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Publications
2021
Degree Adjusted Large-Scale Network Analysis Reveals Novel Putative Metabolic Disease Genes.; ; ; ; ;
in Biology (2021), 10(2),
A dynamic multi-tissue model to study human metabolism.; ; ;
in NPJ systems biology and applications (2021), 7(1), 5
Is serine racemase (SRR) a second hit target for LRRK2-G2019S induced Parkinson’s disease?;
in Neural Regeneration Research (2021)
2020
Impaired Mitochondrial-Endoplasmic Reticulum Interaction and Mitophagy in Miro1-Mutant Neurons in Parkinson’s Disease; ; ; ; ; ; ; ; ; ;
in Human Molecular Genetics (2020)
Towards the routine use of in silico screenings for drug discovery using metabolic modelling; ;
in Biochemical Society Transactions (2020)
Excess of singleton loss-of-function variants in Parkinson's disease contributes to genetic risk.; ; ;
in Journal of Medical Genetics (2020)
Evaluating the Use of Circulating MicroRNA Profiles for Lung Cancer Detection in Symptomatic Patients; ; ; ; ; ; ; ; ; ;
in JAMA Oncology (2020)
Synapse alterations precede neuronal damage and storage pathology in a human cerebral organoid model of CLN3-juvenile neuronal ceroid lipofuscinosis; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Acta Neuropathologica Communications (2020)
Human telomerase reverse transcriptase depletion potentiates the growth- T inhibitory activity of imatinib in chronic myeloid leukemia stem cells; ; ; ; ; ; ;
in Cancer Letters (2020)
Pituitary Tumor Transforming Gene 1 Orchestrates Gene Regulatory Variation in Mouse Ventral Midbrain During Aging; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Frontiers in Genetics (2020)
Integration of time-series meta-omics data reveals how microbial ecosystems respond to disturbance; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Nature Communications (2020)
Adverse events reporting in stage III NSCLC trials investigating surgery and radiotherapy; ; ; ; ; ; ;
in ERJ Open Research (2020)
Passive controlled flow for Parkinson’s disease neuronal cell culture in 3D microfluidic devices; ; ; ;
in Organs-on-a-Chip (2020)
Systematic transcriptional profiling of responses to STAT1- and STAT3- activating cytokines in different cancer types; ; ; ; ; ; ; ; ;
in Journal of Molecular Biology (2020)
Reduced sialylation triggers homeostatic synapse and neuronal loss in middle-aged mice; ; ; ; ; ; ; ; ; ; ;
in Neurobiology of Aging (2020)
Prognostic and Predictive Molecular Biomarkers for Colorectal Cancer: Updates and Challenges; ; ;
in Cancers (2020)
Fibroblast mitochondria in idiopathic Parkinson’s disease display morphological changes and enhanced resistance to depolarization; ; ; ; ; ; ; ; ; ; ;
in Scientific Reports (2020)
Unraveling Molecular Mechanisms of THAP1 Missense Mutations in DYT6 Dystonia; ; ; ; ; ; ; ; ; ;
in Journal of Molecular Neuroscience (2020)
Emerging concepts for precision medicine in Parkinson's disease with focus on genetics;
in Fortschritte der Neurologie-Psychiatrie (2020)
Induced pluripotent stem cell line (LCSBi001-A) derived from a patient with Parkinson's disease carrying the p.D620N mutation in VPS35; ; ; ; ; ;
in Stem Cell Research (2020)
European Respiratory Society Statement on Thoracic Ultrasound; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in European Respiratory Journal (2020)
Peptide-Imprinted Poly(hydroxymethyl 3,4-ethylenedioxythiophene) Nanotubes for Detection of Alpha Synuclein in Human Brain Organoids; ; ; ; ; ; ; ; ; ;
in ACS Applied Nano Materials (2020)
An efficient machine learning-based approach for screening individuals at risk of hereditary haemochromatosis.; ;
in Scientific reports (2020), 10(1), 20613
Bidirectional Relation Between Parkinson’s Disease and Glioblastoma Multiforme; ; ; ; ;
in Frontiers in Neurology (2020)
The atypical chemokine receptor ACKR3/CXCR7 is a broad-spectrum scavenger for opioid peptides.; ; ; ; ; ; ; ; ; ; ; ; ;
in Nature communications (2020), 11(1), 3033
Machine learning-assisted neurotoxicity prediction in human midbrain organoids; ; ; ; ; ; ; ; ; ;
in Parkinsonism and Related Disorders (2020)
Cancer Cells Employ Nuclear Caspase-8 to Overcome the p53-Dependent G2/M Checkpoint through Cleavage of USP28.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Molecular cell (2020)
Haploinsufficiency due to a novel ACO2 deletion causes mitochondrial dysfunction in fibroblasts from a patient with dominant optic nerve atrophy; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Scientific Reports (2020)
Reproducible generation of human midbrain organoids for in vitro modeling of Parkinson’s disease; ; ; ; ;
in Stem Cell Research (2020)
Severe metabolic alterations in liver cancer lead to ERK pathway activation and drug resistance; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in EBioMedicine (2020)
Missing heritability in Parkinson’s disease: the emerging role of non‑coding genetic variation; ; ;
in Journal of Neural Transmission (2020)
Mental health impact of the confinement measures during the COVID-19 pandemic; ; ; ; ;
in Innovation in Aging (2020), 4(S1), 952
Genetic Architecture of Parkinson's Disease in the Indian Population: Harnessing Genetic Diversity to Address Critical Gaps in Parkinson's Disease Research.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Frontiers in neurology (2020), 11
Testing informed SIR based epidemiological model for COVID-19 in Luxembourg;
E-print/Working paper (2020)
Causal dynamical modelling predicts novel regulatory genes of FOXP3 in human regulatory T cells; ; ; ; ; ; ; ; ;
E-print/Working paper (2020)
Programme Démence Prévention (pdp ): A Nation-Wide Programme for Dementia Prevention in Luxembourg; ; ; ; ; ; ; ; ; ;
Poster (2020, April)
PDE6D Inhibitors with a New Design Principle Selectively Block K‑Ras Activity; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in ACS Omega (2020), 5(1), 832-842
Does lobar or size-reduced lung transplantation offer satisfactory early and late outcomes?; ; ;
in Interactive Cardiovascular and Thoracic Surgery (2020)
Single-cell transcriptomics reveals multiple neuronal cell types in human midbrain-specific organoids; ; ; ; ; ; ; ; ; ;
in Cell and Tissue Research (2020)
Midbrain organoids: A new tool to investigate Parkinson's disease;
in Frontiers in Cell and Developmental Biology (2020)
ZEB1/miR-200c/AGR2: A New Regulatory Loop Modulating the Epithelial-Mesenchymal Transition in Lung Adenocarcinomas; ; ; ; ;
in Cancers (2020), 12
Microbiome in Colorectal Cancer: How to Getfrom Meta-omics to Mechanism?; ; ; ; ;
in Trends in Microbiology (2020)
Hypoxia-Induced Adaptations of miRNomes and Proteomes in Melanoma Cells and Their Secreted Extracellular Vesicles; ; ; ; ; ; ; ; ; ;
in Cancers (2020)
Distinct Cargos of Small Extracellular Vesicles Derived from Hypoxic Cells and Their Effect on Cancer Cells; ; ;
in International Journal of Molecular Sciences (2020)
Grundlagen und Stellenwert der COMT- und MAO-B-Inhibitoren in der Therapie des idiopathischen Parkinson-Syndroms.; ; ; ; ; ; ;
in Fortschritte der Neurologie-Psychiatrie (2020)
2019
Clinical update on head and neck cancer: molecular biology and ongoing challenges.; ; ; ; ; ;
in Cell death & disease (2019), 10(8), 540
Automated high-throughput high-content autophagy and mitophagy analysis platform; ; ; ; ; ; ;
in Scientific Reports (2019)
Identification of genes under dynamic post-transcriptional regulation from time-series epigenomic data; ; ; ;
in Epigenomics (2019)
Cross-disease analysis of Alzheimer’s disease and type-2 Diabetes highlights the role of autophagy in the pathophysiology of two highly comorbid diseases; ; ; ; ; ; ; ; ;
in Scientific Reports (2019), 9(1), 3965
Early Pleistocene enamel proteome from Dmanisi resolves Stephanorhinus phylogeny.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Nature (2019)
An Efficient Machine Learning Method to Solve Imbalanced Data in Metabolic Disease Prediction; ; ; ;
in Cecchini, Vania Filipa (Ed.) An Efficient Machine Learning Method to Solve Imbalanced Data in Metabolic Disease Prediction (2019)
Inflammation Regulates Long Non-Coding RNA-PTTG1-1:1 In Myeloid Leukemia.; ; ; ; ; ; ; ; ; ;
in Haematologica (2019)
Optimization of logical networks for the modelling of cancer signalling pathwaysDoctoral thesis (2019)
The TNF Family of Ligands and Receptors: Communication Modules in the Immune System and Beyond; ; ;
in Physiological Reviews (2019), 99(1),
miR-873-5p targets mitochondrialGNMT-Complex II interface contributing tonon-alcoholic fatty liver disease; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Molecular Metabolism (2019)
From tech to bench: Deep Learning pipeline for image segmentation of high-throughput high-content microscopy data; ; ; ; ; ; ; ; ; ;
Poster (2019, November 29)
Deep Learning Quality Control for High-Throughput High-Content Screening Microscopy Images; ; ; ;
Poster (2019, October 10)
Integrated In Vitro and In Silico Modeling Delineates the Molecular Effects of a Synbiotic Regimen on Colorectal-Cancer-Derived Cells; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Cell Reports (2019), 27
Mutations in RHOT1 disrupt ER-mitochondria contact sites interfering with calcium homeostasis and mitochondrial dynamics in Parkinson's disease.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Antioxidants & redox signaling (2019)
Calcium signaling and regulation of neutrophil functions: Still a long way to go.; ; ;
in Journal of leukocyte biology (2019)
Quality Control Strategy for CRISPRCas9- based Gene Editing Complicated by a Pseudogene; ; ; ;
in Frontiers in Genetics (2019)
Creation and analysis of biochemical constraint-based models using the COBRA Toolbox v.3.0.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Nature protocols (2019), 14(3), 639-702
Successes and Hurdles in Stem Cells Application and Production for Brain Transplantation; ; ; ;
in Frontiers in Neuroscience (2019)
Integrated Analyses of Microbiome and Longitudinal Metabolome Data Reveal Microbial-Host Interactions on Sulfur Metabolism in Parkinson’s Disease; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Cell Reports (2019), 29(7), 1767-1777
Guidelines for Fluorescent Guided Biallelic HDR Targeting Selection With PiggyBac System Removal for Gene Editing; ;
in Frontiers in Genetics (2019)
Regulation of neutrophil pro-inflammatory functions sheds new light on the pathogenesis of rheumatoid arthritis.; ; ;
in Biochemical pharmacology (2019), 165
miRNAs Regulate Cytokine Secretion Induced by Phosphorylated S100A8/A9 in Neutrophils.; ; ; ;
in International journal of molecular sciences (2019), 20(22),
Automated microfluidic cell culture of stem cell derived dopaminergic neurons; ; ; ; ; ; ; ; ; ;
in Scientific Reports (2019)
Many ways to resistance: How melanoma cells evade targeted therapies; ; ; ;
in Biochimica et Biophysica Acta - Reviews on Cancer (2019), 1871(2), 313-322
Deep Brain Stimulation for Freezing of Gait in Parkinson’s Disease With Early Motor Complications; ;
in Movement Disorders (2019)
Quality of life predicts outcome of deep brain stimulation in early Parkinson disease; ; ;
in Neurology (2019)
Family-based association study on functional α-synuclein polymorphisms in attention-deficit/hyperactivity disorder; ; ; ; ; ; ;
in ADHD Attention Deficit and Hyperactivity Disorders (2019)
α-Synuclein in Parkinson's disease: causal or bystander?; ; ; ; ; ; ;
in Journal of Neural Transmission (2019)
Using global team science to identify genetic parkinson's disease worldwide; ; ; ;
in Annals of Neurology (2019)
High-throughput amenable fluorescence-assays to screen for calmodulin-inhibitors; ; ; ;
in Analytical Biochemistry (2019), 572
Kinase inhibitor library screening identifies synergistic drug combinations effective in sensitive and resistant melanoma cells; ; ; ; ; ; ; ;
in Journal of Experimental and Clinical Cancer Research (2019), 38(1),
Deconvolution of Transcriptomes and miRNomes by Independent Component Analysis Provides Insights Into Biological Processes and Clinical Outcomes of Melanoma Patients; ; ; ; ; ; ; ;
in BMC Medical Genomics (2019), 12 (1)(132),
Impaired serine metabolism complements LRRK2-G2019S pathogenicity in PD patients; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Parkinsonism and Related Disorders (2019)
In search of definitions: Cancer-associated fibroblasts and their markers; ; ; ;
in International Journal of Cancer (2019)
Sphingolipid-mediated inflammatory signaling leading to autophagy inhibition converts erythropoiesis to myelopoiesis in human hematopoietic stem/progenitor cells; ; ; ; ; ; ; ;
in Cell Death and Differentiation (2019), 26(9), 17961812
Towards the Integration of Metabolic Network Modelling and Machine Learning for the Routine Analysis of High-Throughput Patient Data; ;
in Automated Reasoning for Systems Biology and Medicine (2019)
Towards the network-based prediction of repurposed drugs using patient-specific metabolic models.; ;
in EBioMedicine (2019)
Identifying and targeting cancer-specific metabolism with network-based drug target prediction; ; ; ; ; ;
in EBioMedicine (2019), 43(May 2019), 98-106
Hypoxia-induced Autophagy Drives Colorectal Cancer Initiation and Progression by Activating the PRKC/PKC-EZR (Ezrin) Pathway; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Autophagy (2019)
The Power of LC-MS Based Multiomics: Exploring Adipogenic Differentiation of Human Mesenchymal Stem/Stromal Cells; ; ; ; ; ; ;
in Molecules (2019)
Anodal tDCS modulates cortical activity and synchronization in Parkinson's disease depending on motor processing.; ; ; ; ; ; ;
in NeuroImage. Clinical (2019), 22
Connecting environmental exposure and neurodegeneration using cheminformatics and high resolution mass spectrometry: potential and challenges; ; ; ; ; ; ; ; ; ;
in Environmental Science. Processes and Impacts (2019)
Modulation of the IL-6 signaling pathway in liver cells by miRNAs targeting gp130, JAK1 and/or STAT3; ; ; ; ; ; ;
in Molecular Therapy: Nucleic Acids (2019), 16
Comparative effectiveness of antiepileptic drugs in juvenile myoclonic epilepsy; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Epilepsia Open (2019), 0(0),
Multilingual Validation of the First French Version of Munich Dysphagia Test-Parkinson's Disease (MDT-PD) in the Luxembourg Parkinson's Study; ; ; ; ; ;
in Frontiers in Neurology (2019)
Single-cell transcriptomics reveals multiple neuronal cell types in human midbrain-specific organoids; ; ; ; ; ; ;
E-print/Working paper (2019)
Modeling Parkinson’s disease in midbrain-like organoids; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in NPJ Parkinson's Disease (2019)
Cultivation and characterization of human midbrain organoids in sensor integrated microfluidic chips; ; ; ; ; ; ; ; ;
E-print/Working paper (2019)
Hypoxia- and MicroRNA-Induced Metabolic Reprogramming of Tumor-Initiating Cells; ; ; ;
in Cells (2019), 8(6),
Tumor suppressor miR-215 counteracts hypoxia-induced colon cancer stem cell activity; ; ; ; ; ; ; ; ; ; ;
in Cancer Letters (2019), 450
Hydrogeological effects on terrestrial gravity measurements; ; ; ; ; ; ; ; ;
Scientific Conference (2019, December 10)
Neural Stem Cells of Parkinson's Disease Patients Exhibit Aberrant Mitochondrial Morphology and Functionality; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Stem Cell Reports (2019)
Non-proteolytic ubiquitination of OTULIN regulates NF-κB signaling pathway; ; ; ; ; ; ; ; ; ; ;
in Journal of Molecular Cell Biology (2019)
