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Publications

2021

Kozar, I., Philippidou, D., Margue, C., Gay, L., Renne, R., & Kreis, S. (2021, March 04). Cross-Linking Ligation and Sequencing of Hybrids (qCLASH) Reveals an Unpredicted miRNA Targetome in Melanoma Cells. Cancers.
Randic, T., Kozar, I., Margue, C., Utikal, J., & Kreis, S. (2021). NRAS mutant melanoma: Towards better therapies. Cancer Treatment Reviews, 99.
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2020

Kirchmeyer, M., Servais, F., Ginolhac, A., Nazarov, P. V., Margue, C., Philippidou, D., Nicot, N., Behrmann, I., Haan, C., & Kreis, S. (2020, September). Systematic transcriptional profiling of responses to STAT1- and STAT3- activating cytokines in different cancer types. Journal of Molecular Biology.
Kozar, I. (2020). From drug resistance mechanisms to microRNA function in melanoma. Unpublished doctoral thesis, University of Luxembourg, ​​Luxembourg.
Walbrecq, G., Lecha, O., Gaigneaux, A., Fougeras, M. R., Philippidou, D., Margue, C., Tetsi Nomigni, M., Bernardin, F., Dittmar, G., Behrmann, I., & Kreis, S. (2020, March 14). Hypoxia-Induced Adaptations of miRNomes and Proteomes in Melanoma Cells and Their Secreted Extracellular Vesicles. Cancers.
Walbrecq, G., Margue, C., Behrmann, I., & Kreis, S. (2020, July 17). Distinct Cargos of Small Extracellular Vesicles Derived from Hypoxic Cells and Their Effect on Cancer Cells. International Journal of Molecular Sciences.
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2019

Fernández-Tussy, P., Fernández-Ramos, D., Lopitz-Otsoa, F., Simón, J., Barbier-Torres, L., Gomez-Santos, B., Nuñez-Garcia, M., Azkargorta, M., Gutiérrez-de Juan, V., Serrano-Macia, M., Rodríguez-Agudo, R., Iruzubieta, P., Anguita, J., Castro, R. E., Champagne, D., Rincón, M., Elortza, F., Arslanow, A., Krawczyk, M., Lammert, F., Kirchmeyer, M., Behrmann, I., Crespo, J., Lu, S., Mato, J., Varela-Rey, M., Aspichueta, P., Cardoso Delgado, T., & Martinez_Chantar, M. (2019, August 16). miR-873-5p targets mitochondrialGNMT-Complex II interface contributing tonon-alcoholic fatty liver disease. Molecular Metabolism.
Kozar, I., Margue, C., Rothengatter, S., Haan, C., & Kreis, S. (2019). Many ways to resistance: How melanoma cells evade targeted therapies. Biochimica et Biophysica Acta - Reviews on Cancer, 1871(2), 313-322.
Margue, C., Philippidou, D., Kozar, I., Cesi, G., Felten, P., Kulms, D., Letellier, E., Haan, C., & Kreis, S. (2019). Kinase inhibitor library screening identifies synergistic drug combinations effective in sensitive and resistant melanoma cells. Journal of Experimental and Clinical Cancer Research, 38(1).
Nazarov, P. V., Wienecke-Baldacchino, A. K., Zinovyev, A., Czerwińska, U., Muller, A., Nashan, D., Dittmar, G., Azuaje, F., & Kreis, S. (2019). Deconvolution of Transcriptomes and miRNomes by Independent Component Analysis Provides Insights Into Biological Processes and Clinical Outcomes of Melanoma Patients. BMC Medical Genomics, 12 (1)(132).
Servais, F., Kirchmeyer, M., Hamdorf, M., Minoungou, W. N., Rose-John, S., Kreis, S., Haan, C., & Behrmann, I. (2019). Modulation of the IL-6 signaling pathway in liver cells by miRNAs targeting gp130, JAK1 and/or STAT3. Molecular Therapy: Nucleic Acids, 16, 419-433.
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2018

Bauer, A. S., Nazarov, P. V., Giese, N. A., Beghelli, S., Heller, A., Greenhalf, W., Costello, E., Muller, A., Bier, M., Strobel, O., Hackert, T., Vallar, L., Scarpa, A., Büchler, M. W., Neoptolemos, J. P., Kreis, S., & Hoheisel, J. D. (2018). Transcriptional variations in the wider peritumoral tissue environment of pancreatic cancer. International Journal of Cancer, 142(5), 1010–1021.
Cesi, G., Philippidou, D., Kozar, I., Kim, Y. J., Bernardin, F., Van Niel, G., Wienecke-Baldacchino, A., Felten, P., Letellier, E., Dengler, S., Nashan, D., Haan, C., & Kreis, S. (2018, October 05). A new ALK isoform transported by extracellular vesicles confers drug resistance to melanoma cells. Molecular Cancer, (17:145).
Genty, J., Tetsi Nomigni, M., Anton, F., & Hanesch, U. (2018). The combination of postnatal maternal separation and social stress in young adulthood does not lead to enhanced inflammatory pain sensitivity and depressionrelated behavior in rats. PLoS ONE, 13(8), 0202599.
Genty, J., Tetsi Nomigni, M., Anton, F., & Hanesch, U. (2018). Maternal separation stress leads to resilience against neuropathic pain in adulthood. Neurobiology of Stress, 8, 21-32.
Genty, J., Tetsi Nomigni, M., Anton, F., & Hanesch, U. (2018). Neonatal maternal separation leads to a dampening of inflammation-related mechanical and thermal hypersensitivity in juvenile rats. Neuroscience Letters, 674, 117-122.
Kirchmeyer, M., Servais, F., Hamdorf, M., Nazarov, P. V., Ginolhac, A., Halder, R., Vallar, L., Glanemann, M., Rubie, C., Lammert, F., Kreis, S., & Behrmann, I. (2018). Cytokine-mediated modulation of the hepatic miRNome: miR-146b-5p is an IL-6-inducible miRNA with multiple targets. Journal of leukocyte biology.
Rolvering, C., Zimmer, A. D., Ginolhac, A., Margue, C., Kirchmeyer, M., Servais, F., Hermanns, H. M., Hergovits, S., Nazarov, P. V., Nicot, N., Kreis, S., Haan, S., Behrmann, I., & Haan, C. (2018). The PD-L1- and IL6-mediated dampening of the IL27/STAT1 anticancer responses are prevented by a-PD-L1 or a-IL6 antibodies. Journal of Leukocyte Biology, 104, 969-985.
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2017

