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Publications
In press
Le Modèle de Partenariat Humaniste en Santé : un modèle conceptuel de soins infirmiers pour mieux comprendre, accepter et accompagner la personne qui refuse une aide ou un soin; ;
in Hesbeen, Walter (Ed.) Face au refus d’aide et de soins. Penser en équipe le positionnement éthique (in press)
2023
Expanding the Disease Network of Glioblastoma Multiforme via Topological Analysis.; ;
in International journal of molecular sciences (2023), 24(4),
A mechanical model for compaction of strands in wire ropes; ;
in International Journal of Solids and Structures (2023), 269
Pratiques et enjeux de la sédation palliative en Belgique; ;
in La Revue de l'Infirmière (2023), 72(289), 32-35
Sustainability assessment of a novel reusable and demountable steel-concrete composite floor system; ; ;
in ECPPM 2022 - eWork and eBusiness in Architecture, Engineering and Construction 2022 (2023)
Ambra1 modulates the tumor immune microenvironment and response to PD-1 blockade in melanoma.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Journal for immunotherapy of cancer (2023), 11(3),
Cardiovascular risk prediction - a systems medicine approach; ; ; ; ; ;
E-print/Working paper (2023)
Expériences d’apprentissages-enseignements des stagiaires infirmiers bacheliers en relation avec le prendre soin humaniste-caringScientific Conference (2023, February 09)
Dispositif réflexif pour l’essor des compétences enseignantes; ; ;
Scientific Conference (2023, May 16)
Impact émotionnel de la covid-19 chez les infirmières; ; ; ; ; ; ; ;
in Santé Mentale (2023), (276),
Digital twin of end-of-life process-chains for a circular economy adapted product design - A case study on PET bottles; ;
in Journal of Cleaner Production (2023), 382
Introduction to Systems Biology - Workbook for Flipped-classroom Teaching;
Book published by OpenBookPublishers (2023)
2022
Semantic Material Bank: A web-based linked data approach for building decommissioning and material reuse; ;
in ECPPM 2022 - eWork and eBusiness in Architecture, Engineering and Construction 2022 (2022)
Mechanistically Coupled PK (MCPK) Model to Describe Enzyme Induction and Occupancy Dependent DDI of Dabrafenib Metabolism.; ; ;
in Pharmaceutics (2022), 14(2),
Single-cell transcriptional profiling and gene regulatory network modeling in Tg2576 mice reveal gender-dependent molecular features preceding Alzheimer-like pathologies; ; ; ; ; ; ; ; ;
in Molecular Neurobiology (2022), in press (doi:10.1007/s12035-022-02985-2)(in press),
Semantic and Interactive Search in an Advanced Note-Taking App for Learning Material; ; ;
in Proceedings of the 24th International Conference on Human-Computer Interaction (HCI International) (2022, June)
Construction and contextualization approaches for protein-protein interaction networks.; ;
in Computational and structural biotechnology journal (2022), 20
Drug Target Prediction Using Context-Specific Metabolic Models Reconstructed from rFASTCORMICS.; ; ; ;
in Methods in Molecular Biology (2022)
The Multifaceted Neurotoxicity of Astrocytes in Ageing and Age-Related Neurodegenerative Diseases: A Translational Perspective.; ; ; ; ;
in Frontiers in Physiology (2022)
Bruceine D Identified as a Drug Candidate against Breast Cancer by a Novel Drug Selection Pipeline and Cell Viability Assay.; ; ; ; ; ;
in Pharmaceuticals (Basel, Switzerland) (2022), 15(2),
Effects of various outdoor conditions on Structural Health Monitoring (SHM) of bridges using data from Luxembourg; ;
in VDI-Berichte 2379, 7. VDI-Fachtagung Baudynamik 27. und 28. April 2022, Würzburg (2022, April)
Bridge damage assessment based on static and dynamic flexibility matrices; ; ; ; ;
in Bridge Safety, Maintenance, Management, Life-Cycle, Resilience and Sustainability (2022)
Evolution of the murine gut resistome following broad-spectrum antibiotic treatment.; ; ; ; ;
in Nature communications (2022), 13(1), 2296
Focal adhesion kinase plays a dual role in TRAIL resistance and metastatic outgrowth of malignant melanoma; ; ; ; ; ; ; ; ; ;
in Cell Death and Disease (2022)
Improving Machine Learning-based Prediction of Frailty in Elderly People with Digital Wearables : Data from the Berlin Aging Study II (BASE-II); ; ; ; ; ;
Poster (2022, October 26)
Machine learning-based prediction of frailty in elderly people : Data from the Berlin Aging Study II (BASE-II); ; ; ; ; ;
Poster (2022, October 09)
Metaheuristics-based Exploration Strategies for Multi-Objective Reinforcement Learning; ; ;
in Proceedings of the 14th International Conference on Agents and Artificial Intelligence (2022)
Neurodegeneration and neuroinflammation are linked, but independent of a-synuclein inclusions, in a seeding/spreading mouse model of Parkinson's disease; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Glia (2022)
Generalising from conventional pipelines using deep learning in high‑throughput screening workfows; ; ; ; ; ; ; ; ; ;
in Scientific Reports (2022)
Flash, who? On the Obsolescence of Digital Technology and Its Impact on E-learning Applications: A Case Study.in Proceedings of the XVII Latin American Conference on Learning Technologies (LACLO) (2022, October)
Reasoning on conflicting information: An empirical study of Formal Argumentation; ; ;
in PLoS ONE (2022), 17(8 August),
Normal and Pathological NRF2 Signalling in the Central Nervous System; ; ; ; ; ;
in Antioxidants (2022), 11(8), 1426
Investigating children's chemical exposome - Description and possible determinants of exposure in the region of Luxembourg based on hair analysisInvestigating children's chemical exposome - Description and possible determinants of exposure in the region of Luxembourg based on hair analysis; ; ; ; ; ;
in Water and Environmental International (2022)
Australian Indigenous Life Writing: Analysing Discourses with Word Embedding ModellingDoctoral thesis (2022)
Review of Current Human Genome-Scale Metabolic Models for Brain Cancer and Neurodegenerative Diseases.; ; ; ; ; ; ;
in Cells (2022), 11(16),
Mitochondria preserve an autarkic one-carbon cycle to confer growth-independent cancer cell migration and metastasis; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Nature Communications (2022)
Validation and verification in domain-specific modeling method engineering: an integrated life-cycle view; ;
in Software and Systems Modeling (2022)
GraphCode2Vec: generic code embedding via lexical and program dependence analyses; ; ; ; ; ; ; ;
in Proceedings of the 19th International Conference on Mining Software Repositories (2022, May 22)
Analysis of End-of-Life Process Data to enable Design Knowledge for CircularityDoctoral thesis (2022)
Preventing active re-identification attacks on social graphs via sybil subgraph obfuscation; ;
in Knowledge and Information Systems (2022), 64
Predicting depression in old age: Combining life course data with machine learning; ; ;
Scientific Conference (2022, June 03)
Vécu des infirmières lors de la pandémie de COVID-19 et conséquences sur leur relation avec les patients : une recherche qualitative consensuelle; ; ;
in Recherche en soins infirmiers (2022), 151(4), 43-59
Integration of external biomass reactions into existing metabolic models; ;
E-print/Working paper (2022)
XAI: Using Smart Photobooth for Explaining History of Art; ; ; ; ; ;
in XAI: Using Smart Photobooth for Explaining History of Art (2022, December)
EGFR-induced suppression of HPV E6/E7 is mediated by microRNA-9-5p silencing of BRD4 protein in HPV-positive head and neck squamous cell carcinoma.; ; ;
in Cell death & disease (2022), 13(11), 921
Retrograde Procedural Memory in Parkinson’s Disease: A Cross-Sectional, Case-Control Study; ; ; ; ; ;
in Journal of Parkinson's Disease (2022)
Drug targeting opportunities en route to Ras nanoclusters.; ;
in Advances in cancer research (2022), 153
IntJect: Vulnerability Intent Bug Seeding; ; ; ;
in 22nd IEEE International Conference on Software Quality, Reliability, and Security (2022)
CCT196969 effectively inhibits growth and survival of melanoma brain metastasis cells; ; ; ; ; ; ; ; ;
in PLoS ONE (2022)
Microglia integration into human midbrain organoids leads to increased neuronal maturation and functionality; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Glia (2022)
Microgliosis: a double-edged sword in the control of food intake; ; ; ; ; ; ; ; ; ; ; ; ;
in FEBS Journal (2022)
Project-based learning course on metabolic network modelling in computational systems biology.; ; ; ; ; ; ; ; ; ; ;
in PLoS computational biology (2022), 18(1), 1009711
On Improving Slant Wet delays for Tracking Severe Weather Events: An evaluation During Two Storms in Europe; ; ; ; ;
Scientific Conference (2022, December 14)
The gut microbial metabolite formate exacerbates colorectal cancer progression; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Nature Metabolism (2022)
An archaeal compound as a driver of Parkinson’s disease pathogenesis; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
E-print/Working paper (2022)
Spatio-temporal programming of lyotropic phase transition in nanoporous microfluidic confinements;
E-print/Working paper (2022)
Waiting as probation: selecting self-disciplining asylum seekers; ;
in Journal of Ethnic and Migration Studies (2022), 48(5), 1013-1032
MiRNAs from serum-derived extracellular vesicles as biomarkers for uveal melanoma progression; ; ; ; ; ; ;
in Frontiers in Cell and Developmental Biology (2022)
Target Control of Boolean Networks with Permanent Edgetic Perturbations;
in Proceedings of the 61st International Conference on Decision and Control (CDC 2022) (2022)
2021
Evaluation of erosion inside AWJC Nozzle by 6-way coupling of DEM+CFD+FEM using preCICE; ; ;
Presentation (2021, February 23)
NRAS is unique among RAS proteins in requiring ICMT for trafficking to the plasma membrane; ; ; ;
in Life Science Alliance (2021)
The Quest and Hope of Majorana Zero Modes in Topological Superconductor for Fault Tolerant Quantum Computing: An Introductory Overview; ;
in AIP Conference Proceedings (2021, August 10), 2382(1), 020007
Degree Adjusted Large-Scale Network Analysis Reveals Novel Putative Metabolic Disease Genes.; ; ; ; ;
in Biology (2021), 10(2),
Student Response Systems in Remote Teaching; ;
in Proceedings of the 23rd International Conference on Human-Computer Interaction (HCI International) (2021, July)
Design model for dry-stacked and demountable masonry blocks;
in POWERSKIN Conference Proceedings (2021, April 09)
Systematic characterization of human gut microbiome-secreted molecules by integrated multi-omics; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in ISME Communications (2021)
Loss of Ambra1 promotes melanoma growth and invasion.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Nature communications (2021), 12(1), 2550
Biomonitoring of fast-elimination endocrine disruptors - Results from a 6-month follow up on human volunteers with repeated urine and hair collection.; ; ; ; ;
in The Science of the total environment (2021), 778
ATG5 and ATG7 Expression Levels Are Reduced in Cutaneous Melanoma and Regulated by NRF1; ; ; ; ; ; ; ; ; ; ;
in Frontiers in Oncology (2021)
Passerelles entre culture palliative et crise covid-19in Soins et spiritualités en temps de pandémie. L’épreuve de la Covid-19 (2021)
Face and Content Validity, Acceptability, and Feasibility of the Adapted Version of the Children's Palliative Outcome Scale: A Qualitative Pilot Study; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Journal of Palliative Medicine (2021)
A Pharmacophore Model for SARS-CoV-2 3CLpro Small Molecule Inhibitors and in Vitro Experimental Validation of Computationally Screened Inhibitors; ;
in Journal of Chemical Information and Modeling (2021), 61(8), 4082-4096
Single‑nuclei chromatin profiling of ventral midbrain reveals cell identity transcription factors and cell‑type‑specific gene regulatory variation; ; ; ; ; ; ; ;
in Epigenetics and Chromatin (2021)
Apomorphine Reduces A53T α‑Synuclein‑Induced Microglial Reactivity Through Activation of NRF2 Signalling Pathway; ; ; ; ; ;
in Cellular and Molecular Neurobiology (2021)
Parkinson’s disease phenotypes in patient neuronal cultures and brain organoids improved by 2-Hydroxypropyl-b-Cyclodextrin treatment; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Movement Disorders (2021)
Eco-construction for sustainable development: Concept of a Material and Component Bank;
in POWERSKIN Conference Proceedings (2021, April 09)
Mapping the Metabolic Networks of Tumor Cells and Cancer-Associated Fibroblasts; ; ; ;
in Cells (2021)
DCcov: Repositioning of drugs and drug combinations for SARS-CoV-2 infected lung through constraint-based modeling.; ;
in iScience (2021), 24(11), 103331
Highly Multiplexed Targeted Proteomics Acquisition on a TIMS-QTOF; ; ; ; ; ;
in Analytical Chemistry (2021)
Nanopore Single-Molecule Sequencing for Mitochondrial DNA Methylation Analysis: Investigating Parkin-Associated Parkinsonism as a Proof of Concept; ; ; ; ; ; ; ; ;
in Frontiers in Aging Neuroscience (2021)
L-plastin Ser5 phosphorylation is modulated by the PI3K/SGK pathway and promotes breast cancer cell invasiveness; ; ; ; ; ;
in Cell Communication and Signaling (2021), 19(22), 1-22
An Innovative Strategy Allowing a Holisitic System Change towards Circular Economy within Supply-Chains; ; ;
in Energies (2021), 14(14),
A dynamic multi-tissue model to study human metabolism.; ; ;
in NPJ systems biology and applications (2021), 7(1), 5
Bead Geometry Prediction in Laser-Wire Additive Manufacturing Process Using Machine Learning: Case of Study; ; ; ;
in Applied Sciences (2021), Volume 11(Issue 24),
Self and Society in the Corona Crisis. Perspectives from the Humanities and Social Sciences;
Book published by Melusina Press (2021)
Importance of the biomass formulation for cancer metabolic modeling and drug prediction.; ; ; ;
in iScience (2021), 24(10), 103110
Investigating Major Recurring Campylobacter jejuni Lineages in Luxembourg Using Four Core or Whole Genome Sequencing Typing Schemes; ; ; ; ; ; ;
in Frontiers in Cellular and Infection Microbiology (2021), 10
Is serine racemase (SRR) a second hit target for LRRK2-G2019S induced Parkinson’s disease?;
in Neural Regeneration Research (2021)
A covalent calmodulin inhibitor as a tool to study cellular mechanisms of K-Ras-driven stemness; ; ; ; ; ; ;
in Frontiers in Cell and Developmental Biology (2021)
FLIM-FRET Analysis of Ras Nanoclustering and Membrane-Anchorage.; ; ;
in Methods in molecular biology (Clifton, N.J.) (2021), 2262
The Moderating Role of Resilience in the Personality-Mental Health Relationship During the COVID-19 Pandemic; ; ; ; ;
in Frontiers in Psychiatry (2021)
The retrograde procedural memory in people with Parkinson’s disease with or without freezing of gait – a cross-sectional study; ; ; ; ; ; ; ;
Poster (2021, September 17)
IDARE2-Simultaneous Visualisation of Multiomics Data in Cytoscape.; ; ;
in Metabolites (2021), 11(5),
Distributed Prediction of Unsafe Reconfiguration Scenarios of Modular Robotic Programmable Matter; ; ; ; ;
in IEEE Transactions on Robotics (2021), 37(6), 2226-2233
Assessment of Mitochondrial Cell Metabolism by Respiratory Chain Electron Flow Assays; ; ;
in Weissig, Volkmar; Edeas, Marvin (Eds.) Methods in Molecular Biology (2021)
Analysis of residual stress relaxation of aluminum alloys EN AW 6061/-82 T6 under cyclic loading; ; ; ;
in Fatigue and Fracture of Engineering Materials and Structures (2021)
Stress-induced inflammation evoked by immunogenic cell death is blunted by the IRE1α kinase inhibitor KIRA6 through HSP60 targeting; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Cell Death and Differentiation (2021)
Elaiophylin Is a Potent Hsp90/ Cdc37 Protein Interface Inhibitor with K-Ras Nanocluster Selectivity; ; ;
in Biomolecules (2021)
Detection of fluid level in bores for batch size one assembly automation using convolutional neural network; ;
in Advances in Production Management Systems. Artificial Intelligence for Sustainable and Resilient Production Systems. (2021, August 31), 632
Stromal fibroblasts shape the myeloid phenotype in normal colon and colorectal cancer and induce CD163 and CCL2 expression in macrophages; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Cancer Letters (2021)
Understanding the role of colorectal cancer-associated bacteria in colorectal cancerDoctoral thesis (2021)
Quantitative trait locus mapping identifies a locus linked to striatal dopamine and points to collagen IV alpha-6 chain as a novel regulator of striatal axonal branching in mice; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Genes, Brain, and Behavior (2021)
Single-Cell Transcriptomics and In Situ Morphological Analyses Reveal Microglia Heterogeneity Across the Nigrostriatal Pathway; ; ; ; ; ; ; ; ;
in Frontiers in Immunology (2021)
Attentional Bias Modification Training for Itch: A Proof-of-Principle Study in Healthy Individuals; ; ; ; ;
in Frontiers in Medicine (2021), 8
The Parkinson’s-disease-associated mutation LRRK2-G2019S alters dopaminergic differentiation dynamics via NR2F1; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Cell Reports (2021)
Role of S100A8/A9 for Cytokine Secretion, Revealed in Neutrophils Derived from ER-Hoxb8 Progenitors; ; ; ; ; ;
in International Journal of Molecular Sciences (2021)
2020
Mechanisms of Ras Membrane Organization and Signaling: Ras Rocks Again.;
in Biomolecules (2020), 10(11),
Impaired Mitochondrial-Endoplasmic Reticulum Interaction and Mitophagy in Miro1-Mutant Neurons in Parkinson’s Disease; ; ; ; ; ; ; ; ; ;
in Human Molecular Genetics (2020)
Towards the routine use of in silico screenings for drug discovery using metabolic modelling; ;
in Biochemical Society Transactions (2020)