Absence of TRIM32 Leads to Reduced GABAergic Interneuron Generation and Autism-like Behaviors in Mice via Suppressing mTOR Signaling; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Cerebral Cortex (2019)
2018
Transcriptional variations in the wider peritumoral tissue environment of pancreatic cancer; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in International Journal of Cancer = Journal International du Cancer (2018), 142(5), 10101021
Millifluidic culture improves human midbrain organoid vitality and differentiation; ; ; ; ; ; ; ;
in Lab on a Chip - Miniaturisation for Chemistry and Biology (2018)
3D Cultures of Parkinson's Disease‐Specific Dopaminergic Neurons for High Content Phenotyping and Drug Testing; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Advanced Science (2018)
Targeting prohibitins at the cell surface prevents Th17-mediated autoimmunity.; ; ; ; ; ; ; ; ; ;
in The EMBO journal (2018), 37(16),
A new ALK isoform transported by extracellular vesicles confers drug resistance to melanoma cells; ; ; ; ; ; ; ; ; ; ; ;
in Molecular Cancer (2018), (17:145),
Using Regularization to Infer Cell Line Specificity in Logical Network Models of Signaling Pathways.; ;
in Frontiers in physiology (2018), 9
Systemic network analysis identifies XIAP and IkappaBalpha as potential drug targets in TRAIL resistant BRAF mutated melanoma.; ; ; ; ; ; ; ; ; ;
in NPJ systems biology and applications (2018), 4
Reply: No evidence for rare TRAP1 mutations influencing the risk of idiopathic Parkinson’s disease; ; ; ; ;
in Brain : A Journal of Neurology (2018)
Temporal enhancer profiling of parallel lineages identifies AHR and GLIS1 as regulators of mesenchymal multipotency; ; ; ; ; ; ; ;
in Nucleic Acids Research (2018)
A Fast Multiple Kernel Learning Framework with Dimensionality Reduction; ; ;
in Giang; Nguyen; Tran, Quoc Vinh; Tran, Dang Hung (Eds.) Integrated Uncertainty in Knowledge Modelling and Decision Making (2018)
Epigenetically Regulated Chromosome 14q32 miRNA Cluster Induces Metastasis and Predicts Poor Prognosis in Lung Adenocarcinoma Patients.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Molecular cancer research : MCR (2018)
Cominatorial effect of dietary fibre and Lactobacillus rhamnosus in the context of colorectal cancer therapy; ; ; ; ; ; ; ; ; ;
Poster (2018, February 16)
Extraction and Analysis of RNA Isolated from Pure Bacteria-Derived Outer Membrane Vesicles; ; ; ; ; ; ;
in Arluison, Véronique; Valverde, Claudio Valverde (Eds.) Bacterial Regulatory RNA (2018)
Long-Term Effect of GPi-DBS in a Patient With Generalized Dystonia Due to GLUT1 Deficiency Syndrome.; ; ; ; ; ; ; ;
in Frontiers in neurology (2018), 9
Mitochondrial Morphology, Function and Homeostasis Are Impaired by Expression of an N-terminal Calpain Cleavage Fragment of Ataxin-3.; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Frontiers in molecular neuroscience (2018), 11
In vivo Phenotyping of Human Parkinson’s Disease-Specific Stem Cells Carrying the LRRK2-G2019S Mutation Reveals Increased a-Synuclein Levels but Absence of Spreading; ; ;
in Opera Medica et Physiologica (2018)
Integrated time-resolved multi-omics for understanding microbial niche ecology; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
Poster (2018, August)
The Luxembourg Parkinson’s Study: A Comprehensive Approach for Stratification and Early Diagnosis; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Frontiers in Aging Neuroscience (2018), 10
Activity of translation regulator eukaryotic elongation factor-2 kinase is increased in Parkinson disease brain and its inhibition reduces alpha synuclein toxicity; ; ; ; ; ; ; ; ; ; ; ;
in Acta Neuropathologica Communications (2018)
THE PARKINSON’S DISEASE ASSOCIATED PINK1-PARKIN PATHWAY IN PATHOLOGY AND DEVELOPMENTDoctoral thesis (2018)
Large-scale validation of miRNAs by disease association, evolutionary conservation and pathway activity.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in RNA biology (2018)
Cytokine-mediated modulation of the hepatic miRNome: miR-146b-5p is an IL-6-inducible miRNA with multiple targets.; ; ; ; ; ; ; ; ; ; ;
in Journal of leukocyte biology (2018)
Insufficient Evidence for Pathogenicity of SNCA His50Gln (H50Q) in Parkinson's Disease; ;
in Neurobiology of Aging (2018)
Understanding the role of genetic variability in LRRK2 in Indian population; ; ;
in Movement Disorders (2018)
Management of Parkinson’s Disease 20 Years from Now: Towards Digital Health Pathways; ; ;
in Journal of Parkinson's Disease (2018)
The genetic architecture of mitochondrial dysfunction in Parkinson's Disease; ;
in Cell and Tissue Research (2018)
Cytostatic hydroxycoumarin OT52 induces ER/Golgi stress and STAT3 inhibition triggering non-canonical cell death and synergy with BH3 mimetics in lung cancer.; ; ; ; ; ; ; ; ; ; ; ;
in Cancer Letters (2018)
Behavioural outcomes of subthalamic stimulation and medical therapy versus medical therapy alone for Parkinson's disease with early motor complications (EARLYSTIM trial): secondary analysis of an open-label randomised trial.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in The Lancet. Neurology (2018), 17(3), 223-231
Hydroxycoumarin OT-55 kills CML cells alone or in synergy with imatinib or Synribo: Involvement of ER stress and DAMP release; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Cancer Letters (2018)
A complex of the ubiquitin ligase TRIM32 and the deubiquitinase USP7 balances the level of c-Myc ubiquitination and thereby determines neural stem cell fate specification; ; ; ; ; ; ;
in Cell Death & Differentiation (2018)
The FASTCORE Family: For the Fast Reconstruction of Compact Context-Specific Metabolic Networks Models;
in Fondi, Marco (Ed.) Metabolic Network Reconstruction and Modeling (2018)
The FASTCORE Family: For the Fast Reconstruction of Compact Context-Specific Metabolic Networks Models.;
in Methods in Molecular Biology (Clifton, N.J.) (2018), (1716), 101-110
Advanced Good Cell Culture Practice for human primary, stem cell-derived and organoid models as well as microphysiological systems; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in ALTEX : Alternativen zu Tierexperimenten (2018)
Transcriptional and epigenetic mechanisms underlying astrocyte identity; ; ; ;
in Progress in Neurobiology (2018)
The intertwined metabolism during symbiotic nitrogen fixation elucidated by metabolic modelling; ; ; ; ;
in Scientific Reports (2018), 8
Nuclear localization and phosphorylation modulate pathological effects of Alpha-Synuclein; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Human Molecular Genetics (2018)
Annexin A1 regulates EGFR activity and alters EGFR-containing tumour-derived exosomes in head and neck cancers.; ; ; ; ; ;
in European journal of cancer (Oxford, England : 1990) (2018), 102
The PD-L1- and IL6-mediated dampening of the IL27/STAT1 anticancer responses are prevented by a-PD-L1 or a-IL6 antibodies; ; ; ; ; ; ; ; ; ; ; ; ;
in Journal of Leukocyte Biology (2018), 104
Phosphoprotein patterns predict trametinib responsiveness and optimal trametinib sensitisation strategies in melanoma.; ; ; ; ; ; ; ; ; ; ; ;
in Cell death and differentiation (2018)
Secretion of the Phosphorylated Form of S100A9 from Neutrophils Is Essential for the Proinflammatory Functions of Extracellular S100A8/A9.; ; ; ; ; ; ;
in Frontiers in immunology (2018), 9
Is Parkinson’s disease a neurodevelopmental disorder and will brain organoids help us to understand it?in Stem Cells & Development (2018)
"Stroma-induced phenotypic plasticity offers phenotype-specific targeting to improve melanoma treatment".; ; ; ; ; ; ; ; ; ;
in Cancer letters (2018)
The microRNA-371~373 cluster represses colon cancer initiation and metastatic colonization by inhibiting the TGFBR2/ID1 signaling axis.; ; ; ; ; ; ; ; ; ; ; ;
in Cancer research (2018)
Thiazole- and selenazole-comprising high-affinity inhibitors possess bright microsecond-scale photoluminescence in complex with protein kinase CK2.; ; ; ;
in Bioorganic & medicinal chemistry (2018), 26(18), 5062-5068
2017
TTCA: an R package for the identification of differentially expressed genes in time course microarray data; ; ; ; ; ; ; ;
in BMC Bioinformatics (2017), 18(1), 33
FACS-Assisted CRISPR-Cas9 Genome Editing Facilitates Parkinson's Disease Modeling; ; ; ; ; ; ; ;
in Stem Cell Reports (2017)
Insights into ligand stimulation effects on gastro-intestinal stromal tumors signalling.; ; ; ; ; ;
in Cell Signal (2017)
Tumor-Initiating Cells: a criTICal review of isolation approaches and new challenges in targeting strategies; ; ;
in Molecular Cancer (2017)
NeuroChip, an updated version of the NeuroX genotyping platform to rapidly screen for variants associated with neurological diseases; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Neurobiology of Aging (2017)
Rare variant analysis of the PPMI dataset to uncover the complex genetic architecture of Parkinson’s disease; ;
in Movement Disorders : Official Journal of the Movement Disorder Society (2017, June 02), 322(Supplement S2), 405
The multi-site docking protein Gab1 is constitutively phosphorylated independent from its recruitment to the plasma membrane in Jak2-V617Fpositive cells and mediates proliferation of human erythroleukaemia cells; ; ; ; ; ; ; ; ; ;
in Cellular Signalling (2017), 35
Analysis of primary microRNA loci from nascent transcriptomes reveals regulatory domains governed by chromatin architecture; ; ; ; ; ; ; ;
in Nucleic Acids Research (2017)
Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson's disease.; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Science (New York, N.Y.) (2017), 357(6357), 1255-1261
Functionally Convergent B Cell Receptor Sequences in Transgenic Rats Expressing a Human B Cell Repertoire in Response to Tetanus Toxoid and Measles Antigens.; ; ; ; ; ; ;
in Frontiers in immunology (2017), 8
ROS production induced by BRAF inhibitor treatment rewires metabolic processes affecting cell growth of melanoma cells; ; ; ;
in Molecular Cancer (2017), 8(june),
FALCON: A Toolbox for the Fast Contextualisation of Logical Networks.; ; ;
in Bioinformatics (Oxford, England) (2017)
An evaluation of real-time troposphere estimation based on GNSS Precise Point Positioning; ; ; ;
in Journal of Geophysical Research: Atmospheres (2017), 122(5), 2779--2790
An Evaluaton of Real-Time Troposphere Products Based on mult-GNSS Precise Point Posi)oning; ; ; ;
Scientific Conference (2017, February 21)
Metformin reverses TRAP1 mutation-associated alterations in mitochondrial function in Parkinson's disease; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Brain : A Journal of Neurology (2017), 140(9), 2444-2459
Unravelling a p73-regulated network: The role of a novel p73-dependent target, MIR3158, in cancer cell migration and invasiveness; ; ; ; ; ; ; ;
in Cancer Letters (2017), 388
Stratifying cancer patients based on multiple kernel learning and dimensionality reduction; ;
in Giang, Thanh Trung; Nguyen, Thanh-Phuong; Tran (Eds.) 9th International Conference on Knowledge and Systems Engineering (KSE) (2017)
Parkinson’s Disease-Associated Mutant LRRK2-Mediated Inhibition of miRNA Activity is Antagonized by TRIM32; ; ; ;
in Molecular Neurobiology (2017)
Aberrant splicing of the tumor suppressor CYLD promotes the development of chronic lymphocytic leukemia via sustained NF-kappaB signaling.; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Leukemia (2017), 32(1), 72-82
Reverse Bayesian poisoning: How to use spam filters to manipulate online elections; ;
in Krimmer, L. (Ed.) Proc. 2nd International Joint Conference on Electronic Voting (2017)
Automated micro uidic cell culture of stem cell derived dopaminergic neurons in Parkinson's disease; ; ; ; ; ; ; ; ;
in bioRxiv (2017)
Impact of BRAF kinase inhibitors on the miRNomes and transcriptomes of melanoma cells; ; ; ;
in Biochimica et Biophysica Acta (2017)
Classification of advanced stages of Parkinson's disease: translation into stratified treatments.; ; ; ; ; ; ; ; ;
in Journal of neural transmission (Vienna, Austria : 1996) (2017), 124(124), 1015-1027
An Observational Study of the Effect of Levodopa-Carbidopa Intestinal Gel on Activities of Daily Living and Quality of Life in Advanced Parkinson's Disease Patients.; ; ; ; ; ; ; ; ; ; ;
in Advances in therapy (2017)
Loss of Myosin Vb in colorectal cancer is a strong prognostic factor for disease recurrence; ; ; ; ; ; ; ;
in British Journal of Cancer (2017), 117(11), 1689-1701
Resolving the Combinatorial Complexity of Smad Protein Complex Formation and Its Link to Gene Expression.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Cell Systems (2017)
Problematic Gaming Behaviour in Finnish Adolescents and Young Adults: Relation to Game Genres, Gaming Motives and Self-Awareness of Problematic Use; ; ; ;
in International Journal of Mental Health and Addiction (2017), 15
Targeting autophagy inhibits growth by enhancing NK cells infiltration in a CCL5-dependent manner; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Proceedings of the National Academy of Sciences of the United States of America (2017), 114((44)), 9271-9279
Derivation of Human Midbrain-Specific Organoids from Neuroepithelial Stem Cells; ; ; ; ; ; ; ; ; ; ; ; ;
in Stem Cell Reports (2017)
Cellular models as tools for the study of the role of alpha-synuclein in Parkinson's disease; ;
in Experimental Neurology (2017)
rapalogs can promote cancer cell stemness in vitro in a Galectin-1 and H-ras-dependent manner; ; ; ; ; ; ;
in Oncotarget (2017), Vol. 8((No. 27)), 44550-44566
Opposite feedback from mTORC1 to H-ras and K-ras4B downstream of SREBP1; ; ; ; ;
in Scientific Reports (2017)
CRISPR/CAS9 AND PIGGYBAC MEDIATED LRRK2-G2019S IN VITRO PARKINSON’S DISEASE MODELINGDoctoral thesis (2017)
Crosstalk between different family members: IL27 recapitulates IFNγ responses in HCC cells, but is inhibited by IL6-type cytokines; ; ; ; ; ; ; ; ; ; ;
in BBA Molecular Cell Research (2017)
Tailored Approaches in Drug Development and Diagnostics: From Molecular Design to Biological Model Systems; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Advanced Healthcare Materials (2017)
The PET and LIM1-2 domains of testin contribute to intramolecular and homodimeric interactions; ; ; ; ;
in PLoS ONE (2017)
Expanding the Interactome of TES by Exploiting TES Modules with Different Subcellular Localizations; ; ; ; ; ; ; ;
in Journal of Proteome Research (2017), doi: 10.1021/acs.jproteome.7b00034
Angiotensin II regulates phosphorylation of actin-associated proteins in human podocytes; ; ; ; ; ; ;
in FASEB Journal (2017)
Effects of Subthalamic and Nigral Stimulation on Gait Kinematics in Parkinson's Disease.; ; ; ; ; ; ; ;
in Frontiers in neurology (2017), 8
Involvement of the cerebellum in Parkinson disease and dementia with Lewy bodies.; ; ; ; ; ; ;
in Annals of neurology (2017), 81(6), 898-903
Regulated in development and DNA damage responses 1 (REDD1) links stress with IL-1β-mediated familial Mediterranean fever attack through autophagy-driven neutrophil extracellular traps; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Journal of Allergy and Clinical Immunology (2017)
Model Based Targeting of IL-6-Induced Inflammatory Responses in Cultured Primary Hepatocytes to Improve Application of the JAK Inhibitor Ruxolitinib.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Frontiers in physiology (2017), 8
Nurr1:RXRα heterodimer activation as monotherapy for Parkinson’s disease; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Proceedings of the National Academy of Sciences of the United States of America (2017)