Bongartz, H., Hessenkemper, W., Müller, C., Fensky, M., Fritsch, J., Mandel, K., Behrmann, I., Haan, C., Fischer, T., Feller, S. M., & Schaper, F. (2017). The multi-site docking protein Gab1 is constitutively phosphorylated independent from its recruitment to the plasma membrane in Jak2-V617Fpositive cells and mediates proliferation of human erythroleukaemia cells. Cellular Signalling, 35, 37-47.
Cesi, G., Walbrecq, G., Zimmer, A. D., Kreis, S., & Haan, C. (2017). ROS production induced by BRAF inhibitor treatment rewires metabolic processes affecting cell growth of melanoma cells. Molecular Cancer, 8(june).
Genty, J., Tetsi Nomigni, M., Anton, F., & Hanesch, U. (2017, November 14). Early life stress reduces neuropathic pain in adulthood -is alteration of spinal microglial reactivity critically involved? Poster session presented at Society for neuroscience's meeting 2017, Washington DC.
Kreis, S., Kozar, I., Cesi, G., Margue, C., & Philippidou, D. (2017, April 10). Impact of BRAF kinase inhibitors on the miRNomes and transcriptomes of melanoma cells. Biochimica et Biophysica Acta.
Mgrditchian, T., Arakelian, T., Paggetti, J., Noman, M., Viry, E., Moussay, E., Van Moer, K., Kreis, S., Guerin, C., Buart, S., Robert, C., Borg, C., Vielh, P., Chouaib, S., Berchem, G., & Janji, B. (2017). Targeting autophagy inhibits growth by enhancing NK cells infiltration in a CCL5-dependent manner. Proceedings of the National Academy of Sciences of the United States of America, 114((44)), 9271-E9279.
Rolvering, C., Zimmer, A., Kozar, I., Hermanns, Letellier, E., Vallar, L., Nazarov, P., Nicot, N., Ginolhac, A., Haan, S., Behrmann, I., & Haan, C. (2017, March). Crosstalk between different family members: IL27 recapitulates IFNγ responses in HCC cells, but is inhibited by IL6-type cytokines. BBA Molecular Cell Research, 516-526.
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2016

Battello, N., Zimmer, A. D., Goebel, C., Dong, X., Behrmann, I., Haan, C., Hiller, K., & Wegner, A. (2016). The role of HIF-1 in oncostatin M-dependent metabolic reprogramming of hepatic cells. Cancer and Metabolism, 4, 3.
Casper, M., Krawczyk, M., Behrmann, I., Glanemann, M., & Lammert, F. (2016). Variant PNPLA3 increases the HCC risk: prospective study in patients treated at the Saarland University Medical Center. Zeitschrift für Gastroenterologie, 54, 585-586.
Cesi, G., Walbrecq, G., Margue, C., & Kreis, S. (2016). Transferring intercellular signals and traits between cancer cells: extracellular vesicles as "homing pigeons". Cell Communication and Signaling, 14(1), 13.
Heulot, M., Chevalier, N., Puyal, J., Margue, C., Michel, S., Kreis, S., Kulms, D., Barras, D., Nahimana, A., & Widmann, C. (2016). The TAT-RasGAP317-326 anti-cancer peptide can kill in a caspase-, apoptosis-, and necroptosis-independent manner. Oncotarget, 7(39).
Keller, A., Kreis, S., Leidinger, P., Maixner, F., Ludwig, N., Backes, C., Galata, V., Guerriero, G., Fehlmann, T., Franke, A., Meder, B., Zink, A., & Meese, E. (2016). miRNAs in ancient tissue specimens of the Tyrolean Iceman. Molecular Biology and Evolution, 34(4), 793-801.
Reinsbach, S., Wienecke, A., Ginolhac, A., Vallar, L., Krishna, Krishna, A., Nazarov, P., May, P., & Kreis, S. (2016). “Melanomics”: analysis and integration of whole genomes, transcriptomes and miRNomes of primary melanoma patients. European Journal of Cancer, 61(Suppl.1), 32.
Zimmer, A. D., Walbrecq, G., Kozar, I., Behrmann, I., & Haan, C. (2016). Phosphorylation of the PDH complex precedes HIF-1-mediated effects and PDK1 upregulation during the first hours of hypoxic treatment in HCC cells. Hypoxia, 4, 135-145.
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2015