Excess of singleton loss-of-function variants in Parkinson's disease contributes to genetic risk.; ; ;
in Journal of Medical Genetics (2020)
Inflammation regulates long non-coding RNA-PTTG1-1:1 in myeloid leukemia; ; ; ; ; ; ; ; ; ;
in Haematologica (2020), 105(6), 280-284
Evaluating the Use of Circulating MicroRNA Profiles for Lung Cancer Detection in Symptomatic Patients; ; ; ; ; ; ; ; ; ;
in JAMA Oncology (2020)
La liaison pédiatrique. Un modèle original de soins palliatifs pédiatriques transmurauxin Manuel de soins palliatifs (2020)
Anticipatory grief and bereavement support; ;
in Julia Downing ; "Children's Palliative Care: an International Case-Based Manual" (2020)
Synapse alterations precede neuronal damage and storage pathology in a human cerebral organoid model of CLN3-juvenile neuronal ceroid lipofuscinosis; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Acta Neuropathologica Communications (2020)
Human telomerase reverse transcriptase depletion potentiates the growth- T inhibitory activity of imatinib in chronic myeloid leukemia stem cells; ; ; ; ; ; ;
in Cancer Letters (2020)
Pituitary Tumor Transforming Gene 1 Orchestrates Gene Regulatory Variation in Mouse Ventral Midbrain During Aging; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Frontiers in Genetics (2020)
Unmet Needs of People With Parkinson's Disease and Their Caregivers During COVID-19-Related Confinement: An Explorative Secondary Data Analysis.; ; ; ; ; ; ; ; ;
in Frontiers in neurology (2020), 11
Integration of time-series meta-omics data reveals how microbial ecosystems respond to disturbance; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Nature Communications (2020)
The need for standardisation in life science research - an approach to excellence and trust.; ; ; ; ; ; ; ; ; ; ; ; ; ;
in F1000Research (2020), 9(1398),
Adverse events reporting in stage III NSCLC trials investigating surgery and radiotherapy; ; ; ; ; ; ;
in ERJ Open Research (2020)
Passive controlled flow for Parkinson’s disease neuronal cell culture in 3D microfluidic devices; ; ; ;
in Organs-on-a-Chip (2020)
Systematic transcriptional profiling of responses to STAT1- and STAT3- activating cytokines in different cancer types; ; ; ; ; ; ; ; ;
in Journal of Molecular Biology (2020)
Reduced sialylation triggers homeostatic synapse and neuronal loss in middle-aged mice; ; ; ; ; ; ; ; ; ; ;
in Neurobiology of Aging (2020)
Augmented Reality in Manual Assembly Processes; ; ;
in Kolla, Sri Sudha Vijay Keshav; Sanchez, Andre; Minoufekr, Meysam; Plapper, Peter (Eds.) Augmented Reality in Manual Assembly Processes (2020, September 23)
Prognostic and Predictive Molecular Biomarkers for Colorectal Cancer: Updates and Challenges; ; ;
in Cancers (2020)
Fibroblast mitochondria in idiopathic Parkinson’s disease display morphological changes and enhanced resistance to depolarization; ; ; ; ; ; ; ; ; ; ;
in Scientific Reports (2020)
Unraveling Molecular Mechanisms of THAP1 Missense Mutations in DYT6 Dystonia; ; ; ; ; ; ; ; ; ;
in Journal of Molecular Neuroscience (2020)
Emerging concepts for precision medicine in Parkinson's disease with focus on genetics;
in Fortschritte der Neurologie-Psychiatrie (2020)
Induced pluripotent stem cell line (LCSBi001-A) derived from a patient with Parkinson's disease carrying the p.D620N mutation in VPS35; ; ; ; ; ;
in Stem Cell Research (2020)
European Respiratory Society Statement on Thoracic Ultrasound; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in European Respiratory Journal (2020)
Peptide-Imprinted Poly(hydroxymethyl 3,4-ethylenedioxythiophene) Nanotubes for Detection of Alpha Synuclein in Human Brain Organoids; ; ; ; ; ; ; ; ; ;
in ACS Applied Nano Materials (2020)
Novel HDAC inhibitor MAKV-8 and imatinib synergistically kill chronic myeloid leukemia cells via inhibition of BCR-ABL/MYC-signaling: effect on imatinib resistance and stem cells; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Clinical Epigenetics (2020), 12(1), 69
Myosins: Driving us towards novel targets and biomarkers in cancer;
in Actin Cytoskeleton in Cancer Progression and Metastasis - Part B (2020)
The HDAC6 inhibitor 7b induces BCR-ABL ubiquitination and downregulation and synergizes with imatinib to trigger apoptosis in chronic myeloid leukemia; ; ; ; ; ; ; ; ; ; ; ; ;
in Pharmacological Research (2020), 160
An efficient machine learning-based approach for screening individuals at risk of hereditary haemochromatosis.; ;
in Scientific reports (2020), 10(1), 20613
Bidirectional Relation Between Parkinson’s Disease and Glioblastoma Multiforme; ; ; ; ;
in Frontiers in Neurology (2020)
The atypical chemokine receptor ACKR3/CXCR7 is a broad-spectrum scavenger for opioid peptides.; ; ; ; ; ; ; ; ; ; ; ; ;
in Nature communications (2020), 11(1), 3033
Machine learning-assisted neurotoxicity prediction in human midbrain organoids; ; ; ; ; ; ; ; ; ;
in Parkinsonism and Related Disorders (2020)
Cancer Cells Employ Nuclear Caspase-8 to Overcome the p53-Dependent G2/M Checkpoint through Cleavage of USP28.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Molecular cell (2020)
Haploinsufficiency due to a novel ACO2 deletion causes mitochondrial dysfunction in fibroblasts from a patient with dominant optic nerve atrophy; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Scientific Reports (2020)
Reproducible generation of human midbrain organoids for in vitro modeling of Parkinson’s disease; ; ; ; ;
in Stem Cell Research (2020)
Effects of environmental stress factors on colon cancer and its microenvironmentDoctoral thesis (2020)
Postprandial hyperglycemia stimulates neuroglial plasticity in hypothalamic POMC neurons after a balanced meal; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Cell Reports (2020), 30
Severe metabolic alterations in liver cancer lead to ERK pathway activation and drug resistance; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in EBioMedicine (2020)
Demountable and reusable construction system for steel-concrete composite structures;
in Odenbreit, Christoph; Kozma, Andras (Eds.) Demountable and reusable construction system for steel-concrete composite structures (2020, October 30)
Missing heritability in Parkinson’s disease: the emerging role of non‑coding genetic variation; ; ;
in Journal of Neural Transmission (2020)
Mental health impact of the confinement measures during the COVID-19 pandemic; ; ; ; ;
in Innovation in Aging (2020), 4(S1), 952
Genetic Architecture of Parkinson's Disease in the Indian Population: Harnessing Genetic Diversity to Address Critical Gaps in Parkinson's Disease Research.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Frontiers in neurology (2020), 11
Testing informed SIR based epidemiological model for COVID-19 in Luxembourg;
E-print/Working paper (2020)
Causal dynamical modelling predicts novel regulatory genes of FOXP3 in human regulatory T cells; ; ; ; ; ; ; ; ;
E-print/Working paper (2020)
The actin-bundling protein L-plastin—A double-edged sword: Beneficial for the immune response, maleficent in cancer;
in INTERNATIONAL REVIEW OF CELL AND MOLECULAR BIOLOGY (2020)
Programme Démence Prévention (pdp ): A Nation-Wide Programme for Dementia Prevention in Luxembourg; ; ; ; ; ; ; ; ; ;
Poster (2020, April)
Conversion from video-assisted thoracic surgery (VATS) to thoracotomy during major lung resection: how does it affect perioperative outcomes?; ; ; ;
in Interactive Cardiovascular and Thoracic Surgery (2020)
PDE6D Inhibitors with a New Design Principle Selectively Block K‑Ras Activity; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in ACS Omega (2020), 5(1), 832-842
Does lobar or size-reduced lung transplantation offer satisfactory early and late outcomes?; ; ;
in Interactive Cardiovascular and Thoracic Surgery (2020)
Single-cell transcriptomics reveals multiple neuronal cell types in human midbrain-specific organoids; ; ; ; ; ; ; ; ; ;
in Cell and Tissue Research (2020)
Midbrain organoids: A new tool to investigate Parkinson's disease;
in Frontiers in Cell and Developmental Biology (2020)
ZEB1/miR-200c/AGR2: A New Regulatory Loop Modulating the Epithelial-Mesenchymal Transition in Lung Adenocarcinomas; ; ; ; ;
in Cancers (2020), 12
Tetrahydrobenzimidazole TMQ0153 triggers apoptosis, autophagy and necroptosis crosstalk in chronic myeloid leukemia; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Cell Death and Disease (2020), 11(2),
Understanding the role of Fusobacterium nucleatum metabolism in colon cancer initiation and progression; ; ; ; ; ; ; ; ; ; ;
Poster (2020, February 22)
Microbiome in Colorectal Cancer: How to Getfrom Meta-omics to Mechanism?; ; ; ; ;
in Trends in Microbiology (2020)
Hypoxia-Induced Adaptations of miRNomes and Proteomes in Melanoma Cells and Their Secreted Extracellular Vesicles; ; ; ; ; ; ; ; ; ;
in Cancers (2020)
Distinct Cargos of Small Extracellular Vesicles Derived from Hypoxic Cells and Their Effect on Cancer Cells; ; ;
in International Journal of Molecular Sciences (2020)
Grundlagen und Stellenwert der COMT- und MAO-B-Inhibitoren in der Therapie des idiopathischen Parkinson-Syndroms.; ; ; ; ; ; ;
in Fortschritte der Neurologie-Psychiatrie (2020)
A subset of flavaglines inhibits KRAS nanoclustering and activation.; ; ; ; ; ; ; ; ; ; ; ;
in Journal of cell science (2020), 133(12),
2019
Clinical update on head and neck cancer: molecular biology and ongoing challenges.; ; ; ; ; ;
in Cell Death and Disease (2019), 10(8), 540
Automated high-throughput high-content autophagy and mitophagy analysis platform; ; ; ; ; ; ;
in Scientific Reports (2019)
Identification of genes under dynamic post-transcriptional regulation from time-series epigenomic data; ; ; ;
in Epigenomics (2019)
Resilience factors in children with juvenile idiopathic arthritis and their parents : the role of child and parent psychological flexibility; ; ; ; ; ;
in Pain Medicine (2019), 20(6), 1120--1131
Cross-disease analysis of Alzheimer’s disease and type-2 Diabetes highlights the role of autophagy in the pathophysiology of two highly comorbid diseases; ; ; ; ; ; ; ; ;
in Scientific Reports (2019), 9(1), 3965
Early Pleistocene enamel proteome from Dmanisi resolves Stephanorhinus phylogeny.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Nature (2019)
An Efficient Machine Learning Method to Solve Imbalanced Data in Metabolic Disease Prediction; ; ; ;
in Cecchini, Vania Filipa (Ed.) An Efficient Machine Learning Method to Solve Imbalanced Data in Metabolic Disease Prediction (2019)
Inflammation Regulates Long Non-Coding RNA-PTTG1-1:1 In Myeloid Leukemia.; ; ; ; ; ; ; ; ; ;
in Haematologica (2019)
Optimization of logical networks for the modelling of cancer signalling pathwaysDoctoral thesis (2019)
The TNF Family of Ligands and Receptors: Communication Modules in the Immune System and Beyond; ; ;
in Physiological Reviews (2019), 99(1),
miR-873-5p targets mitochondrialGNMT-Complex II interface contributing tonon-alcoholic fatty liver disease; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Molecular Metabolism (2019)
Instruments to Measure Outcomes in Pediatric Palliative Care: A Systematic Review; ; ;
in Pediatrics (2019), 143(1), 1-22
Access to paediatric palliative care in children and adolescents with complex chronic conditions: a retrospective hospital-based study in Brussels, Belgium; ; ; ; ; ; ; ; ; ;
in BMJ Paediatrics Open (2019)
From tech to bench: Deep Learning pipeline for image segmentation of high-throughput high-content microscopy data; ; ; ; ; ; ; ; ; ;
Poster (2019, November 29)
Deep Learning Quality Control for High-Throughput High-Content Screening Microscopy Images; ; ; ;
Poster (2019, October 10)
Integrated In Vitro and In Silico Modeling Delineates the Molecular Effects of a Synbiotic Regimen on Colorectal-Cancer-Derived Cells; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Cell Reports (2019), 27
Mutations in RHOT1 disrupt ER-mitochondria contact sites interfering with calcium homeostasis and mitochondrial dynamics in Parkinson's disease.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Antioxidants & redox signaling (2019)
The role of heparan sulfate maturation in cancer: A focus on the 3O-sulfation and the enigmatic 3O-sulfotransferases (HS3STs); ; ;
in Seminars in Cancer Biology (2019), 62
Calcium signaling and regulation of neutrophil functions: Still a long way to go.; ; ;
in Journal of leukocyte biology (2019)
Quality Control Strategy for CRISPRCas9- based Gene Editing Complicated by a Pseudogene; ; ; ;
in Frontiers in Genetics (2019)
Creation and analysis of biochemical constraint-based models using the COBRA Toolbox v.3.0.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Nature protocols (2019), 14(3), 639-702
Successes and Hurdles in Stem Cells Application and Production for Brain Transplantation; ; ; ;
in Frontiers in Neuroscience (2019)
Integrated Analyses of Microbiome and Longitudinal Metabolome Data Reveal Microbial-Host Interactions on Sulfur Metabolism in Parkinson’s Disease; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Cell Reports (2019), 29(7), 1767-1777
Guidelines for Fluorescent Guided Biallelic HDR Targeting Selection With PiggyBac System Removal for Gene Editing; ;
in Frontiers in Genetics (2019)
Regulation of neutrophil pro-inflammatory functions sheds new light on the pathogenesis of rheumatoid arthritis.; ; ;
in Biochemical pharmacology (2019), 165
miRNAs Regulate Cytokine Secretion Induced by Phosphorylated S100A8/A9 in Neutrophils.; ; ; ;
in International journal of molecular sciences (2019), 20(22),
Automated microfluidic cell culture of stem cell derived dopaminergic neurons; ; ; ; ; ; ; ; ; ;
in Scientific Reports (2019)
Detailed Analysis of IRIS Recognition Performance; ; ; ; ;
in 2019 International Conference on Computing, Electronics Communications Engineering (iCCECE) (2019)
Many ways to resistance: How melanoma cells evade targeted therapies; ; ; ;
in Biochimica et Biophysica Acta - Reviews on Cancer (2019), 1871(2), 313-322
Deep Brain Stimulation for Freezing of Gait in Parkinson’s Disease With Early Motor Complications; ;
in Movement Disorders (2019)
Quality of life predicts outcome of deep brain stimulation in early Parkinson disease; ; ;
in Neurology (2019)
Family-based association study on functional α-synuclein polymorphisms in attention-deficit/hyperactivity disorder; ; ; ; ; ; ;
in ADHD Attention Deficit and Hyperactivity Disorders (2019)
α-Synuclein in Parkinson's disease: causal or bystander?; ; ; ; ; ; ;
in Journal of Neural Transmission (2019)
Using global team science to identify genetic parkinson's disease worldwide; ; ; ;
in Annals of Neurology (2019)
Applied Directional Statistics : Modern Methods and Case Studies;
Book published by Chapman and Hall/CRC (2019)
High-throughput amenable fluorescence-assays to screen for calmodulin-inhibitors; ; ; ;
in Analytical Biochemistry (2019), 572
Kinase inhibitor library screening identifies synergistic drug combinations effective in sensitive and resistant melanoma cells; ; ; ; ; ; ; ;
in Journal of Experimental and Clinical Cancer Research (2019), 38(1),
Deconvolution of Transcriptomes and miRNomes by Independent Component Analysis Provides Insights Into Biological Processes and Clinical Outcomes of Melanoma Patients; ; ; ; ; ; ; ;
in BMC Medical Genomics (2019), 12 (1)(132),
Impaired serine metabolism complements LRRK2-G2019S pathogenicity in PD patients; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Parkinsonism and Related Disorders (2019)
In search of definitions: Cancer-associated fibroblasts and their markers; ; ; ;
in International Journal of Cancer (2019)
Sphingolipid-mediated inflammatory signaling leading to autophagy inhibition converts erythropoiesis to myelopoiesis in human hematopoietic stem/progenitor cells; ; ; ; ; ; ; ;
in Cell Death and Differentiation (2019), 26(9), 17961812
Towards the Integration of Metabolic Network Modelling and Machine Learning for the Routine Analysis of High-Throughput Patient Data; ;
in Automated Reasoning for Systems Biology and Medicine (2019)
Towards the network-based prediction of repurposed drugs using patient-specific metabolic models.; ;
in EBioMedicine (2019)
Identifying and targeting cancer-specific metabolism with network-based drug target prediction; ; ; ; ; ;
in EBioMedicine (2019), 43(May 2019), 98-106
Hypoxia-induced Autophagy Drives Colorectal Cancer Initiation and Progression by Activating the PRKC/PKC-EZR (Ezrin) Pathway; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Autophagy (2019)
The Power of LC-MS Based Multiomics: Exploring Adipogenic Differentiation of Human Mesenchymal Stem/Stromal Cells; ; ; ; ; ; ;
in Molecules (2019)
Anodal tDCS modulates cortical activity and synchronization in Parkinson's disease depending on motor processing.; ; ; ; ; ; ;
in NeuroImage: Clinical (2019), 22
Connecting environmental exposure and neurodegeneration using cheminformatics and high resolution mass spectrometry: potential and challenges; ; ; ; ; ; ; ; ; ;
in Environmental Science. Processes and Impacts (2019)
Modulation of the IL-6 signaling pathway in liver cells by miRNAs targeting gp130, JAK1 and/or STAT3; ; ; ; ; ; ;
in Molecular Therapy: Nucleic Acids (2019), 16
Comparative effectiveness of antiepileptic drugs in juvenile myoclonic epilepsy; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Epilepsia Open (2019), 0(0),
Multilingual Validation of the First French Version of Munich Dysphagia Test-Parkinson's Disease (MDT-PD) in the Luxembourg Parkinson's Study; ; ; ; ; ;
in Frontiers in Neurology (2019)
Single-cell transcriptomics reveals multiple neuronal cell types in human midbrain-specific organoids; ; ; ; ; ; ;
E-print/Working paper (2019)
Modeling Parkinson’s disease in midbrain-like organoids; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in NPJ Parkinson's Disease (2019)