The GBAP1 pseudogene acts as a ceRNA for the glucocerebrosidase gene GBA by sponging miR-22-3p.; ; ; ; ; ; ; ; ; ;
in Scientific reports (2017), 7(1), 12702
From meta-genomics to causality: Understanding the role of colon cancer-associated bacteria in colorectal cancer; ; ;
Poster (2017, February 05)
Human induced pluripotent stem cell-derived neuronal progenitors are a suitable and effective drug discovery model for neurological mtDNA disorders; ;
in Stem Cell Investigation (2017)
Evaluation of the interaction between LRRK2 and PARK16 loci in determining risk of Parkinson's disease: analysis of a large multicenter study.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Neurobiology of aging (2017), 49
On definition and inference of nonlinear Boolean dynamic networks; ; ;
in On definition and inference of nonlinear Boolean dynamic networks (2017, December)
Linear Dynamic Network Reconstruction from Heterogeneous Datasets; ; ;
in Linear Dynamic Network Reconstruction from Heterogeneous Datasets (2017, July)
2016
Thermodynamically constrained averaging theory for cancer growth modelling; ; ;
in IFAC-PapersOnLine (2016), 49(26), 289-294
Alkyl and aryl sulfonyl p-pyridine ethanone oximes are efficient DNA photo-cleavage agents; ; ; ; ; ;
in Journal of Photochemistry and Photobiology B: Biology (2016), 158
Data on quantification of signaling pathways activated by KIT and PDGFRA mutants.; ; ; ; ; ;
in Data in Brief (2016), (9), 828-838
What Do We Learn from Spheroid Culture Systems? Insights from Tumorspheres Derived from Primary Colon Cancer Tissue.; ; ; ; ; ;
in PLoS ONE (2016), 11
The role of HIF-1 in oncostatin M-dependent metabolic reprogramming of hepatic cells.; ; ; ; ; ; ;
in Cancer & metabolism (2016), 4
Prox1 is required for oligodendrocyte cell identity in adult neural stem cells of the subventricular zone; ; ; ; ; ; ; ; ; ; ; ;
in Stem Cells (2016)
Systems biology integration of proteomic data in rodent models of depression reveals involvement of the immune response and glutamatergic signalling; ;
in Proteomics. Clinical Applications (2016)
Mitochondrial Defects and Neurodegeneration in Mice Overexpressing Wild Type or G399S Mutant HtrA2; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Human Molecular Genetics (2016), 25(3), 459-71
Variant PNPLA3 increases the HCC risk: prospective study in patients treated at the Saarland University Medical Center; ; ; ;
in Zeitschrift für Gastroenterologie (2016), 54
Transferring intercellular signals and traits between cancer cells: extracellular vesicles as "homing pigeons"; ; ;
in Cell Communication and Signaling (2016), 14(1), 13
Cost-Effectiveness of Neurostimulation in Parkinson's Disease With Early Motor Complications; ; ; ; ; ; ; ; ; ; ;
in Movement Disorders : Official Journal of the Movement Disorder Society (2016), 31(8), 1183-1191
Tripartite Containing Motif 32 Modulates Proliferation of Human Neural Precursor Cells in HIV-1 Neurodegeneration; ; ; ; ; ;
in Cell Death & Differentiation (2016)
6-hydroxydopamine-induced Parkinson's disease-like degeneration generates acute micro- and astrogliosis in the nigrostriatal system but no Bioluminescence Imaging detectable alteration in adult neurogenesis; ; ; ; ; ; ; ; ; ; ; ; ;
in European Journal of Neuroscience (2016)
A study of the molecular mechanisms underlying the response of human colorectal adenomacarcinoma enterocytes to prebiotics and probiotics; ; ; ; ; ; ; ; ; ;
Poster (2016, June)
Optimum stochastic modeling for GNSS tropospheric delay estimation in real-time; ; ; ;
in GPS Solutions (2016)
Prodromal Markers in Parkinson's Disease: Limitations in Longitudinal Studies and Lessons Learned.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Frontiers in aging neuroscience (2016), 8
The TAT-RasGAP317-326 anti-cancer peptide can kill in a caspase-, apoptosis-, and necroptosis-independent manner; ; ; ; ; ; ; ; ;
in Oncotarget (2016), 7(39),
Utilization of stem cells to model Parkinson's disease – current state and future challenges;
in Future Neurology (2016)
Alpha-Synuclein Proteins Promote Pro-Inflammatory Cascades in Microglia: Stronger Effects of the A53T Mutant.; ; ; ; ; ; ; ;
in PLoS ONE (2016)
Context-specific flow through the MEK/ERK module produces cell- and ligand-specific patterns of ERK single and double phosphorylation.; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Science signaling (2016), 9(413), 13
miRNAs in ancient tissue specimens of the Tyrolean Iceman; ; ; ; ; ; ; ; ; ; ; ;
in Molecular Biology and Evolution (2016), 34(4), 793-801
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition); ;
in Autophagy (2016), 12(1), 1-222
Advanced stages of PD: interventional therapies and related patient-centered care; ; ; ; ; ; ;
in Journal of neural transmission (Vienna, Austria : 1996) (2016)
Aiming for Study Comparability in Parkinson's Disease: Proposal for a Modular Set of Biomarker Assessments to be Used in Longitudinal Studies.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Frontiers in aging neuroscience (2016), 8
SOCS2: physiological and pathological functions.;
in Frontiers in bioscience (Elite edition) (2016), 8
L-plastin Ser5 phosphorylation in breast cancer cells and in vitro is mediated by RSK downstream of the ERK/MAPK pathway; ; ; ; ; ; ; ;
in FASEB Journal (2016)
Tragbare und aktiv vom Parkinson-Patienten genutzte Technologie im hauslichen Umfeld: Was bringt die Zukunft?; ; ; ; ; ;
in Fortschritte der Neurologie-Psychiatrie (2016), 84 Suppl 1
Combining chemical and genetic approaches for development of responsive FRET-based sensor systems for protein kinases; ;
in Biophysical Chemistry (2016), 211
Dissecting functions of the N-terminal domain and GAS-site recognition in STAT3; ; ; ; ;
in Cellular Signalling (2016), 28(8), 810-25
Constraint based modelling going multicellular; ;
in Frontiers in Molecular Biosciences (2016), 3(3),
Downregulation of the TGF-beta pseudoreceptor BAMBI in non-small cell lung cancer enhances TGF-beta signaling and invasion.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Cancer research (2016)
Loss of DJ-1 impairs antioxidant response by altered glutamine and serine metabolism; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Neurobiology of disease (2016), 89
ΔNp63α expression induces loss of cell adhesion in triple-negative breast cancer cells; ; ; ; ; ; ; ; ; ; ;
in BMC Cancer (2016), 16(1),
A generalized gene regulatory network model of stem cell differentiation for predicting lineage specifiers; ; ; ;
in Stem Cell Reports (2016)
Benchmarking procedures for high-throughput context specific reconstruction algorithms; ;
in Frontiers in Physiology (2016)
Expression of the Parkinson’s Disease-Associated Gene Alpha-Synuclein is Regulated by the Neuronal Cell Fate Determinant TRIM32; ; ; ; ; ; ;
in Molecular Neurobiology (2016)
“Melanomics”: analysis and integration of whole genomes, transcriptomes and miRNomes of primary melanoma patients; ; ; ; ; ; ; ;
in European Journal of Cancer (2016), 61(Suppl.1), 32
Environmental enrichment and physical exercise revert behavioral and electrophysiological impairments caused by reduced adult neurogenesis; ; ; ; ; ; ; ; ;
in Hippocampus (2016)
Cortical correlates of susceptibility to upper limb freezing in Parkinson's disease.; ; ; ; ; ; ;
in Clinical Neurophysiology (2016), 127(6), 2386-93
Neuromuscular correlates of subthalamic stimulation and upper limb freezing in Parkinson's disease.; ; ; ; ; ; ; ; ; ; ;
in Clinical Neurophysiology (2016)
Cyclooxygenase-2 contributes to the selective induction of cell death by the endocannabinoid 2-arachidonoyl glycerol in hepatic stellate cells.; ; ; ; ; ; ; ;
in Biochemical and biophysical research communications (2016), 470(3), 678-84
Multi-GNSS Benefits to Real-Time and Long-Term Monitoring Applications; ; ; ; ; ; ;
Scientific Conference (2016, July 30)
An Iterative Projection method for Synchronization of Invertible Matrices Over Graphs; ; ;
in 22nd International Symposium on Mathematical Theory of Networks and Systems (2016)
A Probabilistic Boolean Network Approach for the Analysis of Cancer-Specific Signalling: A Case Study of Deregulated PDGF Signalling in GIST.; ; ; ;
in PloS one (2016), 11(5), 0156223
Hypoxia-responsive miR-210 promotes self-renewal capacity of colon tumor-initiating cells by repressing ISCU and by inducing lactate production; ; ; ; ; ; ; ; ; ; ;
in Oncotarget (2016), 7(40), 97-114
miR-661 expression in SNAI1-induced epithelial to mesenchymal transition contributes to breast cancer cell invasion by targeting Nectin-1 and StarD10 messengers; ; ; ; ; ; ; ; ; ;
in Oncogene (2016), 35(5), 670
Synthesis, characterization and in vivo evaluation of a magnetic cisplatin delivery nanosystem based on PMAA-graft-PEG copolymers; ; ; ; ; ; ; ; ; ; ; ;
in Journal of Controlled Release (2016), 243
Alpha-synuclein gene variants may predict neurostimulation outcome.; ; ; ; ; ; ; ; ;
in Movement disorders : official journal of the Movement Disorder Society (2016)
Inverse Problems for Matrix Exponential in System Identification: System Aliasing; ;
in 22nd International Symposium on Mathematical Theory of Networks and Systems (2016)
2015
Insight into metabolic pathways of the potential biofuel producer, Paenibacillus polymyxa ICGEB2008; ; ;
in Biotechnology for Biofuels (2015), 8(159),
Goals in Nutrition Science 2015–2020; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Frontiers in Nutrition (2015), 2(26),
Constitutive activation of oncogenic PDGFRalpha-mutant proteins occurring in GIST patients induces receptor mislocalisation and alters PDGFRalpha signalling characteristics.; ; ; ; ; ; ; ; ; ; ;
in Cell Communication and Signaling (2015), 13
TRIM32 modulates pluripotency entry and exit by directly regulating Oct4 stability; ; ; ; ; ; ; ; ;
in Scientific Reports (2015)
Circulating microRNAs as candidate biomarkers for the surveillance of melanoma patients; ;
in EBioMedicine (2015)
Transcriptomic analyses of primary astrocytes under TNFα treatment; ; ; ; ; ;
in Genomics Data (2015), 7
TRIM32 Senses and Restricts Influenza A Virus by Ubiquitination of PB1 Polymerase; ; ; ; ;
in PLoS Pathogens (2015)
Short- and long-term outcome of chronic pallidal neurostimulation in monogenic isolated dystonia; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Neurology (2015), 84(9), 895-903
Low-bias phosphopeptide enrichment from scarce samples using plastic antibodies; ; ; ; ; ; ; ; ; ; ; ;
in Scientific reports (2015), 5
Constitutive expression of tdTomato protein as a cytotoxicity and proliferation marker for space radiation biology; ; ; ; ; ;
in Life Sciences in Space Research (2015), 4
Effects of Endocrine Disruptor Compounds, Alone or in Combination, on Human Macrophage-Like THP-1 Cell Response; ; ; ; ; ; ;
in PLoS ONE (2015), 10(7), 0131428
Role of Calprotectin as a Modulator of the IL27-Mediated Proinflammatory Effect on Endothelial Cells; ; ; ; ; ;
in Mediators of Inflammation (2015), 2015
Do Genome-scale Models Need Exact Solvers or Clearer Standards?; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Molecular Systems Biology (2015), 11(10), 1
Insights from ENCODE on Missing Proteins: Why beta-Defensin Expression Is Scarcely Detected.; ; ; ; ; ; ; ; ; ; ; ;
in Journal of proteome research (2015), 14(9), 3635-44
Inflammation Promotes a Conversion of Astrocytes into Neural Progenitor Cells via NF-κB Activation; ; ; ; ; ; ; ;
in Molecular Neurobiology (2015), 53(8), 5041-5055
Cell type-selective disease-association of genes under high regulatory load; ; ; ;
in Nucleic Acids Research (2015), 43(18), 8839-8855
NLRP3 Inflammasome Is Expressed and Functional in Mouse Brain Microglia but Not in Astrocytes.; ; ; ; ; ; ; ;
in PLoS ONE (2015), 10(6),
The oncogenic FIP1L1-PDGFRalpha fusion protein displays skewed signaling properties compared to its wild-type PDGFRalpha counterpart.; ; ; ; ; ; ; ; ; ; ;
in JAK-STAT (2015), 4(1), 1062596
Delineating the Tes Interaction Site in Zyxin and Studying Cellular Effects of Its Disruption; ; ; ; ; ; ; ; ; ;
in PLoS ONE (2015)
MiR-128 represses L1 retrotransposition by binding directly to L1 RNA; ; ; ; ; ;
in Nature Structural and Molecular Biology (2015), 22(10), 824-831
The neural stem cell fate determinant TRIM32 regulates complex behavioral traits; ; ; ; ; ; ;
in Frontiers in Cellular Neuroscience (2015)
Diversity of key players in the microbial ecosystems of the human body.; ; ; ; ; ;
in Scientific reports (2015), 5
Changes in the human gastrointestinal microbiome during cancer treatments; ; ; ; ; ; ; ;
Poster (2015, March)
Assessing Transcription Regulatory Elements To Evaluate the Expression Status of Missing Protein Genes on Chromosomes 11 and 19.; ; ; ; ; ; ; ; ; ; ; ;
in Journal of proteome research (2015), 14(12), 4967-75
Neural stem cells in Parkinson’s disease: a role for neurogenesis defects in onset and progression; ; ;
in Cellular and Molecular Life Sciences : CMLS (2015)
Inhibition of αIIbβ3 Ligand Binding by an αIIb Peptide that Clasps the Hybrid Domain to the βI Domain of β3; ; ; ; ; ; ; ; ; ;
in PLoS ONE (2015)
Methods in Neuroepidemiology Characterization of European Longitudinal Cohort Studies in Parkinson's Disease - Report of the JPND Working Group BioLoC-PD; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Neuroepidemiology (2015), 45(4), 282-297
Hind limb unloading, a model of spaceflight conditions, leads to decreased B lymphopoiesis similar to aging; ; ; ; ; ; ; ; ; ; ;
in FASEB Journal (2015), 29(2), 455-63
Initiation and dose optimization for levodopa-carbidopa intestinal gel: Insights from phase 3 clinical trials; ; ; ; ; ; ; ;
in Parkinsonism & related disorders (2015), 21(7), 742-748
Differentiation of neuroepithelial stem cells into functional dopaminergic neurons in 3D microfluidic cell culture; ; ; ; ; ; ; ;
in Lab on a Chip - Miniaturisation for Chemistry & Biology (2015), 15
Multiscale model of dynamic neuromodulation integrating neuropeptide-induced signaling pathway activity with membrane electrophysiology.; ; ; ; ;
in Biophysical journal (2015), 108(1), 211-23
FRET-based screening assay using small-molecule photoluminescent probes in lysate of cells overexpressing RFP-fused protein kinases; ; ; ; ; ; ; ;
in Analytical Biochemistry (2015)
Comparison of a healthy miRNome with melanoma patient miRNomes: are microRNAs suitable serum biomarkers for cancer?; ; ; ; ; ; ; ;
in Oncotarget (2015), 6(14), 12110-27
The NG2 Proteoglycan Protects Oligodendrocyte Precursor Cells against Oxidative Stress via Interaction with OMI/HtrA2; ; ; ; ; ; ; ; ; ; ; ;
in PLoS ONE (2015), 10(9), 0137311
Regulation of Neutrophil Degranulation and Cytokine Secretion: A Novel Model Approach Based on Linear Fitting; ; ; ; ;
in Journal of Immunology Research (2015), 2015
Novel drug target identification for the treatment of dementia using multi-relational association mining; ;
in Scientific Reports (2015), 5
The RNA helicase DDX6 regulates cell-fate specification in neural stem cells via miRNAs; ; ; ; ;
in Nucleic Acids Research (2015)
The COMT Val/Met polymorphism modulates effects of tDCS on response inhibition; ; ; ;
in Brain stimulation (2015), 8(2), 283-288
Collective physician perspectives on non-oral medication approaches for the management of clinically relevant unresolved issues in Parkinson's disease: Consensus from an international survey and discussion program; ; ; ; ; ; ; ; ; ; ; ; ;
in Parkinsonism & Related Disorders (2015)
TREM2 R47H variant and risk of essential tremor: a cross-sectional international multicenter study; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Parkinsonism & related disorders (2015), 21(3), 306-309
