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Dr. Elisabeth Schaffner-Reckinger
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| Faculty or Centre | Faculty of Science, Technology and Medicine | ||||
| Department | Department of Life Sciences and Medicine | ||||
| Postal Address |
Campus Belval, Université du Luxembourg 7, Avenue des Hauts Fourneaux L-4362 Esch-sur-Alzette |
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| Campus Office | BioTech I, 3.05B | ||||
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| Telephone | (+352) 46 66 44 6398 | ||||
2022
Bruceine D Identified as a Drug Candidate against Breast Cancer by a Novel Drug Selection Pipeline and Cell Viability Assay.; ; ; ; ; ;
in Pharmaceuticals (Basel, Switzerland) (2022), 15(2),
2021
L-plastin Ser5 phosphorylation is modulated by the PI3K/SGK pathway and promotes breast cancer cell invasiveness; ; ; ; ; ;
in Cell Communication and Signaling (2021), 19(22), 1-22
2020
The actin-bundling protein L-plastin—A double-edged sword: Beneficial for the immune response, maleficent in cancer;
in INTERNATIONAL REVIEW OF CELL AND MOLECULAR BIOLOGY (2020)
2017
The PET and LIM1-2 domains of testin contribute to intramolecular and homodimeric interactions; ; ; ; ;
in PLoS ONE (2017)
Expanding the Interactome of TES by Exploiting TES Modules with Different Subcellular Localizations; ; ; ; ; ; ; ;
in Journal of Proteome Research (2017), doi: 10.1021/acs.jproteome.7b00034
Angiotensin II regulates phosphorylation of actin-associated proteins in human podocytes; ; ; ; ; ; ;
in FASEB Journal (2017)
2016
L-plastin Ser5 phosphorylation in breast cancer cells and in vitro is mediated by RSK downstream of the ERK/MAPK pathway; ; ; ; ; ; ; ;
in FASEB Journal (2016)
2015
Delineating the Tes Interaction Site in Zyxin and Studying Cellular Effects of Its Disruption; ; ; ; ; ; ; ; ; ;
in PLoS ONE (2015)
Inhibition of αIIbβ3 Ligand Binding by an αIIb Peptide that Clasps the Hybrid Domain to the βI Domain of β3; ; ; ; ; ; ; ; ; ;
in PLoS ONE (2015)
2010
Quantitative kinetic study of the actin-bundling protein L-plastin and of its impact on actin turn-over.; ; ; ; ; ; ; ;
in PloS one (2010), 5(2), 9210
The actin filament cross-linker L-plastin confers resistance to TNF-alpha in MCF-7 breast cancer cells in a phosphorylation-dependent manner.; ; ; ; ; ; ; ;
in Journal of Cellular and Molecular Medicine (2010), 14(6A), 1264-75
2009
Overexpression of the partially activated alpha(IIb)beta3D723H integrin salt bridge mutant downregulates RhoA activity and induces microtubule-dependent proplatelet-like extensions in Chinese hamster ovary cells; ; ; ; ; ; ;
in Journal of Thrombosis and Haemostasis (2009), 7(7), 1207-1217
2008
A nonsynonymous SNP in the ITGB3 gene disrupts the conserved membrane-proximal cytoplasmic salt bridge in the αIIbβ3 integrin and cosegregates dominantly with abnormal proplatelet formation and macrothrombocytopenia; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Blood (2008), 111(7), 3407-3414
The talin rod IBS2 alpha-helix interacts with the beta3 integrin cytoplasmic tail membrane-proximal helix by establishing charge complementary salt bridges.; ; ; ; ; ; ; ;
in The Journal of biological chemistry (2008), 283(35), 24212-23
2006
2005
A new functional role of the fibrinogen RGD motif as the molecular switch that selectively triggers integrin alphaIIbbeta3-dependent RhoA activation during cell spreading; ; ; ;
in Journal of Biological Chemistry (2005), 280(39), 33610-33619
2004
The effect of recombinant IgG antibodies against the leucine-33 form of the platelet beta3 integrin (HPA-1a) on platelet function.; ; ; ; ; ; ; ; ; ; ;
in Thrombosis and haemostasis (2004), 91(4), 743-54
2003
Beta3 integrins: major therapeutic targets of the near future.in Bulletin de la Société des Sciences Médicales du Grand-Duché de Luxembourg (2003), (1), 23-34
2002
HPA-1a phenotype-genotype discrepancy reveals a naturally occurring Arg93Gln substitution in the platelet beta 3 integrin that disrupts the HPA-1a epitope.; ; ; ; ; ; ; ; ;
in Blood (2002), 99(5), 1833-9
2001
Green fluorescent protein (GFP) tagged to the cytoplasmic tail of alphaIIb or beta3 allows the expression of a fully functional integrin alphaIIb(beta3): effect of beta3GFP on alphaIIb(beta3) ligand binding.; ; ; ;
in The Biochemical journal (2001), 357(Pt 2), 529-36
Evidence from site-directed mutagenesis that the cytoplasmic domain of the beta3 subunit influences the conformational state of the alphaVbeta3 integrin ectodomain.; ;
in Thrombosis and haemostasis (2001), 85(4), 716-23
1998
Distinct involvement of beta3 integrin cytoplasmic domain tyrosine residues 747 and 759 in integrin-mediated cytoskeletal assembly and phosphotyrosine signaling.; ; ; ;
in The Journal of biological chemistry (1998), 273(20), 12623-32