Cultivation and characterization of human midbrain organoids in sensor integrated microfluidic chips; ; ; ; ; ; ; ; ;
E-print/Working paper (2019)
Hypoxia- and MicroRNA-Induced Metabolic Reprogramming of Tumor-Initiating Cells; ; ; ;
in Cells (2019), 8(6),
Tumor suppressor miR-215 counteracts hypoxia-induced colon cancer stem cell activity; ; ; ; ; ; ; ; ; ; ;
in Cancer Letters (2019), 450
Hydrogeological effects on terrestrial gravity measurements; ; ; ; ; ; ; ; ;
Scientific Conference (2019, December 10)
Neural Stem Cells of Parkinson's Disease Patients Exhibit Aberrant Mitochondrial Morphology and Functionality; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Stem Cell Reports (2019)
Non-proteolytic ubiquitination of OTULIN regulates NF-κB signaling pathway; ; ; ; ; ; ; ; ; ; ;
in Journal of Molecular Cell Biology (2019)
Absence of TRIM32 Leads to Reduced GABAergic Interneuron Generation and Autism-like Behaviors in Mice via Suppressing mTOR Signaling; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Cerebral Cortex (2019)
2018
Transcriptional variations in the wider peritumoral tissue environment of pancreatic cancer; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in International Journal of Cancer (2018), 142(5), 10101021
Millifluidic culture improves human midbrain organoid vitality and differentiation; ; ; ; ; ; ; ;
in Lab on a Chip - Miniaturisation for Chemistry and Biology (2018)
3D Cultures of Parkinson's Disease‐Specific Dopaminergic Neurons for High Content Phenotyping and Drug Testing; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Advanced Science (2018)
Targeting prohibitins at the cell surface prevents Th17-mediated autoimmunity.; ; ; ; ; ; ; ; ; ;
in The EMBO journal (2018), 37(16),
A new ALK isoform transported by extracellular vesicles confers drug resistance to melanoma cells; ; ; ; ; ; ; ; ; ; ; ;
in Molecular Cancer (2018), (17:145),
Using Regularization to Infer Cell Line Specificity in Logical Network Models of Signaling Pathways.; ;
in Frontiers in physiology (2018), 9
Systemic network analysis identifies XIAP and IkappaBalpha as potential drug targets in TRAIL resistant BRAF mutated melanoma.; ; ; ; ; ; ; ; ; ;
in NPJ systems biology and applications (2018), 4
Reply: No evidence for rare TRAP1 mutations influencing the risk of idiopathic Parkinson’s disease; ; ; ; ;
in Brain : A Journal of Neurology (2018)
Temporal enhancer profiling of parallel lineages identifies AHR and GLIS1 as regulators of mesenchymal multipotency; ; ; ; ; ; ; ;
in Nucleic Acids Research (2018)
A Fast Multiple Kernel Learning Framework with Dimensionality Reduction; ; ;
in Giang; Nguyen; Tran, Quoc Vinh; Tran, Dang Hung (Eds.) Integrated Uncertainty in Knowledge Modelling and Decision Making (2018)
Epigenetically Regulated Chromosome 14q32 miRNA Cluster Induces Metastasis and Predicts Poor Prognosis in Lung Adenocarcinoma Patients.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Molecular Cancer Research (2018)
Cominatorial effect of dietary fibre and Lactobacillus rhamnosus in the context of colorectal cancer therapy; ; ; ; ; ; ; ; ; ;
Poster (2018, February 16)
Extraction and Analysis of RNA Isolated from Pure Bacteria-Derived Outer Membrane Vesicles; ; ; ; ; ; ;
in Arluison, Véronique; Valverde, Claudio Valverde (Eds.) Bacterial Regulatory RNA (2018)
Long-Term Effect of GPi-DBS in a Patient With Generalized Dystonia Due to GLUT1 Deficiency Syndrome.; ; ; ; ; ; ; ;
in Frontiers in Neurology (2018), 9
Mitochondrial Morphology, Function and Homeostasis Are Impaired by Expression of an N-terminal Calpain Cleavage Fragment of Ataxin-3.; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Frontiers in Molecular Neuroscience (2018), 11
In vivo Phenotyping of Human Parkinson’s Disease-Specific Stem Cells Carrying the LRRK2-G2019S Mutation Reveals Increased a-Synuclein Levels but Absence of Spreading; ; ;
in Opera Medica et Physiologica (2018)
Integrated time-resolved multi-omics for understanding microbial niche ecology; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
Poster (2018, August)
The Luxembourg Parkinson’s Study: A Comprehensive Approach for Stratification and Early Diagnosis; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Frontiers in Aging Neuroscience (2018), 10
Activity of translation regulator eukaryotic elongation factor-2 kinase is increased in Parkinson disease brain and its inhibition reduces alpha synuclein toxicity; ; ; ; ; ; ; ; ; ; ; ;
in Acta Neuropathologica Communications (2018)
THE PARKINSON’S DISEASE ASSOCIATED PINK1-PARKIN PATHWAY IN PATHOLOGY AND DEVELOPMENTDoctoral thesis (2018)
Large-scale validation of miRNAs by disease association, evolutionary conservation and pathway activity.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in RNA biology (2018)
Cytokine-mediated modulation of the hepatic miRNome: miR-146b-5p is an IL-6-inducible miRNA with multiple targets.; ; ; ; ; ; ; ; ; ; ;
in Journal of leukocyte biology (2018)
Insufficient Evidence for Pathogenicity of SNCA His50Gln (H50Q) in Parkinson's Disease; ;
in Neurobiology of Aging (2018)
Understanding the role of genetic variability in LRRK2 in Indian population; ; ;
in Movement Disorders (2018)
Management of Parkinson’s Disease 20 Years from Now: Towards Digital Health Pathways; ; ;
in Journal of Parkinson's Disease (2018)
The genetic architecture of mitochondrial dysfunction in Parkinson's Disease; ;
in Cell and Tissue Research (2018)
Cytostatic hydroxycoumarin OT52 induces ER/Golgi stress and STAT3 inhibition triggering non-canonical cell death and synergy with BH3 mimetics in lung cancer.; ; ; ; ; ; ; ; ; ; ; ;
in Cancer Letters (2018)
Behavioural outcomes of subthalamic stimulation and medical therapy versus medical therapy alone for Parkinson's disease with early motor complications (EARLYSTIM trial): secondary analysis of an open-label randomised trial.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in The Lancet. Neurology (2018), 17(3), 223-231
Hydroxycoumarin OT-55 kills CML cells alone or in synergy with imatinib or Synribo: Involvement of ER stress and DAMP release; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Cancer Letters (2018)
A complex of the ubiquitin ligase TRIM32 and the deubiquitinase USP7 balances the level of c-Myc ubiquitination and thereby determines neural stem cell fate specification; ; ; ; ; ; ;
in Cell Death and Differentiation (2018)
The FASTCORE Family: For the Fast Reconstruction of Compact Context-Specific Metabolic Networks Models;
in Fondi, Marco (Ed.) Metabolic Network Reconstruction and Modeling (2018)
The FASTCORE Family: For the Fast Reconstruction of Compact Context-Specific Metabolic Networks Models.;
in Methods in Molecular Biology (2018), (1716), 101-110
Advanced Good Cell Culture Practice for human primary, stem cell-derived and organoid models as well as microphysiological systems; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in ALTEX : Alternativen zu Tierexperimenten (2018)
Transcriptional and epigenetic mechanisms underlying astrocyte identity; ; ; ;
in Progress in Neurobiology (2018)
The intertwined metabolism during symbiotic nitrogen fixation elucidated by metabolic modelling; ; ; ; ;
in Scientific Reports (2018), 8
Nuclear localization and phosphorylation modulate pathological effects of Alpha-Synuclein; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Human Molecular Genetics (2018)
Annexin A1 regulates EGFR activity and alters EGFR-containing tumour-derived exosomes in head and neck cancers.; ; ; ; ; ;
in European Journal of Cancer (2018), 102
The PD-L1- and IL6-mediated dampening of the IL27/STAT1 anticancer responses are prevented by a-PD-L1 or a-IL6 antibodies; ; ; ; ; ; ; ; ; ; ; ; ;
in Journal of Leukocyte Biology (2018), 104
Phosphoprotein patterns predict trametinib responsiveness and optimal trametinib sensitisation strategies in melanoma.; ; ; ; ; ; ; ; ; ; ; ;
in Cell death and differentiation (2018)
Secretion of the Phosphorylated Form of S100A9 from Neutrophils Is Essential for the Proinflammatory Functions of Extracellular S100A8/A9.; ; ; ; ; ; ;
in Frontiers in immunology (2018), 9
Is Parkinson’s disease a neurodevelopmental disorder and will brain organoids help us to understand it?in Stem Cells and Development (2018)
"Stroma-induced phenotypic plasticity offers phenotype-specific targeting to improve melanoma treatment".; ; ; ; ; ; ; ; ; ;
in Cancer letters (2018)
Burden of cardiovascular disease across 29 countries and GPs’ decision to treat hypertension in oldest-old; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Scandinavian Journal of Primary Health Care (2018)
The microRNA-371~373 cluster represses colon cancer initiation and metastatic colonization by inhibiting the TGFBR2/ID1 signaling axis.; ; ; ; ; ; ; ; ; ; ; ;
in Cancer research (2018)
Thiazole- and selenazole-comprising high-affinity inhibitors possess bright microsecond-scale photoluminescence in complex with protein kinase CK2.; ; ; ;
in Bioorganic & medicinal chemistry (2018), 26(18), 5062-5068
2017
TTCA: an R package for the identification of differentially expressed genes in time course microarray data; ; ; ; ; ; ; ;
in BMC Bioinformatics (2017), 18(1), 33
FACS-Assisted CRISPR-Cas9 Genome Editing Facilitates Parkinson's Disease Modeling; ; ; ; ; ; ; ;
in Stem Cell Reports (2017)
Insights into ligand stimulation effects on gastro-intestinal stromal tumors signalling.; ; ; ; ; ;
in Cell Signal (2017)
Tumor-Initiating Cells: a criTICal review of isolation approaches and new challenges in targeting strategies; ; ;
in Molecular Cancer (2017)
NeuroChip, an updated version of the NeuroX genotyping platform to rapidly screen for variants associated with neurological diseases; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Neurobiology of Aging (2017)
Rare variant analysis of the PPMI dataset to uncover the complex genetic architecture of Parkinson’s disease; ;
in Movement Disorders (2017, June 02), 322(Supplement S2), 405
The multi-site docking protein Gab1 is constitutively phosphorylated independent from its recruitment to the plasma membrane in Jak2-V617Fpositive cells and mediates proliferation of human erythroleukaemia cells; ; ; ; ; ; ; ; ; ;
in Cellular Signalling (2017), 35
Analysis of primary microRNA loci from nascent transcriptomes reveals regulatory domains governed by chromatin architecture; ; ; ; ; ; ; ;
in Nucleic Acids Research (2017)
Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson's disease.; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Science (2017), 357(6357), 1255-1261
Functionally Convergent B Cell Receptor Sequences in Transgenic Rats Expressing a Human B Cell Repertoire in Response to Tetanus Toxoid and Measles Antigens.; ; ; ; ; ; ;
in Frontiers in immunology (2017), 8
ROS production induced by BRAF inhibitor treatment rewires metabolic processes affecting cell growth of melanoma cells; ; ; ;
in Molecular Cancer (2017), 8(june),
An evaluation of real-time troposphere estimation based on GNSS Precise Point Positioning; ; ; ;
in Journal of Geophysical Research: Atmospheres (2017), 122(5), 2779--2790
An Evaluaton of Real-Time Troposphere Products Based on mult-GNSS Precise Point Posi)oning; ; ; ;
Scientific Conference (2017, February 21)
Metformin reverses TRAP1 mutation-associated alterations in mitochondrial function in Parkinson's disease; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Brain : A Journal of Neurology (2017), 140(9), 2444-2459
Unravelling a p73-regulated network: The role of a novel p73-dependent target, MIR3158, in cancer cell migration and invasiveness; ; ; ; ; ; ; ;
in Cancer Letters (2017), 388
Stratifying cancer patients based on multiple kernel learning and dimensionality reduction; ;
in Giang, Thanh Trung; Nguyen, Thanh-Phuong; Tran (Eds.) 9th International Conference on Knowledge and Systems Engineering (KSE) (2017)
Parkinson’s Disease-Associated Mutant LRRK2-Mediated Inhibition of miRNA Activity is Antagonized by TRIM32; ; ; ;
in Molecular Neurobiology (2017)
Aberrant splicing of the tumor suppressor CYLD promotes the development of chronic lymphocytic leukemia via sustained NF-kappaB signaling.; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Leukemia (2017), 32(1), 72-82
Reverse Bayesian poisoning: How to use spam filters to manipulate online elections; ;
in Krimmer, L. (Ed.) Proc. 2nd International Joint Conference on Electronic Voting (2017)
Automated micro uidic cell culture of stem cell derived dopaminergic neurons in Parkinson's disease; ; ; ; ; ; ; ; ;
in bioRxiv (2017)
Impact of BRAF kinase inhibitors on the miRNomes and transcriptomes of melanoma cells; ; ; ;
in Biochimica et Biophysica Acta (2017)
Classification of advanced stages of Parkinson's disease: translation into stratified treatments.; ; ; ; ; ; ; ; ;
in Journal of Neural Transmission (2017), 124(124), 1015-1027
An Observational Study of the Effect of Levodopa-Carbidopa Intestinal Gel on Activities of Daily Living and Quality of Life in Advanced Parkinson's Disease Patients.; ; ; ; ; ; ; ; ; ; ;
in Advances in therapy (2017)
Loss of Myosin Vb in colorectal cancer is a strong prognostic factor for disease recurrence; ; ; ; ; ; ; ;
in British Journal of Cancer (2017), 117(11), 1689-1701
Resolving the Combinatorial Complexity of Smad Protein Complex Formation and Its Link to Gene Expression.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Cell Systems (2017)
Problematic Gaming Behaviour in Finnish Adolescents and Young Adults: Relation to Game Genres, Gaming Motives and Self-Awareness of Problematic Use; ; ; ;
in International Journal of Mental Health and Addiction (2017), 15
Targeting autophagy inhibits growth by enhancing NK cells infiltration in a CCL5-dependent manner; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Proceedings of the National Academy of Sciences of the United States of America (2017), 114((44)), 9271-9279
Derivation of Human Midbrain-Specific Organoids from Neuroepithelial Stem Cells; ; ; ; ; ; ; ; ; ; ; ; ;
in Stem Cell Reports (2017)
Embryonic development of selectively vulnerable neurons in Parkinson’s disease; ; ;
in NPJ Parkinson's Disease (2017), 3
Sodium butyrate rescues dopaminergic cells from alpha-synuclein-induced transcriptional deregulation and DNA damage; ;
in Human Molecular Genetics (2017), 26(12), 2231-2246
Cellular models as tools for the study of the role of alpha-synuclein in Parkinson's disease; ;
in Experimental Neurology (2017)
rapalogs can promote cancer cell stemness in vitro in a Galectin-1 and H-ras-dependent manner; ; ; ; ; ; ;
in Oncotarget (2017), Vol. 8((No. 27)), 44550-44566
Opposite feedback from mTORC1 to H-ras and K-ras4B downstream of SREBP1; ; ; ; ;
in Scientific Reports (2017)
CRISPR/CAS9 AND PIGGYBAC MEDIATED LRRK2-G2019S IN VITRO PARKINSON’S DISEASE MODELINGDoctoral thesis (2017)
Crosstalk between different family members: IL27 recapitulates IFNγ responses in HCC cells, but is inhibited by IL6-type cytokines; ; ; ; ; ; ; ; ; ; ;
in BBA Molecular Cell Research (2017)
Tailored Approaches in Drug Development and Diagnostics: From Molecular Design to Biological Model Systems; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Advanced Healthcare Materials (2017)
The PET and LIM1-2 domains of testin contribute to intramolecular and homodimeric interactions; ; ; ; ;
in PLoS ONE (2017)
Expanding the Interactome of TES by Exploiting TES Modules with Different Subcellular Localizations; ; ; ; ; ; ; ;
in Journal of Proteome Research (2017), doi: 10.1021/acs.jproteome.7b00034
Angiotensin II regulates phosphorylation of actin-associated proteins in human podocytes; ; ; ; ; ; ;
in FASEB Journal (2017)
Effects of Subthalamic and Nigral Stimulation on Gait Kinematics in Parkinson's Disease.; ; ; ; ; ; ; ;
in Frontiers in Neurology (2017), 8
Involvement of the cerebellum in Parkinson disease and dementia with Lewy bodies.; ; ; ; ; ; ;
in Annals of neurology (2017), 81(6), 898-903
Regulated in development and DNA damage responses 1 (REDD1) links stress with IL-1β-mediated familial Mediterranean fever attack through autophagy-driven neutrophil extracellular traps; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Journal of Allergy and Clinical Immunology (2017)
Model Based Targeting of IL-6-Induced Inflammatory Responses in Cultured Primary Hepatocytes to Improve Application of the JAK Inhibitor Ruxolitinib.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Frontiers in physiology (2017), 8
Nurr1:RXRα heterodimer activation as monotherapy for Parkinson’s disease; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Proceedings of the National Academy of Sciences of the United States of America (2017)
The GBAP1 pseudogene acts as a ceRNA for the glucocerebrosidase gene GBA by sponging miR-22-3p.; ; ; ; ; ; ; ; ; ;
in Scientific reports (2017), 7(1), 12702
From meta-genomics to causality: Understanding the role of colon cancer-associated bacteria in colorectal cancer; ; ;
Poster (2017, February 05)
Human induced pluripotent stem cell-derived neuronal progenitors are a suitable and effective drug discovery model for neurological mtDNA disorders; ;
in Stem Cell Investigation (2017)
Evaluation of the interaction between LRRK2 and PARK16 loci in determining risk of Parkinson's disease: analysis of a large multicenter study.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Neurobiology of Aging (2017), 49
On definition and inference of nonlinear Boolean dynamic networks; ; ;
in On definition and inference of nonlinear Boolean dynamic networks (2017, December)
Linear Dynamic Network Reconstruction from Heterogeneous Datasets; ; ;
in Linear Dynamic Network Reconstruction from Heterogeneous Datasets (2017, July)
2016
Thermodynamically constrained averaging theory for cancer growth modelling; ; ;
in IFAC-PapersOnLine (2016), 49(26), 289-294