Integrated metabolic modelling reveals cell-type specific epigenetic control points of the macrophage metabolic network; ; ; ; ; ; ; ;
in BMC Genomics (2015), 16(809),
Rapid and robust generation of long-term self-renewing human neural stem cells with the ability to generate mature astroglia; ; ; ; ; ; ; ; ;
in Scientific Reports (2015), 5
Towards improved genome-scale metabolic network reconstructions: unification, transcript specificity and beyond.; ;
in Briefings in bioinformatics (2015)
Clinically meaningful parameters of progression and long-term outcome of Parkinson disease: An international consensus statement; ; ; ; ; ; ; ; ; ; ; ;
in Parkinsonism & related disorders (2015), 21(7), 675-682
A draft network of ligand–receptor-mediated multicellular signalling in human; ; ; ; ; ; ; ; ; ;
in Nature Communications (2015), 6
Comparative integrated omics: identification of key functionalities in microbial community-wide metabolic networks; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Biofilms and Microbiomes (2015), 1(15007),
IL-1beta mediates MMP secretion and IL-1beta neosynthesis via upregulation of p22phox and NOX4 activity in human articular chondrocytes; ; ; ; ; ; ; ; ;
in Osteoarthritis and Cartilage (2015), 23(11), 1972-1980
CK2 phosphorylation of C/EBPdelta regulates its transcription factor activity.; ; ;
in The international journal of biochemistry & cell biology (2015), 61
ID: 194: Role of microRNAs in signal transduction pathways of the inflammatory cytokine Interleukin-6: Relevance for liver diseases; ; ; ; ; ; ; ; ;
in Cytokine (2015), 76(1), 99-
Synthesis of folate- pegylated polyester nanoparticles encapsulating ixabepilone for targeting folate receptor overexpressing breast cancer cells; ; ; ; ; ; ; ; ;
in Journal of Materials Science: Materials in Medicine (2015), 26(12), 1-14
Studying Signal Transduction Networks with a Probabilistic Boolean Network ApproachDoctoral thesis (2015)
Development of Alternative Proteomics Methods for Lung Cancer Biomarker EvaluationDoctoral thesis (2015)
A microtubule-independent role of p150glued in secretory cargo concentration at endoplasmic reticulum exit sites; ; ;
in Journal of Cell Science (2015), 128(22), 4160-4170
Large-scale assessment of polyglutamine repeat expansions in Parkinson disease; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Neurology (2015), 85(15), 1283-92
Subthalamic stimulation modulates cortical motor network activity and synchronization in Parkinson's disease; ; ; ; ; ; ; ; ; ;
in Brain : a journal of neurology (2015), 138(Pt 3), 679-93
Long-term outcome of deep brain stimulation in fragile X-associated tremor/ataxia syndrome; ; ; ; ; ; ; ; ;
in Parkinsonism & related disorders (2015), 21(3), 310-313
2014
Mitochondrial proteolytic stress induced by loss of mortalin function is rescued by Parkin and PINK1.; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Cell death & disease (2014), 5
Overexpression of synphilin-1 promotes clearance of soluble and misfolded alpha-synuclein without restoring the motor phenotype in aged A30P transgenic mice.; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Human molecular genetics (2014), 23(3), 767-81
Alpha-synuclein repeat variants and survival in Parkinson's disease.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Movement disorders : official journal of the Movement Disorder Society (2014)
A mathematical model of metabolism and regulation provides a systems-level view of how Escherichia coli responds to oxygen; ; ; ; ; ; ; ; ; ; ;
in Frontiers in Microbiology (2014), 5(124),
Gene regulatory network analysis reveals differences in site-specific cell fate determination in mammalian brain; ; ;
in Frontiers in Cellular Neuroscience (2014)
ChIP-seq profiling of the active chromatin marker H3K4me3 and PPARγ, CEBPα and LXR target genes in human SGBS adipocytes; ; ; ; ;
in Genomics Data (2014), 2
Molecular cloning and expression analysis of Pleurodeles waltl complement component C3 under normal physiological conditions and environmental stresses; ; ; ;
in Developmental and Comparative Immunology (2014), 46(2), 180-185
Origin-Dependent Neural Cell Identities in Differentiated Human iPSCs In Vitro and after Transplantation into the Mouse Brain; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Cell Reports (2014)
Protective effect of LRRK2 p.R1398H on risk of Parkinson's disease is independent of MAPT and SNCA variants.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Neurobiology of aging (2014), 35(1), 2665-14
Kapitel 34: Mediatoren; ; ; ;
in Heinrich, Peter C.; Müller, Matthias; Graeve, Lutz (Eds.) Biochemie und Pathobiochemie (2014)
Kapitel 35: Rezeptoren und ihre Signaltransduktion; ; ; ;
in Heinrich, Peter C.; Müller, Matthias; Graeve, Lutz (Eds.) Biochemie und Pathobiochemie (2014)
Induced Neural Stem Cells Achieve Long-Term Survival and Functional Integration in the Adult Mouse Brain; ; ; ; ; ; ; ; ; ;
in Stem Cell Reports (2014)
Basic Regulatory Principles of Escherichia coli's Electron Transport Chain for Varying Oxygen Conditions.; ; ; ; ; ; ; ;
in PloS one (2014), 9(9), 107640
EIF4G1 is neither a strong nor a common risk factor for Parkinson's disease: evidence from large European cohorts; ; ; ; ; ; ; ; ; ; ;
in Journal of medical genetics (2014), 0
Comparison of beamformers for EEG source signal reconstruction; ; ; ; ;
in Biomedical Signal Processing and Control (2014), 14
Identification of New IkappaBalpha Complexes by an Iterative Experimental and Mathematical Modeling Approach.; ; ;
in PLoS computational biology (2014), 10(3), 1003528
MMP13 mutations are the cause of recessive metaphyseal dysplasia, Spahr type; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in American Journal of Medical Genetics. Part A (2014), 164(5), 1175-1179
Identification of SOCS2 and SOCS6 as biomarkers in human colorectal cancer.; ; ; ; ; ; ; ; ; ; ;
in British journal of cancer (2014), 111(4), 726-35
Combinatorial regulation of lipoprotein lipase by microRNAs during mouse adipogenesis; ; ; ; ;
in RNA Biology (2014), 11(1), 76-91
An essential role of syntaxin 3 protein for granule exocytosis and secretion of IL-1α, IL-1β, IL-12b, and CCL4 from differentiated HL-60 cells; ; ; ; ; ; ;
in Journal of Leukocyte Biology (2014), 97
From genome-wide association studies to next-generation sequencing: lessons from the past and planning for the future.; ;
in JAMA neurology (2014), 71(1), 5-6
Mutant COQ2 in multiple-system atrophy.; ;
in The New England journal of medicine (2014), 371(1), 80-1
Water Chemistry and Hydrometeorology in a Glacierized Catchment in the Polar Urals, Russia; ; ; ; ;
in Journal of Mountain Science (2014), 11(5), 1097-1111
Global investigation and meta-analysis of the C9orf72 (G4C2)n repeat in Parkinson disease.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Neurology (2014)
optPBN: An Optimisation Toolbox for Probabilistic Boolean Networks; ; ; ;
in PLoS ONE (2014), 9(7), 980011-15
Fast reconstruction of compact context-specific metabolic network models; ;
in PLoS Computational Biology (2014), 10(1), 1003424
The subthalamic nucleus modulates the early phase of probabilistic classification learning.; ; ; ; ; ;
in Experimental brain research (2014), 232(7), 2255-62
2013
The Parkinson's Disease-Associated LRRK2 Mutation R1441G Inhibits Neuronal Differentiation of Neural Stem Cells.; ; ; ; ; ;
in Stem Cells & Development (2013)
Tocopherol derivative TFA-12 promotes myelin repair in experimental models of multiple sclerosis.; ;
in Journal of Neuroscience (2013), 33(28), 11633-42
New Insights into the Regulation of Neutrophil NADPH Oxidase Activity in the Phagosome: A Focus on the Role of Lipid and Ca(2+) Signaling; ;
in Antioxidants & Redox Signaling (2013), 18(6), 661-676
On different aspects of network analysis in systems biology; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Systems Biology (2013), 1
Predicting missing expression values in gene regulatory networks using a discrete logic modeling optimization guided by network stable states; ; ; ;
in Nucleic Acids Research (2013), 41(1), 8
Innate and adaptive effects of inflammasomes on T cell responses; ;
in Current Opinion in Immunology (2013), 25(3), 359-365
The recruitment of p47 and Rac2G12V at the phagosome is transient and phosphatidylserine dependent.; ; ; ; ; ; ; ; ;
in Biology of the Cell (2013)
JAK2 mutants (e.g., JAK2V617F) and their importance as drug targets in myeloproliferative neoplasms; ;
in JAK-STAT (2013), 2(3), 25025
Cooperative effects of Janus and Aurora kinase inhibition by CEP701 in cells expressing Jak2V617F; ; ; ; ; ; ; ;
in Journal of Cellular & Molecular Medicine (2013), 17(2), 265-276
Integrated analysis of transcript-level regulation of metabolism reveals disease-relevant nodes of the human metabolic network; ; ; ; ;
in Nucleic Acids Research (2013)
A novel heterozygous OPA3 mutation located in the mitochondrial target sequence results in altered steady-state levels and fragmented mitochondrial network.; ; ; ; ; ; ; ; ; ; ;
in Journal of medical genetics (2013), 50(12), 848-58
Co-immunoprecipitation protocol to investigate cytokine receptor-associated proteins, e.g., Janus kinases or other associated signaling proteins.;
in Methods in Molecular Biology (Clifton, N.J.) (2013), 967
Detection of activated STAT species using electrophoretic mobility shift assay (EMSA) and potential pitfalls arising from the use of detergents.;
in Methods in Molecular Biology (Clifton, N.J.) (2013), 967
Population-specific frequencies for LRRK2 susceptibility variants in the Genetic Epidemiology of Parkinson's Disease (GEO-PD) Consortium.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Movement disorders : official journal of the Movement Disorder Society (2013), 28(12), 1740-4
Meta-omic Analyses of the Microbiome in a Family Study of Diabetes Mellitus; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
Poster (2013, October)
TRIM32-dependent transcription in adult neural progenitor cells regulates neuronal differentiation; ; ; ; ; ; ;
in Cell Death & Disease (2013)
Gravity changes during animal development affect IgM heavy-chain transcription and probably lymphopoiesis; ; ; ; ; ; ;
in FASEB Journal (2013), 27(1), 333-341
De novo mutations in hereditary diffuse leukoencephalopathy with axonal spheroids (HDLS).; ; ; ; ; ; ; ;
in Neurology (2013), 81(23), 2039-44
Broad RNA interference-mediated antiviral immunity and virus-specific inducible responses in Drosophila; ; ; ; ; ; ; ; ; ; ; ;
in Journal of Immunology (2013), 190(2), 650-658
Tripolin A, a Novel Small-Molecule Inhibitor of Aurora A Kinase, Reveals New Regulation of HURP’s Distribution on Microtubules; ; ; ; ; ; ; ;
in PLoS ONE (2013), 8(3),
CHD4 Is a RanGTP-Dependent MAP that Stabilizes Microtubules and Regulates Bipolar Spindle Formation; ; ; ; ; ;
in Current Biology (2013), 23(24), 2443-2451
Functions, divergence and clinical value of TAp73 isoforms in cancer.; ; ; ;
in Cancer and Metastasis Reviews (2013), 32(3-4), 511534
New Target Genes of MITF-Induced microRNA-211 Contribute to Melanoma Cell Invasion; ; ; ; ;
in PLoS ONE (2013), 8(9),
A balancing act: Parameter estimation for biological models with steady-state measurements; ; ;
in Proceedings of 11th Conference on Computational Methods in Systems Biology (CMSB'13) (2013)
Mathematical modelling of the Platelet-Derived Growth Factor (PDGF) signalling pathway; ; ;
in Proceedings of 4th Workshop on Computational Models for Cell Processes (CompMod'13) (2013)
Interplay of microRNAs, transcription factors and target genes: Linking dynamic expression changes to function; ; ; ; ; ;
in Nucleic Acids Research (2013), 41(5), 2817-2831
Oligodendrocyte lineage cells contribute unique features to rett syndrome neuropathology; ; ; ; ; ;
in Journal of Neuroscience (2013), 33(48), 18764-18774
Quinone compounds regulate the level of ROS production by the NADPH oxidase Nox4; ; ; ; ; ; ; ;
in Biochemical Pharmacology (2013), 85(11), 1644-1654
A systemic transcriptome analysis reveals the regulation of neural stem cell maintenance by an E2F1-miRNA feedback loop.; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Nucleic Acids Research (2013), 41(6), 3699-712
Gonadotropin-releasing hormone neuropeptides and receptor in human breast cancer: Correlation to poor prognosis parameters; ; ; ; ; ; ; ; ; ; ; ; ;
in Peptides (2013), 42
Effects of transcranial direct current stimulation (tDCS) on executive functions: influence of COMT Val/Met polymorphism.; ; ; ; ;
in Cortex : A Journal Devoted to the Study of the Nervous System & Behavior (2013), 49(7), 1801-7
Derivation and expansion using only small molecules of human neural progenitors for neurodegenerative disease modeling.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in PLoS ONE (2013), 8(3), 59252
Genetic correction of a LRRK2 mutation in human iPSCs links parkinsonian neurodegeneration to ERK-dependent changes in gene expression.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Cell Stem Cell (2013), 12(3), 354-67
Novel SLC9A6 mutations in two families with Christianson syndrome.; ; ; ; ; ; ; ; ;
in Clinical genetics (2013), 83(6), 596-7
Modulation of Pleurodeles waltl DNA Polymerase mu Expression by Extreme Conditions Encountered during Spaceflight; ; ;
in PLoS ONE (2013), 8(7),
Neurostimulation for Parkinson's disease with early motor complications.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in The New England journal of medicine (2013), 368(7), 610-22
Excemplify: a flexible template based solution, parsing and managing data in spreadsheets for experimentalists.; ; ; ; ; ; ; ;
in Journal of integrative bioinformatics (2013), 10(2), 220
Recent development and biomedical applications of probabilistic Boolean networks; ; ; ; ;
in Cell Communication and Signaling (2013), 11(46),
FAM111A mutations result in hypoparathyroidism and impaired skeletal development; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in American Journal of Human Genetics (2013), 92(6), 990-995
Fast reconstruction of compact context-specific metabolic network models; ;
E-print/Working paper (2013)
Fastcore: An algorithm for fast reconstruction of context-specific metabolic network models; ;
in Proc. 8th BeNeLux Bioinformatics Conference (2013)
Nigral stimulation for resistant axial motor impairment in Parkinson's disease? A randomized controlled trial.; ; ; ; ; ; ; ; ; ;
in Brain : a journal of neurology (2013), 136(Pt 7), 2098-108
JAK2-V617F-induced MAPK activity is regulated by PI3K and acts synergistically with PI3K on the proliferation of JAK2-V617F-positive cells.; ; ; ; ; ; ; ;
in JAK-STAT (2013), 2(3), 24574
CNP/cGMP signaling regulates axon branching and growth by modulating microtubule polymerization; ; ; ; ; ;
in Developmental Neurobiology (2013), 73(9), 673-687
Knockdown of Hsc70-5/mortalin induces loss of synaptic mitochondria in a Drosophila Parkinson's disease model.; ; ; ; ; ; ; ; ;
in PloS one (2013), 8(12), 83714
2012
Guidelines for the use and interpretation of assays for monitoring autophagy.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; et al
in Autophagy (2012), 8(4), 445-544
Targeting autophagy and glycolysis: in vitro and in vivo studies in GlioblastomaDoctoral thesis (2012)
Molecular interface of S100A8 with cytochrome b558 and NADPH oxidase activation; ; ; ; ; ;
in PLoS ONE (2012), 7(7),
Role of the Neutrophil NADPH Oxidase and S100A8/A9 in the Pathophysiology of Chronic Inflammation; ;