Behrmann, I., Margue, C., & Kreis, S. (2015, July). Circulating microRNAs as candidate biomarkers for the surveillance of melanoma patients. EBioMedicine.
Haan, S., Bahlawane, C., Wang, J., Nazarov, P. V., Muller, A., Eulenfeld, R., Haan, C., Rolvering, C., Vallar, L., Satagopam, V., Sauter, T., & Wiesinger, M. (2015). The oncogenic FIP1L1-PDGFRalpha fusion protein displays skewed signaling properties compared to its wild-type PDGFRalpha counterpart. JAK-STAT, 4(1), 1062596.
Kaysen, A., Buschart, A., May, P., Laczny, C. C., Narayanasamy, S., Graf, N., Simon, A., Bittenbring, J., Kreis, S., Schneider, J., & Wilmes, P. (2015, June). Dynamic change of host gastrointestinal microbiome and immune status in relation to mucosal barrier effects during chemotherapy and immune ablative intervention in humans. Poster session presented at The Human Microbiome, Heidelberg, Germany.
Kaysen, A., Heintz, A., Lebrun, L., Graf, N., Simon, A., Bittenbring, J., Kreis, S., Schneider, J., & Wilmes, P. (2015, March). Changes in the human gastrointestinal microbiome during cancer treatments. Poster session presented at 5th International Human Microbiome Congress, Luxembourg-City, Luxembourg.
Margue, C., Reinsbach, S., Philippidou, D., Beaume, N., Walters, C., Schneider, J., Nashan, D., Behrmann, I., & Kreis, S. (2015). Comparison of a healthy miRNome with melanoma patient miRNomes: are microRNAs suitable serum biomarkers for cancer? Oncotarget, 6(14), 12110-27.
Servais, F., Kirchmeyer, M., Hamdorf, M., Haan, C., Casper, M., Lammert, F., Nazarov, P., Vallar, L., Kreis, S., & Behrmann, I. (2015). ID: 194: Role of microRNAs in signal transduction pathways of the inflammatory cytokine Interleukin-6: Relevance for liver diseases. Cytokine, 76(1), 99.
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2014

Kaysen, A., Heintz, A., Lebrun, L., Graf, N., Simon, A., Bittenbring, J., Kreis, S., Schneider, J., & Wilmes, P. (2014, April). Dynamic change of host gastrointestinal microbiome and immune status in relation to mucosal barrier effects during chemotherapy and immune ablative intervention in humans. Poster session presented at Exploring Human Host-Microbiome Interactions in Health and Disease.
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2013

Gäbler, K., Behrmann, I., & Haan, C. (2013). JAK2 mutants (e.g., JAK2V617F) and their importance as drug targets in myeloproliferative neoplasms. JAK-STAT, 2(3), 25025.
Gäbler, K., Rolvering, C., Kaczor, J., Eulenfeld, R., Méndez, S. A., Berchem, G., Palissot, V., Behrmann, I., & Haan, C. (2013). Cooperative effects of Janus and Aurora kinase inhibition by CEP701 in cells expressing Jak2V617F. Journal of Cellular and Molecular Medicine, 17(2), 265-276.
Haan, C., & Haan, S. (2013). Co-immunoprecipitation protocol to investigate cytokine receptor-associated proteins, e.g., Janus kinases or other associated signaling proteins. Methods in Molecular Biology, 967, 21-38.
Haan, S., & Haan, C. (2013). Detection of activated STAT species using electrophoretic mobility shift assay (EMSA) and potential pitfalls arising from the use of detergents. Methods in Molecular Biology, 967, 147-59.
Margue, C., Philippidou, D., Reinsbach, S., Schmitt, M., Behrmann, I., & Kreis, S. (2013). New Target Genes of MITF-Induced microRNA-211 Contribute to Melanoma Cell Invasion. PLoS ONE, 8(9).
Nazarov, P. V. A., Reinsbach, S., Muller, A. A., Nicot, N. A., Philippidou, D., Vallar, L. A., & Kreis, S. (2013). Interplay of microRNAs, transcription factors and target genes: Linking dynamic expression changes to function. Nucleic Acids Research, 41(5), 2817-2831.
Wolf, A., Eulenfeld, R., Gäbler, K., Rolvering, C., Haan, S., Behrmann, I., Denecke, B., Haan, C., & Schaper, F. (2013). JAK2-V617F-induced MAPK activity is regulated by PI3K and acts synergistically with PI3K on the proliferation of JAK2-V617F-positive cells. JAK-STAT, 2(3), 24574.
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2012

Haan, C., Ungureanu, D., Pekkala, T., Silvennoinen, O., & Haan, S. (2012). Regulation of JAKs: Insights gleaned from the functional protein domains. In T., Decker & M., Müller (Eds.), JAK-STAT Signaling – From Basics to Disease (pp. 5-25). Wien, Austria: Springer-Verlag.
Reinsbach, S., Nazarov, P. V., Philippidou, D., Schmitt, M., Wienecke, A., Muller, A., Vallar, L., Behrmann, I., & Kreis, S. (2012). Dynamic regulation of microRNA expression following interferonγ- induced gene transcription. RNA Biology, 9(7), 987-989.
Schmitt, M. J., Philippidou, D., Reinsbach, S., Margue, C., Wienecke-Baldacchino, A., Nashan, D., Behrmann, I., & Kreis, S. (2012). Interferon-γ-induced activation of Signal Transducer and Activator of Transcription 1 (STAT1) up-regulates the tumor suppressing microRNA-29 family in melanoma cells. Cell Communication and Signaling, 10.
Schmitt, M., Margue, C., Behrmann, I., & Kreis, S. (2012). MiRNA-29: A microRNA family with tumor-suppressing and immune-modulating properties. Current Molecular Medicine, 13(4), 572-585.
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2011

