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Lasse Sinkkonen

Lasse Sinkkonen

Research scientist

Faculty or Centre Faculty of Science, Technology and Medicine
Department Department of Life Sciences and Medicine
Postal Address Université du Luxembourg
6, avenue du Swing
L-4367 Belvaux
Campus Office BioTech II, 4.23
Email
Telephone (+352) 46 66 44 6839
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2020

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See detailPituitary Tumor Transforming Gene 1 Orchestrates Gene Regulatory Variation in Mouse Ventral Midbrain During Aging
Gui, Yujuan; Thomas, Mélanie H.; Garcia, Pierre; Karout, Mona; Halder, Rashi; Michelucci, Alessandro; Kollmus, Heike; Zhou, Cuiqi; Melmed, Shlomo; Schughart, Klaus; Balling, Rudolf; Mittelbronn, Michel; Nadeau, Joseph H.; Williams, Robert W.; Sauter, Thomas; Buttini, Manuel; Sinkkonen, Lasse

in Frontiers in Genetics (2020)

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See detailReduced sialylation triggers homeostatic synapse and neuronal loss in middle-aged mice
Klaus, Christine; Hansen, Jan N.; Ginolhac, Aurélien; Gérard, Deborah; Gnanapragassam, Vinayaga S.; Horstkorte, Rüdiger; Rossdam, Charlotte; Buettner, Falk F. R.; Sauter, Thomas; Sinkkonen, Lasse; Neumann, Harald; Linnartz-Gerlach, Bettina

in Neurobiology of Aging (2020)

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See detailMissing heritability in Parkinson’s disease: the emerging role of non‑coding genetic variation
Ohnmacht, Jochen; May, Patrick; Sinkkonen, Lasse; Krüger, Rejko

in Journal of Neural Transmission (2020)

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See detailPhagocytosis‐related NADPH oxidase 2 subunit gp91phox contributes to neurodegeneration after repeated systemic challenge with lipopolysaccharides
Shahraz, Anahita; Wißfeld, Jannis; Ginolhac, Aurélien; Matthews, Mona; Sinkkonen, Lasse; Neumann, Harald

in Glia (2020)

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2019

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See detailIdentification of genes under dynamic post-transcriptional regulation from time-series epigenomic data
Becker, Julia Christina; Gerard, Déborah; Ginolhac, Aurélien; Sauter, Thomas; Sinkkonen, Lasse

in Epigenomics (2019)

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See detailImpaired serine metabolism complements LRRK2-G2019S pathogenicity in PD patients
Nickels, Sarah; Walter, Jonas; Bolognin, Silvia; Gerard, Deborah; Jaeger, Christian; Qing, Xiaobing; Tisserand, Johan; Jarazo, Javier; Hemmer, Kathrin; Harms, Amy; Halder, Rashi; Lucarelli, Philippe; Berger, Emanuel; Antony, Paul; Glaab, Enrico; Hankemeier, Thomas; Klein, Christine; Sauter, Thomas; Sinkkonen, Lasse; Schwamborn, Jens Christian

in Parkinsonism and Related Disorders (2019)

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2018

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See detailTemporal enhancer profiling of parallel lineages identifies AHR and GLIS1 as regulators of mesenchymal multipotency
Gerard, Déborah; Schmidt, Florian; Ginolhac, Aurélien; Schmitz, Martine; Halder, Rashi; Ebert, Peter; Schulz, Marcel; Sauter, Thomas; Sinkkonen, Lasse

in Nucleic Acids Research (2018)

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See detailTREM2 triggers microglial density and age‐related neuronal loss
Linnartz-Gerlach, Bettina; Bodea, Liviu-Gabriel; Klaus, Christine; Ginolhac, Aurélien; Halder, Rashi; Sinkkonen, Lasse; Walter, Jochen; Colonna, Marco; Neumann, Harald

in Glia (2018)

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2017

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See detailAnalysis of primary microRNA loci from nascent transcriptomes reveals regulatory domains governed by chromatin architecture
Bouvy-Liivrand, Maria; Hernandez de Sande, Ana; Pölönen, Petri; Mehtonen, Juha; Vuorenmaa, Tapio; Niskanen, Henri; Sinkkonen, Lasse; Kaikkonen, Minna; Heinäniemi, Merja

in Nucleic Acids Research (2017)