in Khatami, Mahin (Ed.) Inflammation, Chronic Diseases and Cancer - Cell and Molecular Biology, Immunology and Clinical Bases (2012)
The use of primary human fibroblasts for monitoring mitochondrial phenotypes in the field of Parkinson's disease.;
in Journal of visualized experiments : JoVE (2012), (68),
ETV5 cooperates with LPP as a sensor of extracellular signals and promotes EMT in endometrial carcinomas.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Oncogene (2012), 31(45), 4778-88
Gene regulatory network analysis supports inflammation as a key neurodegeneration process in prion disease.; ; ; ;
in BMC Systems Biology (2012), 6(132),
Increased apoptotic activity on inflammatory human placentas in spontaneous abortions during the first and second trimester of gestation: A histochemical and immunohistochemical study; ; ; ; ; ; ; ; ; ;
in Folia Histochemica et Cytobiologica (2012), 50(1), 118-124
Gene therapy in liver diseases: State-of-the-art and future perspectives; ; ; ; ; ; ; ;
in Current Gene Therapy (2012), 12(6), 463-483
Phosphorylation of HtrA2 by cyclin-dependent kinase-5 is important for mitochondrial function.; ; ; ; ; ; ; ;
in Cell death and differentiation (2012), 19(2), 257-66
The modulation of Amyotrophic Lateral Sclerosis risk by ataxin-2 intermediate polyglutamine expansions is a specific effect.; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Neurobiology of disease (2012), 45(1), 356-61
Modifications de l'immunité humorale induites par des changements de la gravitéDoctoral thesis (2012)
Pharmacological countermeasures to spaceflight-induced alterations of the immune system; ;
in Stress Challenges and Immunity in Space: From Mechanisms to Monitoring and Preventive Strategies (2012)
Stress response and humoral immune system alterations related to chronic hypergravity in mice; ; ; ; ; ; ;
in Psychoneuroendocrinology (2012), 37(1), 137-147
Regulation of JAKs: Insights gleaned from the functional protein domains; ; ; ;
in Decker, Thomas; Müller, Mathias (Eds.) JAK-STAT Signaling – From Basics to Disease (2012)
Direct reprogramming of fibroblasts into neural stem cells by defined factors.; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Cell Stem Cell (2012), 10(4), 465-72
Discovery of inhibitors of microglial neurotoxicity acting through multiple mechanisms using a stem-cell-based phenotypic assay.; ; ; ; ; ; ; ; ; ; ; ; ;
in Cell Stem Cell (2012), 11(5), 620-32
Regrowing the adult brain: NF-kappaB controls functional circuit formation and tissue homeostasis in the dentate gyrus.; ; ; ; ; ; ; ; ; ; ; ;
in PLoS ONE (2012), 7(2), 30838
Dataset integration identifies transcriptional regulation of microRNA genes by PPARgamma in differentiating mouse 3T3-L1 adipocytes; ; ; ; ;
in Nucleic Acids Research (2012), 40(10), 4446-4460
Autophagy Mediates the Delivery of Thrombogenic Tissue Factor to Neutrophil Extracellular Traps in Human Sepsis; ; ; ; ; ; ; ; ; ;
in PLoS ONE (2012), 7(9),
Abundant occurrence of basal radial glia in the subventricular zone of embryonic neocortex of a lissencephalic primate, the common marmoset Callithrix jacchus.; ; ; ; ; ; ; ; ; ; ; ;
in Cerebral Cortex (2012), 22(2), 469-81
Deep-brain-stimulation does not impair deglutition in Parkinson's disease.; ; ; ; ; ; ; ;
in Parkinsonism & related disorders (2012), 18(7), 847-53
Employing live microbes for vaccine delivery; ; ; ; ;
in Development of Novel Vaccines: Skills, Knowledge and Translational Technologies (2012)
An efficient method to limit microglia-dependent effects in astroglial cultures.; ; ; ; ; ; ;
in Journal of Neuroscience Methods (2012), 207(1), 59-71
A Novel Network Integrating a miRNA-203/SNAI1 Feedback Loop which Regulates Epithelial to Mesenchymal Transition.; ; ; ; ; ; ;
in PLoS ONE (2012), 7(4), 35440
The chemokine receptor CXCR3 limits injury after acute toxic liver damage; ; ; ; ; ; ; ; ;
in Laboratory Investigation (2012), 92(5), 724-734
Chemokine Cxcl9 attenuates liver fibrosis-associated angiogenesis in mice; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Hepatology (Baltimore, Md.) (2012), 55(5), 1610-1619
MeCP2 is critical for maintaining mature neuronal networks and global brain anatomy during late stages of postnatal brain development and in the mature adult brain; ; ; ; ; ; ;
in Journal of Neuroscience (2012), 32(29), 10021-10034
Recombinant Nox4 cytosolic domain produced by a cell or cell-free base systems exhibits constitutive diaphorase activity; ; ; ; ; ;
in Biochemical and Biophysical Research Communications (2012), 419(3), 453-458
TRIM32 regulates skeletal muscle stem cell differentiation and is necessary for normal adult muscle regeneration.; ; ; ; ; ; ; ; ; ;
in PLoS ONE (2012), 7(1), 30445
Evolutionary conservation and network structure characterize genes of phenotypic relevance for mitosis in human; ;
in PLoS ONE (2012), 7(5), 36488
MiRNAs and neural stem cells: a team to treat Parkinson's disease?; ;
in RNA Biology (2012), 9(6), 720-30
Genome-wide landscape of liver X receptor chromatin binding and gene regulation in human macrophages; ; ; ; ; ; ; ;
in BMC Genomics (2012), 13(50),
The non-autonomous retrotransposon SVA is trans-mobilized by the human LINE-1 protein machinery; ; ; ; ; ; ; ; ;
in Nucleic Acids Research (2012), 40(4), 1666-1683
Dynamic regulation of microRNA expression following interferonγ- induced gene transcription; ; ; ; ; ; ; ;
in RNA Biology (2012), 9(7), 987-989
Systems analysis of transcription factor activities in environments with stable and dynamic oxygen concentrations; ; ; ; ; ; ; ; ;
in Open Biology (2012), 2(7), 120091
Interferon-γ-induced activation of Signal Transducer and Activator of Transcription 1 (STAT1) up-regulates the tumor suppressing microRNA-29 family in melanoma cells; ; ; ; ; ; ;
in Cell Communication and Signaling (2012), 10
MiRNA-29: A microRNA family with tumor-suppressing and immune-modulating properties; ; ;
in Current Molecular Medicine (2012), 13(4), 572-585
A multi-centre clinico-genetic analysis of the VPS35 gene in Parkinson disease indicates reduced penetrance for disease-associated variants.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Journal of medical genetics (2012), 49(11), 721-6
Large-scale replication and heterogeneity in Parkinson disease genetic loci.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Neurology (2012), 79(7), 659-67
LRRK2: Understanding the role of common and rare variants in Parkinson's disease.; ;
in Movement disorders : official journal of the Movement Disorder Society (2012), 27(4), 475
JAM-C is an apical surface marker for neural stem cells.; ; ; ; ; ; ; ; ; ; ;
in Stem Cells & Development (2012), 21(5), 757-66
Regulation of gene expression dynamics driven by PPARd and VDR nuclear receptorsDoctoral thesis (2012)
Dynamics and feedback loops in the transforming growth factor beta signaling pathway.; ; ; ; ; ; ; ; ;
in Biophysical chemistry (2012), 162
Subthalamic nucleus stimulation restores the efferent cortical drive to muscle in parallel to functional motor improvement.; ; ; ; ; ; ; ;
in The European journal of neuroscience (2012), 35(6), 896-908
Long-term follow-up of subthalamic nucleus stimulation in glucocerebrosidase-associated Parkinson's disease.; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Journal of neurology (2012), 259(9), 1970-2
Induced pluripotent stem cells generated from adult bone marrow-derived cells of the nonhuman primate (Callithrix jacchus) using a novel quad-cistronic and excisable lentiviral vector.; ; ; ; ; ; ; ; ; ;
in Cellular reprogramming (2012), 14(6), 485-96
In Silico prediction of transcription factor binding sites by probabilistic modelsDoctoral thesis (2012)
Analysing the role of UVB-induced translational inhibition and PP2Ac deactivation in NF-kappaB signalling using a minimal mathematical model.; ; ; ; ;
in PLoS ONE (2012), 7(7), 40274
Anti-inflammatory treatment induced regenerative oligodendrogenesis in parkinsonian mice.; ; ;
in Stem cell research & therapy (2012), 3(4), 33
Probabilistic model checking of the PDGF signaling pathway; ; ; ; ;
in Transactions on Computational Systems Biology (2012), XIV
2011
Effects of subthalamic nucleus stimulation on emotional prosody comprehension in Parkinson's disease.; ; ; ;
in PloS one (2011), 6(4), 19140
Cellular organization of adult neurogenesis in the Common Marmoset.; ; ; ; ;
in Aging Cell (2011), 10(1), 28-38
Converging environmental and genetic pathways in the pathogenesis of Parkinson's disease.;
in Journal of the neurological sciences (2011), 306(1-2), 1-8
Independent and joint effects of the MAPT and SNCA genes in Parkinson disease.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Annals of neurology (2011), 69(5), 778-92
Designing logical rules to model the response of biomolecular networks with complex interactions: an application to cancer modeling.; ; ; ; ;
in IEEE/ACM Transactions on Computational Biology and Bioinformatics (2011), 8(5), 1223-34
Jak1 has a dominant role over Jak3 in signal transduction through γc-containing cytokine receptors; ; ; ; ; ; ;
in Chemistry & Biology (2011), 18(3), 314-323
A systems biology approach to analyse leaf carbohydrate metabolism in Arabidopsis thaliana.; ; ; ; ; ;
in EURASIP Journal on Bioinformatics & Systems Biology (2011), 2011(1), 2
Neural stem cells maintain their stemness through protein kinase C zeta-mediated inhibition of TRIM32.; ; ;
in Stem Cells (2011), 29(9), 1437-47
PPARγ population shift produces disease-related changes in molecular networks associated with metabolic syndrome; ; ; ;
in Cell Death & Disease (2011), 2(8), 192
The E3-ubiquitin ligase TRIM2 regulates neuronal polarization.; ; ; ; ; ; ;
in Journal of Neurochemistry (2011), 117(1), 29-37
A large-scale genetic association study to evaluate the contribution of Omi/HtrA2 (PARK13) to Parkinson's disease.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Neurobiology of aging (2011), 32(3), 5489-18
Olfactory neuron-specific expression of A30P alpha-synuclein exacerbates dopamine deficiency and hyperactivity in a novel conditional model of early Parkinson's disease stages.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Neurobiology of disease (2011), 44(2), 192-204
Association of LRRK2 exonic variants with susceptibility to Parkinson's disease: a case-control study.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Lancet neurology (2011), 10(10), 898-908
Suppression of extrapyramidal side effects of doxepin by thalamic deep brain stimulation for Tourette syndrome.; ; ; ;
in Neurology (2011), 77(18), 1708-9
Sphingosine kinases regulate NOX2 activity via p38 MAPK-dependent translocation of S100A8/A9; ; ; ;
in Journal of Leukocyte Biology (2011), 89(4), 587-596
Role of sepiapterin reductase gene at the PARK3 locus in Parkinson's disease.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Neurobiology of aging (2011), 32(11), 21081-5
An essential role of STIM1, Orai1, and S100A8-A9 proteins for Ca2+ signaling and FcγR-mediated phagosomal oxidative activity; ; ; ;
in Journal of Immunology (2011), 186(4), 2182-2191
Slowly progressive Parkinson syndrome due to thalamic butterfly astrocytoma.; ; ; ; ;
in Neurology (2011), 77(4), 404-5
Rapid emergence of temporal and pulvinar lesions in MELAS mimicking Creutzfeldt-Jakob disease.; ; ; ;
in Neurology (2011), 77(9), 914
Combined stimulation of the substantia nigra pars reticulata and the subthalamic nucleus is effective in hypokinetic gait disturbance in Parkinson's disease.; ; ; ; ;
in Journal of neurology (2011), 258(6), 1183-5
Central oscillators in a patient with neuropathic tremor: evidence from intraoperative local field potential recordings.; ; ; ; ; ; ; ; ;
in Movement disorders : official journal of the Movement Disorder Society (2011), 26(2), 323-7
Modeling time delay in the NFkappaB signaling pathway following low dose IL-1 stimulation.; ; ; ; ;
in EURASIP Journal on Bioinformatics & Systems Biology (2011), 2011(1), 3
A study of the PDGF signaling pathway with PRISM; ; ; ; ;
in Proceedings of the 3rd Workshop on Computational Models for Cell Processes (2011), EPTCS 67
2010
Quantitative kinetic study of the actin-bundling protein L-plastin and of its impact on actin turn-over.; ; ; ; ; ; ; ;
in PloS one (2010), 5(2), 9210
Localizing potentially active post-transcriptional regulations in the Ewing's sarcoma gene regulatory network.; ; ; ; ; ;
in BMC Systems Biology (2010), 4
Effective long-term subthalamic stimulation in PARK8 positive Parkinson's disease.; ; ; ; ; ; ; ;
in Journal of neurology (2010), 257(7), 1205-7
Balance is the challenge--the impact of mitochondrial dynamics in Parkinson's disease.; ;
in European journal of clinical investigation (2010), 40(11), 1048-60
Dissecting the role of the mitochondrial chaperone mortalin in Parkinson's disease: functional impact of disease-related variants on mitochondrial homeostasis.; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Human molecular genetics (2010), 19(22), 4437-52
An alpaca single-domain antibody blocks filopodia formation by obstructing L-plastin-mediated F-actin bundling.; ; ; ; ;
in FASEB Journal (2010), 24(1), 105-18
Signal transduction, receptors, mediators and genes: Younger than ever - The 13th meeting of the Signal Transduction Society focused on aging and immunology; ; ; ; ; ; ; ; ; ; ; ;
in Cell Communication and Signaling (2010), 8
Perspectives for the use of structural information and chemical genetics to develop inhibitors of Janus kinases.; ;
in Journal of Cellular & Molecular Medicine (2010), 14(3), 504-27
A mathematical model of actin filament turnover for fitting FRAP data; ; ; ; ;
in European Biophysics Journal [=EBJ] (2010), 39(4), 669-677
New biological investigations on 3-bromophenyl 6-acetoxymethyl-2-oxo-2H-1-benzopyran-3-carboxylate as anti-angiogenic agent; ; ; ; ; ; ; ; ; ;
in Drug Development Research (2010), 71
Microglial activation depends on beta-amyloid conformation: role of the formylpeptide receptor 2; ; ; ; ; ; ; ;
in Journal of Neurochemistry (2010), 114(2), 576-586
The actin filament cross-linker L-plastin confers resistance to TNF-alpha in MCF-7 breast cancer cells in a phosphorylation-dependent manner.; ; ; ; ; ; ; ;
in Journal of Cellular & Molecular Medicine (2010), 14(6A), 1264-75
Modulation of mitochondrial function and morphology by interaction of Omi/HtrA2 with the mitochondrial fusion factor OPA1.; ; ; ; ; ; ; ; ;
in Experimental cell research (2010), 316(7), 1213-24
Reduced basal autophagy and impaired mitochondrial dynamics due to loss of Parkinson's disease-associated protein DJ-1.; ; ; ; ; ; ; ; ; ; ; ; ;
in PloS one (2010), 5(2), 9367
Time-Resolved Expression Profiling of the Nuclear Receptor Superfamily in Human Adipogenesis; ; ; ;
in PLoS ONE (2010), 5(9),
IL-24: Physiological and supraphysiological effects on normal and malignant cells;
in Current Medicinal Chemistry (2010), 17(29), 3318-3326
Mathematical modeling of the central carbohydrate metabolism in Arabidopsis reveals a substantial regulatory influence of vacuolar invertase on whole plant carbon metabolism.; ; ; ; ; ;
in Plant Physiology (2010), 153(1), 260-72
Transgenic overexpression of the alpha-synuclein interacting protein synphilin-1 leads to behavioral and neuropathological alterations in mice.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Neurogenetics (2010), 11(1), 107-20
Signatures of MicroRNAs and selected MicroRNA target genes in human melanoma; ; ; ; ; ; ; ; ;
in Cancer Research (2010), 70(10), 4163-4173
Psychological preparation and postoperative outcomes for adults undergoing surgery under general anaesthesia (Protocol); ; ; ; ; ;