Haan, C., Rolvering, C., Raulf, F., Kapp, M., Drückes, P., Thoma, G., Behrmann, I., & Zerwes, H.-G. (2011). Jak1 has a dominant role over Jak3 in signal transduction through γc-containing cytokine receptors. Chemistry and Biology, 18(3), 314-323.
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2010

Entschladen, F., Altschmied, J., Baumgrass, R., Behrmann, I., Giehl, K., Hermanns, H., Huber, O., Kieser, A., Klotz, L.-O., Kubatzky, K. F., Hass, R., Janssen, O., & Friedrich, K. (2010). Signal transduction, receptors, mediators and genes: Younger than ever - The 13th meeting of the Signal Transduction Society focused on aging and immunology. Cell Communication and Signaling, 8.
Haan, C., Behrmann, I., & Haan, S. (2010). Perspectives for the use of structural information and chemical genetics to develop inhibitors of Janus kinases. Journal of Cellular and Molecular Medicine, 14(3), 504-27.
Margue, C., & Kreis, S. (2010). IL-24: Physiological and supraphysiological effects on normal and malignant cells. Current Medicinal Chemistry, 17(29), 3318-3326.
Philippidou, D., Schmitt, M., Moser, D., Margue, C., Nazarov, P. V., Muller, A., Vallar, L., Nashan, D., Behrmann, I., & Kreis, S. (2010). Signatures of MicroRNAs and selected MicroRNA target genes in human melanoma. Cancer Research, 70(10), 4163-4173.
Radtke, S., Wüller, S., Yang, X.-P., Lippok, B. E., Mütze, B., Mais, C., Schmitz-Van De Leur, H., Bode, J. G., Gaestel, M., Heinrich, P. C., Behrmann, I., Schaper, F. A., & Hermanns, H. M. (2010). Cross-regulation of cytokine signalling: Pro-inflammatory cytokines restrict IL-6 signalling through receptor internalisation and degradation. Journal of Cell Science, 123(6), 947-959.
Vollmer, S., Haan, C., & Behrmann, I. (2010). Oncostatin M up-regulates the ER chaperone Grp78/BiP in liver cells. Biochemical Pharmacology, 80(12), 2066-2073.
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2009

Bender, H., Wiesinger, M., Nordhoff, C., Schoenherr, C., Haan, C., Ludwig, S., Weiskirchen, R., Kato, N., Heinrich, P. C., & Haan, S. (2009). Interleukin-27 displays interferon-gamma-like functions in human hepatoma cells and hepatocytes. Hepatology, 50(2), 585-91.
Friedrich, K., & Behrmann, I. (2009). Zelluläre Signalprozesse. Biochemie und Molekularbiologie des Menschen (pp. 631-669). DE: Elsevier.
Haan, C., Kroy, D. C., Wüller, S., Sommer, U., Nöcker, T., Rolvering, C., Behrmann, I., Heinrich, P. C., & Haan, S. (2009). An unusual insertion in Jak2 is crucial for kinase activity and differentially affects cytokine responses. Journal of Immunology, 182(5), 2969-2977.
Haan, S., Wuller, S., Kaczor, J., Rolvering, C., Nocker, T., Behrmann, I., & Haan, C. (2009). SOCS-mediated downregulation of mutant Jak2 (V617F, T875N and K539L) counteracts cytokine-independent signaling. Oncogene, 28(34), 3069-80.
Hintzen, C., Haan, C., Tuckermann, J. P., Heinrich, P. C., & Hermanns, H. M. (2009). Oncostatin M-induced and constitutive activation of the JAK2/STAT5/CIS pathway suppresses CCL1, but not CCL7 and CCL8, chemokine expression. Journal of Immunology, 181(10), 7341-7349.
Vollmer, S., Kappler, V., Kaczor, J., Flügel, D., Rolvering, C., Kato, N., Kietzmann, T., Behrmann, I., & Haan, C. (2009). Hypoxia-inducible factor 1alpha is up-regulated by oncostatin M and participates in oncostatin M signaling. Hepatology, 2009(3).
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2008

Haan, S., Margue, C., Engrand, A., Rolvering, C., Schmitz-Van de Leur, H., Heinrich, P. C., Behrmann, I., & Haan, C. (2008). Dual role of the Jak1 FERM and kinase domains in cytokine receptor binding and in stimulation-dependent Jak activation. Journal of Immunology, 180(2), 998-1007.
Kreis, S., Munz, G. A., Haan, S., Heinrich, P. C., & Behrmann, I. (2008). Cell density dependent increase of constitutive signal transducers and activators of transcription 3 activity in melanoma cells is mediated by Janus kinases. Molecular Cancer Research, 5(12), 1331-41.
Kreis, S., Philippidou, D., Margue, C., & Behrmann, I. (2008). IL-24: a classic cytokine and/or a potential cure for cancer? Journal of Cellular and Molecular Medicine, 12(6A), 2505-2510.
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2007