Alkyl and aryl sulfonyl p-pyridine ethanone oximes are efficient DNA photo-cleavage agents; ; ; ; ; ;
in Journal of Photochemistry and Photobiology B: Biology (2016), 158
Data on quantification of signaling pathways activated by KIT and PDGFRA mutants.; ; ; ; ; ;
in Data in Brief (2016), (9), 828-838
What Do We Learn from Spheroid Culture Systems? Insights from Tumorspheres Derived from Primary Colon Cancer Tissue.; ; ; ; ; ;
in PLoS ONE (2016), 11
The role of HIF-1 in oncostatin M-dependent metabolic reprogramming of hepatic cells.; ; ; ; ; ; ;
in Cancer and Metabolism (2016), 4
Enteric neurons from Parkinson's disease patients display ex vivo aberrations in mitochondrial structure.; ; ; ; ; ; ; ; ; ;
in Scientific reports (2016), 6
Prox1 is required for oligodendrocyte cell identity in adult neural stem cells of the subventricular zone; ; ; ; ; ; ; ; ; ; ; ;
in Stem Cells (2016)
Systems biology integration of proteomic data in rodent models of depression reveals involvement of the immune response and glutamatergic signalling; ;
in Proteomics. Clinical Applications (2016)
Mitochondrial Defects and Neurodegeneration in Mice Overexpressing Wild Type or G399S Mutant HtrA2; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Human Molecular Genetics (2016), 25(3), 459-71
Variant PNPLA3 increases the HCC risk: prospective study in patients treated at the Saarland University Medical Center; ; ; ;
in Zeitschrift für Gastroenterologie (2016), 54
Impact of HIV Perception on the on the Quality of Life of People Living with HIV - Mediation Effects of Flexible and Tenacious Goal Pursuit; ;
in Psychology, Health and Medicine (2016), 22
Transferring intercellular signals and traits between cancer cells: extracellular vesicles as "homing pigeons"; ; ;
in Cell Communication and Signaling (2016), 14(1), 13
Cost-Effectiveness of Neurostimulation in Parkinson's Disease With Early Motor Complications; ; ; ; ; ; ; ; ; ; ;
in Movement Disorders (2016), 31(8), 1183-1191
Tripartite Containing Motif 32 Modulates Proliferation of Human Neural Precursor Cells in HIV-1 Neurodegeneration; ; ; ; ; ;
in Cell Death and Differentiation (2016)
6-hydroxydopamine-induced Parkinson's disease-like degeneration generates acute micro- and astrogliosis in the nigrostriatal system but no Bioluminescence Imaging detectable alteration in adult neurogenesis; ; ; ; ; ; ; ; ; ; ; ; ;
in European Journal of Neuroscience (2016)
D'un passage à l'autre, analogies entre l'accouchement et la mortin Soins. Pédiatrie, Puériculture (2016)
A study of the molecular mechanisms underlying the response of human colorectal adenomacarcinoma enterocytes to prebiotics and probiotics; ; ; ; ; ; ; ; ; ;
Poster (2016, June)
Optimum stochastic modeling for GNSS tropospheric delay estimation in real-time; ; ; ;
in GPS Solutions (2016)
Prodromal Markers in Parkinson's Disease: Limitations in Longitudinal Studies and Lessons Learned.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Frontiers in aging neuroscience (2016), 8
The TAT-RasGAP317-326 anti-cancer peptide can kill in a caspase-, apoptosis-, and necroptosis-independent manner; ; ; ; ; ; ; ; ;
in Oncotarget (2016), 7(39),
Utilization of stem cells to model Parkinson's disease – current state and future challenges;
in Future Neurology (2016)
Alpha-Synuclein Proteins Promote Pro-Inflammatory Cascades in Microglia: Stronger Effects of the A53T Mutant.; ; ; ; ; ; ; ;
in PLoS ONE (2016)
Context-specific flow through the MEK/ERK module produces cell- and ligand-specific patterns of ERK single and double phosphorylation.; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Science signaling (2016), 9(413), 13
miRNAs in ancient tissue specimens of the Tyrolean Iceman; ; ; ; ; ; ; ; ; ; ; ;
in Molecular Biology and Evolution (2016), 34(4), 793-801
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition); ;
in Autophagy (2016), 12(1), 1-222
Advanced stages of PD: interventional therapies and related patient-centered care; ; ; ; ; ; ;
in Journal of Neural Transmission (2016)
Aiming for Study Comparability in Parkinson's Disease: Proposal for a Modular Set of Biomarker Assessments to be Used in Longitudinal Studies.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Frontiers in aging neuroscience (2016), 8
SOCS2: physiological and pathological functions.;
in Frontiers in Bioscience (Elite Edition) (2016), 8
L-plastin Ser5 phosphorylation in breast cancer cells and in vitro is mediated by RSK downstream of the ERK/MAPK pathway; ; ; ; ; ; ; ;
in FASEB Journal (2016)
Tragbare und aktiv vom Parkinson-Patienten genutzte Technologie im hauslichen Umfeld: Was bringt die Zukunft?; ; ; ; ; ;
in Fortschritte der Neurologie-Psychiatrie (2016), 84 Suppl 1
Combining chemical and genetic approaches for development of responsive FRET-based sensor systems for protein kinases; ;
in Biophysical Chemistry (2016), 211
Dissecting functions of the N-terminal domain and GAS-site recognition in STAT3; ; ; ; ;
in Cellular Signalling (2016), 28(8), 810-25
Constraint based modelling going multicellular; ;
in Frontiers in Molecular Biosciences (2016), 3(3),
Downregulation of the TGF-beta pseudoreceptor BAMBI in non-small cell lung cancer enhances TGF-beta signaling and invasion.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Cancer research (2016)
Loss of DJ-1 impairs antioxidant response by altered glutamine and serine metabolism; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Neurobiology of Disease (2016), 89
ΔNp63α expression induces loss of cell adhesion in triple-negative breast cancer cells; ; ; ; ; ; ; ; ; ; ;
in BMC Cancer (2016), 16(1),
A generalized gene regulatory network model of stem cell differentiation for predicting lineage specifiers; ; ; ;
in Stem Cell Reports (2016)
Benchmarking procedures for high-throughput context specific reconstruction algorithms; ;
in Frontiers in Physiology (2016)
Expression of the Parkinson’s Disease-Associated Gene Alpha-Synuclein is Regulated by the Neuronal Cell Fate Determinant TRIM32; ; ; ; ; ; ;
in Molecular Neurobiology (2016)
“Melanomics”: analysis and integration of whole genomes, transcriptomes and miRNomes of primary melanoma patients; ; ; ; ; ; ; ;
in European Journal of Cancer (2016), 61(Suppl.1), 32
Environmental enrichment and physical exercise revert behavioral and electrophysiological impairments caused by reduced adult neurogenesis; ; ; ; ; ; ; ; ;
in Hippocampus (2016)
Cortical correlates of susceptibility to upper limb freezing in Parkinson's disease.; ; ; ; ; ; ;
in Clinical Neurophysiology (2016), 127(6), 2386-93
Neuromuscular correlates of subthalamic stimulation and upper limb freezing in Parkinson's disease.; ; ; ; ; ; ; ; ; ; ;
in Clinical Neurophysiology (2016)
Cyclooxygenase-2 contributes to the selective induction of cell death by the endocannabinoid 2-arachidonoyl glycerol in hepatic stellate cells.; ; ; ; ; ; ; ;
in Biochemical and biophysical research communications (2016), 470(3), 678-84
Multi-GNSS Benefits to Real-Time and Long-Term Monitoring Applications; ; ; ; ; ; ;
Scientific Conference (2016, July 30)
An Iterative Projection method for Synchronization of Invertible Matrices Over Graphs; ; ;
in 22nd International Symposium on Mathematical Theory of Networks and Systems (2016)
A Probabilistic Boolean Network Approach for the Analysis of Cancer-Specific Signalling: A Case Study of Deregulated PDGF Signalling in GIST.; ; ; ;
in PloS one (2016), 11(5), 0156223
Hypoxia-responsive miR-210 promotes self-renewal capacity of colon tumor-initiating cells by repressing ISCU and by inducing lactate production; ; ; ; ; ; ; ; ; ; ;
in Oncotarget (2016), 7(40), 97-114
miR-661 expression in SNAI1-induced epithelial to mesenchymal transition contributes to breast cancer cell invasion by targeting Nectin-1 and StarD10 messengers; ; ; ; ; ; ; ; ; ;
in Oncogene (2016), 35(5), 670
Synthesis, characterization and in vivo evaluation of a magnetic cisplatin delivery nanosystem based on PMAA-graft-PEG copolymers; ; ; ; ; ; ; ; ; ; ; ;
in Journal of Controlled Release (2016), 243
Alpha-synuclein gene variants may predict neurostimulation outcome.; ; ; ; ; ; ; ; ;
in Movement Disorders (2016)
Inverse Problems for Matrix Exponential in System Identification: System Aliasing; ;
in 22nd International Symposium on Mathematical Theory of Networks and Systems (2016)
2015
Insight into metabolic pathways of the potential biofuel producer, Paenibacillus polymyxa ICGEB2008; ; ;
in Biotechnology for Biofuels (2015), 8(159),
Goals in Nutrition Science 2015–2020; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Frontiers in Nutrition (2015), 2(26),
Constitutive activation of oncogenic PDGFRalpha-mutant proteins occurring in GIST patients induces receptor mislocalisation and alters PDGFRalpha signalling characteristics.; ; ; ; ; ; ; ; ; ; ;
in Cell Communication and Signaling (2015), 13
TRIM32 modulates pluripotency entry and exit by directly regulating Oct4 stability; ; ; ; ; ; ; ; ;
in Scientific Reports (2015)
Circulating microRNAs as candidate biomarkers for the surveillance of melanoma patients; ;
in EBioMedicine (2015)
Transcriptomic analyses of primary astrocytes under TNFα treatment; ; ; ; ; ;
in Genomics Data (2015), 7
TRIM32 Senses and Restricts Influenza A Virus by Ubiquitination of PB1 Polymerase; ; ; ; ;
in PLoS Pathogens (2015)
Short- and long-term outcome of chronic pallidal neurostimulation in monogenic isolated dystonia; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Neurology (2015), 84(9), 895-903
Low-bias phosphopeptide enrichment from scarce samples using plastic antibodies; ; ; ; ; ; ; ; ; ; ; ;
in Scientific reports (2015), 5
Constitutive expression of tdTomato protein as a cytotoxicity and proliferation marker for space radiation biology; ; ; ; ; ;
in Life Sciences in Space Research (2015), 4
Effects of Endocrine Disruptor Compounds, Alone or in Combination, on Human Macrophage-Like THP-1 Cell Response; ; ; ; ; ; ;
in PLoS ONE (2015), 10(7), 0131428
Role of Calprotectin as a Modulator of the IL27-Mediated Proinflammatory Effect on Endothelial Cells; ; ; ; ; ;
in Mediators of Inflammation (2015), 2015
Do Genome-scale Models Need Exact Solvers or Clearer Standards?; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Molecular Systems Biology (2015), 11(10), 1
Insights from ENCODE on Missing Proteins: Why beta-Defensin Expression Is Scarcely Detected.; ; ; ; ; ; ; ; ; ; ; ;
in Journal of proteome research (2015), 14(9), 3635-44
Inflammation Promotes a Conversion of Astrocytes into Neural Progenitor Cells via NF-κB Activation; ; ; ; ; ; ; ;
in Molecular Neurobiology (2015), 53(8), 5041-5055
Cell type-selective disease-association of genes under high regulatory load; ; ; ;
in Nucleic Acids Research (2015), 43(18), 8839-8855
Inflammation Promotes a Conversion of Astrocytes into Neural Progenitor Cells via NF-κB Activationin Molecular Neurobiology (2015)
NLRP3 Inflammasome Is Expressed and Functional in Mouse Brain Microglia but Not in Astrocytes.; ; ; ; ; ; ; ;
in PLoS ONE (2015), 10(6),
The oncogenic FIP1L1-PDGFRalpha fusion protein displays skewed signaling properties compared to its wild-type PDGFRalpha counterpart.; ; ; ; ; ; ; ; ; ; ;
in JAK-STAT (2015), 4(1), 1062596
Delineating the Tes Interaction Site in Zyxin and Studying Cellular Effects of Its Disruption; ; ; ; ; ; ; ; ; ;
in PLoS ONE (2015)
MiR-128 represses L1 retrotransposition by binding directly to L1 RNA; ; ; ; ; ;
in Nature Structural and Molecular Biology (2015), 22(10), 824-831
The neural stem cell fate determinant TRIM32 regulates complex behavioral traits; ; ; ; ; ; ;
in Frontiers in Cellular Neuroscience (2015)
Diversity of key players in the microbial ecosystems of the human body.; ; ; ; ; ;
in Scientific reports (2015), 5
Changes in the human gastrointestinal microbiome during cancer treatments; ; ; ; ; ; ; ;
Poster (2015, March)
Assessing Transcription Regulatory Elements To Evaluate the Expression Status of Missing Protein Genes on Chromosomes 11 and 19.; ; ; ; ; ; ; ; ; ; ; ;
in Journal of proteome research (2015), 14(12), 4967-75
Neural stem cells in Parkinson’s disease: a role for neurogenesis defects in onset and progression; ; ;
in Cellular and Molecular Life Sciences (2015)
Inhibition of αIIbβ3 Ligand Binding by an αIIb Peptide that Clasps the Hybrid Domain to the βI Domain of β3; ; ; ; ; ; ; ; ; ;
in PLoS ONE (2015)
Methods in Neuroepidemiology Characterization of European Longitudinal Cohort Studies in Parkinson's Disease - Report of the JPND Working Group BioLoC-PD; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Neuroepidemiology (2015), 45(4), 282-297
Hind limb unloading, a model of spaceflight conditions, leads to decreased B lymphopoiesis similar to aging; ; ; ; ; ; ; ; ; ; ;
in FASEB Journal (2015), 29(2), 455-63
Initiation and dose optimization for levodopa-carbidopa intestinal gel: Insights from phase 3 clinical trials; ; ; ; ; ; ; ;
in Parkinsonism and Related Disorders (2015), 21(7), 742-748
Differentiation of neuroepithelial stem cells into functional dopaminergic neurons in 3D microfluidic cell culture; ; ; ; ; ; ; ;
in Lab on a Chip - Miniaturisation for Chemistry and Biology (2015), 15
Multiscale model of dynamic neuromodulation integrating neuropeptide-induced signaling pathway activity with membrane electrophysiology.; ; ; ; ;
in Biophysical journal (2015), 108(1), 211-23
FRET-based screening assay using small-molecule photoluminescent probes in lysate of cells overexpressing RFP-fused protein kinases; ; ; ; ; ; ; ;
in Analytical Biochemistry (2015)
Comparison of a healthy miRNome with melanoma patient miRNomes: are microRNAs suitable serum biomarkers for cancer?; ; ; ; ; ; ; ;
in Oncotarget (2015), 6(14), 12110-27
The NG2 Proteoglycan Protects Oligodendrocyte Precursor Cells against Oxidative Stress via Interaction with OMI/HtrA2; ; ; ; ; ; ; ; ; ; ; ;
in PLoS ONE (2015), 10(9), 0137311
Regulation of Neutrophil Degranulation and Cytokine Secretion: A Novel Model Approach Based on Linear Fitting; ; ; ; ;
in Journal of Immunology Research (2015), 2015
Novel drug target identification for the treatment of dementia using multi-relational association mining; ;
in Scientific Reports (2015), 5
The RNA helicase DDX6 regulates cell-fate specification in neural stem cells via miRNAs; ; ; ; ;
in Nucleic Acids Research (2015)
The COMT Val/Met polymorphism modulates effects of tDCS on response inhibition; ; ; ;
in Brain stimulation (2015), 8(2), 283-288
Collective physician perspectives on non-oral medication approaches for the management of clinically relevant unresolved issues in Parkinson's disease: Consensus from an international survey and discussion program; ; ; ; ; ; ; ; ; ; ; ; ;
in Parkinsonism and Related Disorders (2015)
TREM2 R47H variant and risk of essential tremor: a cross-sectional international multicenter study; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Parkinsonism and Related Disorders (2015), 21(3), 306-309
Integrated metabolic modelling reveals cell-type specific epigenetic control points of the macrophage metabolic network; ; ; ; ; ; ; ;
in BMC Genomics (2015), 16(809),
Rapid and robust generation of long-term self-renewing human neural stem cells with the ability to generate mature astroglia; ; ; ; ; ; ; ; ;
in Scientific Reports (2015), 5
Towards improved genome-scale metabolic network reconstructions: unification, transcript specificity and beyond.; ;
in Briefings in bioinformatics (2015)
Clinically meaningful parameters of progression and long-term outcome of Parkinson disease: An international consensus statement; ; ; ; ; ; ; ; ; ; ; ;
in Parkinsonism and Related Disorders (2015), 21(7), 675-682
A draft network of ligand–receptor-mediated multicellular signalling in human; ; ; ; ; ; ; ; ; ;
in Nature Communications (2015), 6
Comparative integrated omics: identification of key functionalities in microbial community-wide metabolic networks; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Biofilms and Microbiomes (2015), 1(15007),
IL-1beta mediates MMP secretion and IL-1beta neosynthesis via upregulation of p22phox and NOX4 activity in human articular chondrocytes; ; ; ; ; ; ; ; ;
in Osteoarthritis and Cartilage (2015), 23(11), 1972-1980
CK2 phosphorylation of C/EBPdelta regulates its transcription factor activity.; ; ;
in The international journal of biochemistry & cell biology (2015), 61
ID: 194: Role of microRNAs in signal transduction pathways of the inflammatory cytokine Interleukin-6: Relevance for liver diseases; ; ; ; ; ; ; ; ;
in Cytokine (2015), 76(1), 99-
Synthesis of folate- pegylated polyester nanoparticles encapsulating ixabepilone for targeting folate receptor overexpressing breast cancer cells; ; ; ; ; ; ; ; ;
in Journal of Materials Science (2015), 26(12), 1-14
Studying Signal Transduction Networks with a Probabilistic Boolean Network ApproachDoctoral thesis (2015)
Development of Alternative Proteomics Methods for Lung Cancer Biomarker EvaluationDoctoral thesis (2015)
A microtubule-independent role of p150glued in secretory cargo concentration at endoplasmic reticulum exit sites; ; ;
in Journal of Cell Science (2015), 128(22), 4160-4170
Large-scale assessment of polyglutamine repeat expansions in Parkinson disease; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Neurology (2015), 85(15), 1283-92
Subthalamic stimulation modulates cortical motor network activity and synchronization in Parkinson's disease; ; ; ; ; ; ; ; ; ;
in Brain : a journal of neurology (2015), 138(Pt 3), 679-93
Long-term outcome of deep brain stimulation in fragile X-associated tremor/ataxia syndrome; ; ; ; ; ; ; ; ;
in Parkinsonism and Related Disorders (2015), 21(3), 310-313
2014
Mitochondrial proteolytic stress induced by loss of mortalin function is rescued by Parkin and PINK1.; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Cell Death and Disease (2014), 5