in Cochrane Database of Systematic Reviews (Online) (2010), (8), 1-15
Cross-regulation of cytokine signalling: Pro-inflammatory cytokines restrict IL-6 signalling through receptor internalisation and degradation; ; ; ; ; ; ; ; ; ; ; ;
in Journal of Cell Science (2010), 123(6), 947-959
iPLA 2 , a novel determinant in Ca2+ - and phosphorylation-dependent S100A8/A9 regulated NOX2 activity; ; ; ; ;
in Biochimica et Biophysica Acta-Molecular Cell Research (2010), 1803(7), 840-847
Interleukin-27 acts on hepatic stellate cells and induces signal transducer and activator of transcription 1-dependent responses.; ;
in Cell Communication and Signaling (2010), 8
First appraisal of brain pathology owing to A30P mutant alpha-synuclein.; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Annals of neurology (2010), 67(5), 684-9
Periphilin is a novel interactor of synphilin-1, a protein implicated in Parkinson's disease.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Neurogenetics (2010), 11(2), 203-15
JAM-A is a novel surface marker for NG2-Glia in the adult mouse brain.; ;
in BMC Neuroscience (2010), 11
Complex hyperkinetic movement disorders associated with POLG mutations.; ; ; ; ; ;
in Movement disorders : official journal of the Movement Disorder Society (2010), 25(14), 2472-5
Severe orthostatic dysregulation associated with Wolfram syndrome.; ; ; ;
in Journal of neurology (2010), 257(10), 1751-3
Oncostatin M up-regulates the ER chaperone Grp78/BiP in liver cells; ;
in Biochemical Pharmacology (2010), 80(12), 2066-2073
Involuntary eyelid closure after STN-DBS: evidence for different pathophysiological entities.; ; ; ; ; ; ; ; ; ;
in Journal of neurology, neurosurgery, and psychiatry (2010), 81(9), 1002-7
2009
Spaceflight-associated changes in immunoglobulin VH gene expression in the amphibian Pleurodeles waltl; ; ; ;
in FASEB Journal (2009), 23(5), 1607-1615
Interleukin-27 displays interferon-gamma-like functions in human hepatoma cells and hepatocytes.; ; ; ; ; ; ; ; ;
in Hepatology (Baltimore, Md.) (2009), 50(2), 585-91
STIM1 but not STIM2 is an essential regulator of Ca2+ influx-mediated NADPH oxidase activity in neutrophil-like HL-60 cells; ; ;
in Biochemical Pharmacology (2009), 78(5), 504-513
OAG induces an additional PKC-, PI3K-, and Rac2-mediated signaling pathway up-regulating NOX2 activity, independently of Ca 2+ entry; ;
in Journal of Leukocyte Biology (2009), 85(4), 638-647
Effective thalamic deep brain stimulation for neuropathic tremor in a patient with severe demyelinating neuropathy.; ; ; ; ; ;
in Journal of neurology, neurosurgery, and psychiatry (2009), 80(2), 235-6
Transmissions cholinergiquesin Landry, Yves; Gies, Jean-Pierre (Eds.) Pharmacologie. Des cibles vers l’indication thérapeutique (2009)
Methyl side-chain dynamics prediction based on protein structure;
in Bioinformatics (2009), 25(19), 2552-8
Energetic determinants of protein binding specificity: insights into protein interaction networks; ;
in Proteomics (2009), 9(7), 1744-53
Residues crucial for maintaining short paths in network communication mediate signaling in proteins; ; ;
in Molecular Systems Biology (2009), 2
The origin of Allosteric Modulation: Multiple Pre-existing Pathways Selection; ; ;
in Structure (2009), 17(8), 1042-1050
Single-cell expression profiling of dopaminergic neurons combined with association analysis identifies pyridoxal kinase as Parkinson's disease gene.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Annals of neurology (2009), 66(6), 792-8
Could spaceflight-associated immune system weakening preclude the expansion of human presence beyond Earth’s orbit?; ; ; ; ; ;
in Journal of Leukocyte Biology (2009), 86(5), 1027-1038
An unusual insertion in Jak2 is crucial for kinase activity and differentially affects cytokine responses; ; ; ; ; ; ; ;
in Journal of Immunology (2009), 182(5), 2969-2977
SOCS-mediated downregulation of mutant Jak2 (V617F, T875N and K539L) counteracts cytokine-independent signaling.; ; ; ; ; ;
in Oncogene (2009), 28(34), 3069-80
An integrative simulation model linking major biochemical reactions of actin-polymerization to structural properties of actin filaments; ; ; ; ; ;
in Biophysical Chemistry (2009), 140(1-3), 24-34
Oncostatin M-induced and constitutive activation of the JAK2/STAT5/CIS pathway suppresses CCL1, but not CCL7 and CCL8, chemokine expression; ; ; ;
in Journal of Immunology (2009), 181(10), 7341-7349
Characterization of the microglial phenotype under specific pro-inflammatory and anti-inflammatory conditions: Effects of oligomeric and fibrillar amyloid-beta; ; ; ;
in Journal of Neuroimmunology (2009), 210(1-2), 3-12
Transcriptional repression of microRNA genes by PML-RARA increases expression of key cancer proteins in acute promyelocytic leukemia.; ; ; ; ; ; ; ; ; ; ; ; ;
in Blood (2009), 113(2), 412-21
Overexpression of the partially activated alpha(IIb)beta3D723H integrin salt bridge mutant downregulates RhoA activity and induces microtubule-dependent proplatelet-like extensions in Chinese hamster ovary cells; ; ; ; ; ; ;
in Journal of Thrombosis and Haemostasis [=JTH] (2009), 7(7), 1207-1217
Analysis of an apoptotic core model focused on experimental design using artificial data.; ; ; ;
in IET Systems Biology (2009), 3(4), 255-65
ON/OFF and beyond--a boolean model of apoptosis.; ; ; ; ; ; ; ;
in PLoS Computational Biology (2009), 5(12), 1000595
The stimulation of dendrite growth by Sema3A requires integrin engagement and focal adhesion kinase.; ; ; ;
in Journal of Cell Science (2009), 122(Pt 12), 2034-42
The TRIM-NHL protein TRIM32 activates microRNAs and prevents self-renewal in mouse neural progenitors.; ;
in Cell (2009), 136(5), 913-25
Further delineation of the association signal on chromosome 5 from the first whole genome association study in Parkinson's disease.; ; ; ; ; ; ;
in Neurobiology of aging (2009), 30(10), 1706-9
Genome-wide association study reveals genetic risk underlying Parkinson's disease.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Nature genetics (2009), 41(12), 1308-12
Protein allostery, signal transmission and dynamics: a classification scheme of allosteric mechanisms; ;
in Molecular Biosystems (2009), 5(3), 207-16
Les peptides opioïdes et autres médiateurs de la nociceptionin Landry, Yves; Gies, Jean-Pierre (Eds.) Pharmacologie. Des cibles vers l’indication thérapeutique (2009)
Time-resolved analysis of transcriptional events during SNAI1-triggered epithelial to mesenchymal transition; ; ; ; ; ; ; ; ;
in Biochemical and Biophysical Research Communications (2009), 385(4), 485-91
Hypoxia-inducible factor 1alpha is up-regulated by oncostatin M and participates in oncostatin M signaling; ; ; ; ; ; ; ;
in Hepatology (Baltimore, Md.) (2009), 2009(3),
Severe muscular fasciculations as an uncommon side-effect due to microdefect of an extension wire in deep brain stimulation.; ; ; ; ;
in Movement disorders : official journal of the Movement Disorder Society (2009), 24(14), 2161-2
Indibulin, a Novel Microtubule Inhibitor, Discriminates between Mature Neuronal and Nonneuronal Tubulin;
in Cancer Research (2009), 69(1), 171-177
Development of an IL-6 inhibitor based on the functional analysis of murine IL-6Ralpha(1).; ; ; ; ; ; ;
in Chemistry & Biology (2009), 16(7), 783-94
Mechanism of PP2A-mediated IKK beta dephosphorylation: a systems biological approach.; ; ; ; ; ;
in BMC Systems Biology (2009), 3
2008
Cell passaging rapidly affects expression, secretion and activity of MMP9 as well as mobility of HL60 leukemia cells; ; ; ;
in Journal of Cell and Animal Biology (2008), 2(9), 160-165
Microarray expression analysis reveals genetic pathways implicated in C621 synphilin-1-mediated toxicity.; ; ; ;
in Journal of neural transmission (Vienna, Austria : 1996) (2008), 115(7), 941-58
Regulation of superoxide production in neutrophils: role of calcium influx;
in Journal of Leukocyte Biology (2008), 84(5), 1223-1237
Analyse der evolutiven Adaptation am Beispiel einer pyruvat-auxotrophen Escherichia coli-Mutante; ; ; ; ;
in Automatisierungstechnik (2008), 56
In colon carcinogenesis, the cytoskeletal protein gelsolin is down-regulated during the transition from adenoma to carcinoma.; ; ; ; ; ;
in Human pathology (2008), 39(10), 1420-30
A nonsynonymous SNP in the ITGB3 gene disrupts the conserved membrane-proximal cytoplasmic salt bridge in the αIIbβ3 integrin and cosegregates dominantly with abnormal proplatelet formation and macrothrombocytopenia; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Blood (2008), 111(7), 3407-3414
Dual role of the Jak1 FERM and kinase domains in cytokine receptor binding and in stimulation-dependent Jak activation; ; ; ; ; ; ;
in Journal of Immunology (2008), 180(2), 998-1007
Novel ATP1A3 mutation in a sporadic RDP patient with minimal benefit from deep brain stimulation.; ; ; ; ; ; ;
in Neurology (2008), 70(16 Pt 2), 1501-3
Cell density dependent increase of constitutive signal transducers and activators of transcription 3 activity in melanoma cells is mediated by Janus kinases; ; ; ;
in Molecular Cancer Research (2008), 5(12), 1331-41
IL-24: a classic cytokine and/or a potential cure for cancer?; ; ;
in Journal of Cellular & Molecular Medicine (2008), 12(6A), 2505-2510
LRRK2 in Parkinson's disease - drawing the curtain of penetrance: a commentary.in BMC medicine (2008), 6
Sustained improvement of obsessive-compulsive disorder by deep brain stimulation in a woman with residual schizophrenia.; ; ; ; ; ; ; ; ;
in The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) (2008), 11(8), 1181-3
Mitochondrial protein quality control by the proteasome involves ubiquitination and the protease Omi.; ; ; ; ; ;
in The Journal of biological chemistry (2008), 283(19), 12681-5
The talin rod IBS2 alpha-helix interacts with the beta3 integrin cytoplasmic tail membrane-proximal helix by establishing charge complementary salt bridges.; ; ; ; ; ; ; ;
in The Journal of biological chemistry (2008), 283(35), 24212-23
Ca2+-dependent regulation of NOX2 activity via MRP proteins in HL-60 granulocytes; ; ; ; ;
in Calcium Binding Proteins (2008), 3(1), 25-30
Review: Familial Parkinson's disease--genetics, clinical phenotype and neuropathology in relation to the common sporadic form of the disease.; ; ;
in Neuropathology and applied neurobiology (2008), 34(3), 255-71
Vertebral artery dissection presenting with ispilateral acute C5 and C6 sensorimotor radiculopathy: A case report.; ; ; ;
in Cases journal (2008), 1(1), 139
A comprehensive genetic study of the proteasomal subunit S6 ATPase in German Parkinson's disease patients.; ; ; ; ; ; ; ;
in Journal of neural transmission (Vienna, Austria : 1996) (2008), 115(8), 1141-8
Advanced spot quality analysis in two-colour microarray experiments; ; ; ; ; ;
in BMC Research Notes (2008), 1
2007
Mitochondrial translation initiation factor 3 gene polymorphism associated with Parkinson's disease.; ; ; ; ; ;
in Neuroscience letters (2007), 414(2), 126-9
Correlation between growth rates, EIIACrr phosphorylation, and intracellular cyclic AMP levels in Escherichia coli K-12.; ; ; ; ;
in Journal of Bacteriology (2007), 189(19), 6891-900
Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in The Journal of neuroscience : the official journal of the Society for Neuroscience (2007), 27(45), 12413-8
Methods for analysis of evolutive adaptation of E. coli; ; ; ; ; ;
in Proceedings of the SICE Annual Conference, September 17-20, 2007 Kagawa University, Takamatsu City, Japan (2007)
Special issue: Integrated approaches to cytoskeleton researchin Biochimica et Biophysica Acta-Molecular Cell Research (2007), 1773(5), 603
Notch signaling modulates the activation of microglial cells; ; ; ; ;
in Glia (2007), 55(15), 1519-30
A cost effective non-commercial ECL-solution for Western blot detections yielding strong signals and low background;
in Journal of Immunological Methods (2007), 318(1-2), 11-9
Dual bioactivity of resveratrol fatty alcohols: differentiation of neural stem cells and modulation of neuroinflammation; ; ; ; ; ;
in Bioorganic & Medicinal Chemistry Letters (2007), 17(15), 4218-4222
Constitutive suppressor of cytokine signaling 3 expression confers a growth advantage to a human melanoma cell line; ; ; ;
in Molecular Cancer Research (2007), 5(3), 271-81
Recombinant interleukin-24 lacks apoptosis-inducing properties in melanoma cells; ; ; ; ; ; ;
in PLoS ONE (2007), 2(12), 1300
Elongation of axons during regeneration involves retinal crystallin beta b2 (crybb2).; ; ;
in Molecular and Cellular Proteomics (2007), 6(5), 895-907
Acute parkinsonism with corresponding lesions in the basal ganglia after heroin abuse.; ; ;
in Neurology (2007), 68(6), 414
Characterization of the Interleukin (IL)-6 Inhibitor IL-6-RFP: fused receptor domains act as high affinity cytokine-binding proteins.; ; ; ; ; ;
in Journal of Biological Chemistry (2007), 282(2), 1238-48
The integrin binding site 2 (IBS2) in the talin rod domain is essential for linking integrin beta subunits to the cytoskeleton.; ; ; ; ; ; ; ; ;
in The Journal of biological chemistry (2007), 282(23), 17280-8
Design and evaluation of Actichip, a thematic microarray for the study of the actin cytoskeleton; ; ; ; ; ; ; ;
in BMC Genomics (2007), 8
Complete loss of PTEN expression as a possible early prognostic marker for prostate cancer metastasis.; ; ; ; ; ; ; ; ;
in International Journal of Cancer = Journal International du Cancer (2007), 120(6), 1284-92
The histone deacetylase inhibitor trichostatin A mediates upregulation of 5-lipoxygenase promoter activity by recruitment of Sp1 to distinct GC-boxes; ; ; ;
in Biochimica et Biophysica Acta (2007), 1771(10), 1271-1282
Transcranial ultrasound in different monogenetic subtypes of Parkinson's disease.; ; ; ; ; ; ; ;
in Journal of neurology (2007), 254(5), 613-6
STAT1 regulates p73-mediated Bax gene expression; ; ; ; ; ; ; ;
in FEBS Letters (2007), 581(6), 1217-26
Identification of a novel BBS gene (BBS12) highlights the major role of a vertebrate-specific branch of chaperonin-related proteins in Bardet-Biedl syndrome.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in American Journal of Human Genetics (2007), 80(1), 1-11
Modeling and Analysis of UVB Influence on IL-1 induced NF-kappaB Signaling; ; ; ; ;
in Proceedings of the FOSBE, September 9-12, Stuttgart, Germany (2007)
2006
A quantitative approach to catabolite repression in Escherichia coli.; ; ; ; ;
in Journal of Biological Chemistry (2006), 281(5), 2578-84
Modulation by cADPr of Ca2+ mobilization and oxidative response in dimethylsulfoxide- or retinoic acid-differentiated HL-60 cells; ; ;
in Biochimica et Biophysica Acta (2006), 1763(1), 129-36
A domain-oriented approach to the reduction of combinatorial complexity in signal transduction networks.; ; ; ;
in BMC Bioinformatics (2006), 7
Sensitivity analysis of programmed cell death and implications for crosstalk phenomena during Tumor Necrosis Factor stimulation; ; ; ; ; ; ;
in Proceedings of IEEE International Conference on Control Applications (CCA), October 4-6, 2006, Technische Universität München, Germany (2006)
Lack of replication of thirteen single-nucleotide polymorphisms implicated in Parkinson's disease: a large-scale international study.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Lancet neurology (2006), 5(11), 917-23
Jaks and cytokine receptors - an intimate relationship; ; ;
in Biochemical Pharmacology (2006), 72(11), 1538-46
Modeling the VPAC2-activated cAMP/PKA signaling pathway: from receptor to circadian clock gene induction.; ; ; ;