Haan, C., & Behrmann, I. (2007). A cost effective non-commercial ECL-solution for Western blot detections yielding strong signals and low background. Journal of Immunological Methods, 318(1-2), 11-9.
Komyod, W., Böhm, M., Metze, D., Heinrich, P. C., & Behrmann, I. (2007). Constitutive suppressor of cytokine signaling 3 expression confers a growth advantage to a human melanoma cell line. Molecular Cancer Research, 5(3), 271-81.
Kreis, S., Philippidou, D., Margue, C., Rolvering, C., Haan, C., Dumoutier, L., Renauld, J.-C., & Behrmann, I. (2007). Recombinant interleukin-24 lacks apoptosis-inducing properties in melanoma cells. PLoS ONE, 2(12), 1300.
Schmitz, M., Grignard, G., Margue, C., Dippel, W., Capesius, C., Mossong, J., Nathan, M., Giacchi, S., Scheiden, R., & Kieffer, N. (2007). Complete loss of PTEN expression as a possible early prognostic marker for prostate cancer metastasis. International Journal of Cancer, 120(6), 1284-92.
Soond, S. M., Carroll, C., Townsend, P. A., Sayan, E., Melino, G., Behrmann, I., Knight, R. A., Latchman, D. S., & Stephanou, A. (2007). STAT1 regulates p73-mediated Bax gene expression. FEBS Letters, 581(6), 1217-26.
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2006

Haan, C., Kreis, S., Margue, C., & Behrmann, I. (2006). Jaks and cytokine receptors - an intimate relationship. Biochemical Pharmacology, 72(11), 1538-46.
Radtke, S., Jörissen, A., de Leur, H. S., Heinrich, P. C., & Behrmann, I. (2006). Three dileucine-like motifs within the interbox1/2 region of the human oncostatin M receptor prevent efficient surface expression in the absence of an associated Janus kinase. Journal of Biological Chemistry, 281(7), 4024-34.
van Roeyen, C. R., Ostendorf, T., Denecke, B., Bokemeyer, D., Behrmann, I., Strutz, F., Lichenstein, H. S., LaRochelle, W. J., Pena, C. E., Chaudhuri, A., & Floege, J. (2006). Biological responses to PDGF-BB versus PDGF-DD in human mesangial cells. Kidney International, 69(8), 1393-402.
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2005

Haan, S., Keller, J. F., Behrmann, I., Heinrich, P. C., & Haan, C. (2005). Multiple reasons for an inefficient STAT1 response upon IL-6-type cytokine stimulation. Cellular Signalling, 17(12), 1542-50.
Hellerbrand, C., Mühlbauer, M., Wallner, S., Schuierer, M., Behrmann, I., Bataille, F., Weiss, T., Schölmerich, J., & Bosserhoff, A. K. (2005). Promoter-hypermethylation is causing functional relevant downregulation of methylthioadenosine phosphorylase (MTAP) expression in hepatocellular carcinoma. Carcinogenesis, 27(1), 64-72.
Komyod, W., Bauer, U. M., Heinrich, P. C., Haan, S., & Behrmann, I. (2005). Are STATS arginine-methylated? Journal of Biological Chemistry, 280(23), 21700-5.
Kreis, S., Schönfeld, H.-J. B., Melchior, C. A., Steiner, B. B. C., & Kieffer, N. A. (2005). The intermediate filament protein vimentin binds specifically to a recombinant integrin α2/β1 cytoplasmic tail complex and co-localizes with native α2/β1 in endothelial cell focal adhesions. Experimental Cell Research, 305(1), 110-121.
Radtke, S.* , Haan, S.* , Jörissen, A.* , Hermanns, H. M., Diefenbach, S., Smyczek, T., Schmitz-Vandeleur, H., Heinrich, P. C., Behrmann, I., & Haan, C. (2005). The Jak1 SH2 domain does not fulfill a classical SH2 function in Jak/STAT signaling but plays a structural role for receptor interaction and up-regulation of receptor surface expression. Journal of Biological Chemistry, 280(27), 25760-8.
* These authors have contributed equally to this work.
Wellbrock, C., Weisser, C., Hassel, J. C., Fischer, P., Becker, J., Vetter, C. S., Behrmann, I., Kortylewski, M., Heinrich, P. C., & Schartl, M. (2005). STAT5 contributes to interferon resistance of melanoma cells. Current Biology, 15(18), 1629-39.
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2004

Behrmann, I., Smyczek, T., Heinrich, P. C., Schmitz-Van de Leur, H., Komyod, W., Giese, B., Muller-Newen, G., Haan, S., & Haan, C. (2004). Janus kinase (Jak) subcellular localization revisited: the exclusive membrane localization of endogenous Janus kinase 1 by cytokine receptor interaction uncovers the Jak.receptor complex to be equivalent to a receptor tyrosine kinase. Journal of Biological Chemistry, 279(34), 35486-93.
Fischer, P., Lehmann, U., Sobota, R. M., Schmitz, J., Niemand, C., Linnemann, S., Haan, S., Behrmann, I., Yoshimura, A., Johnston, J. A., Müller-Newen, G., Heinrich, P. C., & Schaper, F. (2004). The role of the inhibitors of interleukin-6 signal transduction SHP2 and SOCS3 for desensitization of interleukin-6 signalling. Biochemical Journal, 378(Pt 2), 449-60.
Kortylewski, M., Komyod, W., Kauffmann, M. E., Bosserhoff, A. K., Heinrich, P. C., & Behrmann, I. (2004). Interferon-gamma-mediated growth regulation of melanoma cells: involvement of STAT1-dependent and STAT1-independent signals. Journal of Investigative Dermatology, 122(2), 414-22.
Tremuth, L. A., Kreis, S., Melchior, C., Hoebeke, J., Rondé, P., Plançon, S., Takeda, K., & Kieffer, N. (2004). A fluorescence cell biology approach to map the second integrin-binding site of talin to a 130-amino acid sequence within the rod domain. Journal of Biological Chemistry, 279(21), 22258-22266.
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2003