Overexpression of synphilin-1 promotes clearance of soluble and misfolded alpha-synuclein without restoring the motor phenotype in aged A30P transgenic mice.; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Human molecular genetics (2014), 23(3), 767-81
Alpha-synuclein repeat variants and survival in Parkinson's disease.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Movement Disorders (2014)
A mathematical model of metabolism and regulation provides a systems-level view of how Escherichia coli responds to oxygen; ; ; ; ; ; ; ; ; ; ;
in Frontiers in Microbiology (2014), 5(124),
Gene regulatory network analysis reveals differences in site-specific cell fate determination in mammalian brain; ; ;
in Frontiers in Cellular Neuroscience (2014)
ChIP-seq profiling of the active chromatin marker H3K4me3 and PPARγ, CEBPα and LXR target genes in human SGBS adipocytes; ; ; ; ;
in Genomics Data (2014), 2
Molecular cloning and expression analysis of Pleurodeles waltl complement component C3 under normal physiological conditions and environmental stresses; ; ; ;
in Developmental and Comparative Immunology (2014), 46(2), 180-185
Origin-Dependent Neural Cell Identities in Differentiated Human iPSCs In Vitro and after Transplantation into the Mouse Brain; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Cell Reports (2014)
Protective effect of LRRK2 p.R1398H on risk of Parkinson's disease is independent of MAPT and SNCA variants.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Neurobiology of Aging (2014), 35(1), 2665-14
Kapitel 34: Mediatoren; ; ; ;
in Heinrich, Peter C.; Müller, Matthias; Graeve, Lutz (Eds.) Biochemie und Pathobiochemie (2014)
Kapitel 35: Rezeptoren und ihre Signaltransduktion; ; ; ;
in Heinrich, Peter C.; Müller, Matthias; Graeve, Lutz (Eds.) Biochemie und Pathobiochemie (2014)
Induced Neural Stem Cells Achieve Long-Term Survival and Functional Integration in the Adult Mouse Brain; ; ; ; ; ; ; ; ; ;
in Stem Cell Reports (2014)
Basic Regulatory Principles of Escherichia coli's Electron Transport Chain for Varying Oxygen Conditions.; ; ; ; ; ; ; ;
in PloS one (2014), 9(9), 107640
EIF4G1 is neither a strong nor a common risk factor for Parkinson's disease: evidence from large European cohorts; ; ; ; ; ; ; ; ; ; ;
in Journal of medical genetics (2014), 0
Comparison of beamformers for EEG source signal reconstruction; ; ; ; ;
in Biomedical Signal Processing and Control (2014), 14
Identification of New IkappaBalpha Complexes by an Iterative Experimental and Mathematical Modeling Approach.; ; ;
in PLoS computational biology (2014), 10(3), 1003528
MMP13 mutations are the cause of recessive metaphyseal dysplasia, Spahr type; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in American Journal of Medical Genetics. Part A (2014), 164(5), 1175-1179
Identification of SOCS2 and SOCS6 as biomarkers in human colorectal cancer.; ; ; ; ; ; ; ; ; ; ;
in British journal of cancer (2014), 111(4), 726-35
Combinatorial regulation of lipoprotein lipase by microRNAs during mouse adipogenesis; ; ; ; ;
in RNA Biology (2014), 11(1), 76-91
An essential role of syntaxin 3 protein for granule exocytosis and secretion of IL-1α, IL-1β, IL-12b, and CCL4 from differentiated HL-60 cells; ; ; ; ; ; ;
in Journal of Leukocyte Biology (2014), 97
From genome-wide association studies to next-generation sequencing: lessons from the past and planning for the future.; ;
in JAMA neurology (2014), 71(1), 5-6
Mutant COQ2 in multiple-system atrophy.; ;
in The New England journal of medicine (2014), 371(1), 80-1
Water Chemistry and Hydrometeorology in a Glacierized Catchment in the Polar Urals, Russia; ; ; ; ;
in Journal of Mountain Science (2014), 11(5), 1097-1111
Global investigation and meta-analysis of the C9orf72 (G4C2)n repeat in Parkinson disease.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Neurology (2014)
optPBN: An Optimisation Toolbox for Probabilistic Boolean Networks; ; ; ;
in PLoS ONE (2014), 9(7), 980011-15
Fast reconstruction of compact context-specific metabolic network models; ;
in PLoS Computational Biology (2014), 10(1), 1003424
The subthalamic nucleus modulates the early phase of probabilistic classification learning.; ; ; ; ; ;
in Experimental brain research (2014), 232(7), 2255-62
2013
The Parkinson's Disease-Associated LRRK2 Mutation R1441G Inhibits Neuronal Differentiation of Neural Stem Cells.; ; ; ; ; ;
in Stem Cells and Development (2013)
Tocopherol derivative TFA-12 promotes myelin repair in experimental models of multiple sclerosis.; ;
in Journal of Neuroscience (2013), 33(28), 11633-42
New Insights into the Regulation of Neutrophil NADPH Oxidase Activity in the Phagosome: A Focus on the Role of Lipid and Ca(2+) Signaling; ;
in Antioxidants & Redox Signaling (2013), 18(6), 661-676
Lessons from the Hvidoere International Study Group on childhood diabetes: Be dogmatic about outcome and flexible in approach; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Pediatric Diabetes (2013), 14(7), 473-480
On different aspects of network analysis in systems biology; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Systems Biology (2013), 1
Predicting missing expression values in gene regulatory networks using a discrete logic modeling optimization guided by network stable states; ; ; ;
in Nucleic Acids Research (2013), 41(1), 8
Innate and adaptive effects of inflammasomes on T cell responses; ;
in Current Opinion in Immunology (2013), 25(3), 359-365
The recruitment of p47 and Rac2G12V at the phagosome is transient and phosphatidylserine dependent.; ; ; ; ; ; ; ; ;
in Biology of the Cell (2013)
JAK2 mutants (e.g., JAK2V617F) and their importance as drug targets in myeloproliferative neoplasms; ;
in JAK-STAT (2013), 2(3), 25025
Cooperative effects of Janus and Aurora kinase inhibition by CEP701 in cells expressing Jak2V617F; ; ; ; ; ; ; ;
in Journal of Cellular and Molecular Medicine (2013), 17(2), 265-276
Integrated analysis of transcript-level regulation of metabolism reveals disease-relevant nodes of the human metabolic network; ; ; ; ;
in Nucleic Acids Research (2013)
Regulatory feedback loop between TP73 and TRIM32.; ; ; ; ; ; ; ;
in Cell Death and Disease (2013), 4
A novel heterozygous OPA3 mutation located in the mitochondrial target sequence results in altered steady-state levels and fragmented mitochondrial network.; ; ; ; ; ; ; ; ; ; ;
in Journal of medical genetics (2013), 50(12), 848-58
Co-immunoprecipitation protocol to investigate cytokine receptor-associated proteins, e.g., Janus kinases or other associated signaling proteins.;
in Methods in Molecular Biology (2013), 967
Detection of activated STAT species using electrophoretic mobility shift assay (EMSA) and potential pitfalls arising from the use of detergents.;
in Methods in Molecular Biology (2013), 967
Population-specific frequencies for LRRK2 susceptibility variants in the Genetic Epidemiology of Parkinson's Disease (GEO-PD) Consortium.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Movement Disorders (2013), 28(12), 1740-4
Meta-omic Analyses of the Microbiome in a Family Study of Diabetes Mellitus; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
Poster (2013, October)
TRIM32-dependent transcription in adult neural progenitor cells regulates neuronal differentiation; ; ; ; ; ; ;
in Cell Death and Disease (2013)
Gravity changes during animal development affect IgM heavy-chain transcription and probably lymphopoiesis; ; ; ; ; ; ;
in FASEB Journal (2013), 27(1), 333-341
De novo mutations in hereditary diffuse leukoencephalopathy with axonal spheroids (HDLS).; ; ; ; ; ; ; ;
in Neurology (2013), 81(23), 2039-44
Broad RNA interference-mediated antiviral immunity and virus-specific inducible responses in Drosophila; ; ; ; ; ; ; ; ; ; ; ;
in Journal of Immunology (2013), 190(2), 650-658
Tripolin A, a Novel Small-Molecule Inhibitor of Aurora A Kinase, Reveals New Regulation of HURP’s Distribution on Microtubules; ; ; ; ; ; ; ;
in PLoS ONE (2013), 8(3),
CHD4 Is a RanGTP-Dependent MAP that Stabilizes Microtubules and Regulates Bipolar Spindle Formation; ; ; ; ; ;
in Current Biology (2013), 23(24), 2443-2451
Functions, divergence and clinical value of TAp73 isoforms in cancer.; ; ; ;
in Cancer and Metastasis Reviews (2013), 32(3-4), 511534
New Target Genes of MITF-Induced microRNA-211 Contribute to Melanoma Cell Invasion; ; ; ; ;
in PLoS ONE (2013), 8(9),
A balancing act: Parameter estimation for biological models with steady-state measurements; ; ;
in Proceedings of 11th Conference on Computational Methods in Systems Biology (CMSB'13) (2013)
Mathematical modelling of the Platelet-Derived Growth Factor (PDGF) signalling pathway; ; ;
in Proceedings of 4th Workshop on Computational Models for Cell Processes (CompMod'13) (2013)
Interplay of microRNAs, transcription factors and target genes: Linking dynamic expression changes to function; ; ; ; ; ;
in Nucleic Acids Research (2013), 41(5), 2817-2831
Oligodendrocyte lineage cells contribute unique features to rett syndrome neuropathology; ; ; ; ; ;
in Journal of Neuroscience (2013), 33(48), 18764-18774
Quinone compounds regulate the level of ROS production by the NADPH oxidase Nox4; ; ; ; ; ; ; ;
in Biochemical Pharmacology (2013), 85(11), 1644-1654
A systemic transcriptome analysis reveals the regulation of neural stem cell maintenance by an E2F1-miRNA feedback loop.; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Nucleic Acids Research (2013), 41(6), 3699-712
Gonadotropin-releasing hormone neuropeptides and receptor in human breast cancer: Correlation to poor prognosis parameters; ; ; ; ; ; ; ; ; ; ; ; ;
in Peptides (2013), 42
Effects of transcranial direct current stimulation (tDCS) on executive functions: influence of COMT Val/Met polymorphism.; ; ; ; ;
in Cortex: A Journal Devoted to the Study of the Nervous System and Behavior (2013), 49(7), 1801-7
Derivation and expansion using only small molecules of human neural progenitors for neurodegenerative disease modeling.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in PLoS ONE (2013), 8(3), 59252
Genetic correction of a LRRK2 mutation in human iPSCs links parkinsonian neurodegeneration to ERK-dependent changes in gene expression.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Cell Stem Cell (2013), 12(3), 354-67
Novel SLC9A6 mutations in two families with Christianson syndrome.; ; ; ; ; ; ; ; ;
in Clinical genetics (2013), 83(6), 596-7
Modulation of Pleurodeles waltl DNA Polymerase mu Expression by Extreme Conditions Encountered during Spaceflight; ; ;
in PLoS ONE (2013), 8(7),
Neurostimulation for Parkinson's disease with early motor complications.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in The New England journal of medicine (2013), 368(7), 610-22
Excemplify: a flexible template based solution, parsing and managing data in spreadsheets for experimentalists.; ; ; ; ; ; ; ;
in Journal of integrative bioinformatics (2013), 10(2), 220
De novo loss-of-function mutations in CHD2 cause a fever-sensitive myoclonic epileptic encephalopathy sharing features with dravet syndrome; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in American Journal of Human Genetics (2013), 93(5), 967-975
Recent development and biomedical applications of probabilistic Boolean networks; ; ; ; ;
in Cell Communication and Signaling (2013), 11(46),
FAM111A mutations result in hypoparathyroidism and impaired skeletal development; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in American Journal of Human Genetics (2013), 92(6), 990-995
Fast reconstruction of compact context-specific metabolic network models; ;
E-print/Working paper (2013)
Fastcore: An algorithm for fast reconstruction of context-specific metabolic network models; ;
in Proc. 8th BeNeLux Bioinformatics Conference (2013)
Nigral stimulation for resistant axial motor impairment in Parkinson's disease? A randomized controlled trial.; ; ; ; ; ; ; ; ; ;
in Brain : a journal of neurology (2013), 136(Pt 7), 2098-108
JAK2-V617F-induced MAPK activity is regulated by PI3K and acts synergistically with PI3K on the proliferation of JAK2-V617F-positive cells.; ; ; ; ; ; ; ;
in JAK-STAT (2013), 2(3), 24574
CNP/cGMP signaling regulates axon branching and growth by modulating microtubule polymerization; ; ; ; ; ;
in Developmental Neurobiology (2013), 73(9), 673-687
Knockdown of Hsc70-5/mortalin induces loss of synaptic mitochondria in a Drosophila Parkinson's disease model.; ; ; ; ; ; ; ; ;
in PloS one (2013), 8(12), 83714
2012
Guidelines for the use and interpretation of assays for monitoring autophagy.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; et al
in Autophagy (2012), 8(4), 445-544
Targeting autophagy and glycolysis: in vitro and in vivo studies in GlioblastomaDoctoral thesis (2012)
Molecular interface of S100A8 with cytochrome b558 and NADPH oxidase activation; ; ; ; ; ;
in PLoS ONE (2012), 7(7),
Role of the Neutrophil NADPH Oxidase and S100A8/A9 in the Pathophysiology of Chronic Inflammation; ;
in Khatami, Mahin (Ed.) Inflammation, Chronic Diseases and Cancer - Cell and Molecular Biology, Immunology and Clinical Bases (2012)
The use of primary human fibroblasts for monitoring mitochondrial phenotypes in the field of Parkinson's disease.;
in Journal of Visualized Experiments (2012), (68),
ETV5 cooperates with LPP as a sensor of extracellular signals and promotes EMT in endometrial carcinomas.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Oncogene (2012), 31(45), 4778-88
Gene regulatory network analysis supports inflammation as a key neurodegeneration process in prion disease.; ; ; ;
in BMC Systems Biology (2012), 6(132),
Increased apoptotic activity on inflammatory human placentas in spontaneous abortions during the first and second trimester of gestation: A histochemical and immunohistochemical study; ; ; ; ; ; ; ; ; ;
in Folia Histochemica et Cytobiologica (2012), 50(1), 118-124
Gene therapy in liver diseases: State-of-the-art and future perspectives; ; ; ; ; ; ; ;
in Current Gene Therapy (2012), 12(6), 463-483
Phosphorylation of HtrA2 by cyclin-dependent kinase-5 is important for mitochondrial function.; ; ; ; ; ; ; ;
in Cell death and differentiation (2012), 19(2), 257-66
The modulation of Amyotrophic Lateral Sclerosis risk by ataxin-2 intermediate polyglutamine expansions is a specific effect.; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Neurobiology of Disease (2012), 45(1), 356-61
Modifications de l'immunité humorale induites par des changements de la gravitéDoctoral thesis (2012)
Pharmacological countermeasures to spaceflight-induced alterations of the immune system; ;
in Stress Challenges and Immunity in Space: From Mechanisms to Monitoring and Preventive Strategies (2012)
Stress response and humoral immune system alterations related to chronic hypergravity in mice; ; ; ; ; ; ;
in Psychoneuroendocrinology (2012), 37(1), 137-147
Regulation of JAKs: Insights gleaned from the functional protein domains; ; ; ;
in Decker, Thomas; Müller, Mathias (Eds.) JAK-STAT Signaling – From Basics to Disease (2012)
Direct reprogramming of fibroblasts into neural stem cells by defined factors.; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Cell Stem Cell (2012), 10(4), 465-72
Discovery of inhibitors of microglial neurotoxicity acting through multiple mechanisms using a stem-cell-based phenotypic assay.; ; ; ; ; ; ; ; ; ; ; ; ;
in Cell Stem Cell (2012), 11(5), 620-32
Regrowing the adult brain: NF-kappaB controls functional circuit formation and tissue homeostasis in the dentate gyrus.; ; ; ; ; ; ; ; ; ; ; ;
in PLoS ONE (2012), 7(2), 30838
Dataset integration identifies transcriptional regulation of microRNA genes by PPARgamma in differentiating mouse 3T3-L1 adipocytes; ; ; ; ;
in Nucleic Acids Research (2012), 40(10), 4446-4460
Autophagy Mediates the Delivery of Thrombogenic Tissue Factor to Neutrophil Extracellular Traps in Human Sepsis; ; ; ; ; ; ; ; ; ;
in PLoS ONE (2012), 7(9),
Abundant occurrence of basal radial glia in the subventricular zone of embryonic neocortex of a lissencephalic primate, the common marmoset Callithrix jacchus.; ; ; ; ; ; ; ; ; ; ; ;
in Cerebral Cortex (2012), 22(2), 469-81
Deep-brain-stimulation does not impair deglutition in Parkinson's disease.; ; ; ; ; ; ; ;
in Parkinsonism and Related Disorders (2012), 18(7), 847-53
Employing live microbes for vaccine delivery; ; ; ; ;
in Development of Novel Vaccines: Skills, Knowledge and Translational Technologies (2012)
An efficient method to limit microglia-dependent effects in astroglial cultures.; ; ; ; ; ; ;
in Journal of Neuroscience Methods (2012), 207(1), 59-71
A Novel Network Integrating a miRNA-203/SNAI1 Feedback Loop which Regulates Epithelial to Mesenchymal Transition.; ; ; ; ; ; ;
in PLoS ONE (2012), 7(4), 35440
The chemokine receptor CXCR3 limits injury after acute toxic liver damage; ; ; ; ; ; ; ; ;
in Laboratory Investigation (2012), 92(5), 724-734
Chemokine Cxcl9 attenuates liver fibrosis-associated angiogenesis in mice; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Hepatology (2012), 55(5), 1610-1619
MeCP2 is critical for maintaining mature neuronal networks and global brain anatomy during late stages of postnatal brain development and in the mature adult brain; ; ; ; ; ; ;
in Journal of Neuroscience (2012), 32(29), 10021-10034
Recombinant Nox4 cytosolic domain produced by a cell or cell-free base systems exhibits constitutive diaphorase activity; ; ; ; ; ;
in Biochemical and Biophysical Research Communications (2012), 419(3), 453-458
TRIM32 regulates skeletal muscle stem cell differentiation and is necessary for normal adult muscle regeneration.; ; ; ; ; ; ; ; ; ;
in PLoS ONE (2012), 7(1), 30445
Evolutionary conservation and network structure characterize genes of phenotypic relevance for mitosis in human; ;
in PLoS ONE (2012), 7(5), 36488
