of microRNAs in signal transduction pathways of the inflammatory cytokine Interleukin-6: Relevance for liver diseases
Servais, Florence; Kirchmeyer, Mélanie; Hamdorf, Matthias; Haan, Claude; Casper, Markus; Lammert, Frank; Nazarov, Petr; Vallar, Laurent; Kreis, Stephanie; Behrmann, Iris

in Cytokine (2015), 76(1), 99-

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See detailJAK2 mutants (e.g., JAK2V617F) and their importance as drug targets in myeloproliferative neoplasms
Gäbler, Karoline; Behrmann, Iris; Haan, Claude

in JAK-STAT (2013), 2(3), 25025

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See detailCooperative effects of Janus and Aurora kinase inhibition by CEP701 in cells expressing Jak2V617F
Gäbler, Karoline; Rolvering, Catherine; Kaczor, Jakub; Eulenfeld, R.; Méndez, S. A.; Berchem, G.; Palissot, V.; Behrmann, Iris; Haan, Claude

in Journal of Cellular and Molecular Medicine (2013), 17(2), 265-276

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See detailJAK2-V617F-induced MAPK activity is regulated by PI3K and acts synergistically with PI3K on the proliferation of JAK2-V617F-positive cells.
Wolf, Alexandra; Eulenfeld, Rene; Gäbler, Karoline; Rolvering, Catherine; Haan, Serge; Behrmann, Iris; Denecke, Bernd; Haan, Claude; Schaper, Fred

in JAK-STAT (2013), 2(3), 24574

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See detailRegulation of JAKs: Insights gleaned from the functional protein domains
Haan, Claude; Ungureanu, Daniela; Pekkala, Tuija; Silvennoinen, Olli; Haan, Serge

in Decker, Thomas; Müller, Mathias (Eds.) JAK-STAT Signaling – From Basics to Disease (2012)

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See detailJak1 has a dominant role over Jak3 in signal transduction through γc-containing cytokine receptors
Haan, Claude; Rolvering, Catherine; Raulf, F.; Kapp, M.; Drückes, P.; Thoma, G.; Behrmann, Iris; Zerwes, H.-G.

in Chemistry and Biology (2011), 18(3), 314-323

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See detailPerspectives for the use of structural information and chemical genetics to develop inhibitors of Janus kinases.
Haan, Claude; Behrmann, Iris; Haan, Serge

in Journal of Cellular and Molecular Medicine (2010), 14(3), 504-27

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See detailOncostatin M up-regulates the ER chaperone Grp78/BiP in liver cells
Vollmer, Stefan; Haan, Claude; Behrmann, Iris

in Biochemical Pharmacology (2010), 80(12), 2066-2073

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See detailInterleukin-27 displays interferon-gamma-like functions in human hepatoma cells and hepatocytes.
Bender, Herdis; Wiesinger, Monique; Nordhoff, Carolin; Schoenherr, Caroline; Haan, Claude; Ludwig, Stephan; Weiskirchen, Ralf; Kato, Nobuyuki; Heinrich, Peter C.; Haan, Serge

in Hepatology (2009), 50(2), 585-91

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See detailAn unusual insertion in Jak2 is crucial for kinase activity and differentially affects cytokine responses
Haan, Claude; Kroy, Daniela C.; Wüller, Stefan; Sommer, Ulrike; Nöcker, Tanja; Rolvering, Catherine; Behrmann, Iris; Heinrich, Peter C.; Haan, Serge

in Journal of Immunology (2009), 182(5), 2969-2977

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See detailSOCS-mediated downregulation of mutant Jak2 (V617F, T875N and K539L) counteracts cytokine-independent signaling.
Haan, Serge; Wuller, S.; Kaczor, Jakub; Rolvering, Catherine; Nocker, T.; Behrmann, Iris; Haan, Claude

in Oncogene (2009), 28(34), 3069-80

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See detailOncostatin M-induced and constitutive activation of the JAK2/STAT5/CIS pathway suppresses CCL1, but not CCL7 and CCL8, chemokine expression
Hintzen, Christoph; Haan, Claude; Tuckermann, Jan P.; Heinrich, Peter C.; Hermanns, Heike M.