in Biophysical Journal (2006), 90(5), 1560-71
Phosphorylation on Ser5 increases the F-actin-binding activity of L-plastin and promotes its targeting to sites of actin assembly in cells; ; ; ; ; ; ; ;
in Journal of Cell Science (2006), 119(9), 1947-1960
Collaborative analysis of alpha-synuclein gene promoter variability and Parkinson disease.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in JAMA : the journal of the American Medical Association (2006), 296(6), 661-70
Rosuvastatin treatment protects against nitrate-induced oxidative stress in eNOS knockout mice: implication of the NAD(P)H oxidase pathway; ; ; ;
in British Journal of Pharmacology (2006), 148(4), 544-52
Three dileucine-like motifs within the interbox1/2 region of the human oncostatin M receptor prevent efficient surface expression in the absence of an associated Janus kinase; ; ; ;
in Journal of Biological Chemistry (2006), 281(7), 4024-34
Genetic causes of Parkinson's disease: extending the pathway.; ; ; ; ; ;
in Journal of neural transmission. Supplementum (2006), (70), 181-9
Biological responses to PDGF-BB versus PDGF-DD in human mesangial cells; ; ; ; ; ; ; ; ; ;
in Kidney International (2006), 69(8), 1393-402
2005
Interleukin-8 primes oxidative burst in neutrophil-like HL-60 through changes in cytosolic calcium; ;
in Cell Calcium (2005), 37(6), 531-40
Molecular basis for dissimilar nuclear trafficking of the actin-bundling protein isoforms T- and L-plastin.; ; ; ; ; ; ; ; ;
in Traffic (Copenhagen, Denmark) (2005), 6(4), 335-45
The Use of In Vitro Systems for Evaluating Immunotoxicity: The Report and Recommendations of an ECVAM Workshop; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Journal of Immunotoxicology (2005), 2(2), 61-83
Actin-filament cross-linking protein T-plastin increases Arp2/3-mediated actin-based movement; ; ; ; ; ; ;
in Journal of Cell Science (2005), 118(6), 1255-1265
Multiple reasons for an inefficient STAT1 response upon IL-6-type cytokine stimulation; ; ; ;
in Cellular Signalling (2005), 17(12), 1542-50
Promoter-hypermethylation is causing functional relevant downregulation of methylthioadenosine phosphorylase (MTAP) expression in hepatocellular carcinoma; ; ; ; ; ; ; ;
in Carcinogenesis (2005), 27(1), 64-72
Functional relevance of ceruloplasmin mutations in Parkinson's disease.; ; ; ; ; ; ; ;
in FASEB journal : official publication of the Federation of American Societies for Experimental Biology (2005), 19(13), 1851-3
The role of alpha-synuclein gene multiplications in early-onset Parkinson's disease and dementia with Lewy bodies.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Journal of neural transmission (Vienna, Austria : 1996) (2005), 112(9), 1249-54
The intermediate filament protein vimentin binds specifically to a recombinant integrin α2/β1 cytoplasmic tail complex and co-localizes with native α2/β1 in endothelial cell focal adhesions; ; ; ;
in Experimental Cell Research (2005), 305(1), 110-121
The Jak1 SH2 domain does not fulfill a classical SH2 function in Jak/STAT signaling but plays a structural role for receptor interaction and up-regulation of receptor surface expression; ; ; ; ; ; ; ; ;
in Journal of Biological Chemistry (2005), 280(27), 25760-8
A new functional role of the fibrinogen RGD motif as the molecular switch that selectively triggers integrin alphaIIbbeta3-dependent RhoA activation during cell spreading; ; ; ;
in Journal of Biological Chemistry (2005), 280(39), 33610-33619
Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease.; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Human molecular genetics (2005), 14(15), 2099-111
Oxidative stress activates MMP-2 in cultured human coronary smooth muscle cells; ; ; ;
in Fundamental & Clinical Pharmacology (2005), 19(6), 661-7
STAT5 contributes to interferon resistance of melanoma cells; ; ; ; ; ; ; ; ;
in Current Biology (2005), 15(18), 1629-39
2004
Janus kinase (Jak) subcellular localization revisited: the exclusive membrane localization of endogenous Janus kinase 1 by cytokine receptor interaction uncovers the Jak.receptor complex to be equivalent to a receptor tyrosine kinase; ; ; ; ; ; ; ;
in Journal of Biological Chemistry (2004), 279(34), 35486-93
Reduction of mathematical models of signal transduction networks: simulation-based approach applied to EGF receptor signalling.; ; ; ; ;
in Systems biology (2004), 1(1), 159-69
The role of the inhibitors of interleukin-6 signal transduction SHP2 and SOCS3 for desensitization of interleukin-6 signalling; ; ; ; ; ; ; ; ; ; ; ;
in Biochemical Journal (2004), 378(Pt 2), 449-60
Screening for mutations in synaptotagmin XI in Parkinson's disease.; ; ; ; ; ; ; ;
in Journal of neural transmission. Supplementum (2004), (68), 21-8
Extended mutation analysis and association studies of Nurr1 (NR4A2) in Parkinson disease.; ; ; ; ; ; ; ; ; ;
in Neurology (2004), 62(7), 1231-2
Novel homozygous p.E64D mutation in DJ1 in early onset Parkinson disease (PARK7).; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Human mutation (2004), 24(4), 321-9
The effect of recombinant IgG antibodies against the leucine-33 form of the platelet beta3 integrin (HPA-1a) on platelet function.; ; ; ; ; ; ; ; ; ; ;
in Thrombosis and haemostasis (2004), 91(4), 743-54
Interferon-gamma-mediated growth regulation of melanoma cells: involvement of STAT1-dependent and STAT1-independent signals; ; ; ; ;
in Journal of Investigative Dermatology (2004), 122(2), 414-22
Towards whole cell "in silico" models for cellular systems: model set-up and model validation; ; ; ; ;
in Lecture Notes in Control and Information Sciences: Proceedings of the first multidisciplinary international symposium on Positive Systems (2004)
Time hierarchies in the Escherichia coli carbohydrate uptake and metabolism.; ; ; ;
in Bio Systems (2004), 73(1), 57-71
A benchmark for methods in reverse engineering and model discrimination: problem formulation and solutions.; ; ; ; ; ; ;
in Genome Research (2004), 14(9), 1773-85
Genes in familial parkinsonism and their role in sporadic Parkinson's disease.in Journal of neurology (2004), 251 Suppl 6
The role of synphilin-1 in synaptic function and protein degradation.in Cell and Tissue Research (2004), 318(1), 195-9
UCHL1 is a Parkinson's disease susceptibility gene.; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Annals of neurology (2004), 55(4), 512-21
Antiapoptotic effects of budipine.; ; ;
in Journal of neural transmission (Vienna, Austria : 1996) (2004), 111(10-11), 1365-73
Modeling and experimental validation of the signal transduction via the Escherichia coli sucrose phospho transferase system.;
in Journal of Biotechnology (2004), 110(2), 181-99
Semaphorin 3A stimulates neurite extension and regulates gene expression in PC12 cells.; ; ; ; ;
in Journal of Biological Chemistry (2004), 279(30), 30923-6
The sequential activity of the GTPases Rap1B and Cdc42 determines neuronal polarity.;
in Nature Neuroscience (2004), 7(9), 923-9
New developments in diagnosis and treatment of Parkinson's disease--from basic science to clinical applications.; ; ; ; ;
in Journal of neurology (2004), 251 Suppl 6
A fluorescence cell biology approach to map the second integrin-binding site of talin to a 130-amino acid sequence within the rod domain; ; ; ; ; ; ;
in Journal of Biological Chemistry (2004), 279(21), 22258-22266
2003
Characterization of methylthioadenosin phosphorylase (MTAP) expression in malignant melanoma; ; ; ; ; ;
in American Journal of Pathology (2003), 163(2), 683-90
An approach for dividing models of biological reaction networks into functional units; ; ; ;
in Simulation (2003), 79
Long term association of the cytokine receptor gp130 and the Janus kinase Jak1 revealed by FRAP analysis; ; ; ; ; ; ; ; ; ;
in Journal of Biological Chemistry (2003), 278(40), 39205-13
The actin cytoskeleton as a therapeutic target: state of the art and future directions.;
in Progress in cell cycle research (2003), 5
Polymorphisms of the alpha-synuclein promoter: expression analyses and association studies in Parkinson's disease.; ; ; ; ; ;
in Journal of neural transmission (Vienna, Austria : 1996) (2003), 110(1), 67-76
Haploinsufficiency at the alpha-synuclein gene underlies phenotypic severity in familial Parkinson's disease.; ; ; ; ; ; ; ; ; ;
in Brain : a journal of neurology (2003), 126(Pt 1), 32-42
Akt modulates STAT3-mediated gene expression through a FKHR (FOXO1a)-dependent mechanism; ; ; ; ; ; ; ;
in Journal of Biological Chemistry (2003), 278(7), 5242-9
Mutation analysis of the neurofilament M gene in Parkinson's disease.; ; ; ; ; ; ; ; ; ; ; ;
in Neuroscience letters (2003), 351(2), 125-9
Identification and functional characterization of a novel R621C mutation in the synphilin-1 gene in Parkinson's disease.; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Human molecular genetics (2003), 12(11), 1223-31
Therapeutic strategies for Parkinson's disease based on data derived from genetic research.; ; ;
in Journal of neurology (2003), 250 Suppl 1
Beta3 integrins: major therapeutic targets of the near future.in Bulletin de la Société des Sciences Médicales du Grand-Duché de Luxembourg (2003), (1), 23-34
Modulation of disease risk according to a cathepsin D / apolipoprotein E genotype in Parkinson's disease.; ; ; ; ; ; ; ; ;
in Journal of neural transmission (Vienna, Austria : 1996) (2003), 110(7), 749-55
Microarray analysis of tumor necrosis factor alpha induced gene expression in U373 human glioblastoma cells.; ; ; ; ; ; ; ; ;
in BMC Genomics (2003), 4(1), 46
Giant cavernoma of the brain stem: value of delayed MR imaging after contrast injection.; ; ; ;
in European radiology (2003), 13 Suppl 6
2002
Identification of the critical sequence elements in the cytoplasmic domain of leptin receptor isoforms required for Janus kinase/signal transducer and activator of transcription activation by receptor heterodimers; ; ; ; ; ;
in Molecular Endocrinology (2002), 16(4), 859-72
Orientational constraints of the gp130 intracellular juxtamembrane domain for signaling; ; ; ;
in Journal of Biological Chemistry (2002), 277(30), 26959-65
Parkinson's disease: one biochemical pathway to fit all genes?; ; ;
in Trends in molecular medicine (2002), 8(5), 236-40
SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130; ; ; ; ; ; ; ; ; ; ; ; ;
in Journal of Biological Chemistry (2002), 278(1), 661-71
Promoter characterization and genomic organization of the gene encoding integrin-linked kinase 1; ; ;
in Biochimica et Biophysica Acta-Gene Structure and Expression (2002), 1575(1-3), 117-122
Integrin alpha(v)beta3 expression confers on tumor cells a greater propensity to metastasize to bone.; ; ; ; ; ; ; ; ; ;
in FASEB journal : official publication of the Federation of American Societies for Experimental Biology (2002), 16(10), 1266-8
Novel role of Janus kinase 1 in the regulation of oncostatin M receptor surface expression; ; ; ; ; ;
in Journal of Biological Chemistry (2002), 277(13), 11297-305
Neurofilament L gene is not a genetic factor of sporadic and familial Parkinson's disease.; ; ; ; ;
in Brain research (2002), 951(1), 82-6
Spectrum of phenotypes and genotypes in Parkinson's disease.; ;
in Journal of neurology (2002), 249 Suppl 3
The matrix metalloproteinase 9 (mmp-9) hemopexin domain is a novel gelatin binding domain and acts as an antagonist; ; ; ; ; ; ;
in Journal of Biological Chemistry (2002), 277(52), 50326-32
Polymorphisms in the interleukin-1 alpha and beta genes and the risk for Parkinson's disease.; ; ; ; ;
in Neuroscience letters (2002), 326(1), 70-2
14-3-3 protein is a component of Lewy bodies in Parkinson's disease-mutation analysis and association studies of 14-3-3 eta.; ; ; ; ; ; ;
in Molecular Brain Research (2002), 108(1-2), 33-9
HPA-1a phenotype-genotype discrepancy reveals a naturally occurring Arg93Gln substitution in the platelet beta 3 integrin that disrupts the HPA-1a epitope.; ; ; ; ; ; ; ; ;
in Blood (2002), 99(5), 1833-9
Mutation analysis and association studies of nuclear factor-kappaB1 in sporadic Parkinson's disease patients.; ; ; ; ; ;
in Journal of neural transmission (Vienna, Austria : 1996) (2002), 109(9), 1181-8
2001
Interleukin-6-resistant melanoma cells exhibit reduced activation of STAT3 and lack of inhibition of cyclin E-associated kinase activity; ; ; ; ; ; ; ; ;
in Journal of Investigative Dermatology (2001), 117(1), 132-40
Receptor-independent effects of natural cannabinoids in rat peritoneal mast cells in vitro; ;
in Biochimica et Biophysica Acta (2001), 1538(2-3), 252-9
ActA and human zyxin harbour Arp2/3-independent actin-polymerization activity.; ; ; ; ; ; ;
in Nature cell biology (2001), 3(8), 699-707
Structural requirements of the interleukin-6 signal transducer gp130 for its interaction with Janus kinase 1: the receptor is crucial for kinase activation; ;
in Biochemical Journal (2001), 361(Pt 1), 105-11
A single amino acid substitution (Trp(666)-->Ala) in the interbox1/2 region of the interleukin-6 signal transducer gp130 abrogates binding of JAK1, and dominantly impairs signal transduction; ; ;
in Biochemical Journal (2001), 349(Pt 1), 261-6
Mapping of a region within the N terminus of Jak1 involved in cytokine receptor interaction; ; ; ; ; ; ;
in Journal of Biological Chemistry (2001), 276(40), 37451-8
Non-redundant signal transduction of interleukin-6-type cytokines. The adapter protein Shc is specifically recruited to rhe oncostatin M receptor; ; ; ;
in Journal of Biological Chemistry (2001), 275(52), 40742-8
A region encompassing the FERM domain of Jak1 is necessary for binding to the cytokine receptor gp130; ; ; ; ; ;
in FEBS Letters (2001), 505(1), 87-91
Mitogen-activated protein kinases control p27/Kip1 expression and growth of human melanoma cells; ; ; ; ;
in Biochemical Journal (2001), 357(Pt 1), 297-303
Cytokine-mediated growth inhibition of human melanoma cells; ; ;
in Advances in Experimental Medicine and Biology (2001), 495
Biosystems Engineering: Applying methods from systems theory to biological systems; ; ; ; ;
in Proceedings of the 2nd International Conference on Systems Biology 4.-7.11.2001, Pasadena (2001)
Familial parkinsonism with synuclein pathology: clinical and PET studies of A30P mutation carriers.; ; ; ; ; ; ; ; ; ; ; ; ;
in Neurology (2001), 56(10), 1355-62
Evaluation of the gamma-synuclein gene in German Parkinson's disease patients.; ; ; ; ; ; ;
in Neuroscience letters (2001), 310(2-3), 191-3
STAT3 is constitutively activated in Hodgkin cell lines; ; ; ; ; ; ; ;
in Blood (2001), 98(3), 762-70
Targeting of zyxin to sites of actin membrane interaction and to the nucleus.; ; ; ; ; ;
in The Journal of biological chemistry (2001), 276(37), 34759-67
Role of G(i)-proteins in norepinephrine-mediated vasoconstriction in rat tail artery smooth muscle; ; ; ;
in Biochemical Pharmacology (2001), 61(9), 1169-75
Lack of involvement of pertussis toxin-sensitive G-proteins in norepinephrine-induced vasoconstriction of rat aorta smooth muscle; ; ; ; ;
in Biochemical Pharmacology (2001), 61(4), 485-91
Green fluorescent protein (GFP) tagged to the cytoplasmic tail of alphaIIb or beta3 allows the expression of a fully functional integrin alphaIIb(beta3): effect of beta3GFP on alphaIIb(beta3) ligand binding.; ; ; ;
in The Biochemical journal (2001), 357(Pt 2), 529-36
Evidence from site-directed mutagenesis that the cytoplasmic domain of the beta3 subunit influences the conformational state of the alphaVbeta3 integrin ectodomain.; ;
in Thrombosis and haemostasis (2001), 85(4), 716-23