MiRNAs and neural stem cells: a team to treat Parkinson's disease?; ;
in RNA Biology (2012), 9(6), 720-30
Genome-wide landscape of liver X receptor chromatin binding and gene regulation in human macrophages; ; ; ; ; ; ; ;
in BMC Genomics (2012), 13(50),
The non-autonomous retrotransposon SVA is trans-mobilized by the human LINE-1 protein machinery; ; ; ; ; ; ; ; ;
in Nucleic Acids Research (2012), 40(4), 1666-1683
Dynamic regulation of microRNA expression following interferonγ- induced gene transcription; ; ; ; ; ; ; ;
in RNA Biology (2012), 9(7), 987-989
Systems analysis of transcription factor activities in environments with stable and dynamic oxygen concentrations; ; ; ; ; ; ; ; ;
in Open Biology (2012), 2(7), 120091
Interferon-γ-induced activation of Signal Transducer and Activator of Transcription 1 (STAT1) up-regulates the tumor suppressing microRNA-29 family in melanoma cells; ; ; ; ; ; ;
in Cell Communication and Signaling (2012), 10
MiRNA-29: A microRNA family with tumor-suppressing and immune-modulating properties; ; ;
in Current Molecular Medicine (2012), 13(4), 572-585
A multi-centre clinico-genetic analysis of the VPS35 gene in Parkinson disease indicates reduced penetrance for disease-associated variants.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Journal of medical genetics (2012), 49(11), 721-6
Large-scale replication and heterogeneity in Parkinson disease genetic loci.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Neurology (2012), 79(7), 659-67
LRRK2: Understanding the role of common and rare variants in Parkinson's disease.; ;
in Movement Disorders (2012), 27(4), 475
JAM-C is an apical surface marker for neural stem cells.; ; ; ; ; ; ; ; ; ; ;
in Stem Cells and Development (2012), 21(5), 757-66
Regulation of gene expression dynamics driven by PPARd and VDR nuclear receptorsDoctoral thesis (2012)
Dynamics and feedback loops in the transforming growth factor beta signaling pathway.; ; ; ; ; ; ; ; ;
in Biophysical chemistry (2012), 162
Subthalamic nucleus stimulation restores the efferent cortical drive to muscle in parallel to functional motor improvement.; ; ; ; ; ; ; ;
in The European journal of neuroscience (2012), 35(6), 896-908
Long-term follow-up of subthalamic nucleus stimulation in glucocerebrosidase-associated Parkinson's disease.; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Journal of neurology (2012), 259(9), 1970-2
Induced pluripotent stem cells generated from adult bone marrow-derived cells of the nonhuman primate (Callithrix jacchus) using a novel quad-cistronic and excisable lentiviral vector.; ; ; ; ; ; ; ; ; ;
in Cellular reprogramming (2012), 14(6), 485-96
In Silico prediction of transcription factor binding sites by probabilistic modelsDoctoral thesis (2012)
Analysing the role of UVB-induced translational inhibition and PP2Ac deactivation in NF-kappaB signalling using a minimal mathematical model.; ; ; ; ;
in PLoS ONE (2012), 7(7), 40274
Anti-inflammatory treatment induced regenerative oligodendrogenesis in parkinsonian mice.; ; ;
in Stem Cell Research and Therapy (2012), 3(4), 33
Probabilistic model checking of the PDGF signaling pathway; ; ; ; ;
in Transactions on Computational Systems Biology (2012), XIV
2011
Effects of subthalamic nucleus stimulation on emotional prosody comprehension in Parkinson's disease.; ; ; ;
in PloS one (2011), 6(4), 19140
Cellular organization of adult neurogenesis in the Common Marmoset.; ; ; ; ;
in Aging Cell (2011), 10(1), 28-38
Converging environmental and genetic pathways in the pathogenesis of Parkinson's disease.;
in Journal of the neurological sciences (2011), 306(1-2), 1-8
Birth order and childhood type 1 diabetes risk: A pooled analysis of 31 observational studies; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in International Journal of Epidemiology (2011), 40(2), 363-374
Independent and joint effects of the MAPT and SNCA genes in Parkinson disease.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Annals of neurology (2011), 69(5), 778-92
Designing logical rules to model the response of biomolecular networks with complex interactions: an application to cancer modeling.; ; ; ; ;
in IEEE/ACM Transactions on Computational Biology and Bioinformatics (2011), 8(5), 1223-34
Jak1 has a dominant role over Jak3 in signal transduction through γc-containing cytokine receptors; ; ; ; ; ; ;
in Chemistry and Biology (2011), 18(3), 314-323
A systems biology approach to analyse leaf carbohydrate metabolism in Arabidopsis thaliana.; ; ; ; ; ;
in EURASIP Journal on Bioinformatics and Systems Biology (2011), 2011(1), 2
Neural stem cells maintain their stemness through protein kinase C zeta-mediated inhibition of TRIM32.; ; ;
in Stem Cells (2011), 29(9), 1437-47
PPARγ population shift produces disease-related changes in molecular networks associated with metabolic syndrome; ; ; ;
in Cell Death and Disease (2011), 2(8), 192
The E3-ubiquitin ligase TRIM2 regulates neuronal polarization.; ; ; ; ; ; ;
in Journal of Neurochemistry (2011), 117(1), 29-37
A large-scale genetic association study to evaluate the contribution of Omi/HtrA2 (PARK13) to Parkinson's disease.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Neurobiology of Aging (2011), 32(3), 5489-18
Olfactory neuron-specific expression of A30P alpha-synuclein exacerbates dopamine deficiency and hyperactivity in a novel conditional model of early Parkinson's disease stages.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Neurobiology of Disease (2011), 44(2), 192-204
Association of LRRK2 exonic variants with susceptibility to Parkinson's disease: a case-control study.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Lancet Neurology (2011), 10(10), 898-908
Suppression of extrapyramidal side effects of doxepin by thalamic deep brain stimulation for Tourette syndrome.; ; ; ;
in Neurology (2011), 77(18), 1708-9
Sphingosine kinases regulate NOX2 activity via p38 MAPK-dependent translocation of S100A8/A9; ; ; ;
in Journal of Leukocyte Biology (2011), 89(4), 587-596
Role of sepiapterin reductase gene at the PARK3 locus in Parkinson's disease.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Neurobiology of Aging (2011), 32(11), 21081-5
An essential role of STIM1, Orai1, and S100A8-A9 proteins for Ca2+ signaling and FcγR-mediated phagosomal oxidative activity; ; ; ;
in Journal of Immunology (2011), 186(4), 2182-2191
Slowly progressive Parkinson syndrome due to thalamic butterfly astrocytoma.; ; ; ; ;
in Neurology (2011), 77(4), 404-5
Rapid emergence of temporal and pulvinar lesions in MELAS mimicking Creutzfeldt-Jakob disease.; ; ; ;
in Neurology (2011), 77(9), 914
Combined stimulation of the substantia nigra pars reticulata and the subthalamic nucleus is effective in hypokinetic gait disturbance in Parkinson's disease.; ; ; ; ;
in Journal of neurology (2011), 258(6), 1183-5
Central oscillators in a patient with neuropathic tremor: evidence from intraoperative local field potential recordings.; ; ; ; ; ; ; ; ;
in Movement Disorders (2011), 26(2), 323-7
Modeling time delay in the NFkappaB signaling pathway following low dose IL-1 stimulation.; ; ; ; ;
in EURASIP Journal on Bioinformatics and Systems Biology (2011), 2011(1), 3
A study of the PDGF signaling pathway with PRISM; ; ; ; ;
in Proceedings of the 3rd Workshop on Computational Models for Cell Processes (2011), EPTCS 67
2010
Quantitative kinetic study of the actin-bundling protein L-plastin and of its impact on actin turn-over.; ; ; ; ; ; ; ;
in PloS one (2010), 5(2), 9210
Localizing potentially active post-transcriptional regulations in the Ewing's sarcoma gene regulatory network.; ; ; ; ; ;
in BMC Systems Biology (2010), 4
Effective long-term subthalamic stimulation in PARK8 positive Parkinson's disease.; ; ; ; ; ; ; ;
in Journal of neurology (2010), 257(7), 1205-7
Balance is the challenge--the impact of mitochondrial dynamics in Parkinson's disease.; ;
in European journal of clinical investigation (2010), 40(11), 1048-60
Dissecting the role of the mitochondrial chaperone mortalin in Parkinson's disease: functional impact of disease-related variants on mitochondrial homeostasis.; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Human molecular genetics (2010), 19(22), 4437-52
An alpaca single-domain antibody blocks filopodia formation by obstructing L-plastin-mediated F-actin bundling.; ; ; ; ;
in FASEB Journal (2010), 24(1), 105-18
Signal transduction, receptors, mediators and genes: Younger than ever - The 13th meeting of the Signal Transduction Society focused on aging and immunology; ; ; ; ; ; ; ; ; ; ; ;
in Cell Communication and Signaling (2010), 8
Perspectives for the use of structural information and chemical genetics to develop inhibitors of Janus kinases.; ;
in Journal of Cellular and Molecular Medicine (2010), 14(3), 504-27
A mathematical model of actin filament turnover for fitting FRAP data; ; ; ; ;
in European Biophysics Journal (2010), 39(4), 669-677
New biological investigations on 3-bromophenyl 6-acetoxymethyl-2-oxo-2H-1-benzopyran-3-carboxylate as anti-angiogenic agent; ; ; ; ; ; ; ; ; ;
in Drug Development Research (2010), 71
Microglial activation depends on beta-amyloid conformation: role of the formylpeptide receptor 2; ; ; ; ; ; ; ;
in Journal of Neurochemistry (2010), 114(2), 576-586
The actin filament cross-linker L-plastin confers resistance to TNF-alpha in MCF-7 breast cancer cells in a phosphorylation-dependent manner.; ; ; ; ; ; ; ;
in Journal of Cellular and Molecular Medicine (2010), 14(6A), 1264-75
Modulation of mitochondrial function and morphology by interaction of Omi/HtrA2 with the mitochondrial fusion factor OPA1.; ; ; ; ; ; ; ; ;
in Experimental cell research (2010), 316(7), 1213-24
Reduced basal autophagy and impaired mitochondrial dynamics due to loss of Parkinson's disease-associated protein DJ-1.; ; ; ; ; ; ; ; ; ; ; ; ;
in PloS one (2010), 5(2), 9367
Time-Resolved Expression Profiling of the Nuclear Receptor Superfamily in Human Adipogenesis; ; ; ;
in PLoS ONE (2010), 5(9),
IL-24: Physiological and supraphysiological effects on normal and malignant cells;
in Current Medicinal Chemistry (2010), 17(29), 3318-3326
Mathematical modeling of the central carbohydrate metabolism in Arabidopsis reveals a substantial regulatory influence of vacuolar invertase on whole plant carbon metabolism.; ; ; ; ; ;
in Plant Physiology (2010), 153(1), 260-72
Transgenic overexpression of the alpha-synuclein interacting protein synphilin-1 leads to behavioral and neuropathological alterations in mice.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Neurogenetics (2010), 11(1), 107-20
Signatures of MicroRNAs and selected MicroRNA target genes in human melanoma; ; ; ; ; ; ; ; ;
in Cancer Research (2010), 70(10), 4163-4173
Psychological preparation and postoperative outcomes for adults undergoing surgery under general anaesthesia (Protocol); ; ; ; ; ;
in Cochrane Database of Systematic Reviews (Online) (2010), (8), 1-15
Cross-regulation of cytokine signalling: Pro-inflammatory cytokines restrict IL-6 signalling through receptor internalisation and degradation; ; ; ; ; ; ; ; ; ; ; ;
in Journal of Cell Science (2010), 123(6), 947-959
iPLA 2 , a novel determinant in Ca2+ - and phosphorylation-dependent S100A8/A9 regulated NOX2 activity; ; ; ; ;
in Biochimica et Biophysica Acta-Molecular Cell Research (2010), 1803(7), 840-847
Interleukin-27 acts on hepatic stellate cells and induces signal transducer and activator of transcription 1-dependent responses.; ;
in Cell Communication and Signaling (2010), 8
First appraisal of brain pathology owing to A30P mutant alpha-synuclein.; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Annals of neurology (2010), 67(5), 684-9
Periphilin is a novel interactor of synphilin-1, a protein implicated in Parkinson's disease.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Neurogenetics (2010), 11(2), 203-15
JAM-A is a novel surface marker for NG2-Glia in the adult mouse brain.; ;
in BMC Neuroscience (2010), 11
Complex hyperkinetic movement disorders associated with POLG mutations.; ; ; ; ; ;
in Movement Disorders (2010), 25(14), 2472-5
Severe orthostatic dysregulation associated with Wolfram syndrome.; ; ; ;
in Journal of neurology (2010), 257(10), 1751-3
Oncostatin M up-regulates the ER chaperone Grp78/BiP in liver cells; ;
in Biochemical Pharmacology (2010), 80(12), 2066-2073
Involuntary eyelid closure after STN-DBS: evidence for different pathophysiological entities.; ; ; ; ; ; ; ; ; ;
in Journal of neurology, neurosurgery, and psychiatry (2010), 81(9), 1002-7
2009
Spaceflight-associated changes in immunoglobulin VH gene expression in the amphibian Pleurodeles waltl; ; ; ;
in FASEB Journal (2009), 23(5), 1607-1615
Interleukin-27 displays interferon-gamma-like functions in human hepatoma cells and hepatocytes.; ; ; ; ; ; ; ; ;
in Hepatology (2009), 50(2), 585-91
STIM1 but not STIM2 is an essential regulator of Ca2+ influx-mediated NADPH oxidase activity in neutrophil-like HL-60 cells; ; ;
in Biochemical Pharmacology (2009), 78(5), 504-513
OAG induces an additional PKC-, PI3K-, and Rac2-mediated signaling pathway up-regulating NOX2 activity, independently of Ca 2+ entry; ;
in Journal of Leukocyte Biology (2009), 85(4), 638-647
Effective thalamic deep brain stimulation for neuropathic tremor in a patient with severe demyelinating neuropathy.; ; ; ; ; ;
in Journal of neurology, neurosurgery, and psychiatry (2009), 80(2), 235-6
Transmissions cholinergiquesin Landry, Yves; Gies, Jean-Pierre (Eds.) Pharmacologie. Des cibles vers l’indication thérapeutique (2009)
Methyl side-chain dynamics prediction based on protein structure;
in Bioinformatics (2009), 25(19), 2552-8
Energetic determinants of protein binding specificity: insights into protein interaction networks; ;
in Proteomics (2009), 9(7), 1744-53
Residues crucial for maintaining short paths in network communication mediate signaling in proteins; ; ;
in Molecular Systems Biology (2009), 2
The origin of Allosteric Modulation: Multiple Pre-existing Pathways Selection; ; ;
in Structure (2009), 17(8), 1042-1050
Single-cell expression profiling of dopaminergic neurons combined with association analysis identifies pyridoxal kinase as Parkinson's disease gene.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Annals of neurology (2009), 66(6), 792-8
Could spaceflight-associated immune system weakening preclude the expansion of human presence beyond Earth’s orbit?; ; ; ; ; ;
in Journal of Leukocyte Biology (2009), 86(5), 1027-1038
An unusual insertion in Jak2 is crucial for kinase activity and differentially affects cytokine responses; ; ; ; ; ; ; ;
in Journal of Immunology (2009), 182(5), 2969-2977
SOCS-mediated downregulation of mutant Jak2 (V617F, T875N and K539L) counteracts cytokine-independent signaling.; ; ; ; ; ;
in Oncogene (2009), 28(34), 3069-80
An integrative simulation model linking major biochemical reactions of actin-polymerization to structural properties of actin filaments; ; ; ; ; ;
in Biophysical Chemistry (2009), 140(1-3), 24-34
Oncostatin M-induced and constitutive activation of the JAK2/STAT5/CIS pathway suppresses CCL1, but not CCL7 and CCL8, chemokine expression; ; ; ;
in Journal of Immunology (2009), 181(10), 7341-7349
Characterization of the microglial phenotype under specific pro-inflammatory and anti-inflammatory conditions: Effects of oligomeric and fibrillar amyloid-beta; ; ; ;
in Journal of Neuroimmunology (2009), 210(1-2), 3-12
Transcriptional repression of microRNA genes by PML-RARA increases expression of key cancer proteins in acute promyelocytic leukemia.; ; ; ; ; ; ; ; ; ; ; ; ;
in Blood (2009), 113(2), 412-21
Overexpression of the partially activated alpha(IIb)beta3D723H integrin salt bridge mutant downregulates RhoA activity and induces microtubule-dependent proplatelet-like extensions in Chinese hamster ovary cells; ; ; ; ; ; ;
in Journal of Thrombosis and Haemostasis (2009), 7(7), 1207-1217
Analysis of an apoptotic core model focused on experimental design using artificial data.; ; ; ;
in IET Systems Biology (2009), 3(4), 255-65
ON/OFF and beyond--a boolean model of apoptosis.; ; ; ; ; ; ; ;
in PLoS Computational Biology (2009), 5(12), 1000595
The stimulation of dendrite growth by Sema3A requires integrin engagement and focal adhesion kinase.; ; ; ;
in Journal of Cell Science (2009), 122(Pt 12), 2034-42
The TRIM-NHL protein TRIM32 activates microRNAs and prevents self-renewal in mouse neural progenitors.; ;
in Cell (2009), 136(5), 913-25
Further delineation of the association signal on chromosome 5 from the first whole genome association study in Parkinson's disease.; ; ; ; ; ; ;
in Neurobiology of Aging (2009), 30(10), 1706-9
Genome-wide association study reveals genetic risk underlying Parkinson's disease.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Nature genetics (2009), 41(12), 1308-12
Protein allostery, signal transmission and dynamics: a classification scheme of allosteric mechanisms; ;
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Les peptides opioïdes et autres médiateurs de la nociceptionin Landry, Yves; Gies, Jean-Pierre (Eds.) Pharmacologie. Des cibles vers l’indication thérapeutique (2009)
Time-resolved analysis of transcriptional events during SNAI1-triggered epithelial to mesenchymal transition; ; ; ; ; ; ; ; ;
in Biochemical and Biophysical Research Communications (2009), 385(4), 485-91
Hypoxia-inducible factor 1alpha is up-regulated by oncostatin M and participates in oncostatin M signaling; ; ; ; ; ; ; ;
in Hepatology (2009), 2009(3),
Severe muscular fasciculations as an uncommon side-effect due to microdefect of an extension wire in deep brain stimulation.; ; ; ; ;
in Movement Disorders (2009), 24(14), 2161-2
Indibulin, a Novel Microtubule Inhibitor, Discriminates between Mature Neuronal and Nonneuronal Tubulin;
in Cancer Research (2009), 69(1), 171-177