in Journal of Immunology (2009), 181(10), 7341-7349

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See detailHypoxia-inducible factor 1alpha is up-regulated by oncostatin M and participates in oncostatin M signaling
Vollmer, Stefan; Kappler, Valérie; Kaczor, Jakub; Flügel, Daniela; Rolvering, Catherine; Kato, Nobuyuki; Kietzmann, Thomas; Behrmann, Iris; Haan, Claude

in Hepatology (2009), 2009(3),

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See detailDual role of the Jak1 FERM and kinase domains in cytokine receptor binding and in stimulation-dependent Jak activation
Haan, Serge; Margue, Christiane; Engrand, A.; Rolvering, Catherine; Schmitz-Van de Leur, H.; Heinrich, P. C.; Behrmann, Iris; Haan, Claude

in Journal of Immunology (2008), 180(2), 998-1007

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See detailA cost effective non-commercial ECL-solution for Western blot detections yielding strong signals and low background
Haan, Claude; Behrmann, Iris

in Journal of Immunological Methods (2007), 318(1-2), 11-9

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See detailRecombinant interleukin-24 lacks apoptosis-inducing properties in melanoma cells
Kreis, Stephanie; Philippidou, Demetra; Margue, Christiane; Rolvering, Catherine; Haan, Claude; Dumoutier, Laure; Renauld, Jean-Christophe; Behrmann, Iris

in PLoS ONE (2007), 2(12), 1300

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See detailJaks and cytokine receptors - an intimate relationship
Haan, Claude; Kreis, Stephanie; Margue, Christiane; Behrmann, Iris

in Biochemical Pharmacology (2006), 72(11), 1538-46

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See detailMultiple reasons for an inefficient STAT1 response upon IL-6-type cytokine stimulation
Haan, Serge; Keller, J. F.; Behrmann, Iris; Heinrich, P. C.; Haan, Claude

in Cellular Signalling (2005), 17(12), 1542-50

See detailThe Jak1 SH2 domain does not fulfill a classical SH2 function in Jak/STAT signaling but plays a structural role for receptor interaction and up-regulation of receptor surface expression
Radtke, S.; Haan, Serge; Jörissen, A.; Hermanns, H. M.; Diefenbach, S.; Smyczek, T.; Schmitz-Vandeleur, H.; Heinrich, P. C.; Behrmann, Iris; Haan, Claude

in Journal of Biological Chemistry (2005), 280(27), 25760-8

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See detailJanus kinase (Jak) subcellular localization revisited: the exclusive membrane localization of endogenous Janus kinase 1 by cytokine receptor interaction uncovers the Jak.receptor complex to be equivalent to a receptor tyrosine kinase
Behrmann, Iris; Smyczek, Tanja; Heinrich, Peter C.; Schmitz-Van de Leur, Hildegard; Komyod, Waraporn; Giese, Bernd; Muller-Newen, Gerhard; Haan, Serge; Haan, Claude

in Journal of Biological Chemistry (2004), 279(34), 35486-93

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See detailLong term association of the cytokine receptor gp130 and the Janus kinase Jak1 revealed by FRAP analysis
Giese, B.; Au-Yeung, C. K.; Herrmann, A.; Diefenbach, S.; Haan, Claude; Küster, A.; Wortmann, S. B.; Roderburg, C.; Heinrich, P. C.; Behrmann, Iris; Müller-Newen, G.

in Journal of Biological Chemistry (2003), 278(40), 39205-13

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See detailNovel role of Janus kinase 1 in the regulation of oncostatin M receptor surface expression
Radtke, S.; Hermanns, H. M.; Haan, Claude; Schmitz-Van De Leur, H.; Gascan, H.; Heinrich, P. C.; Behrmann, Iris

in Journal of Biological Chemistry (2002), 277(13), 11297-305

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See detailMapping of a region within the N terminus of Jak1 involved in cytokine receptor interaction
Haan, Claude; Isharc, H.; Hermanns, H. M.; Schmitz-Van De Leur, H.; Kerr, I. M.; Heinrich, P. C.; Grötzinger, J.; Behrmann, Iris

in Journal of Biological Chemistry (2001), 276(40), 37451-8

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See detailSignalling of interleukin-6 type cytokines via gp130, leukemia inhibitory factor (LIF) receptor and oncostatin M receptor
Behrmann, Iris; Hermanns, H. M.; Haan, Claude; Kortylewski, M.; Radtke, S.; Greiser, J. S.; Heinrich, P. C.

in European Cytokine Network (2000), 11(3), 491-2

See detailContributions of leukemia inhibitory factor receptor and oncostatin M receptor to signal transduction in heterodimeric complexes with glycoprotein 130
Hermanns, H. M.; Radtke, S.; Haan, Claude; Schmitz-Van de Leur, H.; Tavernier, J.; Heinrich, P. C.; Behrmann, Iris

in Journal of Immunology (2000), 163(12), 6651-8

See detailTermination of IL-6-induced STAT activation is independent of receptor internalization but requires de novo protein synthesis
Thiel, S.; Sommer, U.; Kortylewski, M.; Haan, Claude; Behrmann, Iris; Heinrich, P. C.; Graeve, L.

in FEBS Letters (2000), 470(1), 15-9

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