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2015

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See detailCell type-selective disease-association of genes under high regulatory load
Galhardo, Mafalda Sofia; Berninger, Philipp; Nguyen, Thanh-Phuong; Sauter, Thomas; Sinkkonen, Lasse

in Nucleic Acids Research (2015), 43(18), 8839-8855

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See detailIntegrated metabolic modelling reveals cell-type specific epigenetic control points of the macrophage metabolic network
Pacheco, Maria; John, Elisabeth; Kaoma, Tony; Heinäniemi, Merja; Nicot, Nathalie; Vallar, Laurent; Bueb, Jean-Luc; Sinkkonen, Lasse; Sauter, Thomas

in BMC Genomics (2015), 16(809),

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2014

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See detailNeurodegeneration by Activation of the Microglial Complement–Phagosome Pathway
Bodea, Liviu-Gabriel; Wang, Yiner; Linnartz-Gerlach, Bettina; Kopatz, Jens; Sinkkonen, Lasse; Musgrove, Ruth; Kaoma, Tony; Muller, Arnaud; Vallar, Laurent; Di Monte, Donato; Balling, Rudi; Neumann, Harald

in Journal of Neuroscience (2014), 34(25), 8546-8556

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See detailTranscriptomics profiling of human SGBS adipogenesis
Galhardo, Mafalda Sofia; Sinkkonen, Lasse; Berninger, Philipp; Lin, Jake; Sauter, Thomas; Heinäniemi, Merja

in Genomics Data (2014), 2

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See detailChIP-seq profiling of the active chromatin marker H3K4me3 and PPARγ, CEBPα and LXR target genes in human SGBS adipocytes
Galhardo, Mafalda Sofia; Sinkkonen, Lasse; Berninger, Philipp; Lin, Jake; Sauter, Thomas; Heinäniemi, Merja

in Genomics Data (2014), 2

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See detailCombinatorial regulation of lipoprotein lipase by microRNAs during mouse adipogenesis
Liivrand, Maria; Heinäniemi, Merja; John, Elisabeth; Schneider, Jochen; Sauter, Thomas; Sinkkonen, Lasse

in RNA Biology (2014), 11(1), 76-91

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2013

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See detailIntegrated analysis of transcript-level regulation of metabolism reveals disease-relevant nodes of the human metabolic network
Galhardo, Mafalda Sofia; Sinkkonen, Lasse; Berninger, Philippe; Lin, Jake; Sauter, Thomas; Heinäniemi, Merja

in Nucleic Acids Research (2013)

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See detailGene-pair expression signatures reveal lineage control
Heinäniemi, Merja; Nykter, Matti; Kramer, Roger; Wienecke, Anke; Sinkkonen, Lasse; Zhou, J. X.; Kreisberg, Richard; Kauffman, Stuart A.; Huang, Sui; Shmulevich, Ilya

in Nature Methods (2013)

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2012

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See detailDataset integration identifies transcriptional regulation of microRNA genes by PPARgamma in differentiating mouse 3T3-L1 adipocytes
John, Elisabeth; Wienecke-Baldacchino, Anke; Liivrand, Maria; Heinäniemi, Merja; Carlberg, Carsten; Sinkkonen, Lasse

in Nucleic Acids Research (2012), 40(10), 4446-4460

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2010

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See detailTime-Resolved Expression Profiling of the Nuclear Receptor Superfamily in Human Adipogenesis
Lahnalampi, Mari; Heinäniemi, Merja; Sinkkonen, Lasse; Wabitsch, Martin; Carlberg, Carsten

in PLoS ONE (2010), 5(9),

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See detailDicer is associated with ribosomal DNA chromatin in mammalian cells
Sinkkonen, Lasse; Hugenschmidt, Tabea; Filipowicz, Witold; Svoboda, Petr

in PLoS ONE (2010), 5(8), 1-2

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2008

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See detailMicroRNAs control de novo DNA methylation through regulation of transcriptional repressors in mouse embryonic stem cells
Sinkkonen, Lasse; Hugenschmidt, Tabea; Berninger, Philipp; Gaidatzis, Dimos; Mohn, Fabio; Artus-Revel, Caroline G.; Zavolan, Mihaela; Svoboda, Petr; Filipowicz, Witold

in Nature Structural & Molecular Biology (2008), 15(3), 259-67

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2005

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See detailRegulation of the human cyclin C gene via multiple vitamin D3-responsive regions in its promoter
Sinkkonen, Lasse; Malinen, Marjo; Saavalainen, Katri; Väisänen, Sami; Carlberg, Carsten

in Nucleic Acids Research (2005), 33(8), 2440-51

See detailSpatio-temporal activation of chromatin on the human CYP24 gene promoter in the presence of 1alpha,25-Dihydroxyvitamin D3
Väisänen, Sami; Dunlop, Thomas W.; Sinkkonen, Lasse; Frank, Christian; Carlberg, Carsten

in Journal of Molecular Biology (2005), 350(1), 65-77

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