Development of an IL-6 inhibitor based on the functional analysis of murine IL-6Ralpha(1).; ; ; ; ; ; ;
in Chemistry and Biology (2009), 16(7), 783-94
Mechanism of PP2A-mediated IKK beta dephosphorylation: a systems biological approach.; ; ; ; ; ;
in BMC Systems Biology (2009), 3
2008
Cell passaging rapidly affects expression, secretion and activity of MMP9 as well as mobility of HL60 leukemia cells; ; ; ;
in Journal of Cell and Animal Biology (2008), 2(9), 160-165
Microarray expression analysis reveals genetic pathways implicated in C621 synphilin-1-mediated toxicity.; ; ; ;
in Journal of Neural Transmission (2008), 115(7), 941-58
Regulation of superoxide production in neutrophils: role of calcium influx;
in Journal of Leukocyte Biology (2008), 84(5), 1223-1237
Analyse der evolutiven Adaptation am Beispiel einer pyruvat-auxotrophen Escherichia coli-Mutante; ; ; ; ;
in Automatisierungstechnik (2008), 56
In colon carcinogenesis, the cytoskeletal protein gelsolin is down-regulated during the transition from adenoma to carcinoma.; ; ; ; ; ;
in Human pathology (2008), 39(10), 1420-30
A nonsynonymous SNP in the ITGB3 gene disrupts the conserved membrane-proximal cytoplasmic salt bridge in the αIIbβ3 integrin and cosegregates dominantly with abnormal proplatelet formation and macrothrombocytopenia; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Blood (2008), 111(7), 3407-3414
Dual role of the Jak1 FERM and kinase domains in cytokine receptor binding and in stimulation-dependent Jak activation; ; ; ; ; ; ;
in Journal of Immunology (2008), 180(2), 998-1007
Novel ATP1A3 mutation in a sporadic RDP patient with minimal benefit from deep brain stimulation.; ; ; ; ; ; ;
in Neurology (2008), 70(16 Pt 2), 1501-3
Cell density dependent increase of constitutive signal transducers and activators of transcription 3 activity in melanoma cells is mediated by Janus kinases; ; ; ;
in Molecular Cancer Research (2008), 5(12), 1331-41
IL-24: a classic cytokine and/or a potential cure for cancer?; ; ;
in Journal of Cellular and Molecular Medicine (2008), 12(6A), 2505-2510
LRRK2 in Parkinson's disease - drawing the curtain of penetrance: a commentary.in BMC medicine (2008), 6
Sustained improvement of obsessive-compulsive disorder by deep brain stimulation in a woman with residual schizophrenia.; ; ; ; ; ; ; ; ;
in The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) (2008), 11(8), 1181-3
Mitochondrial protein quality control by the proteasome involves ubiquitination and the protease Omi.; ; ; ; ; ;
in The Journal of biological chemistry (2008), 283(19), 12681-5
The talin rod IBS2 alpha-helix interacts with the beta3 integrin cytoplasmic tail membrane-proximal helix by establishing charge complementary salt bridges.; ; ; ; ; ; ; ;
in The Journal of biological chemistry (2008), 283(35), 24212-23
Ca2+-dependent regulation of NOX2 activity via MRP proteins in HL-60 granulocytes; ; ; ; ;
in Calcium Binding Proteins (2008), 3(1), 25-30
Review: Familial Parkinson's disease--genetics, clinical phenotype and neuropathology in relation to the common sporadic form of the disease.; ; ;
in Neuropathology and applied neurobiology (2008), 34(3), 255-71
Vertebral artery dissection presenting with ispilateral acute C5 and C6 sensorimotor radiculopathy: A case report.; ; ; ;
in Cases journal (2008), 1(1), 139
A comprehensive genetic study of the proteasomal subunit S6 ATPase in German Parkinson's disease patients.; ; ; ; ; ; ; ;
in Journal of Neural Transmission (2008), 115(8), 1141-8
Advanced spot quality analysis in two-colour microarray experiments; ; ; ; ; ;
in BMC Research Notes (2008), 1
2007
Mitochondrial translation initiation factor 3 gene polymorphism associated with Parkinson's disease.; ; ; ; ; ;
in Neuroscience Letters (2007), 414(2), 126-9
Correlation between growth rates, EIIACrr phosphorylation, and intracellular cyclic AMP levels in Escherichia coli K-12.; ; ; ; ;
in Journal of Bacteriology (2007), 189(19), 6891-900
Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in The Journal of neuroscience : the official journal of the Society for Neuroscience (2007), 27(45), 12413-8
Methods for analysis of evolutive adaptation of E. coli; ; ; ; ; ;
in Proceedings of the SICE Annual Conference, September 17-20, 2007 Kagawa University, Takamatsu City, Japan (2007)
Special issue: Integrated approaches to cytoskeleton researchin Biochimica et Biophysica Acta-Molecular Cell Research (2007), 1773(5), 603
Notch signaling modulates the activation of microglial cells; ; ; ; ;
in Glia (2007), 55(15), 1519-30
A cost effective non-commercial ECL-solution for Western blot detections yielding strong signals and low background;
in Journal of Immunological Methods (2007), 318(1-2), 11-9
Dual bioactivity of resveratrol fatty alcohols: differentiation of neural stem cells and modulation of neuroinflammation; ; ; ; ; ;
in Bioorganic & Medicinal Chemistry Letters (2007), 17(15), 4218-4222
Constitutive suppressor of cytokine signaling 3 expression confers a growth advantage to a human melanoma cell line; ; ; ;
in Molecular Cancer Research (2007), 5(3), 271-81
Recombinant interleukin-24 lacks apoptosis-inducing properties in melanoma cells; ; ; ; ; ; ;
in PLoS ONE (2007), 2(12), 1300
Elongation of axons during regeneration involves retinal crystallin beta b2 (crybb2).; ; ;
in Molecular and Cellular Proteomics (2007), 6(5), 895-907
Acute parkinsonism with corresponding lesions in the basal ganglia after heroin abuse.; ; ;
in Neurology (2007), 68(6), 414
Characterization of the Interleukin (IL)-6 Inhibitor IL-6-RFP: fused receptor domains act as high affinity cytokine-binding proteins.; ; ; ; ; ;
in Journal of Biological Chemistry (2007), 282(2), 1238-48
The integrin binding site 2 (IBS2) in the talin rod domain is essential for linking integrin beta subunits to the cytoskeleton.; ; ; ; ; ; ; ; ;
in The Journal of biological chemistry (2007), 282(23), 17280-8
Design and evaluation of Actichip, a thematic microarray for the study of the actin cytoskeleton; ; ; ; ; ; ; ;
in BMC Genomics (2007), 8
Complete loss of PTEN expression as a possible early prognostic marker for prostate cancer metastasis.; ; ; ; ; ; ; ; ;
in International Journal of Cancer (2007), 120(6), 1284-92
The histone deacetylase inhibitor trichostatin A mediates upregulation of 5-lipoxygenase promoter activity by recruitment of Sp1 to distinct GC-boxes; ; ; ;
in Biochimica et Biophysica Acta (2007), 1771(10), 1271-1282
Transcranial ultrasound in different monogenetic subtypes of Parkinson's disease.; ; ; ; ; ; ; ;
in Journal of neurology (2007), 254(5), 613-6
STAT1 regulates p73-mediated Bax gene expression; ; ; ; ; ; ; ;
in FEBS Letters (2007), 581(6), 1217-26
Identification of a novel BBS gene (BBS12) highlights the major role of a vertebrate-specific branch of chaperonin-related proteins in Bardet-Biedl syndrome.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in American Journal of Human Genetics (2007), 80(1), 1-11
Modeling and Analysis of UVB Influence on IL-1 induced NF-kappaB Signaling; ; ; ; ;
in Proceedings of the FOSBE, September 9-12, Stuttgart, Germany (2007)
2006
A quantitative approach to catabolite repression in Escherichia coli.; ; ; ; ;
in Journal of Biological Chemistry (2006), 281(5), 2578-84
Modulation by cADPr of Ca2+ mobilization and oxidative response in dimethylsulfoxide- or retinoic acid-differentiated HL-60 cells; ; ;
in Biochimica et Biophysica Acta (2006), 1763(1), 129-36
A domain-oriented approach to the reduction of combinatorial complexity in signal transduction networks.; ; ; ;
in BMC Bioinformatics (2006), 7
Sensitivity analysis of programmed cell death and implications for crosstalk phenomena during Tumor Necrosis Factor stimulation; ; ; ; ; ; ;
in Proceedings of IEEE International Conference on Control Applications (CCA), October 4-6, 2006, Technische Universität München, Germany (2006)
Lack of replication of thirteen single-nucleotide polymorphisms implicated in Parkinson's disease: a large-scale international study.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Lancet Neurology (2006), 5(11), 917-23
Jaks and cytokine receptors - an intimate relationship; ; ;
in Biochemical Pharmacology (2006), 72(11), 1538-46
Modeling the VPAC2-activated cAMP/PKA signaling pathway: from receptor to circadian clock gene induction.; ; ; ;
in Biophysical Journal (2006), 90(5), 1560-71
Phosphorylation on Ser5 increases the F-actin-binding activity of L-plastin and promotes its targeting to sites of actin assembly in cells; ; ; ; ; ; ; ;
in Journal of Cell Science (2006), 119(9), 1947-1960
Collaborative analysis of alpha-synuclein gene promoter variability and Parkinson disease.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in JAMA: Journal of the American Medical Association (2006), 296(6), 661-70
Rosuvastatin treatment protects against nitrate-induced oxidative stress in eNOS knockout mice: implication of the NAD(P)H oxidase pathway; ; ; ;
in British Journal of Pharmacology (2006), 148(4), 544-52
Three dileucine-like motifs within the interbox1/2 region of the human oncostatin M receptor prevent efficient surface expression in the absence of an associated Janus kinase; ; ; ;
in Journal of Biological Chemistry (2006), 281(7), 4024-34
Genetic causes of Parkinson's disease: extending the pathway.; ; ; ; ; ;
in Journal of neural transmission. Supplementum (2006), (70), 181-9
Biological responses to PDGF-BB versus PDGF-DD in human mesangial cells; ; ; ; ; ; ; ; ; ;
in Kidney International (2006), 69(8), 1393-402
2005
Interleukin-8 primes oxidative burst in neutrophil-like HL-60 through changes in cytosolic calcium; ;
in Cell Calcium (2005), 37(6), 531-40
Molecular basis for dissimilar nuclear trafficking of the actin-bundling protein isoforms T- and L-plastin.; ; ; ; ; ; ; ; ;
in Traffic (Copenhagen, Denmark) (2005), 6(4), 335-45
The Use of In Vitro Systems for Evaluating Immunotoxicity: The Report and Recommendations of an ECVAM Workshop; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Journal of Immunotoxicology (2005), 2(2), 61-83
Actin-filament cross-linking protein T-plastin increases Arp2/3-mediated actin-based movement; ; ; ; ; ; ;
in Journal of Cell Science (2005), 118(6), 1255-1265
Multiple reasons for an inefficient STAT1 response upon IL-6-type cytokine stimulation; ; ; ;
in Cellular Signalling (2005), 17(12), 1542-50
Promoter-hypermethylation is causing functional relevant downregulation of methylthioadenosine phosphorylase (MTAP) expression in hepatocellular carcinoma; ; ; ; ; ; ; ;
in Carcinogenesis (2005), 27(1), 64-72
Functional relevance of ceruloplasmin mutations in Parkinson's disease.; ; ; ; ; ; ; ;
in FASEB Journal (2005), 19(13), 1851-3
The role of alpha-synuclein gene multiplications in early-onset Parkinson's disease and dementia with Lewy bodies.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Journal of Neural Transmission (2005), 112(9), 1249-54
The intermediate filament protein vimentin binds specifically to a recombinant integrin α2/β1 cytoplasmic tail complex and co-localizes with native α2/β1 in endothelial cell focal adhesions; ; ; ;
in Experimental Cell Research (2005), 305(1), 110-121
The Jak1 SH2 domain does not fulfill a classical SH2 function in Jak/STAT signaling but plays a structural role for receptor interaction and up-regulation of receptor surface expression; ; ; ; ; ; ; ; ;
in Journal of Biological Chemistry (2005), 280(27), 25760-8
A new functional role of the fibrinogen RGD motif as the molecular switch that selectively triggers integrin alphaIIbbeta3-dependent RhoA activation during cell spreading; ; ; ;
in Journal of Biological Chemistry (2005), 280(39), 33610-33619
Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease.; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Human molecular genetics (2005), 14(15), 2099-111
Oxidative stress activates MMP-2 in cultured human coronary smooth muscle cells; ; ; ;
in Fundamental and Clinical Pharmacology (2005), 19(6), 661-7
STAT5 contributes to interferon resistance of melanoma cells; ; ; ; ; ; ; ; ;
in Current Biology (2005), 15(18), 1629-39
2004
Janus kinase (Jak) subcellular localization revisited: the exclusive membrane localization of endogenous Janus kinase 1 by cytokine receptor interaction uncovers the Jak.receptor complex to be equivalent to a receptor tyrosine kinase; ; ; ; ; ; ; ;
in Journal of Biological Chemistry (2004), 279(34), 35486-93
Reduction of mathematical models of signal transduction networks: simulation-based approach applied to EGF receptor signalling.; ; ; ; ;
in Systems biology (2004), 1(1), 159-69
The role of the inhibitors of interleukin-6 signal transduction SHP2 and SOCS3 for desensitization of interleukin-6 signalling; ; ; ; ; ; ; ; ; ; ; ;
in Biochemical Journal (2004), 378(Pt 2), 449-60
Screening for mutations in synaptotagmin XI in Parkinson's disease.; ; ; ; ; ; ; ;
in Journal of neural transmission. Supplementum (2004), (68), 21-8
Extended mutation analysis and association studies of Nurr1 (NR4A2) in Parkinson disease.; ; ; ; ; ; ; ; ; ;
in Neurology (2004), 62(7), 1231-2
Novel homozygous p.E64D mutation in DJ1 in early onset Parkinson disease (PARK7).; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Human mutation (2004), 24(4), 321-9
The effect of recombinant IgG antibodies against the leucine-33 form of the platelet beta3 integrin (HPA-1a) on platelet function.; ; ; ; ; ; ; ; ; ; ;
in Thrombosis and haemostasis (2004), 91(4), 743-54
Interferon-gamma-mediated growth regulation of melanoma cells: involvement of STAT1-dependent and STAT1-independent signals; ; ; ; ;
in Journal of Investigative Dermatology (2004), 122(2), 414-22
Towards whole cell "in silico" models for cellular systems: model set-up and model validation; ; ; ; ;
in Lecture Notes in Control and Information Sciences: Proceedings of the first multidisciplinary international symposium on Positive Systems (2004)
Time hierarchies in the Escherichia coli carbohydrate uptake and metabolism.; ; ; ;
in Bio Systems (2004), 73(1), 57-71
A benchmark for methods in reverse engineering and model discrimination: problem formulation and solutions.; ; ; ; ; ; ;
in Genome Research (2004), 14(9), 1773-85
Genes in familial parkinsonism and their role in sporadic Parkinson's disease.in Journal of neurology (2004), 251 Suppl 6
The role of synphilin-1 in synaptic function and protein degradation.in Cell and Tissue Research (2004), 318(1), 195-9
UCHL1 is a Parkinson's disease susceptibility gene.; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Annals of neurology (2004), 55(4), 512-21
Antiapoptotic effects of budipine.; ; ;
in Journal of Neural Transmission (2004), 111(10-11), 1365-73
Modeling and experimental validation of the signal transduction via the Escherichia coli sucrose phospho transferase system.;
in Journal of Biotechnology (2004), 110(2), 181-99
Semaphorin 3A stimulates neurite extension and regulates gene expression in PC12 cells.; ; ; ; ;
in Journal of Biological Chemistry (2004), 279(30), 30923-6
The sequential activity of the GTPases Rap1B and Cdc42 determines neuronal polarity.;
in Nature Neuroscience (2004), 7(9), 923-9
New developments in diagnosis and treatment of Parkinson's disease--from basic science to clinical applications.; ; ; ; ;
in Journal of neurology (2004), 251 Suppl 6
A fluorescence cell biology approach to map the second integrin-binding site of talin to a 130-amino acid sequence within the rod domain; ; ; ; ; ; ;
in Journal of Biological Chemistry (2004), 279(21), 22258-22266
2003
Characterization of methylthioadenosin phosphorylase (MTAP) expression in malignant melanoma; ; ; ; ; ;
in American Journal of Pathology (2003), 163(2), 683-90
An approach for dividing models of biological reaction networks into functional units; ; ; ;
in Simulation (2003), 79
Long term association of the cytokine receptor gp130 and the Janus kinase Jak1 revealed by FRAP analysis; ; ; ; ; ; ; ; ; ;
in Journal of Biological Chemistry (2003), 278(40), 39205-13
The actin cytoskeleton as a therapeutic target: state of the art and future directions.;
in Progress in cell cycle research (2003), 5
Polymorphisms of the alpha-synuclein promoter: expression analyses and association studies in Parkinson's disease.; ; ; ; ; ;
in Journal of Neural Transmission (2003), 110(1), 67-76
Haploinsufficiency at the alpha-synuclein gene underlies phenotypic severity in familial Parkinson's disease.; ; ; ; ; ; ; ; ; ;
in Brain : a journal of neurology (2003), 126(Pt 1), 32-42
Akt modulates STAT3-mediated gene expression through a FKHR (FOXO1a)-dependent mechanism; ; ; ; ; ; ; ;
in Journal of Biological Chemistry (2003), 278(7), 5242-9
Mutation analysis of the neurofilament M gene in Parkinson's disease.; ; ; ; ; ; ; ; ; ; ; ;
in Neuroscience Letters (2003), 351(2), 125-9
Identification and functional characterization of a novel R621C mutation in the synphilin-1 gene in Parkinson's disease.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Human molecular genetics (2003), 12(11), 1223-31
Therapeutic strategies for Parkinson's disease based on data derived from genetic research.; ; ;
in Journal of neurology (2003), 250 Suppl 1
Beta3 integrins: major therapeutic targets of the near future.in Bulletin de la Société des Sciences Médicales du Grand-Duché de Luxembourg (2003), (1), 23-34
Modulation of disease risk according to a cathepsin D / apolipoprotein E genotype in Parkinson's disease.; ; ; ; ; ; ; ; ;
in Journal of Neural Transmission (2003), 110(7), 749-55
Microarray analysis of tumor necrosis factor alpha induced gene expression in U373 human glioblastoma cells.; ; ; ; ; ; ; ; ;
in BMC Genomics (2003), 4(1), 46
Giant cavernoma of the brain stem: value of delayed MR imaging after contrast injection.; ; ; ;
in European radiology (2003), 13 Suppl 6
2002