Behrmann, I., Wallner, S., Komyod, W., Heinrich, P. C., Schuierer, M., Buettner, R., & Bosserhoff, A. K. (2003). Characterization of methylthioadenosin phosphorylase (MTAP) expression in malignant melanoma. American Journal of Pathology, 163(2), 683-90.
Giese, B., Au-Yeung, C. K., Herrmann, A., Diefenbach, S., Haan, C., Küster, A., Wortmann, S. B., Roderburg, C., Heinrich, P. C., Behrmann, I., & Müller-Newen, G. (2003). Long term association of the cytokine receptor gp130 and the Janus kinase Jak1 revealed by FRAP analysis. Journal of Biological Chemistry, 278(40), 39205-13.
Kortylewski, M., Feld, F., Krüger, K. D., Bahrenberg, G., Roth, R. A., Joost, H. G., Heinrich, P. C., Behrmann, I., & Barthel, A. (2003). Akt modulates STAT3-mediated gene expression through a FKHR (FOXO1a)-dependent mechanism. Journal of Biological Chemistry, 278(7), 5242-9.
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2002

Bahrenberg, G., Behrmann, I., Barthel, A., Hekerman, P., Heinrich, P. C., Joost, H. G., & Becker, W. (2002). Identification of the critical sequence elements in the cytoplasmic domain of leptin receptor isoforms required for Janus kinase/signal transducer and activator of transcription activation by receptor heterodimers. Molecular Endocrinology, 16(4), 859-72.
Greiser, J. S., Stross, C., Heinrich, P. C., Behrmann, I., & Hermanns, H. M. (2002). Orientational constraints of the gp130 intracellular juxtamembrane domain for signaling. Journal of Biological Chemistry, 277(30), 26959-65.
Lehmann, U., Schmitz, J., Weissenbach, M., Sobota, R. M., Hortner, M., Friederichs, K., Behrmann, I., Tsiaris, W., Sasaki, A., Schneider-Mergener, J., Yoshimura, A., Neel, B. G., Heinrich, P. C., & Schaper, F. (2002). SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130. Journal of Biological Chemistry, 278(1), 661-71.
Melchior, C. A., Kreis, S., Janji, B. B., & Kieffer, N. A. (2002). Promoter characterization and genomic organization of the gene encoding integrin-linked kinase 1. Biochimica et Biophysica Acta-Gene Structure and Expression, 1575(1-3), 117-122.
Pecheur, I., Peyruchaud, O., Serre, C.-M., Guglielmi, J., Voland, C., Bourre, F., Margue, C., Cohen-Solal, M., Buffet, A., Kieffer, N., & Clezardin, P. (2002). Integrin alpha(v)beta3 expression confers on tumor cells a greater propensity to metastasize to bone. FASEB Journal, 16(10), 1266-8.
Radtke, S., Hermanns, H. M., Haan, C., Schmitz-Van De Leur, H., Gascan, H., Heinrich, P. C., & Behrmann, I. (2002). Novel role of Janus kinase 1 in the regulation of oncostatin M receptor surface expression. Journal of Biological Chemistry, 277(13), 11297-305.
Roeb, E., Schleinkofer, K., Kernebeck, T., Pötsch, S., Jansen, B., Behrmann, I., Matern, S., & Grötzinger, J. (2002). The matrix metalloproteinase 9 (mmp-9) hemopexin domain is a novel gelatin binding domain and acts as an antagonist. Journal of Biological Chemistry, 277(52), 50326-32.
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2001

