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Dr. Ganesh Manoharan

Ganesh Manoharan

Postdoctoral researcher

Faculty or Centre Faculty of Science, Technology and Medicine
Department Department of Life Sciences and Medicine
Postal Address Campus Belval, Université du Luxembourg
7, Avenue des Hauts Fourneaux
L-4362 Esch-sur-Alzette
Campus Office BioTech I, 3.05B
Email
Telephone (+352) 46 66 44 6025
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2022

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See detailPotential of phenothiazines to synergistically block calmodulin and reactivate PP2A in cancer cells
Manoharan, Ganesh Babu; Okutachi, Sunday; Abankwa, Daniel

in PLoS ONE (2022)

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2021

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See detailA Pharmacophore Model for SARS-CoV-2 3CLpro Small Molecule Inhibitors and in Vitro Experimental Validation of Computationally Screened Inhibitors
Glaab, Enrico; Manoharan, Ganesh Babu; Abankwa, Daniel

in Journal of Chemical Information and Modeling (2021), 61(8), 4082-4096

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See detailA covalent calmodulin inhibitor as a tool to study cellular mechanisms of K-Ras-driven stemness
Okutachi, Sunday Ojochegbe; Manoharan, Ganesh Babu; Kiriazis, Alexandros; Laurini, Christina; Catillon, Marie; McCormick, Franck; Yli-Kauhaluoma, Jari; Abankwa, Daniel

in Frontiers in Cell and Developmental Biology (2021)

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2020

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See detailPDE6D Inhibitors with a New Design Principle Selectively Block K‑Ras Activity
Siddiqui, Farid A.; Alam, Catharina; Rosenqvist, Petja; Ora, Mikko; Sabt, Ahmed; Manoharan, Ganesh Babu; Bindu, Lakshman; Okutachi, Sunday Ojochegbe; Catillon, Marie; Taylor, Troy; Abdelhafez, Omaima M.; Lönnberg, Harri; Stephen, Andrew G.; Papageorgiou, Anastassios C.; Virta, Pasi; Abankwa, Daniel

in ACS Omega (2020), 5(1), 832-842

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2019

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See detailHigh-throughput amenable fluorescence-assays to screen for calmodulin-inhibitors
Manoharan, Ganesh Babu; Kopra, Kari; Eskonen, Ville; Harma, Harri; Abankwa, Daniel

in Analytical Biochemistry (2019), 572

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See detailMedium-Throughput Detection of Hsp90/Cdc37 Protein–Protein Interaction Inhibitors Using a Split Renilla Luciferase-Based Assay
Siddiqui, Farid A.; Parkkola, Hanna; Manoharan, Ganesh Babu; Abankwa, Daniel

in SLAS Discovery (2019)

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2018

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See detailThiazole- and selenazole-comprising high-affinity inhibitors possess bright microsecond-scale photoluminescence in complex with protein kinase CK2.
Vahter, Jurgen; Viht, Kaido; Uri, Asko; Manoharan, Ganesh Babu; Enkvist, Erki

in Bioorganic & medicinal chemistry (2018), 26(18), 5062-5068

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2016

See detailBifunctional Ligands for Inhibition of Tight-Binding Protein–Protein Interactions
Ivan, Taavi; Enkvist, Erki; Viira, Birgit; Manoharan, Ganesh Babu; Raidaru, Gerda; Pflug, Alexander; Alam, Kazi Asraful; Zaccolo, Manuela; Engh, Richard Alan; Uri, Asko

in Bioconjugate Chemistry (2016), 27(8), 1900-1910

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See detailCombining chemical and genetic approaches for development of responsive FRET-based sensor systems for protein kinases
Manoharan, Ganesh Babu; Enkvist, Erki; Uri, Asko

in Biophysical Chemistry (2016), 211

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See detailPhosphorylation of Notch1 by Pim kinases promotes oncogenic signaling in breast and prostate cancer cells
Santio, Niina M.; Landor, Sebastian K.-J.; Vahtera, Laura; Yla-Pelto, Jani; Paloniemi, Elina; Imanishi, Susumu Y.; Corthals, Garry; Varjosalo, Markku; Manoharan, Ganesh Babu; Uri, Asko; Lendahl, Urban; Sahlgren, Cecilia; Koskinen, Paivi J.

in Oncotarget (2016), 7(28), 43220-43238

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2015

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See detailPIM kinase-responsive microsecond-lifetime photoluminescent probes based on selenium-containing heteroaromatic tricycle
Ekambaram, Ramesh; Manoharan, Ganesh Babu; Enkvist, Erki; Ligi, Kadri; Knapp, Stefan; Uri, Asko

in RSC Advances (2015)

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See detailFRET-based screening assay using small-molecule photoluminescent probes in lysate of cells overexpressing RFP-fused protein kinases
Manoharan, Ganesh Babu; Enkvist, Erki; Kasari, Marje; Viht, Kaido; Zenn, Michael; Prinz, Anke; Filhol, Odile; Herbergb, Friedrich W.; Uri, Asko

in Analytical Biochemistry (2015)

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2014

See detailBenzoselenadiazole-based responsive long-lifetime photoluminescent probes for protein kinases
Ekambaram, Ramesh; Enkvist, Erki; Manoharan, Ganesh Babu; Ugandi, Mihkel; Kasari, Marje; Viht, Kaido; Knapp, Stefan; Issinger, Olaf-Georg; Uri, Asko

in Chemical Communications (2014)

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2012

See detailActive site analysis of cis-epoxysuccinate hydrolase from Nocardia tartaricans using homology modeling and site-directed mutagenesis
Vinayagam, Vasu; Jayaraman, Kumaresan; Manoharan, Ganesh Babu; Sankaranarayanan, Meenakshisundaram

in Applied Microbiology and Biotechnology (2012), 93(6), 23772386

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