Identification of the critical sequence elements in the cytoplasmic domain of leptin receptor isoforms required for Janus kinase/signal transducer and activator of transcription activation by receptor heterodimers; ; ; ; ; ;
in Molecular Endocrinology (2002), 16(4), 859-72
Orientational constraints of the gp130 intracellular juxtamembrane domain for signaling; ; ; ;
in Journal of Biological Chemistry (2002), 277(30), 26959-65
Parkinson's disease: one biochemical pathway to fit all genes?; ; ;
in Trends in molecular medicine (2002), 8(5), 236-40
SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130; ; ; ; ; ; ; ; ; ; ; ; ;
in Journal of Biological Chemistry (2002), 278(1), 661-71
Promoter characterization and genomic organization of the gene encoding integrin-linked kinase 1; ; ;
in Biochimica et Biophysica Acta-Gene Structure and Expression (2002), 1575(1-3), 117-122
Integrin alpha(v)beta3 expression confers on tumor cells a greater propensity to metastasize to bone.; ; ; ; ; ; ; ; ; ;
in FASEB Journal (2002), 16(10), 1266-8
Novel role of Janus kinase 1 in the regulation of oncostatin M receptor surface expression; ; ; ; ; ;
in Journal of Biological Chemistry (2002), 277(13), 11297-305
Neurofilament L gene is not a genetic factor of sporadic and familial Parkinson's disease.; ; ; ; ;
in Brain research (2002), 951(1), 82-6
Spectrum of phenotypes and genotypes in Parkinson's disease.; ;
in Journal of neurology (2002), 249 Suppl 3
The matrix metalloproteinase 9 (mmp-9) hemopexin domain is a novel gelatin binding domain and acts as an antagonist; ; ; ; ; ; ;
in Journal of Biological Chemistry (2002), 277(52), 50326-32
Polymorphisms in the interleukin-1 alpha and beta genes and the risk for Parkinson's disease.; ; ; ; ;
in Neuroscience Letters (2002), 326(1), 70-2
14-3-3 protein is a component of Lewy bodies in Parkinson's disease-mutation analysis and association studies of 14-3-3 eta.; ; ; ; ; ; ;
in Molecular Brain Research (2002), 108(1-2), 33-9
HPA-1a phenotype-genotype discrepancy reveals a naturally occurring Arg93Gln substitution in the platelet beta 3 integrin that disrupts the HPA-1a epitope.; ; ; ; ; ; ; ; ;
in Blood (2002), 99(5), 1833-9
Mutation analysis and association studies of nuclear factor-kappaB1 in sporadic Parkinson's disease patients.; ; ; ; ; ;
in Journal of Neural Transmission (2002), 109(9), 1181-8
2001
Interleukin-6-resistant melanoma cells exhibit reduced activation of STAT3 and lack of inhibition of cyclin E-associated kinase activity; ; ; ; ; ; ; ; ;
in Journal of Investigative Dermatology (2001), 117(1), 132-40
Receptor-independent effects of natural cannabinoids in rat peritoneal mast cells in vitro; ;
in Biochimica et Biophysica Acta (2001), 1538(2-3), 252-9
ActA and human zyxin harbour Arp2/3-independent actin-polymerization activity.; ; ; ; ; ; ;
in Nature Cell Biology (2001), 3(8), 699-707
Structural requirements of the interleukin-6 signal transducer gp130 for its interaction with Janus kinase 1: the receptor is crucial for kinase activation; ;
in Biochemical Journal (2001), 361(Pt 1), 105-11
A single amino acid substitution (Trp(666)-->Ala) in the interbox1/2 region of the interleukin-6 signal transducer gp130 abrogates binding of JAK1, and dominantly impairs signal transduction; ; ;
in Biochemical Journal (2001), 349(Pt 1), 261-6
Mapping of a region within the N terminus of Jak1 involved in cytokine receptor interaction; ; ; ; ; ; ;
in Journal of Biological Chemistry (2001), 276(40), 37451-8
Non-redundant signal transduction of interleukin-6-type cytokines. The adapter protein Shc is specifically recruited to rhe oncostatin M receptor; ; ; ;
in Journal of Biological Chemistry (2001), 275(52), 40742-8
A region encompassing the FERM domain of Jak1 is necessary for binding to the cytokine receptor gp130; ; ; ; ; ;
in FEBS Letters (2001), 505(1), 87-91
Mitogen-activated protein kinases control p27/Kip1 expression and growth of human melanoma cells; ; ; ; ;
in Biochemical Journal (2001), 357(Pt 1), 297-303
Cytokine-mediated growth inhibition of human melanoma cells; ; ;
in Advances in Experimental Medicine and Biology (2001), 495
Biosystems Engineering: Applying methods from systems theory to biological systems; ; ; ; ;
in Proceedings of the 2nd International Conference on Systems Biology 4.-7.11.2001, Pasadena (2001)
Familial parkinsonism with synuclein pathology: clinical and PET studies of A30P mutation carriers.; ; ; ; ; ; ; ; ; ; ; ; ;
in Neurology (2001), 56(10), 1355-62
Evaluation of the gamma-synuclein gene in German Parkinson's disease patients.; ; ; ; ; ; ;
in Neuroscience Letters (2001), 310(2-3), 191-3
STAT3 is constitutively activated in Hodgkin cell lines; ; ; ; ; ; ; ;
in Blood (2001), 98(3), 762-70
Targeting of zyxin to sites of actin membrane interaction and to the nucleus.; ; ; ; ; ;
in The Journal of biological chemistry (2001), 276(37), 34759-67
Role of G(i)-proteins in norepinephrine-mediated vasoconstriction in rat tail artery smooth muscle; ; ; ;
in Biochemical Pharmacology (2001), 61(9), 1169-75
Lack of involvement of pertussis toxin-sensitive G-proteins in norepinephrine-induced vasoconstriction of rat aorta smooth muscle; ; ; ; ;
in Biochemical Pharmacology (2001), 61(4), 485-91
Green fluorescent protein (GFP) tagged to the cytoplasmic tail of alphaIIb or beta3 allows the expression of a fully functional integrin alphaIIb(beta3): effect of beta3GFP on alphaIIb(beta3) ligand binding.; ; ; ;
in The Biochemical journal (2001), 357(Pt 2), 529-36
Evidence from site-directed mutagenesis that the cytoplasmic domain of the beta3 subunit influences the conformational state of the alphaVbeta3 integrin ectodomain.; ;
in Thrombosis and haemostasis (2001), 85(4), 716-23
A completely foreign receptor can mediate an interferon-gamma-like response; ; ; ; ; ; ; ; ; ; ; ; ;
in EMBO Journal (2001), 20(19), 5431-42
Rac-1-mediated O2- secretion requires Ca2+ influx in neutrophil-like HL-60 cells; ; ;
in Cell Calcium (2001), 29(6), 409-15
Neutralizing monoclonal antibodies can potentiate IL-5 signaling; ; ; ; ; ; ; ; ;
in European Journal of Immunology (2001), 31(4), 1087-97
Human umbilical cord blood monocyte-derived eosinophils produce superoxide but not nitric oxide;
in Inflammation Research (2001), 50(7), 357-61
2000
Signal transduction of IL-6, leukemia-inhibitory factor, and oncostatin M: structural receptor requirements for signal attenuation; ; ; ; ; ; ; ; ;
in Journal of Immunology (2000), 165(5), 2535-43
Signalling of interleukin-6 type cytokines via gp130, leukemia inhibitory factor (LIF) receptor and oncostatin M receptor; ; ; ; ; ;
in European Cytokine Network (2000), 11(3), 491-2
Characterization of the interaction between zyxin and members of the Ena/vasodilator-stimulated phosphoprotein family of proteins.; ; ; ; ;
in The Journal of biological chemistry (2000), 275(29), 22503-11
Heteroduplex mobility assay (HMA) pre-screening: An improved strategy for the rapid identification of inserts selected from phage-displayed peptide libraries; ; ;
in Molecular Diversity (2000), 5(1), 7-12
Placental transfer and decay of maternally acquired antimeasles antibodies in Nigerian children; ; ; ; ;
in Pediatric Infectious Disease Journal (2000), 19(7), 635-641
Contributions of leukemia inhibitory factor receptor and oncostatin M receptor to signal transduction in heterodimeric complexes with glycoprotein 130; ; ; ; ; ;
in Journal of Immunology (2000), 163(12), 6651-8
Villin-like actin-binding proteins are expressed ubiquitously in Arabidopsis.; ; ; ;
in Plant physiology (2000), 122(1), 35-48
Genetic analysis of immunomodulating factors in sporadic Parkinson's disease.; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Journal of Neural Transmission (2000), 107(5), 553-62
Genetic analysis of the alpha2-macroglobulin gene in early- and late-onset Parkinson's disease.; ; ; ; ; ; ; ; ; ;
in Neuroreport (2000), 11(11), 2439-42
Involvement of alpha-synuclein in Parkinson's disease and other neurodegenerative disorders.; ;
in Journal of Neural Transmission (2000), 107(1), 31-40
Expression patterns of L-plastin isoform in normal and carcinomatous breast tissues.; ; ; ; ; ; ;
in Anticancer research (2000), 20(5A), 3177-82
Transcriptional modulation of the anti-apoptotic protein BCL-XL by the paired box transcription factors PAX3 and PAX3/FKHR; ; ;
in Oncogene (2000), 19(25), 2921
PCR/SSCP detects reliably and efficiently DNA sequence variations in large scale screening projects.; ; ;
in Combinatorial chemistry & high throughput screening (2000), 3(3), 211-8
Growing an actin gel on spherical surfaces.; ; ; ; ; ;
in Biophysical journal (2000), 78(3), 1643-54
LPP, an actin cytoskeleton protein related to zyxin, harbors a nuclear export signal and transcriptional activation capacity.; ; ; ; ; ; ;
in Molecular biology of the cell (2000), 11(1), 117-29
Genetic influence on the development of Parkinson's disease.; ;
in Journal of neurology (2000), 247 Suppl 2
An MMP-9 mutant without gelatinolytic activity as a novel TIMP-1-antagonist; ; ; ;
in FASEB Journal (2000), 14(12), 1671-3
Extrapyramidal motor signs in degenerative ataxias.; ; ; ; ; ; ;
in Archives of neurology (2000), 57(10), 1495-500
Pertussis toxin-sensitive G(i)-proteins and intracellular calcium sensitivity of vasoconstriction in the intact rat tail artery; ; ; ; ;
in British Journal of Pharmacology (2000), 131(7), 1337-44
Differential inhibition of IL-6-type cytokine-induced STAT activation by PMA; ; ; ; ; ; ;
in FEBS Letters (2000), 478(1-2), 100-4
Termination of IL-6-induced STAT activation is independent of receptor internalization but requires de novo protein synthesis; ; ; ; ; ;
in FEBS Letters (2000), 470(1), 15-9
Mutation analysis and association studies of the UCHL1 gene in German Parkinson's disease patients.; ; ; ; ; ; ; ; ; ; ; ;
in Neuroreport (2000), 11(10), 2079-82
1999
Quantitative measurement of proteins by western blotting with Cy5-coupled secondary antibodies.; ; ;
in BioTechniques (1999), 26(3), 484-6488490
Villin function in the organization of the actin cytoskeleton. Correlation of in vivo effects to its biochemical activities in vitro.; ; ;
in The Journal of biological chemistry (1999), 274(38), 26751-60
Effect of SK&F 96365 on extracellular Ca2+ -dependent O2- production in neutrophil-like HL-60 cells; ;
in European Journal of Pharmacology (1999), 361(2-3), 293-8
The alpha1-antichymotrypsin A-allele in German Parkinson disease patients.; ; ; ; ; ;
in Journal of Neural Transmission (1999), 106(7-8), 729-36
Interleukin-6 and oncostatin M-induced growth inhibition of human A375 melanoma cells is STAT-dependent and involves upregulation of the cyclin-dependent kinase inhibitor p27/Kip1; ; ; ; ; ; ; ;
in Oncogene (1999), 18(25), 3742-53
Analysis of the parkin deletion in sporadic and familial Parkinson's disease. Short communication.; ; ; ; ; ; ; ;
in Journal of Neural Transmission (1999), 106(2), 159-63
Increased susceptibility to sporadic Parkinson's disease by a certain combined alpha-synuclein/apolipoprotein E genotype.; ; ; ; ; ; ; ; ; ; ; ; ;
in Annals of neurology (1999), 45(5), 611-7
Analogues and homologues of N-palmitoylethanolamide, a putative endogenous CB(2) cannabinoid, as potential ligands for the cannabinoid receptors; ; ; ; ; ; ; ;
in Biochimica et Biophysica Acta (1999), 1440(2-3), 266-74
Identification of a Leu-lle internalization motif within the cytoplasmic domain of the leukaemia inhibitory factor receptor; ; ; ; ; ; ; ; ;
in Biochemical Journal (1999), 339 (Pt 1)
Genotypic and antigenic characterization of hemagglutinin proteins of African measles virus isolates; ; ; ; ; ; ; ;
in Virus Research (1999), 62(1), 89-95
Isolation of measles virus from a naturally-immune, asymptomatically re-infected individual;
in Journal of Clinical Virology (1999), 13(3), 173-179
Case report and molecular analysis of subacute sclerosing panencephalitis in a South African child; ; ; ;
in Journal of Clinical Microbiology (1999), 37(3), 775-777
Release of O2- by human umbilical cord blood-derived eosinophils: role of intra- and extracellular calcium; ;
in Cell Calcium (1999), 25(5), 381-9
Selective differentiation and proliferation of human eosinophils from umbilical cord blood: calcium fluxes and superoxide ion secretion;
in Thérapie (1999), 54(1), 103-9
1998
The M2 muscarinic receptor antagonist methoctramine activates mast cells via pertussis toxin-sensitive G proteins; ; ; ;
in Naunyn-Schmiedeberg's Archives of Pharmacology (1998), 357(4), 357-62
Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway; ; ; ;
in Biochemical Journal (1998), 334 (Pt 2)
Partial amplification of the measles virus nucleocapsid gene from stored sera and cerebrospinal fluids for molecular epidemiological studies;
in Journal of Medical Virology (1998), 56(2), 174-177
Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease.; ; ; ; ; ; ; ; ;
in Nature genetics (1998), 18(2), 106-8
Selegiline as immunostimulant--a novel mechanism of action?; ; ;
in Journal of neural transmission. Supplementum (1998), 52
Genetic dissection of familial Parkinson's disease.; ;
in Molecular Medicine Today (1998), 4(10), 438-44
Distinct involvement of beta3 integrin cytoplasmic domain tyrosine residues 747 and 759 in integrin-mediated cytoskeletal assembly and phosphotyrosine signaling.; ; ; ;
in The Journal of biological chemistry (1998), 273(20), 12623-32
Spinocerebellar ataxia type 6: genotype and phenotype in German kindreds.; ; ; ; ;
in Journal of neurology, neurosurgery, and psychiatry (1998), 64(1), 67-73
Internalization of the interleukin 6 signal transducer gp130 does not require activation of the Jak/STAT pathway; ; ; ; ; ; ;
in Biochemical Journal (1998), 330 (Pt 1)
1997
A single STAT recruitment module in a chimeric cytokine receptor complex is sufficient for STAT activation; ; ; ; ; ; ; ; ;
in Journal of Biological Chemistry (1997), 272(8), 5269-74
Quantification of wild-type mitochondrial DNA and its 4.8-kb deletion in rat organs.; ;
in Biochemical and biophysical research communications (1997), 233(1), 102-7
Structural and functional similarities between the human cytoskeletal protein zyxin and the ActA protein of Listeria monocytogenes.; ; ;
in Journal of cell science (1997), 110 ( Pt 16)
The role of actin binding proteins in epithelial morphogenesis: models based upon Listeria movement.; ;
in Biophysical chemistry (1997), 68(1-3), 73-82
Sequence analysis of the nucleocapsid gene of measles virus isolates from South Africa identifies a new genotype; ;
in Journal of General Virology (1997), 78(7), 1581-1587
Rapid identification of measles virus strains by the heteroduplex mobility assay;
in Virus Research (1997), 47(2), 472197-203
Measles virus transmission from infected to immune individuals - Implications for measles control and elimination; ; ; ;
in South African Medical Journal (1997), 87(12), 1709
Human umbilical cord blood-derived eosinophils cultured in the presence of IL-3 and IL-5 respond to fMLP with [Ca2+]i variation and O2- production; ; ; ;
in Journal of Immunological Methods (1997), 205(1), 1-9
1996
Endothelin-1 does not modulate O2.release and [Ca(2+)]i variations in resting or differentiated HL-60 cells; ;
in Fundamental and Clinical Pharmacology (1996), 10(1), 28-32
Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor; ; ; ; ; ;
in EMBO Journal (1996), 14(22), 5579-88
Selegiline stimulates biosynthesis of cytokines interleukin-1 beta and interleukin-6.; ; ;
in Neuroreport (1996), 7(18), 2847-8
1995
A double-labelling fluorescent assay for concomitant measurements of [Ca2+]i and O2. production in human macrophages; ; ; ;
in Biochimica et Biophysica Acta (1995), 1244(1), 79-84
APO-I-mediated apoptosis in normal and malignant lymphocytes; ; ; ; ; ; ; ; ;
in Biochemical Society Transactions (1995), 22(3), 598-600
Targeting of Listeria monocytogenes ActA protein to the plasma membrane as a tool to dissect both actin-based cell morphogenesis and ActA function.; ; ; ; ;
in The EMBO journal (1995), 14(12), 2731-44
The role of APO-1-mediated apoptosis in the immune system; ; ; ; ; ; ; ; ;
in Immunological Reviews (1995), 142
Conformational behaviour of a synthetic peptide of the C-terminus of villin that interacts with actin: an NMR, CD and stimulated annealing study.; ; ; ; ; ;
in International journal of peptide and protein research (1995), 45(6), 574-86
1994
Functional differences between L- and T-plastin isoforms.; ; ; ;
in The Journal of cell biology (1994), 127(6 Pt 2), 1995-2008
Regulation of apoptosis in the immune system; ; ; ;
in Current Opinion in Immunology (1994), 6(2), 279-89
1993
An epithelial-dependent contracting factor induced by calcium influx in guinea-pig trachea; ; ; ;
in Pulmonary Pharmacology (1993), 6(1), 69-76
Epithelial factors: modulation of the airway smooth muscle tone;
in Fundamental and Clinical Pharmacology (1993), 7(6), 261-73
Structure-activity studies of bradykinin analogues on rat mast cell histamine release; ; ;
in Peptides (1993), 14(4), 685-9
Villin-induced growth of microvilli is reversibly inhibited by cytochalasin D.; ;
in Journal of cell science (1993), 105 ( Pt 3)
1992
Epithelial modulation of thromboxane A2 and PAF involvement in IgE- and IgG-mediated guinea pig anaphylaxis; ;
in Immunopharmacology (1992), 22(2), 115-25
In vivo analysis of functional domains from villin and gelsolin.; ; ;
in The Journal of cell biology (1992), 116(5), 1145-55
An actin-binding site containing a conserved motif of charged amino acid residues is essential for the morphogenic effect of villin.; ; ; ; ; ;
in Cell (1992), 70(1), 81-92
Purification and molecular cloning of the APO-1 cell surface antigen, a member of the tumor necrosis factor/nerve growth factor receptor superfamily. Sequence identity with the Fas antigen; ; ; ; ; ; ; ; ;
in Journal of Biological Chemistry (1992), 267(15), 10709-15