Böhm, M., Schulte, U., Funk, J. O., Raghunath, M., Behrmann, I., Kortylewski, M., Heinrich, P. C., Kues, T., Luger, T. A., & Schwarz, T. (2001). Interleukin-6-resistant melanoma cells exhibit reduced activation of STAT3 and lack of inhibition of cyclin E-associated kinase activity. Journal of Investigative Dermatology, 117(1), 132-40.
Haan, C., Heinrich, P. C., & Behrmann, I. (2001). Structural requirements of the interleukin-6 signal transducer gp130 for its interaction with Janus kinase 1: the receptor is crucial for kinase activation. Biochemical Journal, 361(Pt 1), 105-11.
Haan, C., Hermanns, H. M., Heinrich, P. C., & Behrmann, I. (2001). A single amino acid substitution (Trp(666)-->Ala) in the interbox1/2 region of the interleukin-6 signal transducer gp130 abrogates binding of JAK1, and dominantly impairs signal transduction. Biochemical Journal, 349(Pt 1), 261-6.
Haan, C., Isharc, H., Hermanns, H. M., Schmitz-Van De Leur, H., Kerr, I. M., Heinrich, P. C., Grötzinger, J., & Behrmann, I. (2001). Mapping of a region within the N terminus of Jak1 involved in cytokine receptor interaction. Journal of Biological Chemistry, 276(40), 37451-8.
Hermanns, H. M., Radtke, S., Schaper, F., Heinrich, P. C., & Behrmann, I. (2001). Non-redundant signal transduction of interleukin-6-type cytokines. The adapter protein Shc is specifically recruited to rhe oncostatin M receptor. Journal of Biological Chemistry, 275(52), 40742-8.
Hilkens, C. M., Isharc, H., Lillemeier, B. F., Strobl, B., Bates, P. A., Behrmann, I., & Kerr, I. M. (2001). A region encompassing the FERM domain of Jak1 is necessary for binding to the cytokine receptor gp130. FEBS Letters, 505(1), 87-91.
Kortylewski, M., Heinrich, P. C., Kauffmann, M. E., Böhm, M., MacKiewicz, A., & Behrmann, I. (2001). Mitogen-activated protein kinases control p27/Kip1 expression and growth of human melanoma cells. Biochemical Journal, 357(Pt 1), 297-303.
Kortylewski, M., Heinrich, P. C., Mackiewicz, A., & Behrmann, I. (2001). Cytokine-mediated growth inhibition of human melanoma cells. Advances in Experimental Medicine and Biology, 495, 169-72.
Kube, D., Holtick, U., Vockerodt, M., Ahmadi, T., Haier, B., Behrmann, I., Heinrich, P. C., Diehl, V., & Tesch, H. (2001). STAT3 is constitutively activated in Hodgkin cell lines. Blood, 98(3), 762-70.
Strobl, B., Arulampalam, V., Isharc, H., Newman, S. J., Schlaak, J. F., Watling, D., Costa-Pereira, A. P., Schaper, F., Behrmann, I., Sheehan, K. C., Schreiber, R. D., Horn, F., Heinrich, P. C., & Kerr, I. M. (2001). A completely foreign receptor can mediate an interferon-gamma-like response. EMBO Journal, 20(19), 5431-42.
Zabeau, L., Van der Heyden, J., Broekaert, D., Verhee, A., Vandekerckhove, J., Wu, S. J., Chaiken, I., Heinrich, P., Behrmann, I., & Tavernier, J. (2001). Neutralizing monoclonal antibodies can potentiate IL-5 signaling. European Journal of Immunology, 31(4), 1087-97.
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2000

Anhuf, D., Weissenbach, M., Schmitz, J., Sobota, R., Hermanns, H. M., Radtke, S., Linnemann, S., Behrmann, I., Heinrich, P. C., & Schaper, F. (2000). Signal transduction of IL-6, leukemia-inhibitory factor, and oncostatin M: structural receptor requirements for signal attenuation. Journal of Immunology, 165(5), 2535-43.
Behrmann, I., Hermanns, H. M., Haan, C., Kortylewski, M., Radtke, S., Greiser, J. S., & Heinrich, P. C. (2000). Signalling of interleukin-6 type cytokines via gp130, leukemia inhibitory factor (LIF) receptor and oncostatin M receptor. European Cytokine Network, 11(3), 491-2.
Fack, F., Deroo, S., Kreis, S., & Muller, C. (2000). Heteroduplex mobility assay (HMA) pre-screening: An improved strategy for the rapid identification of inserts selected from phage-displayed peptide libraries. Molecular Diversity, 5(1), 7-12.
Hartter, H. K., Oyedele, O. I., Dietz, K., Kreis, S., Hoffman, J. P., & Muller, C. (2000). Placental transfer and decay of maternally acquired antimeasles antibodies in Nigerian children. Pediatric Infectious Disease Journal, 19(7), 635-641.
Hermanns, H. M., Radtke, S., Haan, C., Schmitz-Van de Leur, H., Tavernier, J., Heinrich, P. C., & Behrmann, I. (2000). Contributions of leukemia inhibitory factor receptor and oncostatin M receptor to signal transduction in heterodimeric complexes with glycoprotein 130. Journal of Immunology, 163(12), 6651-8.
Margue, C., Bernasconi, M., Barr, F., & Schäfer, B. (2000). Transcriptional modulation of the anti-apoptotic protein BCL-XL by the paired box transcription factors PAX3 and PAX3/FKHR. Oncogene, 19(25), 2921.
Roeb, E., Behrmann, I., Grötzinger, J., Breuer, B., & Matern, S. (2000). An MMP-9 mutant without gelatinolytic activity as a novel TIMP-1-antagonist. FASEB Journal, 14(12), 1671-3.
Terstegen, L., Maassen, B. G., Radtke, S., Behrmann, I., Schaper, F., Heinrich, P. C., Graeve, L., & Gatsios, P. (2000). Differential inhibition of IL-6-type cytokine-induced STAT activation by PMA. FEBS Letters, 478(1-2), 100-4.
Thiel, S., Sommer, U., Kortylewski, M., Haan, C., Behrmann, I., Heinrich, P. C., & Graeve, L. (2000). Termination of IL-6-induced STAT activation is independent of receptor internalization but requires de novo protein synthesis. FEBS Letters, 470(1), 15-9.
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1999