A completely foreign receptor can mediate an interferon-gamma-like response; ; ; ; ; ; ; ; ; ; ; ; ;
in EMBO Journal (2001), 20(19), 5431-42
Rac-1-mediated O2- secretion requires Ca2+ influx in neutrophil-like HL-60 cells; ; ;
in Cell Calcium (2001), 29(6), 409-15
Neutralizing monoclonal antibodies can potentiate IL-5 signaling; ; ; ; ; ; ; ; ;
in European Journal of Immunology (2001), 31(4), 1087-97
Human umbilical cord blood monocyte-derived eosinophils produce superoxide but not nitric oxide;
in Inflammation Research (2001), 50(7), 357-61
2000
Signal transduction of IL-6, leukemia-inhibitory factor, and oncostatin M: structural receptor requirements for signal attenuation; ; ; ; ; ; ; ; ;
in Journal of Immunology (2000), 165(5), 2535-43
Signalling of interleukin-6 type cytokines via gp130, leukemia inhibitory factor (LIF) receptor and oncostatin M receptor; ; ; ; ; ;
in European Cytokine Network (2000), 11(3), 491-2
Characterization of the interaction between zyxin and members of the Ena/vasodilator-stimulated phosphoprotein family of proteins.; ; ; ; ;
in The Journal of biological chemistry (2000), 275(29), 22503-11
Heteroduplex mobility assay (HMA) pre-screening: An improved strategy for the rapid identification of inserts selected from phage-displayed peptide libraries; ; ;
in Molecular Diversity (2000), 5(1), 7-12
Placental transfer and decay of maternally acquired antimeasles antibodies in Nigerian children; ; ; ; ;
in Pediatric Infectious Disease Journal (2000), 19(7), 635-641
Contributions of leukemia inhibitory factor receptor and oncostatin M receptor to signal transduction in heterodimeric complexes with glycoprotein 130; ; ; ; ; ;
in Journal of Immunology (2000), 163(12), 6651-8
Villin-like actin-binding proteins are expressed ubiquitously in Arabidopsis.; ; ; ;
in Plant physiology (2000), 122(1), 35-48
Genetic analysis of immunomodulating factors in sporadic Parkinson's disease.; ; ; ; ; ; ; ; ; ; ; ; ; ; ;
in Journal of neural transmission (Vienna, Austria : 1996) (2000), 107(5), 553-62
Genetic analysis of the alpha2-macroglobulin gene in early- and late-onset Parkinson's disease.; ; ; ; ; ; ; ; ; ;
in Neuroreport (2000), 11(11), 2439-42
Involvement of alpha-synuclein in Parkinson's disease and other neurodegenerative disorders.; ;
in Journal of neural transmission (Vienna, Austria : 1996) (2000), 107(1), 31-40
Expression patterns of L-plastin isoform in normal and carcinomatous breast tissues.; ; ; ; ; ; ;
in Anticancer research (2000), 20(5A), 3177-82
Transcriptional modulation of the anti-apoptotic protein BCL-XL by the paired box transcription factors PAX3 and PAX3/FKHR; ; ;
in Oncogene (2000), 19(25), 2921
PCR/SSCP detects reliably and efficiently DNA sequence variations in large scale screening projects.; ; ;
in Combinatorial chemistry & high throughput screening (2000), 3(3), 211-8
Growing an actin gel on spherical surfaces.; ; ; ; ; ;
in Biophysical journal (2000), 78(3), 1643-54
LPP, an actin cytoskeleton protein related to zyxin, harbors a nuclear export signal and transcriptional activation capacity.; ; ; ; ; ; ;
in Molecular biology of the cell (2000), 11(1), 117-29
Genetic influence on the development of Parkinson's disease.; ;
in Journal of neurology (2000), 247 Suppl 2
An MMP-9 mutant without gelatinolytic activity as a novel TIMP-1-antagonist; ; ; ;
in FASEB Journal (2000), 14(12), 1671-3
Extrapyramidal motor signs in degenerative ataxias.; ; ; ; ; ; ;
in Archives of neurology (2000), 57(10), 1495-500
Pertussis toxin-sensitive G(i)-proteins and intracellular calcium sensitivity of vasoconstriction in the intact rat tail artery; ; ; ; ;
in British Journal of Pharmacology (2000), 131(7), 1337-44
Differential inhibition of IL-6-type cytokine-induced STAT activation by PMA; ; ; ; ; ; ;
in FEBS Letters (2000), 478(1-2), 100-4
Termination of IL-6-induced STAT activation is independent of receptor internalization but requires de novo protein synthesis; ; ; ; ; ;
in FEBS Letters (2000), 470(1), 15-9
Mutation analysis and association studies of the UCHL1 gene in German Parkinson's disease patients.; ; ; ; ; ; ; ; ; ; ; ;
in Neuroreport (2000), 11(10), 2079-82
1999
Quantitative measurement of proteins by western blotting with Cy5-coupled secondary antibodies.; ; ;
in BioTechniques (1999), 26(3), 484-6488490
Villin function in the organization of the actin cytoskeleton. Correlation of in vivo effects to its biochemical activities in vitro.; ; ;
in The Journal of biological chemistry (1999), 274(38), 26751-60
Effect of SK&F 96365 on extracellular Ca2+ -dependent O2- production in neutrophil-like HL-60 cells; ;
in European Journal of Pharmacology (1999), 361(2-3), 293-8
The alpha1-antichymotrypsin A-allele in German Parkinson disease patients.; ; ; ; ; ;
in Journal of neural transmission (Vienna, Austria : 1996) (1999), 106(7-8), 729-36
Interleukin-6 and oncostatin M-induced growth inhibition of human A375 melanoma cells is STAT-dependent and involves upregulation of the cyclin-dependent kinase inhibitor p27/Kip1; ; ; ; ; ; ; ;
in Oncogene (1999), 18(25), 3742-53
Analysis of the parkin deletion in sporadic and familial Parkinson's disease. Short communication.; ; ; ; ; ; ; ;
in Journal of neural transmission (Vienna, Austria : 1996) (1999), 106(2), 159-63
Increased susceptibility to sporadic Parkinson's disease by a certain combined alpha-synuclein/apolipoprotein E genotype.; ; ; ; ; ; ; ; ; ; ; ; ;
in Annals of neurology (1999), 45(5), 611-7
Analogues and homologues of N-palmitoylethanolamide, a putative endogenous CB(2) cannabinoid, as potential ligands for the cannabinoid receptors; ; ; ; ; ; ; ;
in Biochimica et Biophysica Acta (1999), 1440(2-3), 266-74
Identification of a Leu-lle internalization motif within the cytoplasmic domain of the leukaemia inhibitory factor receptor; ; ; ; ; ; ; ; ;
in Biochemical Journal (1999), 339 (Pt 1)
Genotypic and antigenic characterization of hemagglutinin proteins of African measles virus isolates; ; ; ; ; ; ; ;
in Virus Research (1999), 62(1), 89-95
Isolation of measles virus from a naturally-immune, asymptomatically re-infected individual;
in Journal of Clinical Virology (1999), 13(3), 173-179
Case report and molecular analysis of subacute sclerosing panencephalitis in a South African child; ; ; ;
in Journal of Clinical Microbiology (1999), 37(3), 775-777
Release of O2- by human umbilical cord blood-derived eosinophils: role of intra- and extracellular calcium; ;
in Cell Calcium (1999), 25(5), 381-9
Selective differentiation and proliferation of human eosinophils from umbilical cord blood: calcium fluxes and superoxide ion secretion;
in Thérapie (1999), 54(1), 103-9
1998
The M2 muscarinic receptor antagonist methoctramine activates mast cells via pertussis toxin-sensitive G proteins; ; ; ;
in Naunyn-Schmiedeberg's Archives of Pharmacology (1998), 357(4), 357-62
Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway; ; ; ;
in Biochemical Journal (1998), 334 (Pt 2)
Partial amplification of the measles virus nucleocapsid gene from stored sera and cerebrospinal fluids for molecular epidemiological studies;
in Journal of Medical Virology (1998), 56(2), 174-177
Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease.; ; ; ; ; ; ; ; ;
in Nature genetics (1998), 18(2), 106-8
Selegiline as immunostimulant--a novel mechanism of action?; ; ;
in Journal of neural transmission. Supplementum (1998), 52
Genetic dissection of familial Parkinson's disease.; ;
in Molecular medicine today (1998), 4(10), 438-44
Distinct involvement of beta3 integrin cytoplasmic domain tyrosine residues 747 and 759 in integrin-mediated cytoskeletal assembly and phosphotyrosine signaling.; ; ; ;
in The Journal of biological chemistry (1998), 273(20), 12623-32
Spinocerebellar ataxia type 6: genotype and phenotype in German kindreds.; ; ; ; ;
in Journal of neurology, neurosurgery, and psychiatry (1998), 64(1), 67-73
Internalization of the interleukin 6 signal transducer gp130 does not require activation of the Jak/STAT pathway; ; ; ; ; ; ;
in Biochemical Journal (1998), 330 (Pt 1)
1997
A single STAT recruitment module in a chimeric cytokine receptor complex is sufficient for STAT activation; ; ; ; ; ; ; ; ;
in Journal of Biological Chemistry (1997), 272(8), 5269-74
Quantification of wild-type mitochondrial DNA and its 4.8-kb deletion in rat organs.; ;
in Biochemical and biophysical research communications (1997), 233(1), 102-7
Structural and functional similarities between the human cytoskeletal protein zyxin and the ActA protein of Listeria monocytogenes.; ; ;
in Journal of cell science (1997), 110 ( Pt 16)
The role of actin binding proteins in epithelial morphogenesis: models based upon Listeria movement.; ;
in Biophysical chemistry (1997), 68(1-3), 73-82
Sequence analysis of the nucleocapsid gene of measles virus isolates from South Africa identifies a new genotype; ;
in Journal of General Virology (The) (1997), 78(7), 1581-1587
Rapid identification of measles virus strains by the heteroduplex mobility assay;
in Virus Research (1997), 47(2), 472197-203
Measles virus transmission from infected to immune individuals - Implications for measles control and elimination; ; ; ;
in South African Medical Journal (1997), 87(12), 1709
Human umbilical cord blood-derived eosinophils cultured in the presence of IL-3 and IL-5 respond to fMLP with [Ca2+]i variation and O2- production; ; ; ;
in Journal of Immunological Methods (1997), 205(1), 1-9
1996
Endothelin-1 does not modulate O2.release and [Ca(2+)]i variations in resting or differentiated HL-60 cells; ;
in Fundamental & Clinical Pharmacology (1996), 10(1), 28-32
Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor; ; ; ; ; ;
in EMBO Journal (1996), 14(22), 5579-88
Selegiline stimulates biosynthesis of cytokines interleukin-1 beta and interleukin-6.; ; ;
in Neuroreport (1996), 7(18), 2847-8
1995
A double-labelling fluorescent assay for concomitant measurements of [Ca2+]i and O2. production in human macrophages; ; ; ;
in Biochimica et Biophysica Acta (1995), 1244(1), 79-84
APO-I-mediated apoptosis in normal and malignant lymphocytes; ; ; ; ; ; ; ; ;
in Biochemical Society Transactions (1995), 22(3), 598-600
Targeting of Listeria monocytogenes ActA protein to the plasma membrane as a tool to dissect both actin-based cell morphogenesis and ActA function.; ; ; ; ;
in The EMBO journal (1995), 14(12), 2731-44
The role of APO-1-mediated apoptosis in the immune system; ; ; ; ; ; ; ; ;
in Immunological Reviews (1995), 142
Conformational behaviour of a synthetic peptide of the C-terminus of villin that interacts with actin: an NMR, CD and stimulated annealing study.; ; ; ; ; ;
in International journal of peptide and protein research (1995), 45(6), 574-86
1994
Functional differences between L- and T-plastin isoforms.; ; ; ;
in The Journal of cell biology (1994), 127(6 Pt 2), 1995-2008
Regulation of apoptosis in the immune system; ; ; ;
in Current Opinion in Immunology (1994), 6(2), 279-89
1993
An epithelial-dependent contracting factor induced by calcium influx in guinea-pig trachea; ; ; ;
in Pulmonary Pharmacology (1993), 6(1), 69-76
Epithelial factors: modulation of the airway smooth muscle tone;
in Fundamental & Clinical Pharmacology (1993), 7(6), 261-73
Structure-activity studies of bradykinin analogues on rat mast cell histamine release; ; ;
in Peptides (1993), 14(4), 685-9
Villin-induced growth of microvilli is reversibly inhibited by cytochalasin D.; ;
in Journal of cell science (1993), 105 ( Pt 3)
1992
Epithelial modulation of thromboxane A2 and PAF involvement in IgE- and IgG-mediated guinea pig anaphylaxis; ;
in Immunopharmacology (1992), 22(2), 115-25
In vivo analysis of functional domains from villin and gelsolin.; ; ;
in The Journal of cell biology (1992), 116(5), 1145-55
An actin-binding site containing a conserved motif of charged amino acid residues is essential for the morphogenic effect of villin.; ; ; ; ; ;
in Cell (1992), 70(1), 81-92
Purification and molecular cloning of the APO-1 cell surface antigen, a member of the tumor necrosis factor/nerve growth factor receptor superfamily. Sequence identity with the Fas antigen; ; ; ; ; ; ; ; ;
in Journal of Biological Chemistry (1992), 267(15), 10709-15
1991
Selective implication of thromboxane A2 and PAF-acether in two guinea pig anaphylactic models; ;
in Agents and Actions. Supplements (1991), 31
Activation of Gi-like proteins, a receptor-independent effect of kinins in mast cells; ; ; ;
in Molecular Pharmacology (1991), 38(6), 816-22
Molecular basis for cellular effects of naturally occurring polyamines; ;
in Agents and Actions (1991), 33(1-2), 84-7
Evidence for the interaction of mast cell-degranulating peptide with pertussis toxin-sensitive G proteins in mast cells; ; ;
in European Journal of Pharmacology (1991), 207(3), 249-55
G-proteins as targets for non-immunological histamine releasers; ; ; ;
in Agents and Actions (1991), 33(1-2), 81-3
Endothelins: functional and autoradiographic studies in guinea pig trachea; ; ; ;
in Journal of Pharmacology and Experimental Therapeutics (1991), 258(1), 381-7
Binding characteristics of [125I]endothelin-1 in guinea-pig trachea and its displacement by endothelin-1, endothelin-3 and endothelin (16-21); ;
in Agents and Actions. Supplements (1991), 31
1990
Overexpression of a Streptomyces viridochromogenes gene (glnII) encoding a glutamine synthetase similar to those of eucaryotes confers resistance against the antibiotic phosphinothricyl-alanyl-alanine; ; ; ;
in Journal of Bacteriology (1990), 172(9), 5326-34
Oxatomide and calcium: mechanisms involved in the secretion of mast cell mediators;
in Annales de Dermatologie et de Vénéréologie (1990), 117 Suppl 1
A pertussis toxin-sensitive G protein is required to induce histamine release from rat peritoneal mast cells by bradykinin; ; ;
in Agents and Actions (1990), 30(1-2), 98-101
From the structure to the function of villin, an actin-binding protein of the brush border.; ; ;
in BioEssays : news and reviews in molecular, cellular and developmental biology (1990), 12(9), 403-8
Neuropeptides and inflammation: presumed mechanisms in neurogenic inflammation; ; ; ;
in Pathologie et Biologie (1990), 38(1), 53-6
G protein activation: a receptor-independent mode of action for cationic amphiphilic neuropeptides and venom peptides; ; ; ;
in Trends in Pharmacological Sciences (1990), 11(9), 358-62
Evidence for the involvement of calcitonin gene-related peptide in the epithelium-dependent contraction of guinea-pig trachea in response to capsaicin; ; ;
in Naunyn-Schmiedeberg's Archives of Pharmacology (1990), 342(2), 177-81
1989
Nedocromil sodium inhibits IgE- and IgG-related antigen-induced contraction in guinea-pig trachea; ;
in International Archives of Allergy and Applied Immunology (1989), 88(4), 439-46
Villin induces microvilli growth and actin redistribution in transfected fibroblasts.; ; ;
in Cell (1989), 59(3), 461-75
Activation of rat peritoneal mast cells by substance P and mastoparan; ; ; ; ;
in Journal of Pharmacology and Experimental Therapeutics (1989), 250(1), 329-35
Contractile activity of the N-acylated C-terminal part of substance P7-11 in guinea pig trachea. Effect of epithelium removal; ; ; ; ; ;
in Naunyn-Schmiedeberg's Archives of Pharmacology (1989), 340(1), 107-10
1987
Arachidonic acid metabolites and airway epithelium-dependent relaxant factor; ; ;
in Journal of Pharmacology and Experimental Therapeutics (1987), 243(1), 310-6
Airway epithelium releases a relaxant factor: demonstration with substance P;
in European Journal of Pharmacology (1987), 132(1), 103-4