Kortylewski, M., Heinrich, P. C., Mackiewicz, A., Schniertshauer, U., Klingmüller, U., Nakajima, K., Hirano, T., Horn, F., & Behrmann, I. (1999). Interleukin-6 and oncostatin M-induced growth inhibition of human A375 melanoma cells is STAT-dependent and involves upregulation of the cyclin-dependent kinase inhibitor p27/Kip1. Oncogene, 18(25), 3742-53.
Thiel, S., Behrmann, I., Timmermann, A., Dahmen, H., Müller-Newen, G., Schaper, F., Tavernier, J., Pitard, V., Heinrich, P. C., & Graeve, L. (1999). Identification of a Leu-lle internalization motif within the cytoplasmic domain of the leukaemia inhibitory factor receptor. Biochemical Journal, 339 (Pt 1), 15-9.
Truong, A. T., Kreis, S., Ammerlaan, W., Hartter, H. K., Adu, F., Omilabu, S. A., Oyefolu, A. O., Berbers, G. A. M., & Muller, C. (1999). Genotypic and antigenic characterization of hemagglutinin proteins of African measles virus isolates. Virus Research, 62(1), 89-95.
Vardas, E. A. B., & Kreis, S. (1999). Isolation of measles virus from a naturally-immune, asymptomatically re-infected individual. Journal of Clinical Virology, 13(3), 173-179.
Vardas, E. A. D., Leary, P. M. B., Yeats, J. C., Badrodien, W. B., & Kreis, S. (1999). Case report and molecular analysis of subacute sclerosing panencephalitis in a South African child. Journal of Clinical Microbiology, 37(3), 775-777.
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1998

Heinrich, P. C., Behrmann, I., Müller-Newen, G., Schaper, F., & Graeve, L. (1998). Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway. Biochemical Journal, 334 (Pt 2), 297-314.
Kreis, S., & Schoub, B. D. (1998). Partial amplification of the measles virus nucleocapsid gene from stored sera and cerebrospinal fluids for molecular epidemiological studies. Journal of Medical Virology, 56(2), 174-177.
Thiel, S., Behrmann, I., Dittrich, E., Muys, L., Tavernier, J., Wijdenes, J., Heinrich, P. C., & Graeve, L. (1998). Internalization of the interleukin 6 signal transducer gp130 does not require activation of the Jak/STAT pathway. Biochemical Journal, 330 (Pt 1), 47-54.
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1997

Behrmann, I., Janzen, C., Gerhartz, C., Schmitz-Van de Leur, H., Hermanns, H., Heesel, B., Graeve, L., Horn, F., Tavernier, J., & Heinrich, P. C. (1997). A single STAT recruitment module in a chimeric cytokine receptor complex is sufficient for STAT activation. Journal of Biological Chemistry, 272(8), 5269-74.
Filser, N., Margue, C., & Richter, C. (1997). Quantification of wild-type mitochondrial DNA and its 4.8-kb deletion in rat organs. Biochemical and biophysical research communications, 233(1), 102-7.
Kreis, S., Vardas, E., & Whistler, T. (1997). Sequence analysis of the nucleocapsid gene of measles virus isolates from South Africa identifies a new genotype. Journal of General Virology, 78(7), 1581-1587.
Kreis, S., & Whistler, T. (1997). Rapid identification of measles virus strains by the heteroduplex mobility assay. Virus Research, 47(2), 47(2):197-203.
Vardas, E., Andre, M., Kreis, S., Zachariades, N., & Schoub, B. (1997). Measles virus transmission from infected to immune individuals - Implications for measles control and elimination. South African Medical Journal, 87(12), 1709.
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1996

Kischkel, F. C., Hellbardt, S., Behrmann, I., Germer, M., Pawlita, M., Krammer, P. H., & Peter, M. E. (1996). Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor. EMBO Journal, 14(22), 5579-88.
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1995

Behrmann, I., Walczak, H., & Krammer, P. H. (1995). Structure of the human APO-1 gene. European Journal of Immunology, 24(12), 3057-62.
Dhein, J., Behrmann, I., Daniel, P. T., Debatin, K. M., Klas, C., Möller, P., Oehm, A., Trauth, B. C., Walczak, H., & Krammer, P. H. (1995). APO-I-mediated apoptosis in normal and malignant lymphocytes. Biochemical Society Transactions, 22(3), 598-600.
Krammer, P. H., Dhein, J., Walczak, H., Behrmann, I., Mariani, S., Matiba, B., Fath, M., Daniel, P. T., Knipping, E., & Westendorp, M. O. (1995). The role of APO-1-mediated apoptosis in the immune system. Immunological Reviews, 142, 175-91.
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1994

Krammer, P. H., Behrmann, I., Daniel, P. T., Dhein, J., & Debatin, K. M. (1994). Regulation of apoptosis in the immune system. Current Opinion in Immunology, 6(2), 279-89.
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1992

Oehm, A., Behrmann, I., Falk, W., Pawlita, M., Maier, G., Klas, C., Li-Weber, M., Richards, S., Dhein, J., & Trauth, B. C. (1992). Purification and molecular cloning of the APO-1 cell surface antigen, a member of the tumor necrosis factor/nerve growth factor receptor superfamily. Sequence identity with the Fas antigen. Journal of Biological Chemistry, 267(15), 10709-15.
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1990

Behrmann, I., Hillemann, D., Pühler, A., Strauch, E., & Wohlleben, W. (1990). Overexpression of a Streptomyces viridochromogenes gene (glnII) encoding a glutamine synthetase similar to those of eucaryotes confers resistance against the antibiotic phosphinothricyl-alanyl-alanine. Journal of Bacteriology, 172(9), 5326-34.
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